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Article ; Online: Application and evaluation of topical amphotericin B for the treatment of respiratory fungal infections.

Cui, Ning / Zhao, Jingming

2024 Volume 24, Issue 1, Page(s) 439

Abstract: Background: In recent years, the prevalence of respiratory fungal diseases has increased. Polyene antifungal drugs play a pivotal role in the treatment of these conditions, with amphotericin B (AmB) being the most representative drug. This study aimed ... ...

Abstract	Background: In recent years, the prevalence of respiratory fungal diseases has increased. Polyene antifungal drugs play a pivotal role in the treatment of these conditions, with amphotericin B (AmB) being the most representative drug. This study aimed to evaluate the efficacy and safety of topical administration of AmB in the treatment of respiratory fungal infections. Methods: We conducted a retrospective study on hospitalized patients treated with topical administered AmB for respiratory fungal infections from January 2014 to June 2023. Results: Data from 36 patients with invasive pulmonary fungal infections treated with topical administration of AmB were collected and analyzed. Nebulization was administered to 27 patients. After the treatment, 17 patients evidenced improved conditions, whereas 10 patients did not respond and died in the hospital. One patient experienced an irritating cough as an adverse reaction. Seven patients underwent tracheoscopic instillation, and two received intrapleural irrigation; they achieved good clinical therapeutic efficacy without adverse effects. Conclusion: The combined application of systemic antifungal treatment and topical administration of AmB yielded good therapeutic efficacy and was well-tolerated by the patients. Close monitoring of routine blood tests, liver and kidney function, and levels of electrolytes, troponin, and B-type natriuretic peptide supported this conclusion.
MeSH term(s)	Humans ; Amphotericin B/administration & dosage ; Amphotericin B/therapeutic use ; Amphotericin B/adverse effects ; Male ; Female ; Retrospective Studies ; Middle Aged ; Antifungal Agents/administration & dosage ; Antifungal Agents/therapeutic use ; Antifungal Agents/adverse effects ; Aged ; Administration, Topical ; Adult ; Treatment Outcome ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/microbiology ; Aged, 80 and over ; Lung Diseases, Fungal/drug therapy ; Young Adult
Chemical Substances	Amphotericin B (7XU7A7DROE) ; Antifungal Agents
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09342-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The crosstalk between exosomes and ferroptosis: a review.

Wu, Jiao / Li, Zhongyu / Wu, Yu / Cui, Ning

Cell death discovery

2024 Volume 10, Issue 1, Page(s) 170

Abstract: Exosomes are a subtype of extracellular vesicles composed of bioactive molecules, including nucleic acids, proteins, and lipids. Exosomes are generated by the fusion of intracellular multivesicular bodies (MVBs) with the cell membrane and subsequently ... ...

Abstract	Exosomes are a subtype of extracellular vesicles composed of bioactive molecules, including nucleic acids, proteins, and lipids. Exosomes are generated by the fusion of intracellular multivesicular bodies (MVBs) with the cell membrane and subsequently released into the extracellular space to participate in intercellular communication and diverse biological processes within target cells. As a crucial mediator, exosomes have been implicated in regulating ferroptosis-an iron-dependent programmed cell death characterized by lipid peroxide accumulation induced by reactive oxygen species. The involvement of exosomes in iron, lipid, and amino acid metabolism contributes to their regulatory role in specific mechanisms underlying how exosomes modulate ferroptosis, which remains incompletely understood, and some related studies are still preliminary. Therefore, targeting the regulation of ferroptosis by exosomes holds promise for future clinical treatment strategies across various diseases. This review aims to provide insights into the pathophysiology and mechanisms governing the interaction between exosomes and ferroptosis and their implications in disease development and treatment to serve as a reference for further research.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-024-01938-z
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Article ; Online: Clinical features and management of lymphoepithelial cyst

Cui Ning / Su Wenhao / Zhang Jixiang / Zhou Zhongyin

Open Medicine, Vol 18, Iss 1, Pp e1035-

2023 Volume 43

Abstract: The aim of the study was to analyze clinical features of lymphoepithelial cyst (LEC) to make a more comprehensive and deeper understanding of it. We retrospectively analyzed the hospital records of 201 patients who were diagnosed by pathology results. ... ...

Abstract	The aim of the study was to analyze clinical features of lymphoepithelial cyst (LEC) to make a more comprehensive and deeper understanding of it. We retrospectively analyzed the hospital records of 201 patients who were diagnosed by pathology results. Clinical characteristics like demographic profiles, lesion characteristics, therapeutic schedule, and associated costs were analyzed. Patient’s age ranged from 17 to 83 years old (52.6 ± 14.3, 120 males and 81 females). There were 12 cases of pancreatic LEC, 48 of oral LEC, and 141 of parotid LEC. Single lesion was found to be more than multiple lesions (147:54, 73.1%:26.9%). The majority of patients was primarily diagnosed by imaging test and endoscopy (171, 85.1%). All patients were finally confirmed by pathology results. Different treatment plans were selected according to personal situation, including dynamic observation (21, 10.5%), non-surgical treatment (24, 11.9%), and surgical treatment (156, 77.6%). No recurrence was found in surgical treatment patients for up to 24 months follow-up. To sum up, LEC is a rare and benign lesion, which is mostly located at parotid and oral, rarely located at pancreas. No typical symptoms could be found. EUS-FNA could be a reliable way to obtain pathological diagnosis. LEC could be cured by surgical resection with no recurrence.
Keywords	benign lesion ; asymptomatic ; eus-fna ; surgical treatment ; medical cost ; Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
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Article: Combined allergic bronchopulmonary mycosis and eosinophilic granulomatosis with polyangiitis: A case report and literature review.

Cui, Ning / Wang, Jingluan / Shao, Yanmei / Zhao, Jingming / Cheng, Zhaozhong

Respiratory medicine case reports

2024 Volume 48, Page(s) 102012

Abstract: A 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus ... ...

Abstract	A 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from BALF. Glucocorticoids therapy is effective. These results met the diagnostic criteria for both allergic bronchopulmonary aspergillosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). Special attention should be paid to the possibility of both diseases coexisting in the disease process.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2024.102012
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Article: Clinical features and management of lymphoepithelial cyst.

Cui, Ning / Su, Wenhao / Zhang, Jixiang / Zhou, Zhongyin

Open medicine (Warsaw, Poland)

2023 Volume 18, Issue 1, Page(s) 20230872

Abstract	The aim of the study was to analyze clinical features of lymphoepithelial cyst (LEC) to make a more comprehensive and deeper understanding of it. We retrospectively analyzed the hospital records of 201 patients who were diagnosed by pathology results. Clinical characteristics like demographic profiles, lesion characteristics, therapeutic schedule, and associated costs were analyzed. Patient's age ranged from 17 to 83 years old (52.6 ± 14.3, 120 males and 81 females). There were 12 cases of pancreatic LEC, 48 of oral LEC, and 141 of parotid LEC. Single lesion was found to be more than multiple lesions (147:54, 73.1%:26.9%). The majority of patients was primarily diagnosed by imaging test and endoscopy (171, 85.1%). All patients were finally confirmed by pathology results. Different treatment plans were selected according to personal situation, including dynamic observation (21, 10.5%), non-surgical treatment (24, 11.9%), and surgical treatment (156, 77.6%). No recurrence was found in surgical treatment patients for up to 24 months follow-up. To sum up, LEC is a rare and benign lesion, which is mostly located at parotid and oral, rarely located at pancreas. No typical symptoms could be found. EUS-FNA could be a reliable way to obtain pathological diagnosis. LEC could be cured by surgical resection with no recurrence.
Language	English
Publishing date	2023-12-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2023-0872
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Article ; Online: Characterizing VOCs emissions of coal chemical enterprise in China: a case study in five coal chemical enterprises.

Zhao, Shujie / Duan, Weichao / Cui, Ning / Zhao, Dongfeng

Environmental science and pollution research international

2023 Volume 30, Issue 59, Page(s) 123983–123995

Abstract: Coal chemical-induced climate change has become a global concern. However, the dearth of comprehensive case studies and fundamental data has obstructed the accurate quantification of volatile organic compounds (VOCs) emissions. This has failed to equip ... ...

Abstract	Coal chemical-induced climate change has become a global concern. However, the dearth of comprehensive case studies and fundamental data has obstructed the accurate quantification of volatile organic compounds (VOCs) emissions. This has failed to equip coal chemical industries with the necessary guidelines to implement effective emission reduction strategies. In response to this, the present study meticulously examined and contrasted the VOCs emissions from five distinct coal chemical enterprises in China. This was achieved through the application of life cycle assessment (LCA), a tool used to discern the primary factors influencing VOCs emissions and to identify potential avenues for VOCs emissions reduction. The analysis revealed that BT exhibited the highest emission intensity (5.58E-04 tons/ton), followed by ED (4.89E-04 tons/ton), YL (4.23E-04 tons/ton), XJ (2.94E-04 tons/ton), and SM (1.74E-04 tons/ton). Among these enterprises, coal-to-olefins enterprises predominantly discharged VOCs via sewage treatment (average 69.12%), while coal-to-methanol enterprises primarily emitted VOCs during circulating water cooling (40.02%). In coal-to-oil enterprises, storage and blending emerged as the principal source of VOCs emissions (56.83%). As a result, this study advocates that coal chemical enterprises concentrate on curbing VOCs emissions from highly concentrated wastewater, regulating the concentration of purgeable organic carbon in circulating water cooling systems, and instituting effective treatment methods for methanol storage tank emissions. These findings proffer invaluable insights for devising VOCs control measures in regions affected by intensive coal chemical production.
MeSH term(s)	Volatile Organic Compounds/analysis ; Coal/analysis ; Air Pollutants/analysis ; Methanol/analysis ; Petroleum/analysis ; China ; Water/analysis ; Environmental Monitoring
Chemical Substances	Volatile Organic Compounds ; Coal ; Air Pollutants ; Methanol (Y4S76JWI15) ; Petroleum ; Water (059QF0KO0R)
Language	English
Publishing date	2023-11-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31039-w
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Article ; Online: High-beam-quality low-resistance vertical-cavity surface-emitting laser array with graphene electrode.

Zhang, Feng / Cui, Ning / Yang, Jiawei / Mei, Yu / Fu, Lishan / Liu, Yudong / Guan, Baolu

Optics express

2024 Volume 32, Issue 5, Page(s) 8205–8213

Abstract: Thermal crosstalk and current crowding effects are pressing issues that significantly impact the beam quality and efficiency of vertical-cavity surface-emitting laser (VCSEL) arrays. In this paper, by taking advantage of the excellent current ... ...

Abstract	Thermal crosstalk and current crowding effects are pressing issues that significantly impact the beam quality and efficiency of vertical-cavity surface-emitting laser (VCSEL) arrays. In this paper, by taking advantage of the excellent current transmission characteristics of graphene, what we believe to be a novel VCSEL array based on graphene electrode is designed to realize vertical current injections. The series resistance and self-heating of arrays are reduced by controlling the transport direction of the current, effectively suppressing the thermal crosstalk effect. Furthermore, high array beam quality is obtained by optimizing the current density distribution in active regions. Ultimately, the high-power quasi-single mode emission of VCSEL arrays is achieved by introducing graphene electrodes (Gr-VCSEL array) designs. Compared to traditional VCSEL arrays, the 10 × 10 Gr-VCSEL array demonstrates a 41% reduction in series resistance, a side mode suppression ratio of 32 dB, and a divergence angle around 12 °. This structure simultaneously achieves quasi-single mode emission and effectively suppresses the thermal crosstalk effect, providing a new method for the development of high-beam quality VCSEL arrays.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.510195
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Article: The {332}<113> Twinning Behavior of a Ti-15Mo Medical Alloy during Cyclic Deformation and Its Effect on Microstructure and Performance.

Xu, Tiewei / Sun, Bingqing / Zhang, Shanshan / Liu, Yuancai / Sun, Wei / Cui, Ning / Lv, Binjiang

Materials (Basel, Switzerland)

2024 Volume 17, Issue 7

Abstract: In this study, the microstructural evolution of a Ti-15Mo medical alloy was investigated, when the in situ cyclic tensile strain had 2% amplitude and the tension-compression cyclic deformation had 1%, 2%, and 3% amplitude. The Vickers hardness and wear ... ...

Abstract	In this study, the microstructural evolution of a Ti-15Mo medical alloy was investigated, when the in situ cyclic tensile strain had 2% amplitude and the tension-compression cyclic deformation had 1%, 2%, and 3% amplitude. The Vickers hardness and wear resistance of the alloy were also optimized due to the grain-refining effect after cyclic deformation and annealing. The twinning-induced plasticity (TWIP) was considered the main deformation mechanism of the Ti-15Mo alloy during the tensile-compressive cycle deformation with suitable strain amplitude. The {332}<113> twins and boundaries were the main contributors to the grain refinement. The optimal microstructure, hardness, and wear resistance were obtained in the alloy deformed by tension-compression cyclic strain with a 3% strain amplitude. The wear resistance of the annealed alloy in Hank's solution was excellent in contrast to the original Ti-15Mo alloy due to its reasonable microstructure and hardness. It is clear that abundant twins were formed and retained in the coarse grains of the original alloy after cyclic deformation and annealing, which provided the expected refined grains and performance.
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17071462
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Article ; Online: Avian leukosis virus usurps the cellular SERBP1 protein to enhance its transcription and promote productive infections in avian cells.

Cui, Ning / Han, Xiaoxia / Yang, Xiao / Zhao, Xiaoran / Huang, Qinghua / Xu, Chuantian / Su, Shuai

Poultry science

2024 Volume 103, Issue 6, Page(s) 103755

Abstract: Avian leukosis virus subgroup K (ALV-K) is composed of newly emerging isolates, which cluster separately from the well-characterized subgroups A, B, C, D, E, and J in sequence analysis, and exhibits a specific host range and a unique pattern of ... ...

Abstract	Avian leukosis virus subgroup K (ALV-K) is composed of newly emerging isolates, which cluster separately from the well-characterized subgroups A, B, C, D, E, and J in sequence analysis, and exhibits a specific host range and a unique pattern of superinfection interference. Avian leukosis virus subgroup K replicate more slowly in avian cells than other ALV strains, leading to escaped detection during ALV eradication, but the underlying mechanism are largely unknown. In our previous study, we have reported that JS11C1 and most of other suspected ALV-K strains possessed unique mutations in the U3 region. Here, we selected 5 mutations in some important transcriptional regulation elements to explore the possible factor contributing for the lower activity of LTR, including CA-TG mutation in the CAAT box, 21 nt deletion in the CAAT box, A-G and A-T mutations in the CArG boxes, 11 nt insertion in the PRE boxes, and C-T mutation in the TATA box. On the basis of infectious clone of JS11C1, we demonstrated that the 11 nt fragment in the PRE boxes was associated with the transcription activity of LTR, the enhancer ability of U3, and the replication capacity of the virus. Notably, we determined the differential U3-protein interaction profile of ALVs and found that the 11 nt fragment specifically binds to cellular SERPINE1 mRNA binding protein 1 (SERBP1) to increase the LTR activity and enhance virus replication. Collectively, these findings reveal that a 11 nt fragment in the U3 gene contributed to its binding ability to the cellular SERBP1 to enhance its transcription and the infectious virus productions in avian cells. This study highlighted the vital role of host factor in retrovirus replication and thus provides a new perspective to elucidate the interaction between retrovirus and its host and a molecular basis to develop efficient strategies against retroviruses.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2024.103755
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Article ; Online: Platelet bioenergetic profiling uncovers a metabolic pattern of high dependency on mitochondrial fatty acid oxidation in type 2 diabetic patients who developed in-stent restenosis.

Wang, Xue-Bin / Cui, Ning-Hua / Fang, Zi-Qi / Gao, Mi-Jie / Cai, Dan

Redox biology

2024 Volume 72, Page(s) 103146

Abstract: Although platelet bioenergetic dysfunction is evident early in the pathogenesis of diabetic macrovascular complications, the bioenergetic characteristics in type 2 diabetic patients who developed coronary in-stent restenosis (ISR) and their effects on ... ...

Abstract	Although platelet bioenergetic dysfunction is evident early in the pathogenesis of diabetic macrovascular complications, the bioenergetic characteristics in type 2 diabetic patients who developed coronary in-stent restenosis (ISR) and their effects on platelet function remain unclear. Here, we performed platelet bioenergetic profiling to characterize the bioenergetic alterations in 28 type 2 diabetic patients with ISR compared with 28 type 2 diabetic patients without ISR (non-ISR) and 28 healthy individuals. Generally, platelets from type 2 diabetic patients with ISR exhibited a specific bioenergetic alteration characterized by high dependency on fatty acid (FA) oxidation, which subsequently induced complex III deficiency, causing decreased mitochondrial respiration, increased mitochondrial oxidant production, and low efficiency of mitochondrial ATP generation. This pattern of bioenergetic dysfunction showed close relationships with both α-granule and dense granule secretion as measured by surface P-selectin expression, ATP release, and profiles of granule cargo proteins in platelet releasates. Importantly, ex vivo reproduction of high dependency on FA oxidation by exposing non-ISR platelets to its agonist mimicked the bioenergetic dysfunction observed in ISR platelets and enhanced platelet secretion, whereas pharmaceutical inhibition of FA oxidation normalized the respiratory and redox states of ISR platelets and diminished platelet secretion. Further, causal mediation analyses identified a strong association between high dependency on FA oxidation and increased angiographical severity of ISR, which was significantly mediated by the status of platelet secretion. Our findings, for the first time, uncover a pattern of bioenergetic dysfunction in ISR and enhance current understanding of the mechanistic link of high dependency on FA oxidation to platelet abnormalities in the context of diabetes.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/complications ; Blood Platelets/metabolism ; Mitochondria/metabolism ; Oxidation-Reduction ; Male ; Energy Metabolism ; Fatty Acids/metabolism ; Female ; Middle Aged ; Coronary Restenosis/metabolism ; Coronary Restenosis/etiology ; Aged ; Stents/adverse effects
Chemical Substances	Fatty Acids
Language	English
Publishing date	2024-04-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2024.103146
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