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Article ; Online: Increase the Power of Epigenome-Wide Association Testing Using ICC-Based Hypothesis Weighting.

Cui, Bowen / Cui, Shuya / Huang, Jinyan / Chen, Jun

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2432, Page(s) 113–122

Abstract: For large-scale hypothesis testing such as epigenome-wide association testing, adaptively focusing power on the more promising hypotheses can lead to a much more powerful multiple testing procedure. In this chapter, we introduce a multiple testing ... ...

Abstract	For large-scale hypothesis testing such as epigenome-wide association testing, adaptively focusing power on the more promising hypotheses can lead to a much more powerful multiple testing procedure. In this chapter, we introduce a multiple testing procedure that weights each hypothesis based on the intraclass correlation coefficient (ICC), a measure of "noisiness" of CpG methylation measurement, to increase the power of epigenome-wide association testing. Compared to the traditional multiple testing procedure on a filtered CpG set, the proposed procedure circumvents the difficulty to determine the optimal ICC cutoff value and is overall more powerful. We illustrate the procedure and compare the power to classical multiple testing procedures using an example data.
MeSH term(s)	Epigenome ; Research Design
Language	English
Publishing date	2022-05-03
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1994-0_9
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Article ; Online: PIS-YOLO: Real-Time Detection for Medical Mask Specification in an Edge Device.

Zhao, Zuopeng / Liu, Xiaofeng / Hao, Kai / Zheng, Tianci / Xu, Junjie / Cui, Shuya

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 6170245

Abstract: Wearing masks in a crowded environment can reduce the risk of infection; however, wearing nonstandard cloud does not have a good protective effect on the virus, which makes it necessary to monitor the wearing of masks in real time. You only look once ( ... ...

Abstract	Wearing masks in a crowded environment can reduce the risk of infection; however, wearing nonstandard cloud does not have a good protective effect on the virus, which makes it necessary to monitor the wearing of masks in real time. You only look once (YOLO) series models are widely used in various edge devices. The existing YOLOv5s method meets the requirements of inference time, but it is slightly deficient in terms of accuracy due to its generality. Considering the characteristics of our driver medical mask dataset, a position insensitive loss which is cloud extract shared area feature in different categories and half deformable convolution net methods with cloud concern noteworthy features were introduced into YOLOv5s to improve accuracy, with an increase of 6.7% mean average in @.5 (mAP@.5) and 8.3% in mAP@.5:.95 for our dataset. To ensure that our method can be applied in a real scenario, TensorRT and CUDA were introduced to reduce the inference time in two edge devices (Jetson TX2 and Jetson Nano) and one desktop device, whose inference time was faster than that of previous methods.
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/6170245
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Article ; Online: CARE as a wearable derived feature linking circadian amplitude to human cognitive functions.

Cui, Shuya / Lin, Qingmin / Gui, Yuanyuan / Zhang, Yunting / Lu, Hui / Zhao, Hongyu / Wang, Xiaolei / Li, Xinyue / Jiang, Fan

NPJ digital medicine

2023 Volume 6, Issue 1, Page(s) 123

Abstract: Circadian rhythms are crucial for regulating physiological and behavioral processes. Pineal hormone melatonin is often used to measure circadian amplitude but its collection is costly and time-consuming. Wearable activity data are promising alternative, ... ...

Abstract	Circadian rhythms are crucial for regulating physiological and behavioral processes. Pineal hormone melatonin is often used to measure circadian amplitude but its collection is costly and time-consuming. Wearable activity data are promising alternative, but the most commonly used measure, relative amplitude, is subject to behavioral masking. In this study, we firstly derive a feature named circadian activity rhythm energy (CARE) to better characterize circadian amplitude and validate CARE by correlating it with melatonin amplitude (Pearson's r = 0.46, P = 0.007) among 33 healthy participants. Then we investigate its association with cognitive functions in an adolescent dataset (Chinese SCHEDULE-A, n = 1703) and an adult dataset (UK Biobank, n = 92,202), and find that CARE is significantly associated with Global Executive Composite (β = 30.86, P = 0.016) in adolescents, and reasoning ability, short-term memory, and prospective memory (OR = 0.01, 3.42, and 11.47 respectively, all P < 0.001) in adults. Finally, we identify one genetic locus with 126 CARE-associated SNPs using the genome-wide association study, of which 109 variants are used as instrumental variables in the Mendelian Randomization analysis, and the results show a significant causal effect of CARE on reasoning ability, short-term memory, and prospective memory (β = -59.91, 7.94, and 16.85 respectively, all P < 0.0001). The present study suggests that CARE is an effective wearable-based metric of circadian amplitude with a strong genetic basis and clinical significance, and its adoption can facilitate future circadian studies and potential intervention strategies to improve circadian rhythms and cognitive functions.
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ISSN	2398-6352
ISSN (online)	2398-6352
DOI	10.1038/s41746-023-00865-0
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Article ; Online: SAI-YOLO: A Lightweight Network for Real-Time Detection of Driver Mask-Wearing Specification on Resource-Constrained Devices.

Zhao, Zuopeng / Hao, Kai / Ma, Xiaoping / Liu, Xiaofeng / Zheng, Tianci / Xu, Junjie / Cui, Shuya

Computational intelligence and neuroscience

2021 Volume 2021, Page(s) 4529107

Abstract: Frequent occurrence and long-term existence of respiratory diseases such as COVID-19 and influenza require bus drivers to wear masks correctly during driving. To quickly detect whether the mask is worn correctly on resource-constrained devices, a ... ...

Abstract	Frequent occurrence and long-term existence of respiratory diseases such as COVID-19 and influenza require bus drivers to wear masks correctly during driving. To quickly detect whether the mask is worn correctly on resource-constrained devices, a lightweight target detection network SAI-YOLO is proposed. Based on YOLOv4-Tiny, the network incorporates the Inception V3 structure, replaces two CSPBlock modules with the RES-SEBlock modules to reduce the number of parameters and computational difficulty, and adds a convolutional block attention module and a squeeze-and-excitation module to extract key feature information. Moreover, a modified ReLU (M-ReLU) activation function is introduced to replace the original Leaky_ReLU function. The experimental results show that SAI-YOLO reduces the number of network parameters and calculation difficulty and improves the detection speed of the network while maintaining certain recognition accuracy. The mean average precision (mAP) for face-mask-wearing detection reaches 86% and the average precision (AP) for mask-wearing normative detection reaches 88%. In the resource-constrained device Raspberry Pi 4B, the average detection time after acceleration is 197 ms, which meets the actual application requirements.
MeSH term(s)	Automobile Driving ; COVID-19 ; Humans ; Recognition, Psychology ; SARS-CoV-2
Language	English
Publishing date	2021-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5265
ISSN (online)	1687-5273
ISSN	1687-5265
DOI	10.1155/2021/4529107
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Article: Solid-Liquid Separation Properties of Thermoregulated Dicationic Ionic Liquid as Extractant of Dyes from Aqueous Solution

Lv, Rui / Cui, Shuya / Zou, Yangmei / Zheng, Li

Journal of Analytical Methods in Chemistry (Online). 2018 June 3, v. 2018

2018

Abstract: Two thermoregulated dicationic ionic liquids were synthesized and applied for effective extraction of the common dye malachite green oxalate (MG). The extraction parameters such as amount of ionic liquids, pH of water phase, extraction time, cooling time, ...

Abstract	Two thermoregulated dicationic ionic liquids were synthesized and applied for effective extraction of the common dye malachite green oxalate (MG). The extraction parameters such as amount of ionic liquids, pH of water phase, extraction time, cooling time, and centrifugal time on the extraction efficiency were investigated systematically. It revealed that the dye has been successfully extracted into the ionic liquids, with high extraction efficiency higher than 98%, and recovery of 98.2%–100.8%, respectively. Furthermore, these ionic liquids can be recycled easily after elution. The reusable yields were 87.1% and 88.7%. The extraction of the dye into the thermoregulated ionic liquid provides a method of minimizing pollution of waste water potentially.
Keywords	aqueous solutions ; ionic liquids ; malachite green ; oxalates ; pH ; pollution ; thermoregulation ; wastewater
Language	English
Dates of publication	2018-0603
Publishing place	Hindawi
Document type	Article
ZDB-ID	2654178-6
ISSN	2090-8873 ; 2090-8865
ISSN (online)	2090-8873
ISSN	2090-8865
DOI	10.1155/2018/3980364
Database	NAL-Catalogue (AGRICOLA)

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Article: Solid-Liquid Separation Properties of Thermoregulated Dicationic Ionic Liquid as Extractant of Dyes from Aqueous Solution.

Lv, Rui / Cui, Shuya / Zou, Yangmei / Zheng, Li

Journal of analytical methods in chemistry

2018 Volume 2018, Page(s) 3980364

Abstract	Two thermoregulated dicationic ionic liquids were synthesized and applied for effective extraction of the common dye malachite green oxalate (MG). The extraction parameters such as amount of ionic liquids, pH of water phase, extraction time, cooling time, and centrifugal time on the extraction efficiency were investigated systematically. It revealed that the dye has been successfully extracted into the ionic liquids, with high extraction efficiency higher than 98%, and recovery of 98.2%-100.8%, respectively. Furthermore, these ionic liquids can be recycled easily after elution. The reusable yields were 87.1% and 88.7%. The extraction of the dye into the thermoregulated ionic liquid provides a method of minimizing pollution of waste water potentially.
Language	English
Publishing date	2018-06-03
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2654178-6
ISSN	2090-8873 ; 2090-8865
ISSN (online)	2090-8873
ISSN	2090-8865
DOI	10.1155/2018/3980364
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Article: Enantioseparation of terbutaline by online concentration capillary electrophoresis coupling with partial filling technique

Cui, Shuya / Liu, Jiaqin / Hu, Xiaoli / Li, Juan

Journal of analytical chemistry. 2015 Jan., v. 70, no. 1

2015

Abstract: A novel, simple and sensitive method for the enantioseparation of terbutaline enantiomers was developed using capillary zone electrophoresis (CZE) in combination with partial filling technique and field-amplified sample concentration. Under optimal ... ...

Abstract	A novel, simple and sensitive method for the enantioseparation of terbutaline enantiomers was developed using capillary zone electrophoresis (CZE) in combination with partial filling technique and field-amplified sample concentration. Under optimal conditions, the racemic terbutaline was resolved in less than 21 min by partially filling a fused-silica capillary with 15 mM β-cyclodextrin (β-CD, 1.9 psi, 90 s) and carrying out an electrophoresis with 50 mM phosphate buffer (pH 1.8) at 15 kV separation voltage. The sensitivity was further improved by using field-amplified sample injection (0.2 psi, 2.5 s water plug). Compared with conventional CZE, the resolution and sensitivity of two enantiomers were much improved (the detection limit decreased by 18–25-fold).
Keywords	beta-cyclodextrin ; capillary zone electrophoresis ; detection limit ; enantiomers ; pH
Language	English
Dates of publication	2015-01
Size	p. 81-86.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2057336-4
ISSN	1608-3199 ; 1061-9348
ISSN (online)	1608-3199
ISSN	1061-9348
DOI	10.1134/S1061934815010165
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis, characterization, and DFT studies of a new chiral ionic liquid from (S)-1-phenylethylamine.

Cui, Shuya / Wang, Tao / Hu, Xiaoli

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2014 Volume 133, Page(s) 778–784

Abstract: A new chiral ionic liquid was synthesized from (S)-1-phenylethylamine and it was studied by IR, Raman, polarimetry, NMR and X-ray crystal diffraction. Its vibrational spectral bands are precisely ascribed to the studied structure with the aid of DFT ... ...

Abstract	A new chiral ionic liquid was synthesized from (S)-1-phenylethylamine and it was studied by IR, Raman, polarimetry, NMR and X-ray crystal diffraction. Its vibrational spectral bands are precisely ascribed to the studied structure with the aid of DFT theoretical calculations. The optimized geometries and calculated vibrational frequencies are evaluated via comparison with experimental values. The vibrational spectral data obtained from IR and Raman spectra are assigned based on the results of the theoretical calculations by the DFT-B3LYP method at 6-311G(d,p) level. The computed vibrational frequencies were scaled by scale factors to yield a good agreement with observed experimental vibrational frequencies.The vibrational modes assignments were performed by using the animation option of GaussView5.0 graphical interface for Gaussian program.
MeSH term(s)	Crystallography, X-Ray ; Ionic Liquids/chemical synthesis ; Ionic Liquids/chemistry ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Phenethylamines/chemical synthesis ; Phenethylamines/chemistry ; Quantum Theory ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman
Chemical Substances	Ionic Liquids ; Phenethylamines ; 1-phenethylamine (HZ9DM6B2MT)
Language	English
Publishing date	2014-12-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2014.06.057
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Article ; Online: Inclusion complex formation of ionic liquids with cucurbit[7]uril studied by competitive binding of methylene blue fluorescent probe.

Cui, Shuya / Du, Junliang / Wang, Tao / Hu, Xiaoli

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2012 Volume 96, Page(s) 188–192

Abstract: Methylene blue (MB) was used as a fluorescent probe to study the encapsulation of three kinds of 1-butyl-3-methylimidazolium ionic liquids in cucurbit[7]uril (CB7) at pH 3. Addition of ionic liquids to the aqueous solution of MB-CB7 inclusion complexes ... ...

Abstract	Methylene blue (MB) was used as a fluorescent probe to study the encapsulation of three kinds of 1-butyl-3-methylimidazolium ionic liquids in cucurbit[7]uril (CB7) at pH 3. Addition of ionic liquids to the aqueous solution of MB-CB7 inclusion complexes brought about considerable fluorescence intensity quenching, and it was because that MB was extruded from the cavity of CB7 into the aqueous phase by the ionic liquid. NMR and AM1 semi-empirical calculations indicated that the 1-butyl-imidazolium moiety of ionic liquid was responsible for the complexation with CB7.
MeSH term(s)	Absorption ; Binding, Competitive ; Bridged-Ring Compounds/chemistry ; Fluorescent Dyes/chemistry ; Hydrogen-Ion Concentration ; Imidazoles/chemistry ; Ionic Liquids/chemistry ; Magnetic Resonance Spectroscopy ; Methylene Blue/chemistry ; Models, Molecular ; Solutions ; Spectrometry, Fluorescence ; Water/chemistry
Chemical Substances	1-butyl-3-methylimidazolium ; Bridged-Ring Compounds ; Fluorescent Dyes ; Imidazoles ; Ionic Liquids ; Solutions ; cucurbit(7)uril ; Water (059QF0KO0R) ; Methylene Blue (T42P99266K)
Language	English
Publishing date	2012-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2012.05.025
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Article: Field-Amplified Sample Stacking for Rapid and Sensitive Determination of Aconitine Alkaloids by CE Using an Ionic Liquid Electrolyte System

Hu, Xiaoli / Cui, Shuya / Liu, Jia Qin

Chromatographia. 2010 Nov., v. 72, no. 9-10

2010

Abstract: A new capillary electrophoresis procedure with field-amplified sample stacking (FASS) concentration for analysis of three aconitine alkaloids has been established using 1-butyl-3-methylimidazolium-based ionic liquids as the electrolyte solution. The use ... ...

Abstract	A new capillary electrophoresis procedure with field-amplified sample stacking (FASS) concentration for analysis of three aconitine alkaloids has been established using 1-butyl-3-methylimidazolium-based ionic liquids as the electrolyte solution. The use of a short water plug at the column inlet is essential for improving the reproducibility of FASS with electrokinetic injection, and the water plug injection time affects the sensitivity significantly. With this stacking procedure, the concentration sensitivity was 5-142 fold higher than for pressure injection. After optimization of the separation and concentration conditions, the three alkaloids could be separated within 6 min and quantified with high sensitivity. The detection limits were 0.10 μg mL⁻¹ for aconitine, 0.021 μg mL⁻¹ for hypaconitine and 0.56 μg mL⁻¹ for mesaconitine. The method was used for quantitative analysis of the three aconitine alkaloids in two Aconitum plants with recoveries of 95.8-105.4%.
Keywords	capillary electrophoresis
Language	English
Dates of publication	2010-11
Size	p. 993-997.
Publisher	Vieweg Verlag
Publishing place	Wiesbaden
Document type	Article
ZDB-ID	80097-1
ISSN	0009-5893
ISSN	0009-5893
DOI	10.1365/s10337-010-1762-z
Database	NAL-Catalogue (AGRICOLA)

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