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  1. Article: Response to letter to the editor "noninvasive determinants of pulmonary hypertension in interstitial lung disease".

    Joseph, Phillip / Savarimuthu, Stella / Oakland, Hannah T / Cullinan, Marjorie / Heerdt, Paul M / Singh, Inderjit

    Pulmonary circulation

    2023  Volume 13, Issue 2, Page(s) e12238

    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Noninvasive determinants of pulmonary hypertension in interstitial lung disease.

    Joseph, Phillip / Savarimuthu, Stella / Zhao, Jiayi / Yan, Xiting / Oakland, Hannah T / Cullinan, Marjorie / Heerdt, Paul M / Singh, Inderjit

    Pulmonary circulation

    2023  Volume 13, Issue 1, Page(s) e12197

    Abstract: Pulmonary hypertension (PH) in interstitial lung disease (ILD) is associated with increased mortality and impaired exertional capacity. Right heart catheterization is the diagnostic standard for PH but is invasive and not readily available. Noninvasive ... ...

    Abstract Pulmonary hypertension (PH) in interstitial lung disease (ILD) is associated with increased mortality and impaired exertional capacity. Right heart catheterization is the diagnostic standard for PH but is invasive and not readily available. Noninvasive physiologic evaluation may predict PH in ILD. Forty-four patients with PH and ILD (PH-ILD) were compared with 22 with ILD alone (non-PH ILD). Six-min walk distance (6MWD, 223 ± 131 vs. 331 ± 125 m,
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to Grignola and Trujillo.

    Oakland, Hannah T / Joseph, Phillip / Naeije, Robert / Elassal, Ahmed / Cullinan, Marjorie / Heerdt, Paul M / Singh, Inderjit

    Journal of applied physiology (Bethesda, Md. : 1985)

    2022  Volume 132, Issue 1, Page(s) 219

    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00810.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.249: Show issues Location:
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  4. Article: Diagnostic utility of sub-maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction.

    Oakland, Hannah T / Joseph, Phillip / Elassal, Ahmed / Cullinan, Marjorie / Heerdt, Paul M / Singh, Inderjit

    Pulmonary circulation

    2020  Volume 10, Issue 4, Page(s) 2045894020972273

    Abstract: Pulmonary hypertension is commonly associated with heart failure with preserved ejection fraction. In heart failure with preserved ejection fraction, the elevated left-sided filling pressures result in isolated post-capillary pulmonary hypertension or ... ...

    Abstract Pulmonary hypertension is commonly associated with heart failure with preserved ejection fraction. In heart failure with preserved ejection fraction, the elevated left-sided filling pressures result in isolated post-capillary pulmonary hypertension or combined pre- and post-capillary pulmonary hypertension. Although right heart catheterization is the gold standard for diagnosis, it is an invasive test with associated risks. The ability of sub-maximum cardiopulmonary exercise test as an adjunct diagnostic tool in pulmonary hypertension-associated heart failure with preserved ejection fraction is not known. Forty-six patients with heart failure with preserved ejection fraction and pulmonary hypertension (27 patients with combined pre- and post-capillary pulmonary hypertension and 19 patients with isolated post-capillary pulmonary hypertension) underwent sub-maximum cardiopulmonary exercise test followed by right heart catheterization. The study also included 18 age- and gender-matched control subjects. Several sub-maximum gas exchange parameters were examined to determine the ability of sub-maximum cardiopulmonary exercise test to distinguish between isolated post-capillary pulmonary hypertension and combined pre- and post-capillary pulmonary hypertension. Conventional echocardiogram measures did not distinguish between isolated post-capillary pulmonary hypertension and combined pre- and post-capillary pulmonary hypertension. Compared to isolated post-capillary pulmonary hypertension, combined pre- and post-capillary pulmonary hypertension had greater ventilatory equivalent for carbon dioxide (VE/VCO
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1177/2045894020972273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Arterial load and right ventricular-vascular coupling in pulmonary hypertension.

    Oakland, Hannah / Joseph, Phillip / Naeije, Robert / Elassal, Ahmed / Cullinan, Marjorie / Heerdt, Paul M / Singh, Inderjit

    Journal of applied physiology (Bethesda, Md. : 1985)

    2021  Volume 131, Issue 1, Page(s) 424–433

    Abstract: Right ventricular (RV) functional adaptation to afterload determines outcome in pulmonary hypertension (PH). RV afterload is determined by the dynamic interaction between pulmonary vascular resistance (PVR), characteristic impedance ( ...

    Abstract Right ventricular (RV) functional adaptation to afterload determines outcome in pulmonary hypertension (PH). RV afterload is determined by the dynamic interaction between pulmonary vascular resistance (PVR), characteristic impedance (
    MeSH term(s) Animals ; Heart Failure ; Heart Ventricles ; Humans ; Hypertension, Pulmonary ; Pulmonary Artery ; Stroke Volume ; Ventricular Dysfunction, Right ; Ventricular Function, Right
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00204.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Persistent Exertional Intolerance After COVID-19: Insights From Invasive Cardiopulmonary Exercise Testing.

    Singh, Inderjit / Joseph, Phillip / Heerdt, Paul M / Cullinan, Marjorie / Lutchmansingh, Denyse D / Gulati, Mridu / Possick, Jennifer D / Systrom, David M / Waxman, Aaron B

    Chest

    2021  Volume 161, Issue 1, Page(s) 54–63

    Abstract: Background: Some patients with COVID-19 who have recovered from the acute infection after experiencing only mild symptoms continue to exhibit persistent exertional limitation that often is unexplained by conventional investigative studies.: Research ... ...

    Abstract Background: Some patients with COVID-19 who have recovered from the acute infection after experiencing only mild symptoms continue to exhibit persistent exertional limitation that often is unexplained by conventional investigative studies.
    Research question: What is the pathophysiologic mechanism of exercise intolerance that underlies the post-COVID-19 long-haul syndrome in patients without cardiopulmonary disease?
    Study design and methods: This study examined the systemic and pulmonary hemodynamics, ventilation, and gas exchange in 10 patients who recovered from COVID-19 and were without cardiopulmonary disease during invasive cardiopulmonary exercise testing (iCPET) and compared the results with those from 10 age- and sex-matched control participants. These data then were used to define potential reasons for exertional limitation in the cohort of patients who had recovered from COVID-19.
    Results: The patients who had recovered from COVID-19 exhibited markedly reduced peak exercise aerobic capacity (oxygen consumption [VO
    Interpretation: Patients who have recovered from COVID-19 without cardiopulmonary disease demonstrate a marked reduction in peak VO
    MeSH term(s) COVID-19/complications ; COVID-19/physiopathology ; Connecticut ; Exercise Test/methods ; Exercise Tolerance ; Female ; Hemodynamics/physiology ; Humans ; Male ; Massachusetts ; Middle Aged ; Oxygen Consumption/physiology ; Respiratory Function Tests ; SARS-CoV-2 ; Stroke Volume/physiology
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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