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  1. Article ; Online: Competitive interaction between ATP and GTP regulates mitochondrial ATP-sensitive potassium channels.

    Palácio, Plinio Bezerra / de Freitas Soares, Geovanna Carvalho / Lima, Gabriella Moreira Bezerra / Cunha, Pedro Lourenzo Oliveira / Varela, Anna Lídia Nunes / Facundo, Heberty Tarso

    Chemico-biological interactions

    2023  Volume 381, Page(s) 110560

    Abstract: Mitochondrial ATP-sensitive ... ...

    Abstract Mitochondrial ATP-sensitive K
    MeSH term(s) Humans ; KATP Channels/metabolism ; Molecular Docking Simulation ; Adenosine Triphosphate/metabolism ; Mitochondria ; Guanosine Triphosphate/metabolism ; Guanosine Triphosphate/pharmacology ; Potassium/metabolism
    Chemical Substances KATP Channels ; Adenosine Triphosphate (8L70Q75FXE) ; Guanosine Triphosphate (86-01-1) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2023-05-25
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2023.110560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 686: Show issues Location:
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  2. Article ; Online: Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy.

    David, Cícera Edna Barbosa / Lucas, Aline Maria Brito / Cunha, Pedro Lourenzo Oliveira / Viana, Yuana Ivia Ponte / Yoshinaga, Marcos Yukio / Miyamoto, Sayuri / Filho, Adriano Brito Chaves / Varela, Anna Lídia Nunes / Kowaltowski, Alicia Juliana / Facundo, Heberty Tarso

    Journal of physiology and biochemistry

    2022  Volume 78, Issue 1, Page(s) 283–294

    Abstract: Typically, healthy cardiac tissue utilizes more fat than any other organ. Cardiac hypertrophy induces a metabolic shift leading to a preferential consumption of glucose over fatty acids to support the high energetic demand. Calorie restriction is a ... ...

    Abstract Typically, healthy cardiac tissue utilizes more fat than any other organ. Cardiac hypertrophy induces a metabolic shift leading to a preferential consumption of glucose over fatty acids to support the high energetic demand. Calorie restriction is a dietary procedure that induces health benefits and lifespan extension in many organisms. Given the beneficial effects of calorie restriction, we hypothesized that calorie restriction prevents cardiac hypertrophy, lipid content changes, mitochondrial and redox dysregulation. Strikingly, calorie restriction reversed isoproterenol-induced cardiac hypertrophy. Isolated mitochondria from hypertrophic hearts produced significantly higher levels of succinate-driven H
    MeSH term(s) Caloric Restriction ; Cardiomegaly/chemically induced ; Cardiomegaly/drug therapy ; Cardiomegaly/prevention & control ; Humans ; Hydrogen Peroxide/metabolism ; Isoproterenol/metabolism ; Isoproterenol/toxicity ; Lipidomics ; Mitochondria/metabolism ; Oxidation-Reduction ; Oxidative Stress
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Isoproterenol (L628TT009W)
    Language English
    Publishing date 2022-01-13
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1325104-1
    ISSN 1877-8755 ; 0034-9402 ; 1138-7548
    ISSN (online) 1877-8755
    ISSN 0034-9402 ; 1138-7548
    DOI 10.1007/s13105-021-00863-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 198: Show issues Location:
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  3. Article ; Online: Quercetin treatment increases H

    de Lacerda Alexandre, Joana Varlla / Viana, Yuana Ivia Ponte / David, Cícera Edna Barbosa / Cunha, Pedro Lourenzo Oliveira / Albuquerque, Amanda Cabral / Varela, Anna Lídia Nunes / Kowaltowski, Alicia J / Facundo, Heberty Tarso

    Naunyn-Schmiedeberg's archives of pharmacology

    2020  Volume 394, Issue 2, Page(s) 217–226

    Abstract: Oxidative stress, characterized by the accumulation of reactive oxygen species (ROS), is implicated in the pathogenesis of several diseases, including cardiac hypertrophy. The flavonoid quercetin is a potent ROS scavenger, with several beneficial effects ...

    Abstract Oxidative stress, characterized by the accumulation of reactive oxygen species (ROS), is implicated in the pathogenesis of several diseases, including cardiac hypertrophy. The flavonoid quercetin is a potent ROS scavenger, with several beneficial effects for the cardiovascular system, including antihypertrophic effects. Oxidative imbalance has been implicated in cardiac hypertrophy and heart failure. In this work, we tested whether quercetin could attenuate cardiac hypertrophy by improving redox balance and mitochondrial homeostasis. To test this hypothesis, we treated a group of mice with isoproterenol (30 mg/kg/day) for 4 or 8 consecutive days. Another group received quercetin (10 mg/kg/day) from day 5th of isoproterenol treatment. We carried out the following assays in cardiac tissue: measurement of cardiac hypertrophy, protein sulfhydryl, catalase, Cu/Zn and Mn-superoxide dismutase (SOD) activity, detection of H
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Cardiomegaly/chemically induced ; Cardiomegaly/drug therapy ; Cardiomegaly/metabolism ; Catalase/metabolism ; Hydrogen Peroxide/metabolism ; Isoproterenol ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Myocardium/metabolism ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Superoxide Dismutase/metabolism
    Chemical Substances Antioxidants ; Quercetin (9IKM0I5T1E) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Isoproterenol (L628TT009W)
    Language English
    Publishing date 2020-09-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-020-01953-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.5: Show issues Location:
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