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Article ; Online: ILC2: at home in the thymus.

Cupedo, Tom

2018 Volume 48, Issue 9, Page(s) 1441–1444

Abstract: The relevance of innate lymphoid cells (ILC) for anti-infectious immunity remains a matter of constant debate. At the same time, evidence for additional, non-immune related functions of ILC is steadily increasing. In the thymus, non-immune functions of ... ...

Abstract	The relevance of innate lymphoid cells (ILC) for anti-infectious immunity remains a matter of constant debate. At the same time, evidence for additional, non-immune related functions of ILC is steadily increasing. In the thymus, non-immune functions of ILC were shown for group 3 ILC (ILC3), which regulate differentiation and proliferation of thymic epithelial cells. In this issue of the European Journal of Immunology, Withers and colleagues [Eur. J. Immunol. 2018. 48: 1481-1491] now show that ILC2, a subset of ILCs specialized in tissue protection and regeneration, are the major ILC subset in the adult thymus, heavily outnumbering ILC3. These findings raise novel questions on the function of thymic ILC, and warrant re-evaluation of the importance of ILC2 and their cytokines during thymic function and repair.
MeSH term(s)	Animals ; Mice ; Cell Count ; Cell Differentiation ; Cytokines ; Immunity, Innate ; Lymphocytes
Chemical Substances	Cytokines
Language	English
Publishing date	2018-09-05
Publishing country	Germany
Document type	Journal Article ; Comment
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201847779
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Article ; Online: Bone marrow inflammation in haematological malignancies.

de Jong, Madelon M E / Chen, Lanpeng / Raaijmakers, Marc H G P / Cupedo, Tom

Nature reviews. Immunology

2024

Abstract: Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-associated inflammation impacts normal niches for haematopoietic progenitor cells and mature immune cells and supports the outgrowth and survival of malignant cells ...

Abstract	Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-associated inflammation impacts normal niches for haematopoietic progenitor cells and mature immune cells and supports the outgrowth and survival of malignant cells residing in these niche compartments. This Review provides an overview of our current understanding of inflammatory changes in the bone marrow microenvironment of myeloid and lymphoid malignancies, using acute myeloid leukaemia and multiple myeloma as examples and highlights unique and shared features of inflammation in niches for progenitor cells and plasma cells. Importantly, inflammation exerts profoundly different effects on normal bone marrow niches in these malignancies, and we provide context for possible drivers of these divergent effects. We explore the role of tumour cells in inflammatory changes, as well as the role of cellular constituents of normal bone marrow niches, including myeloid cells and stromal cells. Integrating knowledge of disease-specific dynamics of malignancy-associated bone marrow inflammation will provide a necessary framework for future targeting of these processes to improve patient outcome.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-024-01003-x
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Article ; Online: Innate protection from graft-versus-host disease.

Cupedo, Tom

Blood

2014 Volume 124, Issue 5, Page(s) 673–675

Abstract: n this issue of Blood, Hazenberg and Spits provide a detailed overview of human innate lymphoid cell (ILC) subsets and their development and distribution throughout the human body, discussing these cells in the context of human disease. In the same issue, ...

Abstract	n this issue of Blood, Hazenberg and Spits provide a detailed overview of human innate lymphoid cell (ILC) subsets and their development and distribution throughout the human body, discussing these cells in the context of human disease. In the same issue, Munneke et al for the first time link ILCs to human hematopoietic malignancies by identifying a clear correlation between the presence of activated ILCs after induction chemotherapy and the absence of acute graft-versus-host disease (GVHD) development following subsequent hematopoietic stem cell transplantation (HSCT).
MeSH term(s)	Animals ; Female ; Graft vs Host Disease/immunology ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunity, Innate/physiology ; Leukemia/therapy ; Lymphocytes/cytology ; Lymphocytes/immunology ; Male ; Mucositis/immunology
Language	English
Publishing date	2014-07-31
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2014-06-578971
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Article ; Online: Human lymph node development: An inflammatory interaction.

Cupedo, Tom

Immunology letters

2011 Volume 138, Issue 1, Page(s) 4–6

Abstract: In the developing human fetus, lymph nodes and Peyer's patches are formed during the first and second trimester of pregnancy. The cells responsible for this process, lymphoid tissue inducer (LTi) cells, share a number of characteristics with Natural ... ...

Abstract	In the developing human fetus, lymph nodes and Peyer's patches are formed during the first and second trimester of pregnancy. The cells responsible for this process, lymphoid tissue inducer (LTi) cells, share a number of characteristics with Natural Killer (NK) cells and produce cytokines related to inflammation. Here I will discuss recent advances in our understanding of human lymph node development, in particular the characterization of LTi cells and the relationship of these innate lymphocytes to conventional NK cells.
MeSH term(s)	Animals ; Cell Differentiation/immunology ; Humans ; Inflammation/immunology ; Lymph Nodes/cytology ; Lymph Nodes/embryology ; Lymph Nodes/immunology ; Lymphocytes/immunology ; Lymphoid Progenitor Cells/immunology ; Lymphoid Tissue/cytology ; Lymphoid Tissue/embryology ; Mice ; Organogenesis/immunology
Language	English
Publishing date	2011-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	445150-8
ISSN	1879-0542 ; 0165-2478
ISSN (online)	1879-0542
ISSN	0165-2478
DOI	10.1016/j.imlet.2011.02.008
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Article ; Online: An unexpected role for IL-17 in lymphoid organogenesis.

Cupedo, Tom

Nature immunology

2011 Volume 12, Issue 7, Page(s) 590–592

MeSH term(s)	Animals ; Humans ; Interleukin-17/immunology ; Lung/growth & development ; Lung/immunology ; Lymphangiogenesis/immunology ; Lymphoid Tissue/growth & development ; Lymphoid Tissue/immunology ; Mice ; Stromal Cells/immunology
Chemical Substances	Interleukin-17
Language	English
Publishing date	2011-06-20
Publishing country	United States
Document type	Comment ; News
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/ni.2058
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Article ; Online: Group 3 innate lymphoid cells in tissue damage and graft-versus-host disease pathogenesis.

Karrich, Julien J / Cupedo, Tom

Current opinion in hematology

2016 Volume 23, Issue 4, Page(s) 410–415

Abstract: Purpose of review: Innate lymphoid cells (ILC) have emerged as modulators of conditioning-induced tissue damage and development of graft-versus-host disease (GVHD) in the context of allogeneic hematopoietic stem cell transplantation (HSCT). This review ... ...

Abstract	Purpose of review: Innate lymphoid cells (ILC) have emerged as modulators of conditioning-induced tissue damage and development of graft-versus-host disease (GVHD) in the context of allogeneic hematopoietic stem cell transplantation (HSCT). This review highlights experimental and clinical evidence for a role of ILC in GVHD pathogenesis. Recent findings: ILC are well known for their role in epithelial homeostasis and innate immunity. In addition, recent studies identified ILC as architects of intestinal responses to tissue damage after experimental radio and chemotherapy. Group 3 ILC, and their signature cytokine IL-22, can enhance intestinal stem cell regeneration and protect the stem cell niche from damage during experimental HSCT. Moreover, in leukemia patients undergoing HSCT conditioning, appearance of activated group 3 ILC prior to transplant is correlated to reduced incidence of acute GVHD. Summary: ILC have a profound impact on the recovery from tissue damage and severity of GVHD in experimental models. Together with the available data from leukemia patients, this argues for in-depth analysis of the mechanisms of ILC function and the translation of experimental findings to clinical application. Ultimately, control of ILC activation, or of the cytokines they produce, could be employed to reduce GVHD lesion in patients receiving allogeneic HSCT.
MeSH term(s)	Animals ; Cytokines/metabolism ; Graft vs Host Disease/etiology ; Graft vs Host Disease/metabolism ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Immunity, Innate ; Leukemia/complications ; Leukemia/therapy ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Transplantation, Homologous
Chemical Substances	Cytokines
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1153887-9
ISSN	1531-7048 ; 1065-6251
ISSN (online)	1531-7048
ISSN	1065-6251
DOI	10.1097/MOH.0000000000000262
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Article: Human lymph node development: An inflammatory interaction

Cupedo, Tom

Immunology Letters. 2011 July, v. 138, no. 1

2011

Abstract	In the developing human fetus, lymph nodes and Peyer's patches are formed during the first and second trimester of pregnancy. The cells responsible for this process, lymphoid tissue inducer (LTi) cells, share a number of characteristics with Natural Killer (NK) cells and produce cytokines related to inflammation. Here I will discuss recent advances in our understanding of human lymph node development, in particular the characterization of LTi cells and the relationship of these innate lymphocytes to conventional NK cells.
Keywords	Peyer's patches ; cytokines ; inflammation ; lymph nodes ; natural killer cells ; pregnancy
Language	English
Dates of publication	2011-07
Size	p. 4-6.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	445150-8
ISSN	1879-0542 ; 0165-2478
ISSN (online)	1879-0542
ISSN	0165-2478
DOI	10.1016/j.imlet.2011.02.008
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Innate TCRs: single use only.

Cupedo, Tom / Samsom, Janneke N

Nature immunology

2013 Volume 15, Issue 1, Page(s) 12–13

MeSH term(s)	Adaptive Immunity/immunology ; Animals ; Immunity, Innate/immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocyte Subsets/immunology
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2013-12-19
Publishing country	United States
Document type	News ; Comment
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/ni.2792
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Article ; Online: An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma.

Nature immunology

2024 Volume 25, Issue 5, Page(s) 820–833

Abstract: Human bone marrow permanently harbors high numbers of neutrophils, and a tumor-supportive bias of these cells could significantly impact bone marrow-confined malignancies. In individuals with multiple myeloma, the bone marrow is characterized by ... ...

Abstract	Human bone marrow permanently harbors high numbers of neutrophils, and a tumor-supportive bias of these cells could significantly impact bone marrow-confined malignancies. In individuals with multiple myeloma, the bone marrow is characterized by inflammatory stromal cells with the potential to influence neutrophils. We investigated myeloma-associated alterations in human marrow neutrophils and the impact of stromal inflammation on neutrophil function. Mature neutrophils in myeloma marrow are activated and tumor supportive and transcribe increased levels of IL1B and myeloma cell survival factor TNFSF13B (BAFF). Interactions with inflammatory stromal cells induce neutrophil activation, including BAFF secretion, in a STAT3-dependent manner, and once activated, neutrophils gain the ability to reciprocally induce stromal activation. After first-line myeloid-depleting antimyeloma treatment, human bone marrow retains residual stromal inflammation, and newly formed neutrophils are reactivated. Combined, we identify a neutrophil-stromal cell feed-forward loop driving tumor-supportive inflammation that persists after treatment and warrants novel strategies to target both stromal and immune microenvironments in multiple myeloma.
MeSH term(s)	Multiple Myeloma/immunology ; Multiple Myeloma/pathology ; Humans ; Tumor Microenvironment/immunology ; Neutrophils/immunology ; Neutrophils/metabolism ; Stromal Cells/metabolism ; Stromal Cells/immunology ; B-Cell Activating Factor/metabolism ; Interleukin-1beta/metabolism ; Neutrophil Activation ; STAT3 Transcription Factor/metabolism ; Bone Marrow/immunology ; Bone Marrow/pathology
Chemical Substances	B-Cell Activating Factor ; TNFSF13B protein, human ; Interleukin-1beta ; IL1B protein, human ; STAT3 Transcription Factor ; STAT3 protein, human
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-024-01808-x
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Article ; Online: Innate lymphoid cells: emerging insights in development, lineage relationships, and function.

Spits, Hergen / Cupedo, Tom

Annual review of immunology

2012 Volume 30, Page(s) 647–675

Abstract: Innate lymphoid cells (ILCs) are immune cells that lack a specific antigen receptor yet can produce an array of effector cytokines that in variety match that of T helper cell subsets. ILCs function in lymphoid organogenesis, tissue remodeling, ... ...

Abstract	Innate lymphoid cells (ILCs) are immune cells that lack a specific antigen receptor yet can produce an array of effector cytokines that in variety match that of T helper cell subsets. ILCs function in lymphoid organogenesis, tissue remodeling, antimicrobial immunity, and inflammation, particularly at barrier surfaces. Their ability to promptly respond to insults inflicted by stress-causing microbes strongly suggests that ILCs are critical in first-line immunological defenses. Here, we review current data on developmental requirements, lineage relationships, and effector functions of two families of ILCs: (a) Rorγt-expressing cells involved in lymphoid tissue formation, mucosal immunity, and inflammation and (b) type 2 ILCs that are important for helminth immunity. We also discuss the potential roles of ILCs in the pathology of immune-mediated inflammatory and infectious diseases including allergy.
MeSH term(s)	Animals ; Cell Differentiation/immunology ; Cell Lineage ; Humans ; Immunity, Innate ; Lymphocytes/cytology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism
Chemical Substances	Nuclear Receptor Subfamily 1, Group F, Member 3
Language	English
Publishing date	2012
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604953-9
ISSN	1545-3278 ; 0732-0582
ISSN (online)	1545-3278
ISSN	0732-0582
DOI	10.1146/annurev-immunol-020711-075053
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