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  1. Article ; Online: A pediatric case series of invasive pneumococcal disease caused by

    Cura Yayla, Burcu Ceylan / Bedir Demirdag, Tugba / Akkuzu, Emine / Kara, Nursel / Tezer, Hasan / Tapisiz, Anıl

    Human vaccines & immunotherapeutics

    2023  Volume 19, Issue 2, Page(s) 2219186

    Abstract: Streptococcus ... ...

    Abstract Streptococcus pneumoniae
    MeSH term(s) Child ; Humans ; Infant ; Serogroup ; Pneumococcal Infections/microbiology ; Streptococcus pneumoniae ; Pneumococcal Vaccines ; Pneumonia ; Vaccination ; Vaccines, Conjugate
    Chemical Substances Pneumococcal Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2023.2219186
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  2. Article ; Online: Antimicrobial surgical prophylaxis: Still an issue in paediatrics.

    Bedir Demirdag, Tugba / Cura Yayla, Burcu Ceylan / Tezer, Hasan / Tapısız, Anıl

    Journal of global antimicrobial resistance

    2020  Volume 23, Page(s) 224–227

    Abstract: Objectives: Antimicrobial prophylaxis (AP) is an important means of reducing surgical site infections. The goal of this study was to evaluate the perioperative AP in paediatric practice and its compliance with surgical prophylaxis guidelines.: Methods! ...

    Abstract Objectives: Antimicrobial prophylaxis (AP) is an important means of reducing surgical site infections. The goal of this study was to evaluate the perioperative AP in paediatric practice and its compliance with surgical prophylaxis guidelines.
    Methods: A prospective study was conducted at Gazi University Faculty of Medicine, between September 2015 and April 2016. Paediatric patients who underwent surgical procedures were included in the study. Surgical AP was evaluated.
    Results: During the entire study period, 466 children underwent surgery at our centre; 433 (92.7%) received antimicrobial prophylaxis. Overall adherence to the guidelines regarding surgical prophylaxis was 22.1%. The rate of administration of surgical prophylaxis was significantly lower, and the duration was shorter when the surgical procedure was clean (P = 0.002). When the duration of the procedure was longer, the rate of administration of prophylaxis was higher (P = 0.000). The duration of postoperative prophylaxis was longer than recommended in 72.2% of the patients. In the multivariate analysis, application errors increased with longer surgical time (P = 0.01, OR 2.18, 95% CI 1.19-4.03).
    Conclusions: High rates of misapplication of antimicrobial surgical prophylaxis were observed in this study. Awareness and usage of guidelines should be encouraged. The education of clinicians should be supported by studies regarding surgical prophylaxis in children.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Child ; Guideline Adherence ; Humans ; Pediatrics ; Prospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-10-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2020.09.020
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  3. Article: Evaluation of Tubular Dysfunction Using Urine Biomarkers in Children with COVID-19.

    Taş, Nesrin / Uslu Gökçeoğlu, Arife / Aykaç, Kübra / Cura Yayla, Burcu Ceylan / Şeneş, Mehmet / Demirkapı, Leyla / Çolak Samsun, Emel

    Turkish archives of pediatrics

    2021  Volume 57, Issue 1, Page(s) 99–103

    Abstract: Objective: The coronavirus disease pandemic is a major problem that the world has been facing since December 2019. It mainly affects the respiratory system; however, the disease can affect the kidneys to different degrees. This study aimed to determine ... ...

    Abstract Objective: The coronavirus disease pandemic is a major problem that the world has been facing since December 2019. It mainly affects the respiratory system; however, the disease can affect the kidneys to different degrees. This study aimed to determine the changes in tubular dysfunction and inflammation parameters in children with coronavirus disease using urine biomarkers.
    Materials and methods: We included 36 children who tested positive for severe acute respiratory syndrome coronavirus 2 on real-time reverse transcriptase-polymerase chain reaction using respiratory specimens. Coronavirus disease-positive and -negative period parameters were evaluated. For measurement of interleukin-1β, interleukin-6, and urine β2 microglobulin levels, patients' urine samples were collected at diagnosis and 1 month after discharge. Additionally, routine urine and hematological parameters were evaluated concurrently.
    Results: For all patients, the median urine β2 microglobulin, serum urea, and lactate dehydrogenase levels were significantly higher in the coronavirus disease-positive period than in the coronavirus disease-negative period (P < .05). Further, serum platelet count was significantly lower in the coronavirus disease-positive period than in the coronavirus disease-negative period (P < .05). However, there was no difference in serum creatinine, interleukin-6, or interleukin-1β levels between the 2 periods (P > .05).
    Conclusion: Our results suggest kidney involvement and tubular dysfunction in patients with asymptomatic, mild, and moderate infections. Furthermore, interleukin-1β and interleukin-6 levels were high in the urine, even in non-critically ill patients. We believe that these findings contribute to the accumulation of evidence on continued inflammation in the kidney.
    Language English
    Publishing date 2021-12-18
    Publishing country Turkey
    Document type Journal Article
    ISSN 2757-6256
    ISSN 2757-6256
    DOI 10.5152/TurkArchPediatr.2022.21248
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  4. Article ; Online: Does aeroallergen sensitivity and allergic rhinitis in children cause milder COVID-19 infection?

    Vezir, Emine / Hizal, Mina / Cura Yayla, Burcu / Aykac, Kubra / Yilmaz, Arzu / Kaya, Gamze / Oygar, Pembe Derin / Ozsurekci, Yasemin / Ceyhan, Mehmet

    Allergy and asthma proceedings

    2021  Volume 42, Issue 6, Page(s) 522–529

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Allergens/adverse effects ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/immunology ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Child ; Child, Preschool ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/immunology ; Female ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/epidemiology ; Hypersensitivity/immunology ; Immunoglobulin E/blood ; Male ; Respiratory Function Tests ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/immunology ; SARS-CoV-2 ; Severity of Illness Index ; Skin Tests/statistics & numerical data ; Turkey/epidemiology
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2021.42.210087
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  5. Article ; Online: Fever Without a Focus: A Rare Presentation of Mycoplasma Infections.

    Bedir Demirdağ, Tuğba / Tapisiz, Anil / Ceylan Cura Yayla, Burcu / Özkaya Parlakay, Aslinur / Tezer, Hasan

    The Pediatric infectious disease journal

    2019  Volume 38, Issue 10, Page(s) e277–e278

    MeSH term(s) Child ; Cohort Studies ; Fever ; Humans ; Mycoplasma Infections ; Pneumonia, Mycoplasma
    Language English
    Publishing date 2019-09-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000002402
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    Zs.A 1852: Show issues Location:
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  6. Article ; Online: Letter to the Editor.

    Bedir Demirdag, Tugba / Cura Yayla, Burcu C / Tezer, Hasan / Tapısız, Anıl

    Journal of paediatrics and child health

    2019  Volume 55, Issue 10, Page(s) 1289

    MeSH term(s) Anti-Bacterial Agents ; Antibiotic Prophylaxis ; Child ; Cohort Studies ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-10-17
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.14604
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    Zs.A 227: Show issues Location:
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  7. Article: Hyperimmunoglobulin D Syndrome Presenting with Volvulus Due to Abdominal Fibro-Inflammatory Bands.

    Aslan, Muzaffer Kaan / Cesur, Özkan / Özcan, Ayşegül / Avcı, Nihal / Goncu, Sultan / Ünsal Saç, Rukiye / Sandal, Semih / Cura Yayla, Burcu Ceylan / Vezir, Emine / Tasar, Medine Aysin / Sağ, Erdal

    Turkish archives of pediatrics

    2022  Volume 58, Issue 1, Page(s) 109–111

    Language English
    Publishing date 2022-09-22
    Publishing country Turkey
    Document type Journal Article
    ISSN 2757-6256
    ISSN 2757-6256
    DOI 10.5152/TurkArchPediatr.2022.22125
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  8. Article ; Online: Longitudinal Follow-up of Antibody Responses in Pediatric Patients With COVID-19 up to 9 Months After Infection.

    Oygar, Pembe Derin / Ozsurekci, Yasemin / Gurlevik, Sibel Lacinel / Aykac, Kubra / Kukul, Musa Gurel / Cura Yayla, Burcu Ceylan / Ilbay, Sare / Karakaya, Jale / Teksam, Ozlem / Cengiz, Ali Bulent / Ceyhan, Mehmet

    The Pediatric infectious disease journal

    2021  Volume 40, Issue 8, Page(s) e294–e299

    Abstract: Introduction: Antibody response developed within 2-3 weeks after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to decrease over time; however, there is limited data about antibody levels at 6 months or later ... ...

    Abstract Introduction: Antibody response developed within 2-3 weeks after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to decrease over time; however, there is limited data about antibody levels at 6 months or later postinfection, particularly in children.
    Materials and method: A prospective multicenter study was performed using 315 samples of 74 confirmed and 10 probable coronavirus disease 2019 pediatric cases. About 20% of these cases were classified as asymptomatic, 74% as mild/moderate and 6% as severe/critical. Patients were included if at least 2 samples were available. The antibody response was classified as either early-period or late-period (14 days-3 months and after 6 months, respectively) for IgG response whereas IgA response was tested on various time intervals, including as early as 4 days up to 3 months. Euroimmun Anti-SARS-CoV-2 IgG and IgA and Genscript SARS-CoV-2 Surrogate Virus Neutralization Kits were used for antibody detection.
    Results: There was no difference between the early-period and late-period IgG positivity (P = 0.1). However, the median IgG levels were 11.98 in the early periods and 4.05 in the late periods, with a significance of P < 0.001. Although the decrease in IgG levels was significant in asymptomatic and mild/moderate cases (P < 0.008 and P < 0.001, respectively), the decrease in severe/critical cases was moderate (P = 0.285). The sensitivity of the IgG after 15 days was higher than 94%, and the sensitivity of IgA was 88% on days 8-15.
    Conclusion: SARS-CoV-2 IgG antibody levels decreased after 6 months. The decrease was moderate in severe/critical cases. Overall, 95.8% of the patients remained positive up to 9 months after infection. Although the IgA response may be useful early on, the IgG response is useful after 14 days.
    MeSH term(s) Adolescent ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/immunology ; Antibody Formation ; COVID-19/immunology ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Immunoglobulin A ; Immunoglobulin G/biosynthesis ; Immunoglobulin G/immunology ; Infant ; Longitudinal Studies ; Male ; Prospective Studies ; SARS-CoV-2/immunology
    Chemical Substances Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003199
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  9. Article ; Online: Pneumococcal carriage in children with COVID-19.

    Aykac, Kubra / Ozsurekci, Yasemin / Cura Yayla, Burcu Ceylan / Evren, Kubra / Lacinel Gurlevik, Sibel / Oygar, Pembe Derin / Yucel, Mihriban / Karakoc, Ayse Esra / Alp, Alpaslan / Cengiz, Ali Bulent / Ceyhan, Mehmet

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 6, Page(s) 1628–1634

    Abstract: ... ...

    Abstract Background
    MeSH term(s) COVID-19/complications ; COVID-19/microbiology ; Carrier State/epidemiology ; Carrier State/microbiology ; Child ; Humans ; Nasopharynx/microbiology ; Pandemics ; Pneumococcal Infections/epidemiology ; Retrospective Studies ; Streptococcus pneumoniae ; Turkey
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2020.1849516
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    Zs.A 6967: Show issues Location:
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  10. Article: The comparison and diagnostic accuracy of different types of thermometers.

    Erdem, Nurettin / Demirdağ, Tuğba Bedir / Tezer, Hasan / Cura-Yayla, Burcu Ceylan / Baran-Aksakal, Fatma Nur / Tapısız, Anıl / Derinöz, Okşan / Okur, Arzu / Pınarlı, Faruk Güçlü / Koçak, Ülker / Bideci, Aysun

    The Turkish journal of pediatrics

    2021  Volume 63, Issue 3, Page(s) 434–442

    Abstract: Background: Fever is one of the leading causes of hospital admissions in children. Although there are many ways to measure body temperature, the optimal method and the anatomic site are still controversial. In this study, we aimed to evaluate the ... ...

    Abstract Background: Fever is one of the leading causes of hospital admissions in children. Although there are many ways to measure body temperature, the optimal method and the anatomic site are still controversial. In this study, we aimed to evaluate the performance of new methods of measuring body temperature and to compare the accuracy, sensitivity and specificity of these methods.
    Methods: The body temperatures of the patients who were hospitalized as inpatients or who presented to the emergency room as outpatients between November 2014- March 2015 were measured and recorded. Mercury and digital axillary measurements, tympanic, temporal artery and non-contact skin temperatures were measured. Measurements were compared with each other.
    Results: According to our results temperature tends to increase over time for up to 8 minutes after placement when using axillary thermometers. Non-contact skin thermometers should be used only for follow-up of patients with fever, because of their low sensitivity and low negative predictivity. At the first examination, tympanic thermometers and axillary thermometers may be preferable for the diagnosis of fever.
    Conclusions: According to our results, using non-contact thermometers seems feasible and logical during the follow-up ofpatients with fever, but not in cases whose exact body temperature should be known. For the first examination of the patient to diagnose fever, tympanic thermometers and axillary thermometers may be preferable. Future studies are warranted to expose the optimum way of measuring body temperature in children.
    MeSH term(s) Axilla ; Body Temperature ; Child ; Fever/diagnosis ; Humans ; Sensitivity and Specificity ; Thermometers ; Tympanic Membrane
    Language English
    Publishing date 2021-07-13
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 123487-0
    ISSN 0041-4301
    ISSN 0041-4301
    DOI 10.24953/turkjped.2021.03.010
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