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Article ; Online: A pediatric case series of invasive pneumococcal disease caused by

Cura Yayla, Burcu Ceylan / Bedir Demirdag, Tugba / Akkuzu, Emine / Kara, Nursel / Tezer, Hasan / Tapisiz, Anıl

2023 Volume 19, Issue 2, Page(s) 2219186

Abstract: Streptococcus ... ...

Abstract	Streptococcus pneumoniae
MeSH term(s)	Child ; Humans ; Infant ; Serogroup ; Pneumococcal Infections/microbiology ; Streptococcus pneumoniae ; Pneumococcal Vaccines ; Pneumonia ; Vaccination ; Vaccines, Conjugate
Chemical Substances	Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2023.2219186
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Article ; Online: Antimicrobial surgical prophylaxis: Still an issue in paediatrics.

Bedir Demirdag, Tugba / Cura Yayla, Burcu Ceylan / Tezer, Hasan / Tapısız, Anıl

Journal of global antimicrobial resistance

2020 Volume 23, Page(s) 224–227

Abstract: Objectives: Antimicrobial prophylaxis (AP) is an important means of reducing surgical site infections. The goal of this study was to evaluate the perioperative AP in paediatric practice and its compliance with surgical prophylaxis guidelines.: Methods! ...

Abstract	Objectives: Antimicrobial prophylaxis (AP) is an important means of reducing surgical site infections. The goal of this study was to evaluate the perioperative AP in paediatric practice and its compliance with surgical prophylaxis guidelines. Methods: A prospective study was conducted at Gazi University Faculty of Medicine, between September 2015 and April 2016. Paediatric patients who underwent surgical procedures were included in the study. Surgical AP was evaluated. Results: During the entire study period, 466 children underwent surgery at our centre; 433 (92.7%) received antimicrobial prophylaxis. Overall adherence to the guidelines regarding surgical prophylaxis was 22.1%. The rate of administration of surgical prophylaxis was significantly lower, and the duration was shorter when the surgical procedure was clean (P = 0.002). When the duration of the procedure was longer, the rate of administration of prophylaxis was higher (P = 0.000). The duration of postoperative prophylaxis was longer than recommended in 72.2% of the patients. In the multivariate analysis, application errors increased with longer surgical time (P = 0.01, OR 2.18, 95% CI 1.19-4.03). Conclusions: High rates of misapplication of antimicrobial surgical prophylaxis were observed in this study. Awareness and usage of guidelines should be encouraged. The education of clinicians should be supported by studies regarding surgical prophylaxis in children.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Child ; Guideline Adherence ; Humans ; Pediatrics ; Prospective Studies
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-10-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7165
ISSN (online)	2213-7173
ISSN	2213-7165
DOI	10.1016/j.jgar.2020.09.020
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Article: Evaluation of Tubular Dysfunction Using Urine Biomarkers in Children with COVID-19.

Taş, Nesrin / Uslu Gökçeoğlu, Arife / Aykaç, Kübra / Cura Yayla, Burcu Ceylan / Şeneş, Mehmet / Demirkapı, Leyla / Çolak Samsun, Emel

Turkish archives of pediatrics

2021 Volume 57, Issue 1, Page(s) 99–103

Abstract: Objective: The coronavirus disease pandemic is a major problem that the world has been facing since December 2019. It mainly affects the respiratory system; however, the disease can affect the kidneys to different degrees. This study aimed to determine ... ...

Abstract	Objective: The coronavirus disease pandemic is a major problem that the world has been facing since December 2019. It mainly affects the respiratory system; however, the disease can affect the kidneys to different degrees. This study aimed to determine the changes in tubular dysfunction and inflammation parameters in children with coronavirus disease using urine biomarkers. Materials and methods: We included 36 children who tested positive for severe acute respiratory syndrome coronavirus 2 on real-time reverse transcriptase-polymerase chain reaction using respiratory specimens. Coronavirus disease-positive and -negative period parameters were evaluated. For measurement of interleukin-1β, interleukin-6, and urine β2 microglobulin levels, patients' urine samples were collected at diagnosis and 1 month after discharge. Additionally, routine urine and hematological parameters were evaluated concurrently. Results: For all patients, the median urine β2 microglobulin, serum urea, and lactate dehydrogenase levels were significantly higher in the coronavirus disease-positive period than in the coronavirus disease-negative period (P < .05). Further, serum platelet count was significantly lower in the coronavirus disease-positive period than in the coronavirus disease-negative period (P < .05). However, there was no difference in serum creatinine, interleukin-6, or interleukin-1β levels between the 2 periods (P > .05). Conclusion: Our results suggest kidney involvement and tubular dysfunction in patients with asymptomatic, mild, and moderate infections. Furthermore, interleukin-1β and interleukin-6 levels were high in the urine, even in non-critically ill patients. We believe that these findings contribute to the accumulation of evidence on continued inflammation in the kidney.
Language	English
Publishing date	2021-12-18
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2022.21248
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Article: Hyperimmunoglobulin D Syndrome Presenting with Volvulus Due to Abdominal Fibro-Inflammatory Bands.

Aslan, Muzaffer Kaan / Cesur, Özkan / Özcan, Ayşegül / Avcı, Nihal / Goncu, Sultan / Ünsal Saç, Rukiye / Sandal, Semih / Cura Yayla, Burcu Ceylan / Vezir, Emine / Tasar, Medine Aysin / Sağ, Erdal

Turkish archives of pediatrics

2022 Volume 58, Issue 1, Page(s) 109–111

Language	English
Publishing date	2022-09-22
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2022.22125
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Article ; Online: Longitudinal Follow-up of Antibody Responses in Pediatric Patients With COVID-19 up to 9 Months After Infection.

Oygar, Pembe Derin / Ozsurekci, Yasemin / Gurlevik, Sibel Lacinel / Aykac, Kubra / Kukul, Musa Gurel / Cura Yayla, Burcu Ceylan / Ilbay, Sare / Karakaya, Jale / Teksam, Ozlem / Cengiz, Ali Bulent / Ceyhan, Mehmet

The Pediatric infectious disease journal

2021 Volume 40, Issue 8, Page(s) e294–e299

Abstract: Introduction: Antibody response developed within 2-3 weeks after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to decrease over time; however, there is limited data about antibody levels at 6 months or later ... ...

Abstract	Introduction: Antibody response developed within 2-3 weeks after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to decrease over time; however, there is limited data about antibody levels at 6 months or later postinfection, particularly in children. Materials and method: A prospective multicenter study was performed using 315 samples of 74 confirmed and 10 probable coronavirus disease 2019 pediatric cases. About 20% of these cases were classified as asymptomatic, 74% as mild/moderate and 6% as severe/critical. Patients were included if at least 2 samples were available. The antibody response was classified as either early-period or late-period (14 days-3 months and after 6 months, respectively) for IgG response whereas IgA response was tested on various time intervals, including as early as 4 days up to 3 months. Euroimmun Anti-SARS-CoV-2 IgG and IgA and Genscript SARS-CoV-2 Surrogate Virus Neutralization Kits were used for antibody detection. Results: There was no difference between the early-period and late-period IgG positivity (P = 0.1). However, the median IgG levels were 11.98 in the early periods and 4.05 in the late periods, with a significance of P < 0.001. Although the decrease in IgG levels was significant in asymptomatic and mild/moderate cases (P < 0.008 and P < 0.001, respectively), the decrease in severe/critical cases was moderate (P = 0.285). The sensitivity of the IgG after 15 days was higher than 94%, and the sensitivity of IgA was 88% on days 8-15. Conclusion: SARS-CoV-2 IgG antibody levels decreased after 6 months. The decrease was moderate in severe/critical cases. Overall, 95.8% of the patients remained positive up to 9 months after infection. Although the IgA response may be useful early on, the IgG response is useful after 14 days.
MeSH term(s)	Adolescent ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/immunology ; Antibody Formation ; COVID-19/immunology ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Immunoglobulin A ; Immunoglobulin G/biosynthesis ; Immunoglobulin G/immunology ; Infant ; Longitudinal Studies ; Male ; Prospective Studies ; SARS-CoV-2/immunology
Chemical Substances	Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G
Language	English
Publishing date	2021-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003199
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Article ; Online: Pneumococcal carriage in children with COVID-19.

Aykac, Kubra / Ozsurekci, Yasemin / Cura Yayla, Burcu Ceylan / Evren, Kubra / Lacinel Gurlevik, Sibel / Oygar, Pembe Derin / Yucel, Mihriban / Karakoc, Ayse Esra / Alp, Alpaslan / Cengiz, Ali Bulent / Ceyhan, Mehmet

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 6, Page(s) 1628–1634

Abstract: ... ...

Abstract	Background
MeSH term(s)	COVID-19/complications ; COVID-19/microbiology ; Carrier State/epidemiology ; Carrier State/microbiology ; Child ; Humans ; Nasopharynx/microbiology ; Pandemics ; Pneumococcal Infections/epidemiology ; Retrospective Studies ; Streptococcus pneumoniae ; Turkey
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2020.1849516
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Article: The comparison and diagnostic accuracy of different types of thermometers.

Erdem, Nurettin / Demirdağ, Tuğba Bedir / Tezer, Hasan / Cura-Yayla, Burcu Ceylan / Baran-Aksakal, Fatma Nur / Tapısız, Anıl / Derinöz, Okşan / Okur, Arzu / Pınarlı, Faruk Güçlü / Koçak, Ülker / Bideci, Aysun

The Turkish journal of pediatrics

2021 Volume 63, Issue 3, Page(s) 434–442

Abstract: Background: Fever is one of the leading causes of hospital admissions in children. Although there are many ways to measure body temperature, the optimal method and the anatomic site are still controversial. In this study, we aimed to evaluate the ... ...

Abstract	Background: Fever is one of the leading causes of hospital admissions in children. Although there are many ways to measure body temperature, the optimal method and the anatomic site are still controversial. In this study, we aimed to evaluate the performance of new methods of measuring body temperature and to compare the accuracy, sensitivity and specificity of these methods. Methods: The body temperatures of the patients who were hospitalized as inpatients or who presented to the emergency room as outpatients between November 2014- March 2015 were measured and recorded. Mercury and digital axillary measurements, tympanic, temporal artery and non-contact skin temperatures were measured. Measurements were compared with each other. Results: According to our results temperature tends to increase over time for up to 8 minutes after placement when using axillary thermometers. Non-contact skin thermometers should be used only for follow-up of patients with fever, because of their low sensitivity and low negative predictivity. At the first examination, tympanic thermometers and axillary thermometers may be preferable for the diagnosis of fever. Conclusions: According to our results, using non-contact thermometers seems feasible and logical during the follow-up ofpatients with fever, but not in cases whose exact body temperature should be known. For the first examination of the patient to diagnose fever, tympanic thermometers and axillary thermometers may be preferable. Future studies are warranted to expose the optimum way of measuring body temperature in children.
MeSH term(s)	Axilla ; Body Temperature ; Child ; Fever/diagnosis ; Humans ; Sensitivity and Specificity ; Thermometers ; Tympanic Membrane
Language	English
Publishing date	2021-07-13
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
DOI	10.24953/turkjped.2021.03.010
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Article ; Online: Predictive value of cytokine/chemokine responses for the disease severity and management in children and adult cases with COVID-19.

Ozsurekci, Yasemin / Aykac, Kubra / Er, Ahmet Gorkem / Halacli, Burcin / Arasli, Mehmet / Oygar, Pembe Derin / Gürlevik, Sibel / Cura Yayla, Burcu Ceylan / Karakaya, Jale / Alp, Alparslan / Topeli, Arzu / Cengiz, Ali Bülent / Akova, Murat / Ceyhan, Mehmet

Journal of medical virology

2020 Volume 93, Issue 5, Page(s) 2828–2837

Abstract: The disease course of children with coronavirus disease 2019 (COVID-19) seems milder as compared with adults, however, actual reason of the pathogenesis still remains unclear. There is a growing interest on possible relationship between pathogenicity or ... ...

Abstract	The disease course of children with coronavirus disease 2019 (COVID-19) seems milder as compared with adults, however, actual reason of the pathogenesis still remains unclear. There is a growing interest on possible relationship between pathogenicity or disease severity and biomarkers including cytokines or chemokines. We wondered whether these biomarkers could be used for the prediction of the prognosis of COVID-19 and improving our understanding on the variations between pediatric and adult cases with COVID-19. The acute phase serum levels of 25 cytokines and chemokines in the serum samples from 60 COVID-19 pediatric (n = 30) and adult cases (n = 30) including 20 severe or critically ill, 25 moderate and 15 mild patients and 30 healthy pediatric (n = 15) and adult (n = 15) volunteers were measured using commercially available fluorescent bead immunoassay and analyzed in combination with clinical data. Interferon gamma-induced protein 10 (IP-10) and macrophage inflammatory protein (MIP)-3β levels were significantly higher in patient cohort including pediatric and adult cases with COVID-19 when compared with all healthy volunteers (p ≤ .001 in each) and whereas IP-10 levels were significantly higher in both pediatric and adult cases with severe disease course, MIP-3β were significantly lower in healthy controls. Additionally, IP-10 is an independent predictor for disease severity, particularly in children and interleukin-6 seems a relatively good predictor for disease severity in adults. IP-10 and MIP-3β seem good research candidates to understand severity of COVID-19 in both pediatric and adult population and to investigate possible pathophysiological mechanism of COVID-19.
MeSH term(s)	Adolescent ; Aged ; Biomarkers/blood ; COVID-19/therapy ; Chemokine CCL19/blood ; Chemokine CXCL10/blood ; Chemokines/blood ; Child ; Child, Preschool ; Cytokines/blood ; Disease Progression ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Prognosis ; SARS-CoV-2 ; Severity of Illness Index
Chemical Substances	Biomarkers ; CXCL10 protein, human ; Chemokine CCL19 ; Chemokine CXCL10 ; Chemokines ; Cytokines
Language	English
Publishing date	2020-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26683
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Article ; Online: Characteristics and Management of Children with COVID-19 in Turkey

Cura Yayla, Burcu Ceylan / Özsürekçi, Yasemin / Aykaç, Kübra / Derin Oygar, Pembe / Laçinel Gürlevik, Sibel / İlbay, Sare / Kukul, Musa Gürel / Karahan, Sevilay / Cengiz, Ali Bülent / Ceyhan, Mehmet

Balkan medical journal

2020 Volume 37, Issue 6, Page(s) 341–347

Abstract: Aims: Limited data about disease management strategies are available for pediatric patients with coronavirus disease-2019, particularly in Turkey. This study aimed to share the data on patients aged under 18 years in our country to be beneficial for ... ...

Abstract	Aims: Limited data about disease management strategies are available for pediatric patients with coronavirus disease-2019, particularly in Turkey. This study aimed to share the data on patients aged under 18 years in our country to be beneficial for understanding the disease course in children. Methods: A retrospective review of the medical records of pediatric patients aged under 18 years who were confirmed as coronavirus disease-2019 between March 11, and June 23, 2020, and were admitted to our hospitals was conducted. Results: A total of 220 pediatric patients with coronavirus disease-2019 were evaluated, of which 48.2% were boys, with a median age of 10 years, and 9.5% had underlying diseases. Patients were classified according to severity, with the percentages of asymptomatic, mild, moderate, and critical/severe cases determined to be 25.5%, 45%, 26.8%, and 2.7%, respectively. Extracorporeal membrane oxygenation was required in two patients (0.9%) and mechanical ventilation in three (1.4%). Targeted therapies were used in six patients (2.7%), with hydroxychloroquine being the most commonly used agent either alone (one patient) or in combination with favipiravir (five patients). Two patients (0.9%) died, and nine (4.1%) were still hospitalized during the study period. Conclusion: Although the disease course of coronavirus disease-2019 seems to be mild in children, critical illness is significant, and the treatment strategy primarily should consist of supportive care according to our preliminary observations.
MeSH term(s)	Adolescent ; Amides/therapeutic use ; Antimalarials/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Extracorporeal Membrane Oxygenation ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Infant ; Infant, Newborn ; Intensive Care Units, Pediatric ; Length of Stay ; Male ; Pandemics ; Patient Acuity ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Pyrazines/therapeutic use ; Respiration, Artificial ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome ; Turkey
Chemical Substances	Amides ; Antimalarials ; Antiviral Agents ; Pyrazines ; Hydroxychloroquine (4QWG6N8QKH) ; favipiravir (EW5GL2X7E0)
Keywords	covid19
Language	English
Publishing date	2020-08-31
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3131
ISSN (online)	2146-3131
ISSN	2146-3131
DOI	10.4274/balkanmedj.galenos.2020.2020.7.52
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Article ; Online: The association of viral load and disease severity in children with COVID-19.

Aykac, Kubra / Cura Yayla, Burcu Ceylan / Ozsurekci, Yasemin / Evren, Kubra / Oygar, Pembe Derin / Gurlevik, Sibel Lacinel / Coskun, Tugce / Tasci, Onur / Demirel Kaya, Filiz / Fidanci, Ilknur / Tasar, Medine Aysin / Alp, Alpaslan / Cengiz, Ali Bulent / Karahan, Sevilay / Ceyhan, Mehmet

Journal of medical virology

2021 Volume 93, Issue 5, Page(s) 3077–3083

Abstract: It is still not fully understood how to predict the future prognosis of patients at the diagnosis coronavirus disease 2019 (COVID-19) due to the wide clinical range of the disease. We aimed to evaluate whether severe acute respiratory syndrome ... ...

Abstract	It is still not fully understood how to predict the future prognosis of patients at the diagnosis coronavirus disease 2019 (COVID-19) due to the wide clinical range of the disease. We aimed to evaluate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load could predict the clinical course of pediatric patients. This study was conducted retrospectively with medical records of pediatric patients who were tested for SARS-CoV2 between April 12 and October 25, 2020 in the University of Health Sciences, Ankara Educating and Training Hospital and Hacettepe University Faculty of Medicine. We evaluated 518 pediatric patients diagnosed with COVID-19 and classified according to severity as asymptomatic (16.2%), mild (59.6%), moderate (20.2%), and critical/severe (3.9%) cases. We analyzed patients in four groups in terms of ages: <4, 5-9, 10-14, and 15-17 years. There was no statistically significant difference in terms of ∆C
MeSH term(s)	Adolescent ; COVID-19/pathology ; COVID-19/virology ; Child ; Child, Preschool ; Female ; Humans ; Male ; SARS-CoV-2 ; Severity of Illness Index ; Viral Load
Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26853
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