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  1. AU="Curdy, Nicolas"
  2. AU="Nkfusai, Claude Ngwayu"
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  1. Article: Stress Granules in the Post-transcriptional Regulation of Immune Cells.

    Curdy, Nicolas / Lanvin, Olivia / Cadot, Sarah / Laurent, Camille / Fournié, Jean-Jacques / Franchini, Don-Marc

    Frontiers in cell and developmental biology

    2021  Volume 8, Page(s) 611185

    Abstract: Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response. These dynamic processes require an intricate orchestration of ... ...

    Abstract Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response. These dynamic processes require an intricate orchestration of regulatory mechanisms to control the precise spatiotemporal expression of proteins. Post-transcriptional regulation ensures the control of messenger RNA metabolism and appropriate translation. Among these post-transcriptional regulatory mechanisms, stress granules participate in the control of protein synthesis. Stress granules are ribonucleoprotein complexes that form upon stress, typically under control of the integrated stress response. Such structures assemble upon stimulation of immune cells where they control selective translational programs ensuring the establishment of accurate effector functions. In this review, we summarize the current knowledge about post-transcriptional regulation in immune cells and highlight the role of stress sensors and stress granules in such regulation.
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.611185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cancer cell adaptability: turning ribonucleoprotein granules into targets.

    Lavalée, Margot / Curdy, Nicolas / Laurent, Camille / Fournié, Jean-Jacques / Franchini, Don-Marc

    Trends in cancer

    2021  Volume 7, Issue 10, Page(s) 902–915

    Abstract: Stress granules (SGs) and processing bodies (P-bodies) are membraneless cytoplasmic condensates of ribonucleoproteins (RNPs). They both regulate RNA fate under physiological and pathological conditions, and are thereby involved in the regulation and ... ...

    Abstract Stress granules (SGs) and processing bodies (P-bodies) are membraneless cytoplasmic condensates of ribonucleoproteins (RNPs). They both regulate RNA fate under physiological and pathological conditions, and are thereby involved in the regulation and maintenance of cellular integrity. During tumorigenesis, cancer cells use these granules to thrive, to adapt to the harsh conditions of the tumor microenvironment (TME), and to protect themselves from anticancer treatments. This ability to provide multiple outcomes not only makes RNP granules promising targets for cancer therapy but also emphasizes the need for more knowledge about the biology of these granules to achieve clinical use. In this review we focus on the role of RNP granules in cancer, and on how their composition and regulation might be used to elaborate therapeutic strategies.
    MeSH term(s) Cytoplasmic Granules ; Cytoplasmic Ribonucleoprotein Granules ; Neoplasms ; Processing Bodies ; Ribonucleoproteins ; Stress Granules
    Chemical Substances Ribonucleoproteins
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Contrôle de l’activité lymphocytaire par les granules de stress - Nouvelles cibles pour l’immunothérapie ?

    Franchini, Don-Marc / Lanvin, Olivia / Curdy, Nicolas / Fournié, Jean-Jacques

    Medecine sciences : M/S

    2019  Volume 35, Issue 6-7, Page(s) 507–509

    Title translation Control of lymphocyte activity by stress granules. New targets for immunotherapy ?
    MeSH term(s) B-Lymphocytes/physiology ; Cytoplasmic Granules/physiology ; Humans ; Immunotherapy/methods ; RNA Processing, Post-Transcriptional ; RNA, Messenger/metabolism ; Stress, Physiological ; T-Lymphocytes/physiology
    Chemical Substances RNA, Messenger
    Language French
    Publishing date 2019-07-05
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2019109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.

    Curdy, Nicolas / Lanvin, Olivia / Cerapio, Juan-Pablo / Pont, Fréderic / Tosolini, Marie / Sarot, Emeline / Valle, Carine / Saint-Laurent, Nathalie / Lhuillier, Emeline / Laurent, Camille / Fournié, Jean-Jacques / Franchini, Don-Marc

    Cell reports

    2023  Volume 42, Issue 3, Page(s) 112211

    Abstract: Stress granules (SGs) and processing bodies (PBs) are membraneless cytoplasmic assemblies regulating mRNAs under environmental stress such as viral infections, neurological disorders, or cancer. Upon antigen stimulation, T lymphocytes mediate their ... ...

    Abstract Stress granules (SGs) and processing bodies (PBs) are membraneless cytoplasmic assemblies regulating mRNAs under environmental stress such as viral infections, neurological disorders, or cancer. Upon antigen stimulation, T lymphocytes mediate their immune functions under regulatory mechanisms involving SGs and PBs. However, the impact of T cell activation on such complexes in terms of formation, constitution, and relationship remains unknown. Here, by combining proteomic, transcriptomic, and immunofluorescence approaches, we simultaneously characterized the SGs and PBs from primary human T lymphocytes pre and post stimulation. The identification of the proteomes and transcriptomes of SGs and PBs indicate an unanticipated molecular and functional complementarity. Notwithstanding, these granules keep distinct spatial organizations and abilities to interact with mRNAs. This comprehensive characterization of the RNP granule proteomic and transcriptomic landscapes provides a unique resource for future investigations on SGs and PBs in T lymphocytes.
    MeSH term(s) Stress Granules/metabolism ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Lymphocyte Activation ; Processing Bodies/metabolism ; Proteome/metabolism ; Transcriptome/genetics ; Proteomics ; Gene Expression Profiling ; Humans ; Male ; Female ; Adult ; Cells, Cultured ; RNA/analysis ; Protein Biosynthesis ; Transcription, Genetic ; Cell Fractionation
    Chemical Substances Proteome ; RNA (63231-63-0)
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Regulatory Mechanisms of Inhibitory Immune Checkpoint Receptors Expression.

    Curdy, Nicolas / Lanvin, Olivia / Laurent, Camille / Fournié, Jean-Jacques / Franchini, Don-Marc

    Trends in cell biology

    2019  Volume 29, Issue 10, Page(s) 777–790

    Abstract: T cells responding to persistent tumor or viral antigens progressively lose their functional properties, a feature known as exhaustion. This state is also characterized by cell-surface expression of multiple inhibitory immune checkpoint receptors (IRs). ... ...

    Abstract T cells responding to persistent tumor or viral antigens progressively lose their functional properties, a feature known as exhaustion. This state is also characterized by cell-surface expression of multiple inhibitory immune checkpoint receptors (IRs). Cancer immunotherapy by immune checkpoint targeting has shown impressive clinical outcomes, but requires substantial improvement given the limited number of patients who benefit from the treatment. Targeting the mechanisms controlling immune checkpoint expression could represent a step towards this aim. Accumulating data indicate that this strategy can limit immune checkpoint expression, in some instances simultaneously inhibiting several immune checkpoints. This review discusses various mechanisms through which IRs are activated or regulated, and ways these mechanisms could be exploited to develop more effective future immunotherapies.
    MeSH term(s) Animals ; Antineoplastic Agents, Immunological/pharmacology ; Cell Cycle Checkpoints ; Humans ; Immunotherapy ; Mice ; Neoplasms/immunology ; Neoplasms/therapy ; Receptors, Immunologic/antagonists & inhibitors ; Receptors, Immunologic/genetics ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology
    Chemical Substances Antineoplastic Agents, Immunological ; Receptors, Immunologic
    Language English
    Publishing date 2019-08-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2019.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
    Zs.MO 113: Show issues
    Zs.A 3410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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