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Article ; Online: Newborn Screening Is on a Collision Course with Public Health Ethics.

Currier, Robert J

International journal of neonatal screening

2022 Volume 8, Issue 4

Abstract: Newborn screening was established over 50 years ago to identify cases of disorders that were serious, urgent, and treatable, mirroring the criteria of Wilson and Jungner. In the last decade, conditions have been added to newborn screening that do not ... ...

Abstract	Newborn screening was established over 50 years ago to identify cases of disorders that were serious, urgent, and treatable, mirroring the criteria of Wilson and Jungner. In the last decade, conditions have been added to newborn screening that do not strictly meet these criteria, and genomic newborn screening is beginning to be discussed. Some of these new and proposed additions to newborn screening entail serious public health ethical issues that need to be explored.
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ISSN	2409-515X
ISSN (online)	2409-515X
DOI	10.3390/ijns8040051
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Article ; Online: Single-Gene Sequencing in Newborn Screening: Success, Challenge, Hope.

Currier, Robert J

The Hastings Center report

2018 Volume 48 Suppl 2, Page(s) S37–S38

Abstract: Some state-based newborn screening programs in the United States already use sequencing technology, as a secondary screening test for individual conditions rather than as a broad screening tool. Newborn screening programs sequence an individual gene, ... ...

Abstract	Some state-based newborn screening programs in the United States already use sequencing technology, as a secondary screening test for individual conditions rather than as a broad screening tool. Newborn screening programs sequence an individual gene, such as the cystic fibrosis transmembrane conductance regulator, which causes cystic fibrosis, after an initial biochemical test suggests that a baby might have a condition related to that gene. The experiences of state public health departments with individual-gene sequencing illustrate both the usefulness of the technology and its complexities. Here I discuss how newborn screening programs investigate cystic fibrosis and, as another example, adrenoleukodystrophy through individual gene sequencing.
MeSH term(s)	Adrenoleukodystrophy/diagnosis ; Adrenoleukodystrophy/genetics ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Genetic Testing/ethics ; Genetic Testing/methods ; Humans ; Infant, Newborn ; Neonatal Screening/ethics ; Neonatal Screening/methods ; United States
Chemical Substances	CFTR protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2018-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	194940-8
ISSN	1552-146X ; 0093-0334
ISSN (online)	1552-146X
ISSN	0093-0334
DOI	10.1002/hast.883
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Article ; Online: SCID newborn screening: What we've learned.

Currier, Robert / Puck, Jennifer M

The Journal of allergy and clinical immunology

2021 Volume 147, Issue 2, Page(s) 417–426

Abstract: Newborn screening for severe combined immunodeficiency, the most profound form of primary immune system defects, has long been recognized as a measure that would decrease morbidity and improve outcomes by helping patients avoid devastating infections and ...

Abstract	Newborn screening for severe combined immunodeficiency, the most profound form of primary immune system defects, has long been recognized as a measure that would decrease morbidity and improve outcomes by helping patients avoid devastating infections and receive prompt immune-restoring therapy. The T-cell receptor excision circle test, developed in 2005, proved to be successful in pilot studies starting in the period 2008 to 2010, and by 2019 all states in the United States had adopted versions of it in their public health programs. Introduction of newborn screening for severe combined immunodeficiency, the first immune disorder accepted for population-based screening, has drastically changed the presentation of this disorder while providing important lessons for public health programs, immunologists, and transplanters.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Male ; Neonatal Screening/methods ; Severe Combined Immunodeficiency/diagnosis
Language	English
Publishing date	2021-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2020.10.020
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Article ; Online: NaCl aggregation in water at elevated temperatures and pressures: Comparison of classical force fields.

Patel, Lara A / Yoon, Tae Jun / Currier, Robert P / Maerzke, Katie A

The Journal of chemical physics

2021 Volume 154, Issue 6, Page(s) 64503

Abstract: The properties of water vary dramatically with temperature and density. This can be exploited to control its effectiveness as a solvent. Thus, supercritical water is of keen interest as solvent in many extraction processes. The low solubility of salts in ...

Abstract	The properties of water vary dramatically with temperature and density. This can be exploited to control its effectiveness as a solvent. Thus, supercritical water is of keen interest as solvent in many extraction processes. The low solubility of salts in lower density supercritical water has even been suggested as a means of desalination. The high temperatures and pressures required to reach supercritical conditions can present experimental challenges during collection of required physical property and phase equilibria data, especially in salt-containing systems. Molecular simulations have the potential to be a valuable tool for examining the behavior of solvated ions at these high temperatures and pressures. However, the accuracy of classical force fields under these conditions is unclear. We have, therefore, undertaken a parametric study of NaCl in water, comparing several salt and water models at 200 bar-600 bar and 450 K-750 K for a range of salt concentrations. We report a comparison of structural properties including ion aggregation, hydrogen bonding, density, and static dielectric constants. All of the force fields qualitatively reproduce the trends in the liquid phase density. An increase in ion aggregation with decreasing density holds true for all of the force fields. The propensity to aggregate is primarily determined by the salt force field rather than the water force field. This coincides with a decrease in the water static dielectric constant and reduced charge screening. While a decrease in the static dielectric constant with increasing NaCl concentration is consistent across all model combinations, the salt force fields that exhibit more ionic aggregation yield a slightly smaller dielectric decrement.
Language	English
Publishing date	2021-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0030962
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Article: Optimal design of multi-stage vacuum membrane distillation and integration with supercritical water desalination for improved zero liquid discharge desalination

Sharan, Prashant / Yoon, Tae Jun / Thakkar, Harshul / Currier, Robert P. / Singh, Rajinder / Findikoglu, Alp Tugrul

Elsevier Ltd Journal of cleaner production. 2022 Aug. 10, v. 361

2022

Abstract: This paper proposes a novel concept for the optimal design of multi-stage vacuum membrane distillation (VMD). Generally, a multi-stage VMD is designed with an equal temperature difference between each stage. However, such a design is energy inefficient ... ...

Abstract	This paper proposes a novel concept for the optimal design of multi-stage vacuum membrane distillation (VMD). Generally, a multi-stage VMD is designed with an equal temperature difference between each stage. However, such a design is energy inefficient and increases VMD area. An analytical methodology for calculating the optimal stage temperature is proposed. By selecting the optimal stage temperature, the energy efficiency and required membrane area can be potentially improved by 16% and 30%, respectively. The proposed concept applies to all heat sources, including latent, sensible, and waste heat. To illustrate the method, multi-stage VMD is integrated with the waste heat from a supercritical water desalination (SCWD) system to achieve zero liquid discharge. SCWD is an energy-intensive process, requires high-quality thermal heat (>450 °C), and exhibits high waste heat rejection. The integrated VMD-SCWD approach is approximately 50% more energy-efficient and 35% more cost-efficient than the standalone SCWD system. Compared to the commercially used brine concentrator and crystallizer, the multi-stage VMD-SCWD system is more energy efficient for feed concentrations >5%. VMD-SCWD system is 30% cheaper, due to less expensive membrane distillation modules compared to a brine concentrator. The proposed design concept can replace the brine concentrator and crystallizer as an improved alternative for a zero-liquid discharge desalination system.
Keywords	cost effectiveness ; desalination ; distillation ; energy efficiency ; heat ; liquids ; temperature
Language	English
Dates of publication	2022-0810
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.132189
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Twin chorionicity and zygosity both vary with maternal age.

Yeaton-Massey, Amanda / Sparks, Teresa N / Norton, Mary E / Jelliffe-Pawlowski, Laura / Currier, Robert J

Prenatal diagnosis

2021 Volume 41, Issue 9, Page(s) 1074–1079

Abstract: Objective: To determine the ratio of dichorionic (DC) to monochorionic (MC) twins by maternal age.: Methods: We reviewed all twin pregnancies undergoing first trimester screening (FTS) with nuchal translucency from April 2009 to December 2012 with ... ...

Abstract	Objective: To determine the ratio of dichorionic (DC) to monochorionic (MC) twins by maternal age. Methods: We reviewed all twin pregnancies undergoing first trimester screening (FTS) with nuchal translucency from April 2009 to December 2012 with sonographic determination of chorionicity. Cases were linked to newborn screening (NBS) results and zygosity estimated based on rates of fetal sex discordance. The ratio of DC to MC placentation by maternal age was calculated. Results: We identified 11,351 twin pregnancies with FTS and documented chorionicity. Among these, 7,861 (64.2%) had linked data on FTS and NBS to allow estimation of zygosity based on neonatal sex. Of these, 1,464 (18.6%) were MC and 6,406 (81.4%) DC. The MC twin rate remained constant while the DC twin rate increased with maternal age until 40y. At < 20y, 55% of twin pregnancies were monozygotic (MZ), as compared to 29% at ≥ 40y. Of MZ twins, 38% were DC at < 20y, while 53% were DC at ≥ 40y. Conclusions: Our data suggest a relationship of both zygosity and chorionicity with maternal age. DZ twinning increased with maternal age, while among MZ twins, the proportion that were DC also increased with maternal age.
MeSH term(s)	Chorion/diagnostic imaging ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Maternal Age ; Pregnancy ; Pregnancy, Twin ; Twins, Dizygotic ; Twins, Monozygotic
Language	English
Publishing date	2021-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	82031-3
ISSN	1097-0223 ; 0197-3851
ISSN (online)	1097-0223
ISSN	0197-3851
DOI	10.1002/pd.5997
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Article ; Online: First-Principles Simulations of CuCl in High-Temperature Water Vapor.

Maerzke, Katie A / Yoon, Tae Jun / Jadrich, Ryan B / Leiding, Jeffery A / Currier, Robert P

The journal of physical chemistry. B

2021 Volume 125, Issue 18, Page(s) 4794–4807

Abstract: Experimental data suggest that the solubility of copper in high-temperature water vapor is controlled by the formation of hydrated clusters of the form CuCl( ... ...

Abstract	Experimental data suggest that the solubility of copper in high-temperature water vapor is controlled by the formation of hydrated clusters of the form CuCl(H
Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.1c00083
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Article ; Online: Quantifying Karenia brevis bloom severity and respiratory irritation impact along the shoreline of Southwest Florida.

Stumpf, Richard P / Li, Yizhen / Kirkpatrick, Barbara / Litaker, R Wayne / Hubbard, Katherine A / Currier, Robert D / Harrison, Katherine Kohler / Tomlinson, Michelle C

PloS one

2022 Volume 17, Issue 1, Page(s) e0260755

Abstract: Nearly all annual blooms of the toxic dinoflagellate Karenia brevis (K. brevis) pose a serious threat to coastal Southwest Florida. These blooms discolor water, kill fish and marine mammals, contaminate shellfish, cause mild to severe respiratory ... ...

Abstract	Nearly all annual blooms of the toxic dinoflagellate Karenia brevis (K. brevis) pose a serious threat to coastal Southwest Florida. These blooms discolor water, kill fish and marine mammals, contaminate shellfish, cause mild to severe respiratory irritation, and discourage tourism and recreational activities, leading to significant health and economic impacts in affected communities. Despite these issues, we still lack standard measures suitable for assessing bloom severity or for evaluating the efficacy of modeling efforts simulating bloom initiation and intensity. In this study, historical cell count observations along the southwest Florida shoreline from 1953 to 2019 were used to develop monthly and annual bloom severity indices (BSI). Similarly, respiratory irritation observations routinely reported in Sarasota and Manatee Counties from 2006 to 2019 were used to construct a respiratory irritation index (RI). Both BSI and RI consider spatial extent and temporal evolution of the bloom, and can be updated routinely and used as objective criteria to aid future socioeconomic and scientific studies of K. brevis. These indices can also be used to help managers and decision makers both evaluate the risks along the coast during events and design systems to better respond to and mitigate bloom impacts. Before 1995, sampling was done largely in response to reports of discolored water, fish kills, or respiratory irritation. During this timeframe, lack of sampling during the fall, when blooms typically occur, generally coincided with periods of more frequent-than-usual offshore winds. Consequently, some blooms may have been undetected or under-sampled. As a result, the BSIs before 1995 were likely underestimated and cannot be viewed as accurately as those after 1995. Anomalies in the frequency of onshore wind can also largely account for the discrepancies between BSI and RI during the period from 2006 to 2019. These findings highlighted the importance of onshore wind anomalies when predicting respiratory irritation impacts along beaches.
MeSH term(s)	Dinoflagellida/growth & development ; Dinoflagellida/pathogenicity ; Florida ; Forecasting/methods ; Harmful Algal Bloom/physiology ; Humans ; Marine Toxins/analysis ; Respiratory System ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/etiology
Chemical Substances	Marine Toxins
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0260755
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Article ; Online: Pregnancy loss after amniocentesis in monochorionic and dichorionic twin pregnancies: Results from a large population-based dataset.

Sperling, Jeffrey D / Zlatnik, Marya G / Norton, Mary E / Currier, Robert J

Prenatal diagnosis

2019 Volume 39, Issue 10, Page(s) 896–900

MeSH term(s)	Abortion, Spontaneous/epidemiology ; Abortion, Spontaneous/etiology ; Adult ; Amniocentesis/adverse effects ; Amniocentesis/statistics & numerical data ; Aneuploidy ; California/epidemiology ; Cohort Studies ; Datasets as Topic/statistics & numerical data ; Diseases in Twins/epidemiology ; Female ; Humans ; Neural Tube Defects/diagnosis ; Neural Tube Defects/epidemiology ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy, Twin/statistics & numerical data ; Registries ; Twins, Dizygotic/statistics & numerical data ; Twins, Monozygotic/statistics & numerical data ; Young Adult
Language	English
Publishing date	2019-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	82031-3
ISSN	1097-0223 ; 0197-3851
ISSN (online)	1097-0223
ISSN	0197-3851
DOI	10.1002/pd.5502
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Article ; Online: The Clinical Impact of CLIR Tools toward Rapid Resolution of Post-Newborn Screening Confirmatory Testing for X-Linked Adrenoleukodystrophy in California.

Tang, Hao / Matteson, Jamie / Rinaldo, Piero / Tortorelli, Silvia / Currier, Robert / Sciortino, Stanley

International journal of neonatal screening

2020 Volume 6, Issue 3, Page(s) 62

Abstract: Since the start of X-linked adrenoleukodystrophy (ALD) newborn screening in California, more than half of the diagnosed cases were found to have an ATP binding cassette subfamily D member 1 ( ...

Abstract	Since the start of X-linked adrenoleukodystrophy (ALD) newborn screening in California, more than half of the diagnosed cases were found to have an ATP binding cassette subfamily D member 1 (
Language	English
Publishing date	2020-08-05
Publishing country	Switzerland
Document type	Journal Article
ISSN	2409-515X
ISSN (online)	2409-515X
DOI	10.3390/ijns6030062
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