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  1. Book ; Thesis: Umfassende Untersuchung der Komplikationen bei verschiedenen Operationstechniken zur Korrektur der partiellen Lungenvenenfehlmündung

    Cussigh, Christiane

    2017  

    Institution Universität Heidelberg
    Author's details vorgelegt von Christiane Sophie Cussigh
    Language German
    Size X, 101 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2019
    HBZ-ID HT020238728
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 E 1165 order for loan Magazin

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  2. Article ; Online: Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent but clinically inapparent in cancer patients under immune checkpoint therapy

    Walle, Thomas / Bajaj, Sunanjay / Kraske, Joscha A / Roesner, Thomas / Cussigh, Christiane Sophie / Kaelber, Katharina Anna / Mueller, Lisa Jasmin / Strobel, Sophia Boyoung / Burghaus, Jana / Kallenberger, Stefan / Stein-Thoeringer, Christoph / Jenzer, Maximilian / Schubert, Antonia / Kahle, Steffen / Williams, Anja / Hoyler, Birgit / Zielske, Lin / Skatula, Renate / Sawall, Stefanie /
    Leber, Mathias Felix / Kunes, Russell Z / Krisam, Johannes / Fremd, Carlo / Schneeweiss, Andreas / Krauss, Juergen / Berger, Anne Katrin / Haag, Georg Martin / Zschaebitz, Stefanie / Halama, Niels / Springfeld, Christoph / Kirsten, Romy / Hassel, Jessica C / Jaeger, Dirk / NCT ANTICIPATE Investigators / Ungerechts, Guy

    medRxiv

    Abstract: Cancer patients frequently receive immune checkpoint therapies (ICT) which may modulate immune responses to COVID-19 vaccines. Recently, a cytokine release syndrome (CRS) was observed in a cancer patient who received the BTN162b2 vaccine under ICT. Here, ...

    Abstract Cancer patients frequently receive immune checkpoint therapies (ICT) which may modulate immune responses to COVID-19 vaccines. Recently, a cytokine release syndrome (CRS) was observed in a cancer patient who received the BTN162b2 vaccine under ICT. Here, we analyzed adverse events (AEs) in patients of various solid tumor types undergoing (n=64) or not undergoing (n=26) COVID-19 vaccination under ICT as an exploratory endpoint of a prospectively planned cohort study. We did not observe clinically relevant CRS after vaccination (95% CI [0,0.056]). Short term (<4 weeks) serious AEs were rare (12.5%) and overall AEs under ICT were comparable to unvaccinated patients. Despite the absence of CRS symptoms, we observed a pairwise-correlated set of CRS-associated cytokines upregulated in 42% of patients after vaccination and ICT (>1.5fold). Hence, clinically meaningful CRS appears to be rare in cancer patients under ICT and elevated serum cytokine levels are common but not sufficient to establish CRS diagnosis.
    Keywords covid19
    Language English
    Publishing date 2021-12-11
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.12.08.21267430
    Database COVID19

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