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  1. Article ; Online: Increased rupture of Abdominal Aortic Aneurysm in patients with COPD correlates with high atmospheric levels of PM2.5 and PM10.

    Bozzani, Antonio / Arici, Vittorio / Cutti, Sara / DI Marzo, Luca / Sterpetti, Antonio V

    International journal of cardiology. Cardiovascular risk and prevention

    2024  Volume 21, Page(s) 200266

    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-4875
    ISSN (online) 2772-4875
    DOI 10.1016/j.ijcrp.2024.200266
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  2. Article ; Online: Spatio-temporal correlation between admissions for ruptured abdominal aortic aneurysms and levels of atmospheric pollution in Italy.

    Bozzani, Antonio / Cutti, Sara / Marzo, Luca Di / Gabriele, Raimondo / Sterpetti, Antonio V

    Current problems in cardiology

    2023  Volume 49, Issue 2, Page(s) 102249

    Abstract: Aims: The aim of our study was to determine a correlation between rates and number of patients admitted with ruptured abdominal aortic aneurysms (rAAA) in Italian regions with different levels of atmospheric pollution.: Methods: We analyzed a ... ...

    Abstract Aims: The aim of our study was to determine a correlation between rates and number of patients admitted with ruptured abdominal aortic aneurysms (rAAA) in Italian regions with different levels of atmospheric pollution.
    Methods: We analyzed a possible correlation between the number and rate (ruptured versus not ruptured) of patients with rAAA admitted in eight Italian regions with different levels of atmospheric pollution.
    Results: Number and rates of patients with rAAA were statistically correlated with levels of air pollution and low air temperature (RR = 1.90, 95% CI: 1.42, 2.1.0) (p<0.01). Even if low temperatures amplified the correlation between admissions for rAAA and PMs exposure, also during Summer and Spring there were sudden increases of the number of admissions for rAAA patients in periods with higher air pollution. The regions with high levels of atmospheric pollution had higher rates of admissions of patients with rAAA in comparison with regions with low level of air pollution. However, there was no difference between regions with low and very low level of atmospheric pollution. Mean age, sex distribution, exposure to established risk factors were similar for the population of the eight analyzed Italian regions.
    Conclusions: The findings of this study highlight the potential to reduce AAA related mortality and burden by addressing the negative effects of exposure to high levels of atmospheric pollution. The possibility of a dose-dependent effect of atmospheric pollution on the cardiovascular system opens research initiatives and discussions about when and how to modulate interventions to reduce atmospheric pollutants.
    MeSH term(s) Humans ; Aortic Aneurysm, Abdominal/epidemiology ; Aortic Aneurysm, Abdominal/etiology ; Aortic Rupture/epidemiology ; Aortic Rupture/etiology ; Hospitalization ; Air Pollution/adverse effects ; Risk Factors ; Italy/epidemiology
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2023.102249
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  3. Article ; Online: Venous thromboembolism in hospitalized coronavirus disease 2019 patients stratified by vaccination status.

    Bozzani, Antonio / Cutti, Sara / Arici, Vittorio / Ragni, Franco / Sterpetti, Antonio V / Arbustini, Eloisa

    Journal of vascular surgery. Venous and lymphatic disorders

    2023  Volume 11, Issue 2, Page(s) 473–474

    MeSH term(s) Humans ; COVID-19 ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; SARS-CoV-2 ; Risk Factors ; Vaccination ; Anticoagulants/adverse effects
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Letter
    ISSN 2213-3348
    ISSN (online) 2213-3348
    DOI 10.1016/j.jvsv.2022.10.011
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  4. Article ; Online: Reduced atmospheric levels of PM2.5 and decreased admissions and surgery for Ischemic stroke in Italy.

    Sterpetti, Antonio V / Marzo, Luca Di / Sapienza, Paolo / Borrelli, Valeria / Cutti, Sara / Bozzani, Antonio

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2023  Volume 33, Issue 3, Page(s) 107504

    Abstract: XXXX. ...

    Abstract XXXX.
    MeSH term(s) Humans ; Air Pollution/adverse effects ; Ischemic Stroke ; Stroke/diagnosis ; Stroke/therapy ; Particulate Matter/adverse effects ; Italy/epidemiology ; China
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2023.107504
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    Zs.A 3519: Show issues Location:
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  5. Article ; Online: More on age and gender in COVID-19.

    Ferretti, Virginia V / Klersy, Catherine / Bruno, Raffele / Cutti, Sara / Nappi, Rossella E

    Maturitas

    2022  Volume 163, Page(s) 89

    MeSH term(s) COVID-19 ; Gender Identity ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-06-15
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2022.05.011
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    Zs.A 1432: Show issues Location:
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  6. Article ; Online: Men with COVID-19 die. Women survive.

    Ferretti, Virginia V / Klersy, Catherine / Bruno, Raffaele / Cutti, Sara / Nappi, Rossella E

    Maturitas

    2021  Volume 158, Page(s) 34–36

    Abstract: The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; ... ...

    Abstract The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; the same is true of the role of menopause as a risk factor. A retrospective analysis of patients (=1764) hospitalized in Italy showed a higher mortality (HR 1.58, 95%CI 1.30-1.91, adjusted for age and multi-comorbidities) in males only after the age of 65 (the rate is twice as high in the 65-79-year age group and 1.5-fold higher in those aged over 80). The higher mortality of men is mostly evident among those aged over 65 years, long after the average age of menopause.
    MeSH term(s) Aged ; COVID-19 ; Female ; Gonadal Steroid Hormones ; Humans ; Male ; Menopause ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2021-11-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2021.11.014
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  7. Article: Despite Vaccination: A Real-Life Experience of Severe and Life-Threatening COVID-19 in Vaccinated and Unvaccinated Patients.

    Colaneri, Marta / Asperges, Erika / Calia, Matteo / Sacchi, Paolo / Rettani, Marco / Cutti, Sara / Albi, Giuseppe / Bruno, Raffaele

    Vaccines

    2022  Volume 10, Issue 9

    Abstract: Some vaccinated individuals still develop severe COVID-19, and the underlying causes are not entirely understood. We aimed at identifying demographic, clinical, and coinfection characteristics of vaccinated patients who were hospitalized. We also ... ...

    Abstract Some vaccinated individuals still develop severe COVID-19, and the underlying causes are not entirely understood. We aimed at identifying demographic, clinical, and coinfection characteristics of vaccinated patients who were hospitalized. We also hypothesized that coinfections might play a role in disease severity and mortality. We retrospectively collected data from our COVID-19 registry for whom vaccination data were available. Patients were split into groups based on the number of administered doses (zero, one, two, or three). Data were assessed with Chi-square and Kruskal−Wallis tests and multiple logistic regression analysis. We collected data from 1686 patients and found that intra-hospital mortality was not associated to the vaccination status (e.g., p = 0.2 with three doses), while older age, sepsis, and non-viral pneumonia were (p < 0.001). Unvaccinated patients needed mechanical ventilation more often (8.5%) than vaccinated patients, in whom the probability of mechanical ventilation decreased with increasing doses (8.7%, 2.8%, 0%). We did not find more coinfections in vaccinated people. We concluded that there is a lack of real-life data to adequately characterize the pathophysiology and risk factors of patients who develop severe COVID-19, but coinfections do not appear to play a role in disease severity.
    Language English
    Publishing date 2022-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10091540
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  8. Article: Geriatric Population Triage: The Risk of Real-Life Over- and Under-Triage in an Overcrowded ED: 4- and 5-Level Triage Systems Compared: The CREONTE (Crowding and R E Organization National TriagE) Study.

    Savioli, Gabriele / Ceresa, Iride Francesca / Bressan, Maria Antonietta / Bavestrello Piccini, Gaia / Novelli, Viola / Cutti, Sara / Ricevuti, Giovanni / Esposito, Ciro / Longhitano, Yaroslava / Piccioni, Andrea / Boudi, Zoubir / Venturi, Alessandro / Fuschi, Damiano / Voza, Antonio / Leo, Roberto / Bellou, Abdelouahab / Oddone, Enrico

    Journal of personalized medicine

    2024  Volume 14, Issue 2

    Abstract: Elderly patients, when they present to the emergency department (ED) or are admitted to the hospital, are at higher risk of adverse outcomes such as higher mortality and longer hospital stays. This is mainly due to their age and their increased fragility. ...

    Abstract Elderly patients, when they present to the emergency department (ED) or are admitted to the hospital, are at higher risk of adverse outcomes such as higher mortality and longer hospital stays. This is mainly due to their age and their increased fragility. In order to minimize this already increased risk, adequate triage is of foremost importance for fragile geriatric (>75 years old) patients who present to the ED. The admissions of elderly patients from 1 January 2014 to 31 December 2020 were examined, taking into consideration the presence of two different triage systems, a 4-level (4LT) and a 5-level (5LT) triage system. This study analyzes the difference in wait times and under- (UT) and over-triage (OT) in geriatric and general populations with two different triage models. Another outcome of this study was the analysis of the impact of crowding and its variables on the triage system during the COVID-19 pandemic. A total of 423,257 ED presentations were included. An increase in admissions of geriatric, more fragile, and seriously ill individuals was observed, and a progressive increase in crowding was simultaneously detected. Geriatric patients, when presenting to the emergency department, are subject to the problems of UT and OT in both a 4LT system and a 5LT system. Several indicators and variables of crowding increased, with a net increase in throughput and output factors, notably the length of stay (LOS), exit block, boarding, and processing times. This in turn led to an increase in wait times and an increase in UT in the geriatric population. It has indeed been shown that an increase in crowding results in an increased risk of UT, and this is especially true for 4LT compared to 5LT systems. When observing the pandemic period, an increase in admissions of older and more serious patients was observed. However, in the pandemic period, a general reduction in waiting times was observed, as well as an increase in crowding indices and intrahospital mortality. This study demonstrates how introducing a 5LT system enables better flow and patient care in an ED. Avoiding UT of geriatric patients, however, remains a challenge in EDs.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14020195
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  9. Article ; Online: Trends (2020-2022) toward Reduced Prevalence of Postcoronavirus Disease Syndrome and Improved Quality of Life for Hospitalized Coronavirus Disease 2019 Patients with Severe Infection and Venous Thromboembolism.

    Bozzani, Antonio / Arici, Vittorio / Tavazzi, Guido / Ragni, Franco / Mojoli, Francesco / Cavallini, Elena / Vugt, Floris van / Cutti, Sara / Figini, Silvia / Venturi, Alessandro / Sterpetti, Antonio V / Arbustini, Eloisa

    Seminars in thrombosis and hemostasis

    2023  

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic seems to be at its end. During the first outbreak, alfa was the dominant variant, and in the two following years, delta was the dominant variant. Questions remain about the prevalence and severity of post- ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic seems to be at its end. During the first outbreak, alfa was the dominant variant, and in the two following years, delta was the dominant variant. Questions remain about the prevalence and severity of post-COVID syndrome (PCS). We compared the medium-term outcomes of a selected group of patients considered at high risk for PCS: hospitalized patients with severe COVID-19 infection who presented clinical evidence of the acute onset of venous thromboembolism. Weighted Cox regression was used to estimate the adjusted hazard ratios for the risk of early and medium-term complications and quality of life (QoL) in COVID-19 patients developing acute venous thrombo-embolism according to the period of admission to the hospital. The primary outcome was the modification of QoL at a median follow-up of 24 months in patients hospitalized for COVID-19. The secondary outcome was the modification of QoL related to COVID-19 severity. The absolute risk of mortality for hospitalized COVID-19 patients was higher during the first outbreak (risk difference, 19% [95% confidence interval [CI], 16-22%]). Patients with acute onset of thromboembolism during the first outbreak had increased mortality, hospital stay, and need for intensive care unit treatment (
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0043-1776004
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    Zs.A 1259: Show issues Location:
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  10. Article ; Online: The potential role of ICU capacity strain in COVID-19 mortality: comparison between first and second waves in Pavia, Italy.

    Mojoli, Francesco / Cutti, Sara / Mongodi, Silvia / Bruno, Raffaele / Di Sabatino, Antonio / Corsico, Angelo Guido / Marena, Carlo

    Journal of Anesthesia, Analgesia and Critical Care (Online)

    2021  Volume 1, Issue 1, Page(s) 8

    Language English
    Publishing date 2021-10-22
    Publishing country England
    Document type Letter
    ISSN 2731-3786
    ISSN (online) 2731-3786
    DOI 10.1186/s44158-021-00007-6
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