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  1. Book ; Online: To Go Where Nature Leads: Focus on Palmitoylethanolamide and Related ALIAmides As Innovative Approach to Neuroinflammatory and Pain-Related Disease States in Honor of Doctor Francesco Della Valle

    Cuzzocrea, Salvatore / Crupi, Rosalia

    2023  

    Keywords Research & information: general ; Biology, life sciences ; Palmitoylethanolamide ; ALIAmides ; Neuroinflammation ; Pain
    Language English
    Size 1 electronic resource (210 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030645693
    ISBN 9783036594750 ; 3036594752
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: RE: GITR GENE DELETION AND GITR-FC SOLUBLE PROTEIN ADMINISTRATION INHIBIT MULTIPLE ORGAN FAILURE INDUCED BY ZYMOSAN. DOI: 10.1097/SHK.0B013E3182262C48.

    Cuzzocrea, Salvatore

    Shock (Augusta, Ga.)

    2024  Volume 61, Issue 3, Page(s) 490

    MeSH term(s) Humans ; Zymosan ; Multiple Organ Failure ; Gene Deletion ; T-Lymphocytes, Regulatory
    Chemical Substances Zymosan (9010-72-4)
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000002308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3985: Show issues Location:
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  3. Article ; Online: To Go Where Nature Leads: Focus on Palmitoylethanolamide and Related ALIAmides as Innovative Approach to Neuroinflammatory and Pain-Related Disease States in Honor of Doctor Francesco Della Valle.

    Cuzzocrea, Salvatore / Crupi, Rosalia

    Biomolecules

    2023  Volume 13, Issue 11

    Abstract: ... Dr [ ... ]. ...

    Abstract Dr [...].
    MeSH term(s) Humans ; Amides ; Palmitic Acids/therapeutic use ; Ethanolamines ; Pain/drug therapy
    Chemical Substances palmidrol (6R8T1UDM3V) ; Amides ; Palmitic Acids ; Ethanolamines
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13111583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of EPA in Inflammation: Mechanisms, Effects, and Clinical Relevance.

    Crupi, Rosalia / Cuzzocrea, Salvatore

    Biomolecules

    2022  Volume 12, Issue 2

    Abstract: Many chronic inflammatory processes are linked with the continuous release of inflammatory mediators and the activation of harmful signal-transduction pathways that are able to facilitate disease progression. In this context atherosclerosis represents ... ...

    Abstract Many chronic inflammatory processes are linked with the continuous release of inflammatory mediators and the activation of harmful signal-transduction pathways that are able to facilitate disease progression. In this context atherosclerosis represents the most common pathological substrate of coronary heart disease, and the characterization of the disease as a chronic low-grade inflammatory condition is now validated. The biomarkers of inflammation associated with clinical cardiovascular risk support the theory that targeted anti-inflammatory treatment appears to be a promising strategy in reducing residual cardiovascular risk. Several literature data highlight cardioprotective effects of the long-chain omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA). This PUFA lowers plasma triglyceride levels and has potential beneficial effects on atherosclerotic plaques. Preclinical studies reported that EPA reduces both pro-inflammatory cytokines and chemokines levels. Clinical studies in patients with coronary artery disease that receive pharmacological statin therapy suggest that EPA may decrease plaque vulnerability preventing plaque progression. This review aims to provide an overview of the links between inflammation and cardiovascular risk factors, importantly focusing on the role of diet, in particular examining the proposed role of EPA as well as the success or failure of standard pharmacological therapy for cardiovascular diseases.
    MeSH term(s) Atherosclerosis/drug therapy ; Eicosapentaenoic Acid/pharmacology ; Eicosapentaenoic Acid/therapeutic use ; Fatty Acids, Omega-3/therapeutic use ; Humans ; Inflammation/chemically induced ; Inflammation/drug therapy ; Plaque, Atherosclerotic/drug therapy
    Chemical Substances Fatty Acids, Omega-3 ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12020242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrigendum to "Tyrphostin reduces the organ injury in haemorrhagic shock: Role of inducible nitric oxide synthase" [Resuscitation 58(3) (2003) 349-361].

    McDonald, Michelle / Abdelrahman, Maha / Cuzzocrea, Salvatore / Thiemermann, Christoph

    Resuscitation

    2024  Volume 198, Page(s) 110170

    Language English
    Publishing date 2024-03-11
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2024.110170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
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  6. Article ; Online: Corrigendum to "Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat'' [Biochem. Pharmacol. 58(1) (1999) 171-176].

    Cuzzocrea, Salvatore / Costantino, Giuseppina / Mazzon, Emanuela / Zingarelli, Basilia / De Sarro, Angela / Caputi, Achille P

    Biochemical pharmacology

    2024  Volume 220, Page(s) 115986

    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2023.115986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 19: Show issues Location:
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  7. Article ; Online: The Role of miR-128 in Neurodegenerative Diseases.

    Lanza, Marika / Cuzzocrea, Salvatore / Oddo, Salvatore / Esposito, Emanuela / Casili, Giovanna

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Several neurodegenerative disorders are characterized by the accumulation of misfolded proteins and are collectively known as proteinopathies. Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) represent some of the most ... ...

    Abstract Several neurodegenerative disorders are characterized by the accumulation of misfolded proteins and are collectively known as proteinopathies. Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) represent some of the most common neurodegenerative disorders whose steady increase in prevalence is having a major socio-economic impact on our society. Multiple laboratories have reported hundreds of changes in gene expression in selective brain regions of AD, PD, and HD brains. While the mechanisms underlying these changes remain an active area of investigation, alterations in the expression of noncoding RNAs, which are common in AD, PD, and HD, may account for some of the changes in gene expression in proteinopathies. In this review, we discuss the role of miR-128, which is highly expressed in mammalian brains, in AD, PD, and HD. We highlight how alterations in miR-128 may account, at least in part, for the gene expression changes associated with proteinopathies. Indeed, miR-128 is involved, among other things, in the regulation of neuronal plasticity, cytoskeletal organization, and neuronal death, events linked to various proteinopathies. For example, reducing the expression of miR-128 in a mouse model of AD ameliorates cognitive deficits and reduces neuropathology. Overall, the data in the literature suggest that targeting miR-128 might be beneficial to mitigate the behavioral phenotype associated with these diseases.
    MeSH term(s) Animals ; Mice ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Huntington Disease ; Alzheimer Disease/genetics ; Parkinson Disease ; MicroRNAs/genetics ; Mammals/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Non-invasive brain stimulation techniques in neurological and neuropsychiatric disorders: Physiological and molecular evidence.

    Cambiaghi, Marco / Cordaro, Marika / Dossena, Silvia / Cuzzocrea, Salvatore / Buffelli, Mario

    Frontiers in systems neuroscience

    2023  Volume 17, Page(s) 1128205

    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2023.1128205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reply to Letter to Editor: "Kriek R., Marketing messages in pharmacological papers and scientific chapters: The case of palmitoylethanolamide and its formulations" [Pharmacol Res (2014) 10.1016/j.phrs.2014.04.007].

    Cuzzocrea, Salvatore

    Pharmacological research

    2014  Volume 85, Page(s) 4–5

    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Humans ; Renal Insufficiency, Chronic/drug therapy
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2014-07
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2014.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 721: Show issues Location:
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  10. Article ; Online: An RNAi-Mediated Reduction in Transcription Factor Nrf-2 Blocks the Positive Effects of Dimethyl Fumarate on Metabolic Stress in Alzheimer's Disease.

    Lanza, Marika / Basilotta, Rossella / Cuzzocrea, Salvatore / Bulzomì, Maria / Oddo, Salvatore / Casili, Giovanna / Esposito, Emanuela

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: The prevalence of obesity is rapidly rising around the world, and this will have a significant impact on our society as it is believed to be one of the leading causes of death. One of the main causes of these occurrences is added sugar consumption, which ...

    Abstract The prevalence of obesity is rapidly rising around the world, and this will have a significant impact on our society as it is believed to be one of the leading causes of death. One of the main causes of these occurrences is added sugar consumption, which is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). To this purpose, excess sugar might worsen oxidative damage and brain inflammation: two neuropathological signs of AD. Dimethyl fumarate (DMF) is an orally accessible methyl ester of fumaric acid with putative neuroprotective and immunomodulatory properties. In addition, DMF stimulates the nuclear factor erythroid 2-related factor 2 (Nrf-2), a key regulator of the antioxidant response mechanism in cells. The aim of the current study was to assess the potential therapeutic benefits of DMF in an in vitro model of metabolic stress induced by high and low sugar levels. We discovered that DMF reversed the negative impacts of high and low glucose exposure on the viability and oxidative stress of SH-SY5Y cells. Mechanistically, DMF's actions were mediated by Nrf-2. To this end, we discovered that DMF boosted the expression of the Nrf-2-regulated genes heme-oxygenase-1 (HO1) and manganese superoxide dismutase (MnSOD). More importantly, we found that inhibiting Nrf-2 expression prevented DMF's positive effects. Our combined findings suggest that DMF may be a valuable support for treatments for metabolic diseases.
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Dimethyl Fumarate/pharmacology ; Dimethyl Fumarate/therapeutic use ; Neuroprotective Agents/pharmacology ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; RNA Interference ; Cell Line, Tumor
    Chemical Substances Dimethyl Fumarate (FO2303MNI2) ; Neuroprotective Agents ; NF-E2-Related Factor 2
    Language English
    Publishing date 2023-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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