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  1. Article ; Online: Squamous cell carcinoma evolving from mature cystic teratoma of the ovary.

    Cwynar, Marlena / Kowalczyk, Karolina / Cwynar, Grzegorz / Ptak, Piotr / Chekan, Mykola

    Ginekologia polska

    2023  

    Language English
    Publishing date 2023-09-19
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 130894-4
    ISSN 2543-6767 ; 0017-0011
    ISSN (online) 2543-6767
    ISSN 0017-0011
    DOI 10.5603/gpl.96501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vulvar Merkel cell carcinoma combined with squamous cell carcinoma of the vulva.

    Cwynar, Marlena / Chmielik, Ewa / Cwynar, Grzegorz / Ptak, Piotr / Kowalczyk, Karolina

    Ginekologia polska

    2023  

    Language English
    Publishing date 2023-09-25
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 130894-4
    ISSN 2543-6767 ; 0017-0011
    ISSN (online) 2543-6767
    ISSN 0017-0011
    DOI 10.5603/gpl.96927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 118: Show issues Location:
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  3. Article ; Online: Analysis of long-term outcomes in 44 patients following pelvic exenteration due to cervical cancer.

    Lewandowska, Agnieszka / Szubert, Sebastian / Koper, Krzysztof / Koper, Agnieszka / Cwynar, Grzegorz / Wicherek, Lukasz

    World journal of surgical oncology

    2020  Volume 18, Issue 1, Page(s) 234

    Abstract: Background: Pelvic exenteration (PE) may be associated with prolonged overall survival (OS) in selected patients with advanced or recurrent cervical cancer. However, the factors related to improved survival following PE are not clearly defined. The aim ... ...

    Abstract Background: Pelvic exenteration (PE) may be associated with prolonged overall survival (OS) in selected patients with advanced or recurrent cervical cancer. However, the factors related to improved survival following PE are not clearly defined. The aim of this study was to perform a retrospective analysis of OS rates in a group of patients undergoing PE in order to identify the factors related to improved long-term outcomes.
    Methods: Our study group consisted of 44 patients, including 21 squamous cell cancer (SCC) patients, 22 patients with adenocarcinomas (AC) of the cervix, and one patient with undifferentiated cervical carcinoma. The patients were categorized according to the type of surgery, namely, primary surgery (12 patients) or surgery due to cancer recurrence (32 patients).
    Results: In the group of patients with recurrent cervical cancer, we found that improved OS correlated with the SCC histological type and the presence of vaginal fistula. The need for reoperation within 30 days and the presence of severe adverse events significantly worsened the prognosis. We found a non significant trend toward improved survival in those patients with tumor-free margins. Lymph node metastases, the initial stage of the disease, the time to recurrence, and a history of hysterectomy had no impact on patients' OS. In the group of patients undergoing primary PE, we observed a trend toward improved survival among those diagnosed with vaginal fistula.
    Conclusions: Pelvic exenteration seemed to improve the long-term outcomes for patients with SCC cancer recurrence and vaginal fistula whose surgery was unrelated to severe adverse events.
    MeSH term(s) Female ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging ; Pelvic Exenteration ; Prognosis ; Retrospective Studies ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery
    Language English
    Publishing date 2020-09-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-020-01997-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cesarean scar pregnancy - case report and review.

    Klimek, Mateusz / Cwynar, Grzegorz / Bakon, Igor / Szanecki, Wojciech / Mackiewcz, Mirosława / Cygal, Anna / Witek, Andrzej

    Przeglad lekarski

    2017  Volume 74, Issue 4, Page(s) 183–186

    MeSH term(s) Adult ; Cesarean Section/adverse effects ; Cicatrix/etiology ; Cicatrix/physiopathology ; Female ; Humans ; Pregnancy ; Pregnancy, Ectopic/diagnosis ; Pregnancy, Ectopic/therapy
    Language English
    Publishing date 2017
    Publishing country Poland
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 414053-9
    ISSN 0033-2240 ; 0860-0422
    ISSN 0033-2240 ; 0860-0422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 640: Show issues Location:
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  5. Article: Profil ekspresji genów zwiazanych z układem histaminergicznym wyznaczony technika mikromacierzy oligonukleotydowych HG-U133A u kobiet z gruczolakorakiem endometrium.

    Jeda, Agnieszka / Witek, Andrzej / Janikowska, Grazyna / Cwynar, Grzegorz / Janikowski, Tomasz / Ciałon, Małgorzata / Orchel, Joanna / Mazurek, Urszula

    Ginekologia polska

    2014  Volume 85, Issue 3, Page(s) 172–179

    Abstract: Introduction: Influence of histamine on tumor development remains obscure. The exact mechanism of this action is not known. Different data indicate high concentrations of histamine in tumor tissues, such as malignant melanoma, breast cancer, colon ... ...

    Title translation Expression profile of genes associated with the histaminergic system estimated by oligonucleotide microarray analysis HG-U133A in women with endometrial adenocarcinoma.
    Abstract Introduction: Influence of histamine on tumor development remains obscure. The exact mechanism of this action is not known. Different data indicate high concentrations of histamine in tumor tissues, such as malignant melanoma, breast cancer, colon carcinoma, lymphomas and leukemia. To the best of our knowledge, the literature offers no reports about the role of histamine and of differences between expression patterns of histamine-related genes in endometrial cancer
    Aim: The aim of the study was a comparative analysis of the gene expression profile involved with histaminergic system in endometrioid endometrial cancer in relation to histologically normal endometrium, and identification of differentiation genes whose transcriptional activity significantly differs in pathomorphological grades G1,G2, G3 of endometrial cancer as compared to the control group.
    Material and methods: Total RNA was extracted from 24 endometrial probes using TRIzol reagent (Invitrogen). The expression profile of 119 transcripts associated with histaminergic system was assessed using oligonucleotide microarrays of HG-U 133A (Affymetrix). After normalization of the results with RMA Express software, differentiation genes were mined by the use of one-way analysis ANOVA and U Mann-Whitney test carried out in Gene Spring 11.5 software.
    Results: Among 119 transcripts, 14 expressed more than 1.5-fold change and were significant at p<0.05 in endometrioid endometrial cancer in relation to the normal endometrium. Further analysis led to the identification of differentially expressed genes in grades G1, G2 and G3 of endometrial adenocarcinoma as compared to the control group, which were specific for each of the studied groups in grade G1 (CPA3), in grade G2 (HNMT LYN, DPT ITPKB, RASA4, APR RAB1 1FIP1, YWHAZ, VAMP8, RAB25) and in grade G3 (HRH3).
    Conclusions: Our results confirmed the role of the histaminergic system in the pathogenesis of endometrial adenocarcinoma. The observed differences in the expression of those genes, depending on the grade of adenocarcinoma, may indicate an important role of the isolated differentiation genes in endometrial tumorigenesis.
    MeSH term(s) Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Carcinogenesis/genetics ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/pathology ; Endometrium/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Neoplasm/genetics ; Histamine/genetics ; Histamine/metabolism ; Humans ; Middle Aged ; Neoplasm Grading ; Oligonucleotide Array Sequence Analysis
    Chemical Substances Histamine (820484N8I3)
    Language Polish
    Publishing date 2014-04-29
    Publishing country Poland
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
    DOI 10.17772/gp/1709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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