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  1. Article ; Online: Nuclear imaging and therapy in oncology in Poland in 2021-2022.

    Kunikowska, Jolanta / Królicki, Leszek / Czepczyński, Rafał

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 8, Page(s) 2236–2239

    MeSH term(s) Humans ; Poland ; Medical Oncology ; Diagnostic Imaging ; Neoplasms/diagnostic imaging ; Neoplasms/therapy
    Language English
    Publishing date 2023-04-07
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06216-1
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    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes.

    Andryszak, Natalia / Kurzawa, Paweł / Krzyżaniak, Monika / Ruchała, Marek / Nowicki, Michał / Iżycki, Dariusz / Czepczyński, Rafał

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1969

    Abstract: Breast cancer is a major health concern, and its accurate diagnosis and management depend on identifying its histological type and biological subtype. Semaphorin-3A (SEMA3A) is a membrane protein with diverse roles in cellular processes, including cancer ...

    Abstract Breast cancer is a major health concern, and its accurate diagnosis and management depend on identifying its histological type and biological subtype. Semaphorin-3A (SEMA3A) is a membrane protein with diverse roles in cellular processes, including cancer progression and angiogenesis regulation. However, its role in breast cancer remains poorly understood. This study aimed to evaluate SEMA3A expression in breast cancer and investigate its distribution across breast cancer subtypes: luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). Immunohistochemical evaluation was performed on 98 breast cancer patients' tumor specimens, and SEMA3A expression was assessed in tumor cells and vessels. The study included the analysis of the Ki67 proliferation index, estrogen receptor (ER) expression, progesterone receptor (PR) expression, and HER2 status in conjunction with SEMA3A expression. Analysis indicated positive expression of SEMA3A in breast cancer cells in 60 out of 98 cases. SEMA3A expression correlated positively with Ki67 levels in tumor cells (p = 0.0005, R Spearman 0.338). Notably, a negative correlation was found between SEMA3A expression and ER and PR levels in tumor cells (p = 0.04, Spearman's R = - 0.21 and p = 0.016, Spearman's R = - 0.25 respectively). HER2 status did not significantly influence SEMA3A expression. The study demonstrated positive SEMA3A expression in tumor vessels across all subtypes in 91 out of 98 cases, suggesting its involvement in endothelial cell function. However, no significant differences in SEMA3A expression were observed between breast cancer subtypes either in vessels or tumor cells. These findings suggest that elevated SEMA3A expression may be associated with worse prognosis in breast cancer, especially in ER- and PR-negative tumors. Further investigations are warranted to fully comprehend the role of SEMA3A in breast cancer biology, which may lead to the identification of novel therapeutic targets and personalized treatment strategies for breast cancer patients.
    MeSH term(s) Humans ; Semaphorin-3A ; Ki-67 Antigen ; Triple Negative Breast Neoplasms ; Estrogens ; Progesterone
    Chemical Substances Semaphorin-3A ; Ki-67 Antigen ; Estrogens ; Progesterone (4G7DS2Q64Y) ; SEMA3A protein, human
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51796-z
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  3. Article: Head-to-Head Comparison of [

    Andryszak, Natalia / Świniuch, Daria / Wójcik, Elżbieta / Ramlau, Rodryg / Ruchała, Marek / Czepczyński, Rafał

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Background: Triple-negative breast cancer (TNBC) exhibits high aggressiveness and a notably poorer prognosis at advanced stages. Nuclear medicine offers new possibilities, not only for diagnosis but also potentially promising therapeutic strategies. ... ...

    Abstract Background: Triple-negative breast cancer (TNBC) exhibits high aggressiveness and a notably poorer prognosis at advanced stages. Nuclear medicine offers new possibilities, not only for diagnosis but also potentially promising therapeutic strategies. This prospective study explores the potential of prostate-specific membrane antigen (PSMA) as a diagnostic and therapeutic target in TNBC.
    Methods: the research investigates PSMA expression in vivo among TNBC patients using [
    Results: The study involves 10 TNBC patients, revealing comparable uptake of [
    Conclusions: the findings provide valuable insights into the expression of PSMA in TNBC and underscore the potential clinical significance of [
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030667
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  4. Article ; Online: Teaching nuclear medicine in the pandemic-a new challenge for the faculty.

    Czepczyński, Rafał / Kunikowska, Jolanta

    European journal of nuclear medicine and molecular imaging

    2020  Volume 47, Issue 9, Page(s) 2075–2077

    MeSH term(s) Faculty ; Humans ; Nuclear Medicine ; Pandemics
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-04865-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Highlights of the XIV Congress of the Polish Society of Nuclear Medicine, Lublin, 28-30th May, 2014.

    Czepczyński, Rafał

    Nuclear medicine review. Central & Eastern Europe

    2014  Volume 17, Issue 2, Page(s) 123–126

    MeSH term(s) Humans ; Nuclear Medicine ; Poland ; Societies, Medical
    Language English
    Publishing date 2014
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1467537-7
    ISSN 1644-4345 ; 1506-9680
    ISSN (online) 1644-4345
    ISSN 1506-9680
    DOI 10.5603/NMR.2014.0032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6307: Show issues Location:
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  6. Article: Interference of COVID-19 Vaccination With PET/CT Leads to Unnecessary Additional Imaging in a Patient With Metastatic Cutaneous Melanoma-Case Report.

    Czepczyński, Rafał / Szczurek, Jolanta / Mackiewicz, Jacek / Ruchała, Marek

    Frontiers in oncology

    2021  Volume 11, Page(s) 690443

    Abstract: The COVID-19 pandemic has widely influenced oncological imaging mainly by presenting unexpected pulmonary and mediastinal lesions. The ongoing global program of vaccination has led to incidental diagnosis of axillary lymphadenopathy. We present a case of ...

    Abstract The COVID-19 pandemic has widely influenced oncological imaging mainly by presenting unexpected pulmonary and mediastinal lesions. The ongoing global program of vaccination has led to incidental diagnosis of axillary lymphadenopathy. We present a case of increased accumulation of
    Language English
    Publishing date 2021-08-03
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.690443
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  7. Article ; Online: PET-CT for the staging of breast implant- -associated anaplastic large cell lymphoma.

    Siminiak, Natalia / Czepczyński, Rafał

    Nuclear medicine review. Central & Eastern Europe

    2019  Volume 22, Issue 2, Page(s) 90–91

    MeSH term(s) Adult ; Breast Implants/adverse effects ; Female ; Humans ; Lymphoma, Large-Cell, Anaplastic/diagnostic imaging ; Lymphoma, Large-Cell, Anaplastic/etiology ; Lymphoma, Large-Cell, Anaplastic/pathology ; Middle Aged ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography
    Language English
    Publishing date 2019-09-03
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 1467537-7
    ISSN 1644-4345 ; 1506-9680
    ISSN (online) 1644-4345
    ISSN 1506-9680
    DOI 10.5603/NMR.a2019.0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Tumour-Induced Osteomalacia-A Long Way to the Diagnosis Facilitated by [

    Kunikowska, Jolanta / Andryszak, Natalia / Skowrońska-Jóźwiak, Elżbieta / Pełka, Kacper / Zygmunt, Arkadiusz / Lewiński, Andrzej / Ruchała, Marek / Czepczyński, Rafał

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061817
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  9. Article ; Online: Immunotherapy in Ovarian Cancer.

    Siminiak, Natalia / Czepczyński, Rafał / Zaborowski, Mikołaj Piotr / Iżycki, Dariusz

    Archivum immunologiae et therapiae experimentalis

    2022  Volume 70, Issue 1, Page(s) 19

    Abstract: Despite advances in surgery and chemotherapy, ovarian cancer remains one of the most lethal malignancies. Hence, the implementation of novel treatment approaches is required to improve the outcomes of the disease. Immunotherapy has been proven to be ... ...

    Abstract Despite advances in surgery and chemotherapy, ovarian cancer remains one of the most lethal malignancies. Hence, the implementation of novel treatment approaches is required to improve the outcomes of the disease. Immunotherapy has been proven to be effective in many tumors and has already been incorporated into clinical practice. In this review, we describe key strategies in immunotherapy of ovarian cancer and summarize data from clinical studies assessing immunological prospects which could improve ovarian cancer treatment approaches in the future. The most notable current strategies include checkpoint blockade agents, the use of vaccines, adoptive cell transfer, as well as various combinations of these methods. While several of these options are promising, large controlled randomized studies are still needed to implement new immunotherapeutic options into clinical practice.
    MeSH term(s) Cancer Vaccines/therapeutic use ; Female ; Humans ; Immunotherapy/methods ; Immunotherapy, Adoptive/methods ; Ovarian Neoplasms/drug therapy
    Chemical Substances Cancer Vaccines
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.1007/s00005-022-00655-8
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    Zs.A 393: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Nuclear medicine in the diagnosis of benign thyroid diseases.

    Czepczyński, Rafał

    Nuclear medicine review. Central & Eastern Europe

    2012  Volume 15, Issue 2, Page(s) 113–119

    Abstract: Thyroid gland has the unique ability to concentrate iodine. This phenomenon offers a perfect background for a wide range of diagnostic tests utilizing radioactive iodine nuclides of iodine and technetium. Despite the very good availability of ... ...

    Abstract Thyroid gland has the unique ability to concentrate iodine. This phenomenon offers a perfect background for a wide range of diagnostic tests utilizing radioactive iodine nuclides of iodine and technetium. Despite the very good availability of ultrasonography and other imaging modalities, radionuclide methods are still inevitable in a various cases of thyroid disease. In this article, a comprehensive review of all these methods used in the diagnosis of benign thyroid diseases is presented. Iodine and technetium uptake tests are briefly described. Indications to thyroid scan in the context of iodine supply are also presented. Finally, the significance of thyroid findings in PET images is pointed out. The article is illustrated by some typical patterns of radionuclide thyroid images.
    MeSH term(s) Biological Transport ; Humans ; Nuclear Medicine/methods ; Positron-Emission Tomography ; Radiopharmaceuticals/metabolism ; Thyroid Diseases/diagnosis ; Thyroid Diseases/diagnostic imaging ; Thyroid Diseases/metabolism ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/metabolism
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2012-08-29
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 1467537-7
    ISSN 1644-4345 ; 1506-9680
    ISSN (online) 1644-4345
    ISSN 1506-9680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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