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Article ; Online: Guidelines of prevention, recognition and treatment of osteoporotic bone fractures.

Mazurek, Tomasz / Czubak, Jarosław / Czerwiński, Edward

2023 Volume 24, Issue 4, Page(s) 281–292

Abstract: Population aging makes osteoporotic fractures (OP) an increasingly serious healthcare problem. It is estimated that there are approximately 2,200,000 people with an osteoporotic fracture in Poland, and according to the NFZ (National Health Found) report ... ...

Abstract	Population aging makes osteoporotic fractures (OP) an increasingly serious healthcare problem. It is estimated that there are approximately 2,200,000 people with an osteoporotic fracture in Poland, and according to the NFZ (National Health Found) report 126,100 new fractures were registered in 2018, including 34,700 fractures of the proximal femur (PFF). Surgical treatment of OP fractures is difficult due to local conditions and the general health condition of the patients. Reduced bone strength makes it difficult to achieve permanent bone fixation and union.The current "Guidelines for the prevention, diagnosis and treatment of osteoporotic bone fractures" is an update of the 2017 version (previous versions: 2007, 2012) taking into account the progress made in this area of knowledge and practice. The latest principles of conduct have been created on the basis of contemporary world standards and publications. The recommended methods of treating fractures will be discussed: of the PFF, distal end of the radius, proximal end of the humerus and the spine. Particular attention has been paid to the management of patients with PFF, because the average age - 80 years causes that an average of 29.4% of patients in Poland die within a year after the fracture (data from the National Health Fund). After sustaining a fracture, the risk of a consecutive one increases 210 times, so the surgeon is required not only to treat the fracture, but also to implement fracture prophylaxis. The study will also present the principles of diagnosis and treatment of osteoporosis.The presented guidelines were adopted in August 2022 as an official document of the National Consultant in the field of Orthopedics and Traumatology of the bone and joints system and the President of the Polish Society of Orthopedics and Traumatology. The leading author was Prof. dr hab. med. Edward Czerwiski.
MeSH term(s)	Humans ; Osteoporotic Fractures/prevention & control ; Osteoporotic Fractures/surgery ; Orthopedic Procedures ; Osteoporosis/diagnosis ; Orthopedics ; Aging
Language	English
Publishing date	2023-02-01
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2205282-3
ISSN	2084-4336 ; 1509-3492
ISSN (online)	2084-4336
ISSN	1509-3492
DOI	10.5604/01.3001.0016.0589
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Article ; Online: Letter to the editor: regarding "The utility and limitations of FRAX: a US perspective".

Czerwinski, Edward

Current osteoporosis reports

2012 Volume 10, Issue 1, Page(s) 1–2; author reply 3

MeSH term(s)	Fractures, Bone/epidemiology ; Health Status Indicators ; Humans ; Risk Assessment/methods
Language	English
Publishing date	2012-01-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-011-0092-x
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Article: Atypical subtrochanteric fractures after long-term bisphosphonate therapy.

Czerwiński, Edward

Endokrynologia Polska

2011 Volume 62, Issue 1, Page(s) 84–87

Abstract: There have been many reports published in recent years on atypical subtrochanteric fractures after long-term bisphosphonates therapy. In a description of a few series of cases, fractures of typical clinical course and radiological image have been ... ...

Abstract	There have been many reports published in recent years on atypical subtrochanteric fractures after long-term bisphosphonates therapy. In a description of a few series of cases, fractures of typical clinical course and radiological image have been documented. These fractures are estimated as very rare (2.3 per 10,000 patient-years). It is suggested that a subsequent use of steroids or proton pump inhibitors with bisphosphonates may increase the risk of fracture occurrence.
MeSH term(s)	Alendronate/adverse effects ; Bone Density Conservation Agents/adverse effects ; Diphosphonates/adverse effects ; Drug Interactions ; Drug Therapy, Combination/adverse effects ; Hip Fractures/chemically induced ; Humans ; Proton Pump Inhibitors/administration & dosage ; Steroids/administration & dosage
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; Proton Pump Inhibitors ; Steroids ; Alendronate (X1J18R4W8P)
Language	English
Publishing date	2011-01
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	419270-9
ISSN	0423-104X
ISSN	0423-104X
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Article ; Online: Atypowe złamania podkrętarzowe po długoterminowym leczeniu bisfosfonianami.

Czerwiński, Edward

Endokrynologia Polska

2011 Volume 62 Suppl 2, Page(s) 42–45

Title translation	Atypical subtrochanteric fractures after long-term bisphosphonate therapy.
Abstract	There have been many reports published in recent years on atypical subtrochanteric fractures after long-term bisphosphonates therapy. In a description of a few series of cases, fractures of typical clinical course and radiological image have been documented. These fractures are estimated as very rare (2.3 per 10,000 patient-years). It is suggested that a subsequent use of steroids or proton pump inhibitors with bisphosphonates may increase the risk of fracture occurrence.
MeSH term(s)	Bone Density Conservation Agents/adverse effects ; Diphosphonates/adverse effects ; Drug Interactions ; Drug Therapy, Combination ; Hip Fractures/chemically induced ; Humans ; Osteoporosis/drug therapy ; Proton Pump Inhibitors/adverse effects ; Risk Factors ; Steroids/adverse effects ; Time Factors
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; Proton Pump Inhibitors ; Steroids
Language	Polish
Publishing date	2011
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	419270-9
ISSN	2299-8306 ; 0423-104X
ISSN (online)	2299-8306
ISSN	0423-104X
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Article: Developing a novel positronium biomarker for cardiac myxoma imaging.

Moskal, Paweł / Kubicz, Ewelina / Grudzień, Grzegorz / Czerwiński, Eryk / Dulski, Kamil / Leszczyński, Bartosz / Niedźwiecki, Szymon / Stępień, Ewa Ł

EJNMMI physics

2023 Volume 10, Issue 1, Page(s) 22

Abstract: Purpose: Cardiac myxoma (CM), the most common cardiac tumor in adults, accounts for 50-75% of benign cardiac tumors. The diagnosis of CM is often elusive, especially in young stroke survivors and transthoracic echocardiography (TTE) is the initial ... ...

Abstract	Purpose: Cardiac myxoma (CM), the most common cardiac tumor in adults, accounts for 50-75% of benign cardiac tumors. The diagnosis of CM is often elusive, especially in young stroke survivors and transthoracic echocardiography (TTE) is the initial technique for the differential diagnostics of CM. Less invasive cardiac computed tomography (CT) and magnetic resonance imaging (MRI) are not available for the majority of cardiac patients. Here, a robust imaging approach, ortho-Positronium (o-Ps) imaging, is presented to determine cardiac myxoma extracted from patients undergoing urgent cardiac surgery due to unexpected atrial masses. We aimed to assess if the o-Ps atom, produced copiously in intramolecular voids during the PET imaging, serves as a biomarker for CM diagnosing. Methods: Six perioperative CM and normal (adipose) tissue samples from patients, with primary diagnosis confirmed by the histopathology examination, were examined using positron annihilation lifetime spectroscopy (PALS) and micro-CT. Additionally, cell cultures and confocal microscopy techniques were used to picture cell morphology and origin. Results: We observed significant shortening in the mean o-Ps lifetime in tumor with compare to normal tissues: an average value of 1.92(02) ns and 2.72(05) ns for CM and the adipose tissue, respectively. Microscopic differences between tumor samples, confirmed in histopathology examination and micro-CT, did not influenced the major positronium imaging results. Conclusions: Our findings, combined with o-Ps lifetime analysis, revealed the novel emerging positronium imaging marker (o-PS) for cardiovascular imaging. This method opens the new perspective to facilitate the quantitative in vivo assessment of intracardiac masses on a molecular (nanoscale) level.
Language	English
Publishing date	2023-03-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00543-w
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Article ; Online: Trabecular Bone Score (TBS) in Clinical Practice - Rewiev.

Warzecha, Maja / Czerwiński, Edward / Amarowicz, Jarosław / Berwecka, Małgorzata

Ortopedia, traumatologia, rehabilitacja

2019 Volume 20, Issue 5, Page(s) 347–359

Abstract: Bone mineral density (BMD) assessment is the basic method for assessing fracture risk and diagnosing osteoporosis according to the World Health Organization (WHO). Osteoporosis is diagnosed when the T-score at the proximal femur or spine is T≤-2.5; ... ...

Abstract	Bone mineral density (BMD) assessment is the basic method for assessing fracture risk and diagnosing osteoporosis according to the World Health Organization (WHO). Osteoporosis is diagnosed when the T-score at the proximal femur or spine is T≤-2.5; however, 70% of fractures occur in patients who do not fulfil this criterion. As BMD alone does not adequately predict fracture risk, additional methods supporting risk assessment are needed [3,4]. In 2012, the US Food and Drug Administration (FDA) adopted the Trabecular Bone Score (TBS) as another diagnostic method for osteoporosis. The aim of this study is to evaluate the use of TBS in clinical practice with particular attention to fracture risk assessment, differential diagnosis and assessment of treatment outcomes in patients suffering from primary or secondary osteoporosis. Literature analysis points to the increasing use of TBS in clinical practice. It has been found that, in different subjects with the same BMD, structural bone health is better differentiated using TBS. Additionally, it is valuable to use the DXA along with TBS analysis for improved prediction of fracture risk. Indirect assessment of bone structure with TBS is also helpful in assessing the effect of medications. In conclusion, TBS analysis is a valuable tool in the assessment of bone fracture risk and in the differential diagnosis of structural bone disorders in secondary osteoporosis.
MeSH term(s)	Absorptiometry, Photon/methods ; Adult ; Aged ; Aged, 80 and over ; Bone Density ; Cancellous Bone/chemistry ; Female ; Fractures, Bone/diagnosis ; Humans ; Male ; Middle Aged ; Osteoporosis/diagnosis ; Predictive Value of Tests ; Risk Assessment/methods
Language	English
Publishing date	2019-02-27
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2205282-3
ISSN	2084-4336 ; 1509-3492
ISSN (online)	2084-4336
ISSN	1509-3492
DOI	10.5604/01.3001.0012.7281
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Article: Relation between risk of falls, sarcopenia and parameters assessing quality of skeletal muscles in a group of postmenopausal women.

Warzecha, Maja / Amarowicz, Jarosław / Berwecka, Małgorzata / Czerwiński, Edward / Kumorek, Anna

Przeglad menopauzalny = Menopause review

2020 Volume 19, Issue 3, Page(s) 123–129

Abstract: Introduction: Involutional changes that occur in skeletal muscle are a feature that characterizes the aging process. In women, age-related decreases in muscle mass and function of skeletal muscles occur more rapidly with the onset of menopause. ... ...

Abstract	Introduction: Involutional changes that occur in skeletal muscle are a feature that characterizes the aging process. In women, age-related decreases in muscle mass and function of skeletal muscles occur more rapidly with the onset of menopause. Progressive muscle dysfunction has been directly linked with an increased probability of falls, fractures, disability and mortality. Aim of the study: To assess the relationship between the risk of falls and parameters of skeletal muscle assessment in a group of postmenopausal women together with the identification of patients with sarcopenia. Material and methods: This study was carried among 122 women over 60 years of age. Patients had their muscular system tested with the emphasis on the sarcopenia diagnosis using: Total Body Composition, handgrip and physical performance tests. Patients also underwent a questionnaire survey assessing occurrence of falls. Results: The analysis showed an over 2-fold increase (OR 2.4; 95% CI, 1.02-5.56) in risk of falls in a year among subjects with decreased muscle mass. No such correlation was noted with parameters such as falls in the last 12 months and decrease of muscle strength as well as physical performance. Sarcopenia is more likely to be diagnosed with European Working Group on Sarcopenia in Older People (EWGSOP1) criteria than EWGSOP2 (updated in 2018) (18% vs. 4.1% respectively). The increased risk of falls has not been proven in women with sarcopenia. Conclusions: The decrease of muscle mass is significantly correlated with the risk of falls in the last year in postmenopausal women. Impact of sarcopenia on the risk of falls depends on diagnostic criteria.
Language	English
Publishing date	2020-10-02
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596140-8
ISSN	2299-0038 ; 1643-8876
ISSN (online)	2299-0038
ISSN	1643-8876
DOI	10.5114/pm.2020.99617
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Article: Comparison of the trabeculae structure of the spongy bone of the bilateral pastern bones in racehorses based on the imaging analysis of radiograms.

Dzierzecka, M / Czerwinski, E

Polish journal of veterinary sciences

2010 Volume 13, Issue 3, Page(s) 551–553

Abstract: On the basis of a digital analysis of radiograms it was checked if, and to what extent, the extended loading of one of the sides of the body of racehorses leads to differences in the microstructure of the spongy bone of the bilateral pastern bones of the ...

Abstract	On the basis of a digital analysis of radiograms it was checked if, and to what extent, the extended loading of one of the sides of the body of racehorses leads to differences in the microstructure of the spongy bone of the bilateral pastern bones of the thoracic limbs. The research material consisted of radiograms of the pastern bones of the right and left thoracic limbs of racehorses. On the basis of computer image radiological analysis with the use of the "Trabecula,, programme, a quantative evaluation of the structure of the spongy bone of the pastern bones was conducted. It was noted that the differences between the right and the left pastern bones, despite extensive loading of the left thoracic limb, were not statistically significant as far as all studied parameters of the trabecula structure of the spongy bone were concerned.
MeSH term(s)	Animals ; Bone and Bones/anatomy & histology ; Bone and Bones/diagnostic imaging ; Bone and Bones/physiology ; Forelimb/anatomy & histology ; Forelimb/diagnostic imaging ; Horses/anatomy & histology ; Horses/physiology ; Physical Conditioning, Animal/physiology ; Radiography
Language	English
Publishing date	2010
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1439556-3
ISSN	1505-1773
ISSN	1505-1773
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Article ; Online: Possibilities for Implementing Fracture Liaison Service in Poland in the Light of a Visit to Glasgow Western Infirmary.

Amarowicz, Jarosław / Czerwiński, Edward

Ortopedia, traumatologia, rehabilitacja

2015 Volume 17, Issue 4, Page(s) 415–421

Abstract: Osteoporosis remains one of the top challenges for health services all over the world. Osteoporotic changes in bone structure along with the aging of society result in rapid growth of osteoporotic fractures. Statistics show that approximately 25% of ... ...

Abstract	Osteoporosis remains one of the top challenges for health services all over the world. Osteoporotic changes in bone structure along with the aging of society result in rapid growth of osteoporotic fractures. Statistics show that approximately 25% of women and 20% of men will suffer a subsequent fracture within 5 years of an initial one. In order to deal with the problem, a novel program in secondary fracture prevention was developed in Scotland in the late 1990's. The system was based on a coordinator and focused on identifying, diagnosing and treating patients with osteoporotic fractures. After just a few years, the system, known as Fracture Liaison Services (FLS), proved to be a cost-effective success. For the last several years, FLS has been implemented in countries all over the world. The Glasgow Western Infirmary, where the program started, continues to be one of the top exemplary facilities in the United Kingdom. Each year the Bone Metabolism Unit proves its effectiveness by providing 4000 DXA scans and taking care of 2500 fractures a year. In 2015, the European Foundation of Osteoporosis and Musculoskeletal Diseases successfully implemented a coordinator-based Fracture Liaison Service in Poland.
MeSH term(s)	Absorptiometry, Photon/methods ; Delivery of Health Care, Integrated/organization & administration ; Disease Management ; Female ; Humans ; Male ; Models, Organizational ; Osteoporotic Fractures/prevention & control ; Osteoporotic Fractures/therapy ; Patient Care Team/organization & administration ; Poland ; Scotland ; Secondary Prevention/organization & administration
Language	English
Publishing date	2015-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2205282-3
ISSN	2084-4336 ; 1509-3492
ISSN (online)	2084-4336
ISSN	1509-3492
DOI	10.5604/15093492.1173384
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Article: Diagnostyka radiologiczna i densytometryczna osteoporozy.

Czerwiński, E

Przeglad lekarski

1997 Volume 54, Issue 4, Page(s) 220–225

Abstract: The principles of densitometric and radiological examination in diagnosing of osteoporosis are presented. Peripheral and whole body densitometers are described and their quality is assessed on basis of precision and accuracy of bone mineral density ... ...

Title translation	Radiologic diagnosis and densitometry of osteoporosis.
Abstract	The principles of densitometric and radiological examination in diagnosing of osteoporosis are presented. Peripheral and whole body densitometers are described and their quality is assessed on basis of precision and accuracy of bone mineral density measurements (BMD). WHO criteria of diagnosis, which introduce clinical category of the basis of BMD (expressed in T-scores) are described as follows: normal-(T-score up to -1.0); osteopenia-(T-score below -1.0 but more than -2.5); osteoporosis-(T-score -2.5 or below); severe osteoporosis-(T-score below -2.5 and one or more fractures). Evaluation of osteoporotic changes on the spine, pelvis and hand radiographs are discussed. Quantitative and possible quantitative analysis of radiographs are described.
MeSH term(s)	Aged ; Bone Density ; Densitometry/methods ; Densitometry/standards ; Female ; Hand/diagnostic imaging ; Humans ; Osteoporosis/diagnosis ; Pelvis/diagnostic imaging ; Radiography ; Spine/diagnostic imaging ; World Health Organization
Language	Polish
Publishing date	1997
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	414053-9
ISSN	0033-2240 ; 0860-0422
ISSN	0033-2240 ; 0860-0422
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