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Article ; Online: Infection With Saprochaete Clavata in Children After Hematopoietic Cell Transplantation.

Styczynski, Tomasz / Sadlok, Jagoda / Richert-Przygonska, Monika / Debski, Robert / Zalas-Wiecek, Patrycja / Czyzewski, Krzysztof / Styczynski, Jan

Journal of pediatric hematology/oncology

2023 Volume 45, Issue 8, Page(s) e976–e979

Abstract: Septic shock is a very rare manifestation of invasive fungal disease (IFD) in children after allogeneic hematopoietic cell transplantation (allo-HCT). The objective of this paper is analysis of two cases of pediatric patients with IFD caused by ... ...

Abstract	Septic shock is a very rare manifestation of invasive fungal disease (IFD) in children after allogeneic hematopoietic cell transplantation (allo-HCT). The objective of this paper is analysis of two cases of pediatric patients with IFD caused by Saprochaete clavata after allo-HCT. Literature data on this infection in children and its outcome were also summarized. Infection with Saprochaete clavate presenting with symptoms of septic shock was being reported in 4 children, and 2 of them survived the infection. In conclusion, with quick diagnosis and quick treatment, the outcome of therapy of infection with Saprochaete clavata was successful.
MeSH term(s)	Humans ; Child ; Shock, Septic/complications ; Invasive Fungal Infections/diagnosis ; Invasive Fungal Infections/drug therapy ; Invasive Fungal Infections/etiology ; Saccharomycetales ; Hematopoietic Stem Cell Transplantation/adverse effects
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002686
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Article ; Online: Letermovir Prophylaxis for Cytomegalovirus Infection in Children After Hematopoietic Cell Transplantation.

Richert-Przygonska, Monika / Jaremek, Kamila / Debski, Robert / Konieczek, Joanna / Lecka, Monika / Dziedzic, Magdalena / Bogiel, Tomasz / Styczynski, Jan / Czyzewski, Krzysztof

Anticancer research

2022 Volume 42, Issue 7, Page(s) 3607–3612

Abstract: Background/aim: Cytomegalovirus (CMV) infection is one of the major causes of morbidity following hematopoietic cell transplantation (HCT). Allogeneic HCT (allo-HCT) recipients are at the highest risk of clinically significant CMV reactivation. While ... ...

Abstract	Background/aim: Cytomegalovirus (CMV) infection is one of the major causes of morbidity following hematopoietic cell transplantation (HCT). Allogeneic HCT (allo-HCT) recipients are at the highest risk of clinically significant CMV reactivation. While letermovir has been approved for prophylactic use in CMV seropositive adults, reports on pediatric data are very limited. The objective of the study was to examine the use of letermovir for prophylaxis from CMV infection in children undergoing allo-HCT in a single center. Patients and methods: This retrospective matched-pair analysis study included 39 CMV-seropositive pediatric patients undergoing allo-HCT receiving letermovir as a primary prophylaxis for CMV infection on a compassionate-use basis (LMV group, n=13) or not (control group, n=26). There were no differences in basic characteristics between the analyzed groups. Among patients of the study group, 12 received primary prophylaxis with letermovir from day +1 after HCT. One patient, previously treated with ganciclovir received secondary prophylaxis from day +18. Results: Prophylactic dose of letermovir was adjusted to cyclosporine co-administration, varied in between 120-480 mg, and given orally, once daily. No CMV reactivation was observed during administration of letermovir. Cumulative incidence of CMV reactivation was significantly higher for the control group not receiving prophylaxis. Of the 13 patients of the study group, three died; however, deaths were not attributable to CMV infection. We did not observe any toxicities related to letermovir. Conclusion: Our data support letermovir prophylaxis efficacy and safety in pediatric patients after allo-HCT. Compared with the historical group, prophylactic use of letermovir decreased the number of CMV reactivations in children.
MeSH term(s)	Acetates/therapeutic use ; Adult ; Child ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/etiology ; Cytomegalovirus Infections/prevention & control ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Quinazolines ; Retrospective Studies
Chemical Substances	Acetates ; Quinazolines ; letermovir (1H09Y5WO1F)
Language	English
Publishing date	2022-07-05
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.15848
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Article ; Online: Minimally Invasive Surgery in Pediatric Oncology: Proposal of Guidelines.

Galazka, Przemyslaw / Czyzewski, Krzysztof / Marjanska, Agata / Daniluk-Matras, Irena / Styczynski, Jan

Anticancer research

2019 Volume 39, Issue 11, Page(s) 5853–5859

Abstract: Background/aim: The objective of the study was to propose clinical guidelines for the use of minimally invasive surgery (MIS) in pediatric oncology.: Patients and methods: Two groups of experts, including pediatric surgeons and pediatric oncologists ... ...

Abstract	Background/aim: The objective of the study was to propose clinical guidelines for the use of minimally invasive surgery (MIS) in pediatric oncology. Patients and methods: Two groups of experts, including pediatric surgeons and pediatric oncologists were created in order to establish strategies of diagnostic and therapeutic surgical management in pediatric oncology. Results: On the basis of the analysis of the existing literature, we elaborated guidelines that were graded according to the simple practical clinical system: yes/no. This project was dedicated to the following topics: adrenal tumors including neuroblastoma, renal tumors including Wilms tumor (nephroblastoma), ovarian tumors and pulmonary nodules and metastases (osteosarcoma). Conclusion: Although existing data do not allow the recommendation of the use of MIS for all indications, this technique should currently be regarded as a standard of care in several areas of pediatric oncology.
MeSH term(s)	Child ; Humans ; Minimally Invasive Surgical Procedures/methods ; Neoplasms/surgery ; Practice Guidelines as Topic/standards
Language	English
Publishing date	2019-11-08
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.13789
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Article ; Online: Matched unrelated donor transplantation versus haploidentical transplantation with post-transplant cyclophosphamide in children with acute myeloid leukemia: a PDWP-EBMT study.

Ruggeri, Annalisa / Santoro, Nicole / Galimard, Jacques-Emmanuel / Kalwak, Krzysztof / Algeri, Mattia / Zubarovskaya, Ludmila / Czyzewski, Krzysztof / Skorobogatova, Elena / Sedlacek, Petr / Besley, Caroline / Balduzzi, Adriana / Bertrand, Yves / Peristeri, Julia / Fagioli, Franca / Ifversen, Mariane / Gozdzik, Jolanta / Peters, Christina / Versluijs, Birgitta / Biffi, Alessandra /

Prete, Arcangelo / Faraci, Maura / Ghemlas, Ibrahim / Bodova, Ivana / Aleinikova, Olga / Dalissier, Arnaud / Rocha, Vanderson / Corbacioglu, Selim

Haematologica

2024

Abstract: In children with acute myeloid leukemia (AML) who lack an HLA identical sibling, the donor can be replaced with an HLA matched unrelated donor (MUD) or a haploidentical donor (haplo). We compared outcomes of patients <18 years with AML in first and ... ...

Abstract	In children with acute myeloid leukemia (AML) who lack an HLA identical sibling, the donor can be replaced with an HLA matched unrelated donor (MUD) or a haploidentical donor (haplo). We compared outcomes of patients <18 years with AML in first and second complete remission (CR1 and CR2) undergoing a hematopoietic stem cell transplantation (HCT) either with a MUD with anti-thymocyte globuline (ATG) (n=420) or a haplo HCT with PT-CY (n=96) after a myeloablative conditioning regimen (MAC) between 2011 and 2021, reported to EBMT. A matched pair analysis was performed to adjust for differences among groups. The final analysis was performed on 253 MUD and 95 haplo-HCTs. In the matched cohort, median age at HCT was 11.2 and 10 years and median year of HCT was 2017 and 2018, in MUD and haplo- HCT recipients, respectively. The risk of grade III-IV aGvHD was significantly higher in the haplo group (HR=2.33, 95%CI1.18-4.58, p=0.03). No significant differences were found in 2 years overall survival (OS; 78.4%vs71.5%; HR 1.39, 0.84-2.31, p=0.19), leukemia-free-survival (LFS; 72.7%vs69.5%; HR1.22, 0.76-1.95, p=0.41), CI of relapse (RI; 19.3%vs19.5%; HR=1.14, 0.62-2.08, p=0.68) non-relapse-mortality (NRM; 8%vs11%; HR=1.39, 0.66-2.93, p=0.39) and graft versus host free-relapse free survival (GRFS; 60.7%vs54.5%, HR=1.38, 0.95-2.02, p=0.09) after MUD and haplo-HCT respectively. Our study suggests that haplo-HCT with PT-CY is a suitable option to transplant children with AML lacking a matched related donor.
Language	English
Publishing date	2024-01-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.284445
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Article: Pre-Exposure Prophylaxis and Treatment with Tixagevimab/Cilgavimab for COVID-19 among Immunocompromised Pediatric Patients.

Frączkiewicz, Jowita / Pawińska-Wąsikowska, Katarzyna / Szymbor, Katarzyna / Balwierz, Walentyna / Skoczeń, Szymon / Czyżewski, Krzysztof / Kołtan, Sylwia / Styczyński, Jan / Małecka, Anna / Irga-Jaworska, Ninela / Trelińska, Joanna / Młynarski, Wojciech / Zając-Spychała, Olga / Sobkowiak-Sobierajska, Agnieszka / Derwich, Katarzyna / Bal, Wioletta / Chaber, Radosław / Książek, Agnieszka / Szczepański, Tomasz /

Zawitkowska, Joanna / Drabko, Katarzyna / Chodała-Grzywacz, Agnieszka / Karolczyk, Grażyna / Kobierzycki, Christopher / Kałwak, Krzysztof

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13072029
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Article: Complex profile of multiple hepatobiliary and gastrointestinal complications after hematopoietic stem cell transplantation in a child with Nijmegen breakage syndrome.

Gałązka, Przemysław / Czyżewski, Krzysztof / Szaflarska-Popławska, Anna / Dębski, Robert / Krenska, Anna / Styczyński, Jan

Central-European journal of immunology

2019 Volume 44, Issue 3, Page(s) 327–331

Abstract: Patients with Nijmegen breakage syndrome (NBS) can develop life-threatening immunodeficiency, which should be treated with hematopoietic stem cell transplantation (HSCT). We report the case of a 14-year-old girl with NBS who due to an increasing number ... ...

Abstract	Patients with Nijmegen breakage syndrome (NBS) can develop life-threatening immunodeficiency, which should be treated with hematopoietic stem cell transplantation (HSCT). We report the case of a 14-year-old girl with NBS who due to an increasing number of severe complications was referred for HSCT from a matched unrelated donor. After reduced-intensity conditioning and transplantation of peripheral blood hematopoietic cells, during the early post-transplant period (days 0-30), the girl suffered from severe mucositis, fever episodes, mild acute renal injury and facial vasculitis. All these complications were managed successfully. During the intermediate post-transplant period (days 30-100) a number of hepatic and gastrointestinal complications occurred, including cholecystitis, cholelithiasis with choledocholithiasis, pancreatitis as well as acute bleeding from the lower gastrointestinal tract caused by rectal and recto-sigmoid junction ulcers. All the obstacles were obviously attributable both to the primary congenital disease, its complications, and transplantation itself. We overcame these complications and treated the patient with the best possible and safe methods. The multidisciplinary approach based on combined surgical, endoscopic and conservative management of multiple post-transplant complications was successful for the patient.
Language	English
Publishing date	2019-09-30
Publishing country	Poland
Document type	Case Reports
ZDB-ID	1336421-2
ISSN	1644-4124 ; 1426-3912
ISSN (online)	1644-4124
ISSN	1426-3912
DOI	10.5114/ceji.2019.89612
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Article ; Online: The Successful Sequential Use of Plerixafor and Eltrombopag For Hematopoietic Cell Transplantation in a Child With High-risk Neuroblastoma.

Marjanska, Agata / Czyzewski, Krzysztof / Debski, Robert / Krenska, Anna / Wysocki, Mariusz / Styczynski, Jan

Journal of pediatric hematology/oncology

2019 Volume 42, Issue 7, Page(s) e680–e682

Abstract: High-dose chemotherapy with autologous hematopoietic stem cell transplantation improves event-free survival in patients with high-risk neuroblastoma. However, in heavily pretreated patients, poor marrow function can be an obstacle in the successful ... ...

Abstract	High-dose chemotherapy with autologous hematopoietic stem cell transplantation improves event-free survival in patients with high-risk neuroblastoma. However, in heavily pretreated patients, poor marrow function can be an obstacle in the successful proceeding of therapy. Priming with plerixafor plus filgrastim is an option for effective mobilization and collection of stem cells. In addition, thrombopoietin agonist eltrombopag can improve the outcome of posttransplantation thrombocytopenia and poor graft function in the posttransplant setting. We describe a case of a child with high-risk neuroblastoma, for whom plerixafor and eltrombopag were used as an effective and safe supportive therapy.
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Benzoates/therapeutic use ; Child, Preschool ; Combined Modality Therapy ; Drug Therapy, Combination ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Heterocyclic Compounds/therapeutic use ; Humans ; Hydrazines/therapeutic use ; Neuroblastoma/pathology ; Neuroblastoma/therapy ; Prognosis ; Pyrazoles/therapeutic use
Chemical Substances	Anti-HIV Agents ; Benzoates ; Heterocyclic Compounds ; Hydrazines ; Pyrazoles ; eltrombopag (S56D65XJ9G) ; plerixafor (S915P5499N)
Language	English
Publishing date	2019-07-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000001551
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Article ; Online: Case report: Cellular therapy for hydroa vacciniforme-like lymphoproliferative disorder in pediatric common variable immunodeficiency with chronic active Epstein-Barr virus infection.

Grześk, Elżbieta / Kołtan, Sylwia / Dąbrowska, Anna / Urbańczyk, Anna / Małdyk, Jadwiga / Małkowski, Bogdan / Bogiel, Tomasz / Dębski, Robert / Czyżewski, Krzysztof / Wysocki, Mariusz / Styczyński, Jan

Frontiers in immunology

2022 Volume 13, Page(s) 915986

Abstract: Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a cutaneous form of chronic active Epstein-Barrvirus (EBV) infection, which can develop into the extremely rare systemic lymphoma. Patients with Inborn errors of immunity (IEI), such as ... ...

Abstract	Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a cutaneous form of chronic active Epstein-Barrvirus (EBV) infection, which can develop into the extremely rare systemic lymphoma. Patients with Inborn errors of immunity (IEI), such as common variable immunodeficiency (CVID), are at higher risk of developing a severe course of infections especially viral and malignancies than the general population. The aim of the study was to present complex diagnostic and therapeutic management of HV-LPD. The clinical diagnosis was confirmed at the histological and molecular level with next generation sequencing. HV-LPD was diagnosed in a patient with CVID and chronic active Epstein-Barr virus (CAEBV) infection. The patient was refractory to CHOP chemotherapy and immunosuppressive treatment in combination with antiviral drugs (prednisone, bortezomib, gancyclovir). The third-party donor EBV-specific cytotoxic T cells (EBV-CTL, tabelecleucel) were used, which stabilised the disease course. Finally, matched unrelated donor hematopoietic cell transplantation (MUD-HCT) was performed followed by another cycle of EBV-CTL.
MeSH term(s)	Child ; Common Variable Immunodeficiency/complications ; Common Variable Immunodeficiency/therapy ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/therapy ; Herpesvirus 4, Human ; Humans ; Hydroa Vacciniforme/diagnosis ; Hydroa Vacciniforme/therapy ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/etiology ; Lymphoproliferative Disorders/therapy ; Skin Neoplasms
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.915986
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Article ; Online: Successful Management of Unusual Multiple Gut Colonization With Extremely Drug-resistant Bacteria in an Infant Undergoing Hematopoietic Cell Transplantation.

Zalas-Więcek, Patrycja / Czyżewski, Krzysztof / Bogiel, Tomasz / Gospodarek-Komkowska, Eugenia / Wysocki, Mariusz

Journal of pediatric hematology/oncology

2018 Volume 42, Issue 2, Page(s) e125–e127

Abstract: Enterobacterales represent a serious threat to transplant patients due to their increase frequency of carbapenem resistance and wide spreading. We present a case of an infant with acute lymphoblastic leukemia undergoing hematopoietic stem cell ... ...

Abstract	Enterobacterales represent a serious threat to transplant patients due to their increase frequency of carbapenem resistance and wide spreading. We present a case of an infant with acute lymphoblastic leukemia undergoing hematopoietic stem cell transplantation. Before transplantation an unusual double colonization of the gastrointestinal tract with extremely resistant Escherichia coli and Klebsiella pneumoniae strains producing metallo-beta-lactamase was diagnosed. Respective epidemiologic management was implemented, based on the strict reverse isolation in patient-protective environment, and intensified antimicrobial surveillance. After granulocyte recovery, no extremely drug-resistant strains were found, and no case of isolation and/or transmission of carbapenem-resistant bacteria has been identified in the transplant center during the following 6 months.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Disease Management ; Drug Resistance, Bacterial ; Environment ; Escherichia coli/isolation & purification ; Escherichia coli Infections/etiology ; Escherichia coli Infections/pathology ; Escherichia coli Infections/prevention & control ; Female ; Gastrointestinal Microbiome ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Infant ; Klebsiella Infections/etiology ; Klebsiella Infections/pathology ; Klebsiella Infections/prevention & control ; Klebsiella pneumoniae/isolation & purification ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/microbiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Prognosis ; Protective Factors
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2018-11-23
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000001351
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Article ; Online: Low seroprevalence and low incidence of infection with Toxoplasma gondii (Nicolle et Manceaux, 1908) in pediatric hematopoietic cell transplantation donors and recipients: Polish nationwide study.

Czyzewski, Krzysztof / Fraczkiewicz, Jowita / Salamonowicz, Malgorzata / Pieczonka, Anna / Zajac-Spychala, Olga / Zaucha-Prazmo, Agnieszka / Gozdzik, Jolanta / Styczynski, Jan

Folia parasitologica

2019 Volume 66

Abstract: Toxoplasmosis is a potentially fatal complication after hematopoietic cell transplantation (HCT). Pre-transplant seropositivity of graft recipient to Toxoplasma gondii (Nicolle et Manceaux, 1908) is an important factor for disease reactivation after HCT. ...

Abstract	Toxoplasmosis is a potentially fatal complication after hematopoietic cell transplantation (HCT). Pre-transplant seropositivity of graft recipient to Toxoplasma gondii (Nicolle et Manceaux, 1908) is an important factor for disease reactivation after HCT. As toxoplasmosis epidemiology varies all over the world, we performed a Polish nationwide retrospective cohort study to determine the seroprevalence of toxoplasmosis in donors and pediatric allogeneic and autologous HCT recipients and the incidence of clinically evident toxoplasmosis in this patient group. Polish adult donors had higher anti-T. gondii seroprevalence than Polish pediatric donors (28% vs 8%; OR = 4.4; p = 0.02) and allo-HCT recipients (28% vs 17%; OR = 1.9; p = 0.01). Clinically apparent disease occurred in 1% of allo-HCT recipients: it was diagnosed by PCR as cerebral and/or ocular toxoplasmosis and successfully treated with antiprotozoal therapy. Regarding current practice, no prospective screening for infection of T. gondii in pediatric HCT centres is being performed, but, vast majority of HCT pediatric patients are receiving anti-T. gondii active prophylaxis. Since pre-HCT T. gondii serology was not assessed in all HCT; recipients, we propose this test should be a standard practice. Standardisation of management with infection of T. gondii in children after HCT is needed.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Cohort Studies ; Female ; Hematopoietic Stem Cell Transplantation/statistics & numerical data ; Humans ; Incidence ; Infant ; Male ; Middle Aged ; Poland/epidemiology ; Prevalence ; Retrospective Studies ; Seroepidemiologic Studies ; Tissue Donors/statistics & numerical data ; Toxoplasma/isolation & purification ; Toxoplasmosis/blood ; Toxoplasmosis/epidemiology ; Young Adult
Language	English
Publishing date	2019-11-11
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	162048-4
ISSN	1803-6465 ; 0015-5683
ISSN (online)	1803-6465
ISSN	0015-5683
DOI	10.14411/fp.2019.019
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