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  1. Article ; Online: Prolonged course of Fosfomycin-Trometamol for chronic prostatitis: an unknown good option.

    Denes, Eric

    Scandinavian journal of urology

    2021  Volume 55, Issue 4, Page(s) 344–345

    Abstract: Background: Bacterial prostatitis can be difficult to treat as more and more bacteria are resistant to fluoroquinolone and/or Sulfamethoxazole-Trimethoprim which are the antibiotics of choice. Fosfomycin-Trometamol which is registered for uncomplicated ... ...

    Abstract Background: Bacterial prostatitis can be difficult to treat as more and more bacteria are resistant to fluoroquinolone and/or Sulfamethoxazole-Trimethoprim which are the antibiotics of choice. Fosfomycin-Trometamol which is registered for uncomplicated urinary tract infections can be an option when other treatments can't be used.
    Objective: To describe a case of prostatitis cured using a prolonged course of Fosfomycin-Trometamol. Patient: A 67 years-old man with a chronic bacterial prostatitis, with recurrences for more than 3 years, due to
    Conclusion: Fosfomycin-Trometamol can be a good option for the treatment of bacterial prostatitis when other antibiotics can't be used either for resistance or allergy.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Escherichia coli ; Fosfomycin/therapeutic use ; Humans ; Male ; Prostatitis/drug therapy ; Tromethamine ; Urinary Tract Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Tromethamine (023C2WHX2V) ; Fosfomycin (2N81MY12TE)
    Language English
    Publishing date 2021-06-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2021.1933170
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    Zs.A 601: Show issues Location:
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  2. Article ; Online: Temporal and spatial concomitance of exanthema and dysesthesia in a patient with SARS-cov-2 infection.

    Denes, Eric

    Brain, behavior, & immunity - health

    2020  Volume 9, Page(s) 100165

    Keywords covid19
    Language English
    Publishing date 2020-10-23
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2020.100165
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  3. Article ; Online: Prosthetic joint infections: 6 weeks of oral antibiotics results in a low failure rate.

    Roger, Pierre-Marie / Assi, Frédéric / Denes, Eric

    The Journal of antimicrobial chemotherapy

    2024  Volume 79, Issue 2, Page(s) 327–333

    Abstract: Background: Need for parenteral administration and total duration of antibiotic therapy for prosthetic joint infection (PJI) are debated. We report our PJI management, in which outpatient care is privileged.: Methods: This was a retrospective ... ...

    Abstract Background: Need for parenteral administration and total duration of antibiotic therapy for prosthetic joint infection (PJI) are debated. We report our PJI management, in which outpatient care is privileged.
    Methods: This was a retrospective multicentre cohort study of PJI managed from January 2017 to Jun 2021. Microbial diagnosis was based on surgical samples. Surgical procedures and antibiotic treatments were reported. Chronic PJI was defined by a course >1 month. Oral antibiotic therapy (OAT) was defined by exclusive use of oral antibiotics or by ≤3 days of parenteral treatments. Management failure was defined by clinical and/or microbial relapse of PJI over 24 months after surgical treatment.
    Results: One hundred and seventy-two patients from 13 institutions were included: 103 were male (60%) and mean age was (±SD): 73 ± 12 years. Sites for PJI were mainly hip (50%) and knee (35%), being chronic infections in 70 cases (41%). The main bacterial genus in monomicrobial infections was Staphylococcus spp. (60%). We recorded 41 (24%) implant exchanges. An OAT was prescribed in 76 cases (44%), and the median (range) course for parenteral route was 6 days (4-180) for 96 cases. Median (range) duration of antimicrobials was 42 days (21-180). Management failure was observed in 7/76 (9.2%) cases treated with OAT and 15/96 (15.6%) treated with prolonged parenteral therapy. In multivariate analysis, risk factors for failure were a knee PJI [adjusted OR (95% CI) = 3.27 (1.27-8.40)] and a polymicrobial infection [4.09 (1.46-11.49)].
    Conclusions: OAT for 6 weeks for PJI was associated with a low rate of management failure.
    MeSH term(s) Humans ; Male ; Female ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Arthritis, Infectious/drug therapy ; Knee Joint ; Prosthesis-Related Infections/microbiology ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad382
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  5. Article ; Online: Use of a Porous Alumina Antibiotic-Loaded Ceramic to Treat Bone Defect and Bone Infection After Road Trauma.

    Deluzarches, Philippe / Poli, Evelyne / Barrière, Guislaine / Denes, Eric

    Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

    2022  Volume 6, Issue 6

    Abstract: To describe the use of a porous alumina ceramic loaded with antibiotics for the reconstruction of bilateral tibial fractures in a patient who presented with bone loss and infection after a motorcycle road injury. A 70-year-old man presented open ... ...

    Abstract To describe the use of a porous alumina ceramic loaded with antibiotics for the reconstruction of bilateral tibial fractures in a patient who presented with bone loss and infection after a motorcycle road injury. A 70-year-old man presented open fractures of his both tibiae (proximal involvement on the right side and diaphyseal on the left side). After initial treatment with multiple débridements and the placement of bilateral external fixators, he had bone loss to both tibiae and had developed infections of both legs with multiple organisms identified (Stenotrophomonas maltophilia, Enterobacter cloacae, and Pseudomonas aeruginosa). We used a porous alumina ceramic, designed according to the defects to fill. This ceramic was loaded with antibiotics (gentamicin and vancomycin). The goal was to obtain locally high concentrations of antibiotics to eradicate bacteria that could have remain in the surgical wound. Ceramic parts were placed 4 months after the trauma. Local antibiotic concentrations largely exceeded the pharmacological parameters for antibiotics efficacy. External fixators were removed 3 months after implantation. After a follow-up of more than 1 year, there is no relapse of infection, and the patient resumed walking while ceramic parts were left in place and that bone started colonizing ceramic parts. This ceramic that combines strength and the possibility of antibiotic loading allows thinking of new ways to treat infected fractures with bone loss. Indeed, its mechanical strength provides primary stability, and antibiotics make it possible to secure implantation in an infected area.
    MeSH term(s) Aged ; Aluminum Oxide ; Anti-Bacterial Agents/therapeutic use ; Ceramics/therapeutic use ; Humans ; Male ; Osteomyelitis ; Porosity ; Tibial Fractures/surgery
    Chemical Substances Anti-Bacterial Agents ; Aluminum Oxide (LMI26O6933)
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2898328-2
    ISSN 2474-7661 ; 1067-151X
    ISSN (online) 2474-7661
    ISSN 1067-151X
    DOI 10.5435/JAAOSGlobal-D-21-00257
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  6. Article ; Online: Local Argyria due to Silver-Coated Megaprosthesis.

    Denes, Eric / El Balkhi, Souleiman / Fiorenza, Fabrice

    The American journal of medicine

    2022  Volume 135, Issue 6, Page(s) e116

    MeSH term(s) Argyria/diagnosis ; Argyria/etiology ; Humans ; Silver/adverse effects
    Chemical Substances Silver (3M4G523W1G)
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.01.026
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    Ua VI Zs.289: Show issues Location:
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  7. Article ; Online: Mediastinitis due to highly resistant bacteria treated with the help of locally delivered antibiotics to optimize local antibiotic concentrations.

    Denes, E / Bertin, F / Barraud, O / El Balkhi, S

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2020  Volume 26, Issue 8, Page(s) 1099–1100

    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Bacteria/classification ; Bacteria/drug effects ; Bone Substitutes/therapeutic use ; Drug Administration Routes ; Drug Resistance, Bacterial ; Humans ; Male ; Mediastinitis/drug therapy ; Mediastinitis/microbiology ; Treatment Outcome ; Wound Healing/drug effects
    Chemical Substances Anti-Bacterial Agents ; Bone Substitutes
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.02.025
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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  8. Article ; Online: Fusobacterium nucleatum infections: clinical spectrum and bacteriological features of 78 cases.

    Denes, E / Barraud, O

    Infection

    2016  Volume 44, Issue 4, Page(s) 475–481

    Abstract: Purpose: Few series describe the clinical spectrum of Fusobacterium spp. infections. Among them, fewer discuss F. nucleatum, even though there are many clinical cases.: Methods: We performed a retrospective study over 8 years (from 2007 to 2014) in ... ...

    Abstract Purpose: Few series describe the clinical spectrum of Fusobacterium spp. infections. Among them, fewer discuss F. nucleatum, even though there are many clinical cases.
    Methods: We performed a retrospective study over 8 years (from 2007 to 2014) in Limoges University Hospital, France, to assess clinical and bacteriological aspects of infections due to F. nucleatum.
    Results: Eighty-one patients with F. nucleatum positive cultures were included in this study, irrespective of sample origin. Abscesses (n = 43), bacteraemia (n = 18) and bone infections (n = 8) were the most common types of infections, Abscesses were found in various organs (mostly skin, brain, pleura, liver). Co-morbidities were found in 38 patients (47 %) with neoplasia, diabetes, and alcoholism and history of smoking. There were more neoplasms in patients with bacteraemia than in patients with abscesses (p = 0.007). In 51 cases (65.4 %), infection was polymicrobial, either during bacteraemia or abscesses. Main associations were with Streptococcus spp., Peptostreptococcus spp. and/or Prevotella spp. The sources of infection, when found, were either dental or gastrointestinal. All isolates were susceptible to penicillin, clindamycin and metronidazole.
    Conclusions: Infections involving F. nucleatum are uncommon and potentially severe, with many abscesses requiring surgery. Bacteraemia was mainly associated with co-morbidities such as cancer. Polymicrobial infections were very common and there is probably interaction and/or synergy between F. nucleatum and some other commensal bacteria to cause infections and abscesses.
    MeSH term(s) Abscess ; Adult ; Aged ; Aged, 80 and over ; Bacteremia ; Bone Diseases, Infectious ; Comorbidity ; Diabetes Mellitus ; Female ; Fusobacterium Infections/complications ; Fusobacterium Infections/diagnosis ; Fusobacterium Infections/epidemiology ; Fusobacterium Infections/microbiology ; Fusobacterium nucleatum ; Humans ; Male ; Middle Aged ; Neoplasms ; Retrospective Studies
    Language English
    Publishing date 2016-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-015-0871-x
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    Zs.A 881: Show issues Location:
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    Zs.MO 528: Show issues

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  9. Article ; Online: Infectious sacroiliitis: Retrospective analysis of 18 case patients.

    Matt, M / Denes, E / Weinbreck, P

    Medecine et maladies infectieuses

    2018  Volume 48, Issue 6, Page(s) 383–388

    Abstract: Introduction: Few infectious sacroiliitis reports are available in the literature. There is no standard clinical presentation, and diagnosis and treatments are therefore usually delayed. We aimed to describe this infection.: Methods: We performed a ... ...

    Abstract Introduction: Few infectious sacroiliitis reports are available in the literature. There is no standard clinical presentation, and diagnosis and treatments are therefore usually delayed. We aimed to describe this infection.
    Methods: We performed a single-center retrospective study of patients hospitalized in the infectious diseases unit of the Limoges University Hospital from January 1, 2006 to January 31, 2016. We included all patients presenting with infectious monoarthritis of native sacroiliac joint. Clinical, biological, bacteriological, radiological, and therapeutic characteristics were collected.
    Results: A total of 18 patients were enrolled. The sex ratio was 1.25. Mean age was 39.6years (17-69years). The average progression time at diagnosis was 17.9days (1-110days). The mean hospital stay was 16.2days (3-35days). Temperature at admission was 38.8°C (37-40°C). Identified bacteria were methicillin-susceptible Staphylococcus aureus in 83.3% of cases (n=15), Proteus mirabilis (n=1), and Streptococcus dysgalactiae (n=1). Thirty-two (88.9%) of the 36 imaging examinations were consistent with the diagnosis. The survival rate was 100% at the end of the six-month follow-up.
    Conclusion: Infectious sacroiliitis is a complex pathology requiring precise clinical examination for a rapid diagnosis. The outcome is usually favorable.
    MeSH term(s) Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sacroiliitis/diagnosis ; Sacroiliitis/drug therapy ; Young Adult
    Language English
    Publishing date 2018-04-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 423536-8
    ISSN 1769-6690 ; 0399-077X ; 1166-8237
    ISSN (online) 1769-6690
    ISSN 0399-077X ; 1166-8237
    DOI 10.1016/j.medmal.2018.02.001
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    Zs.A 1410: Show issues Location:
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  10. Article: Case Report: CD8+ T-Lymphocyte Deficit: A Prerequisite for

    Denes, Eric / Fiorenza, Fabrice / Armendariz, Mateo / Martin, Christian

    Frontiers in medicine

    2021  Volume 8, Page(s) 668976

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.668976
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