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  1. Article ; Online: Acute, Severe Hepatitis of Unknown Origin

    Maurizio Aricò / Désirée Caselli

    Pediatric Reports, Vol 14, Iss 29, Pp 217-

    Should We Really Be Afraid of Another Obscure Enemy of Our Children?

    2022  Volume 219

    Abstract: On 31 March 2022, Public Health Scotland was alerted to five children aged 3–5 years, presenting to the Glasgow children’s hospital with severe hepatitis of unknown etiology within a 3-week period [.] ...

    Abstract On 31 March 2022, Public Health Scotland was alerted to five children aged 3–5 years, presenting to the Glasgow children’s hospital with severe hepatitis of unknown etiology within a 3-week period [.]
    Keywords n/a ; Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: SARS-CoV-2 Vaccination for Children—An Open Issue

    Désirée Caselli / Maurizio Aricò

    Pediatric Reports, Vol 13, Iss 1, Pp 95-

    2021  Volume 97

    Abstract: The Covid-19 pandemic is still raging [.] ...

    Abstract The Covid-19 pandemic is still raging [.]
    Keywords n/a ; Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: 2019-nCoV

    Désirée Caselli / Maurizio Aricò

    Pediatric Reports, Vol 12, Iss

    Polite with children!

    2020  Volume 1

    Abstract: A novel epidemic is challenging the global health care system. Starting from probably November to December 2019, another Coronavirus entered the arena of human pathogens, to be then defined 2019- nCoV [.]. ...

    Abstract A novel epidemic is challenging the global health care system. Starting from probably November to December 2019, another Coronavirus entered the arena of human pathogens, to be then defined 2019- nCoV [.].
    Keywords Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effectiveness of Preventive Measures in Keeping Low Prevalence of SARS-CoV-2 Infection in Health Care Workers in a Referral Children’s Hospital in Southern Italy

    Désirée Caselli / Daniela Loconsole / Rita Dario / Maria Chironna / Maurizio Aricò

    Pediatric Reports, Vol 13, Iss 1, Pp 118-

    2021  Volume 124

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic now represents a major threat to public health. Health care workers (HCW) are exposed to biological risk. Little is currently known about the risk of HCW operating in pediatric wards for SARS-CoV-2 ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic now represents a major threat to public health. Health care workers (HCW) are exposed to biological risk. Little is currently known about the risk of HCW operating in pediatric wards for SARS-CoV-2 infection. The aim is to assess the prevalence of SARS-CoV-2 infection in HCW in a third-level children’s hospital in Southern Italy. An observational cohort study of all asymptomatic HCW (physician, technicians, nurses, and logistic and support operators) was conducted. HCW were screened, on a voluntary basis, for SARS-CoV-2 by RT-PCR on nasopharyngeal swab performed during the first wave of COVID-19. The study was then repeated, with the same modalities, at a 7-month interval, during the “second wave” of the COVID-19 pandemic. At the initial screening between 7 and 24 April 2020, 525 HCW were tested. None of them tested positive. At the repeated screening, conducted between 9 and 20 November 2020, 627 HCW were tested, including 61 additional ones resulting from COVID-emergency recruitment. At this second screening, eight subjects (1.3%) tested positive, thus being diagnosed as asymptomatic carriers of SARS-CoV-2. They were one physician, five nurses, and two HCW from the logistic/support services. They were employed in eight different wards/services. In all cases, the epidemiological investigation showed convincing evidence that the infection was acquired through social contacts. The study revealed a very low circulation of SARS-CoV-2 infection in HCW tested with RT-PCR. All the infections documented in the second wave of epidemic of SARS-CoV-2 were acquired outside of the workplace, confirming that in a pediatric hospital setting, HCW education, correct use of personal protective equipment, and separation of the COVID-patient pathway and staff flow may minimize the risk derived from occupational exposure.
    Keywords health care workers ; SARS-CoV-2 ; COVID-19 ; screening ; Medicine ; R ; Pediatrics ; RJ1-570
    Subject code 360
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: SARS-CoV-2 Infection in Children in Southern Italy

    Daniela Loconsole / Desirèe Caselli / Francesca Centrone / Caterina Morcavallo / Silvia Campanella / Maurizio Aricò / Maria Chironna

    International Journal of Environmental Research and Public Health, Vol 17, Iss 6080, p

    A Descriptive Case Series

    2020  Volume 6080

    Abstract: At the beginning of the coronavirus-2019 (COVID-19) pandemic, Italy was one of the most affected countries in Europe. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is less frequent and less severe in children than in adults. This ...

    Abstract At the beginning of the coronavirus-2019 (COVID-19) pandemic, Italy was one of the most affected countries in Europe. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is less frequent and less severe in children than in adults. This study analyzed the frequency of SARS-CoV-2 infection among all children aged <18 years in the Apulia region of southern Italy and the characteristics of the infected children. Clinical and demographic data were collected through the national platform for COVID-19 surveillance. Of the 166 infected children in the Apulia region, 104 (62.6%) were asymptomatic, 37 (22.3%) had mild infections, 22 (13.3%) had moderate infections, and 3 (1.8%) had severe infections. Only ten children (6.0%) were hospitalized, but none required intensive care support and none died. SARS-CoV-2 infection was transmitted mainly from parents or relatives to children. Because of school closure during the lockdown, infection was unlikely to have been transmitted among children. It is unclear whether school reopening would enhance virus spread, leading the Italian government to develop guidelines for safe school reopening. The actual role of children in virus transmission remains unclear. A sensitive surveillance system, prompt identification of cases, testing, and contact tracing will be key to reducing the further spread of infection.
    Keywords COVID-19 ; children ; SARS-CoV-2 ; epidemiology ; surveillance ; health policy ; Medicine ; R ; covid19
    Subject code 360
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Empiric antibiotic therapy in a child with cancer and suspected septicemia

    Desiree Caselli / Olivia Paolicchi

    Pediatric Reports, Vol 4, Iss 1, Pp e2-e

    2012  Volume 2

    Abstract: Improved outcome in the treatment of in childhood cancer results not only from more aggressive and tailored cancer-directed therapy, but also from improved supportive therapy and treatment of life-threatening infectious complications. Prompt and ... ...

    Abstract Improved outcome in the treatment of in childhood cancer results not only from more aggressive and tailored cancer-directed therapy, but also from improved supportive therapy and treatment of life-threatening infectious complications. Prompt and aggressive intervention with empiric antibiotics has reduced the mortality in this group of patients. Physical examination, blood tests, and blood cultures must be performed, and antibiotic therapy must be administered as soon as possible. Beta-lactam monotherapy, such as piperacillin-tazobactam or cefepime, may be an appropriate empiric therapy of choice for all clinically stable patients with neutropenic fever. An anti-pseudomonal beta-lactam antibiotic plus gentamicin is recommended for patients with systemic compromise.
    Keywords antibiotic therapy ; child ; cancer ; Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Guidelines on Vaccinations in Paediatric Haematology and Oncology Patients

    Simone Cesaro / Mareva Giacchino / Francesca Fioredda / Angelica Barone / Laura Battisti / Stefania Bezzio / Stefano Frenos / Raffaella De Santis / Susanna Livadiotti / Serena Marinello / Andrea Giulio Zanazzo / Désirée Caselli

    BioMed Research International, Vol

    2014  Volume 2014

    Abstract: Objective. Vaccinations are the most important tool to prevent infectious diseases. Chemotherapy-induced immune depression may impact the efficacy of vaccinations in children. Patients and Methods. A panel of experts of the supportive care working group ... ...

    Abstract Objective. Vaccinations are the most important tool to prevent infectious diseases. Chemotherapy-induced immune depression may impact the efficacy of vaccinations in children. Patients and Methods. A panel of experts of the supportive care working group of the Italian Association Paediatric Haematology Oncology (AIEOP) addressed this issue by guidelines on vaccinations in paediatric cancer patients. The literature published between 1980 and 2013 was reviewed. Results and Conclusion. During intensive chemotherapy, vaccination turned out to be effective for hepatitis A and B, whilst vaccinations with toxoid, protein subunits, or bacterial antigens should be postponed to the less intensive phases, to achieve an adequate immune response. Apart from varicella, the administration of live-attenuated-virus vaccines is not recommended during this phase. Family members should remain on recommended vaccination schedules, including toxoid, inactivated vaccine (also poliomyelitis), and live-attenuated vaccines (varicella, measles, mumps, and rubella). By the time of completion of chemotherapy, insufficient serum antibody levels for vaccine-preventable diseases have been reported, while immunological memory appears to be preserved. Once immunological recovery is completed, usually after 6 months, response to booster or vaccination is generally good and allows patients to be protected and also to contribute to herd immunity.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Preventing transmission of infectious agents in the pediatric in-patients hematology–oncology setting

    Désirée Caselli / Simone Cesaro / Susanna Livadiotti / Ottavio Ziino / Olivia Paolicchi / Giulio Zanazzo / Giuseppe M. Milano / Maria Licciardello / Angelica Barone / Monica Cellini / De Santis Raffaella / Mareva Giacchino / Mario Renato Rossi / Maurizio Aricò / Elio Castagnola

    Pediatric Reports, Vol 3, Iss 1, Pp e9-e

    what is the role for non-pharmacological prophylaxis?

    2011  Volume 9

    Abstract: Despite a continuous will to protect the immune compromised host from infections, evidence based indications for intervention by non-pharmacological toools are still lacking in oncology. Nevertheless, guidelines on standard precaution and trasmission ... ...

    Abstract Despite a continuous will to protect the immune compromised host from infections, evidence based indications for intervention by non-pharmacological toools are still lacking in oncology. Nevertheless, guidelines on standard precaution and trasmission base precaution are available. They may be important in order to reduce the risk of trasmission of infection in selected healthcare settings, such as the pediatric hematology-oncology wards. . AIEOP Centers agree that for children treated with chemotherapy both of these approaches should be implemented and vigorously enforced, while additional policies, including strict environmental isolation should be restricetd to patients with selected clinical conditions or complications.
    Keywords Medicine ; R ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2011-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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