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  1. Article ; Online: Carga de enfermedad de sepsis en el lactante menor. Un gran desafío multidisciplinario para Latinoamérica.

    Díaz Rubio, Franco

    Revista chilena de pediatria

    2020  Volume 91, Issue 4, Page(s) 492–494

    Title translation The burden of sepsis in infants: a big multidisciplinary challenge for Latin-America.
    MeSH term(s) Cost of Illness ; Humans ; Infant ; Infant, Newborn ; Latin America/epidemiology ; Prognosis ; Sepsis/diagnosis ; Sepsis/epidemiology ; Sepsis/therapy ; Severity of Illness Index
    Language Spanish
    Publishing date 2020-06-23
    Publishing country Chile
    Document type Editorial
    ZDB-ID 954077-5
    ISSN 0717-6228 ; 0034-7396 ; 0370-4106
    ISSN (online) 0717-6228
    ISSN 0034-7396 ; 0370-4106
    DOI 10.32641/rchped.v91i4.2281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Infancia y COVID-19: Los efectos indirectos de la pandemia COVID-19 en el bienestar de niños, niñas y adolescentes.

    Díaz Rubio, Franco / Donoso Fuentes, Alejandro

    Andes pediatrica : revista Chilena de pediatria

    2022  Volume 93, Issue 1, Page(s) 10–18

    Abstract: The impact of the COVID-19 pandemic has been overlooked in children and adolescents since many of the negative effects have been the result of containment and mitigation measures and will only be quantifiable in the medium and long term. Although the ... ...

    Title translation Childhood and COVID-19: The indirect effects of the COVID-19 pandemic on the well-being of children and adolescents.
    Abstract The impact of the COVID-19 pandemic has been overlooked in children and adolescents since many of the negative effects have been the result of containment and mitigation measures and will only be quantifiable in the medium and long term. Although the global response has been successful in reducing the lethality of the disease, the harmful effect on vulnerable populations, such as children and adolescents, is enormous and has been classified as catastrophic by international organizations. The pandemic has deeply affected the physical and mental health of children and adolescents, but also silently its negative effects extend across many areas such as schooling, familiar economy, child labor and food security. The third year of the pandemic is an opportunity to include the multidimen sional well-being of children and adolescents as a cornerstone of society's response to a global crisis, whether health, economic or political.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; Child ; Humans ; Mental Health ; Pandemics
    Language Spanish
    Publishing date 2022-04-14
    Publishing country Chile
    Document type Journal Article
    ISSN 2452-6053
    ISSN (online) 2452-6053
    DOI 10.32641/andespediatr.v93i1.4250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rescate de hipoxemia grave con uso de óxido nítrico inhalado y decúbito prono en neumonía COVID-19 en un lactante.

    Donoso Fuentes, Alejandro / Diaz Rubio, Franco

    Andes pediatrica : revista Chilena de pediatria

    2021  Volume 92, Issue 3, Page(s) 483–484

    Title translation Inhaled nitric oxide and prone position as a rescue therapy for severe hypoxemia in an infant with COVID-19 pneumonia.
    Language Spanish
    Publishing date 2021-08-23
    Publishing country Chile
    Document type Journal Article
    ISSN 2452-6053
    ISSN (online) 2452-6053
    DOI 10.32641/andespediatr.v92i3.3849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Concurrencia de encefalitis diseminada aguda en lactante con Síndrome inflamatorio multisistémico asociado a infección por SARS-CoV-2.

    Ampuero Acuña, Camila / Díaz Rubio, Franco / Donoso Fuentes, Alejandro

    Andes pediatrica : revista Chilena de pediatria

    2021  Volume 92, Issue 4, Page(s) 639–640

    Title translation Concurrence of acute disseminated encephalitis in an infant with Multisystemic Inflammatory Syndrome associated with SARS-CoV-2 infection.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/therapy ; Encephalomyelitis, Acute Disseminated/diagnosis ; Encephalomyelitis, Acute Disseminated/therapy ; Encephalomyelitis, Acute Disseminated/virology ; Female ; Humans ; Infant ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/physiopathology ; Systemic Inflammatory Response Syndrome/therapy
    Language Spanish
    Publishing date 2021-11-02
    Publishing country Chile
    Document type Case Reports ; Letter
    ISSN 2452-6053
    ISSN (online) 2452-6053
    DOI 10.32641/andespediatr.v92i4.3886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Protecting children from iatrogenic harm during COVID19 pandemic.

    Camporesi, Anna / Díaz-Rubio, Franco / Carroll, Christopher L / González-Dambrauskas, Sebastián

    Journal of paediatrics and child health

    2020  Volume 56, Issue 7, Page(s) 1010–1012

    Abstract: Critical care management of patients with COVID-19 has been influenced by a mixture of public, media and societal pressure, as well as clinical and anecdotal observations from many prominent researchers and key opinion leaders. These factors may have ... ...

    Abstract Critical care management of patients with COVID-19 has been influenced by a mixture of public, media and societal pressure, as well as clinical and anecdotal observations from many prominent researchers and key opinion leaders. These factors may have affected the principles of evidence-based medicine and encouraged the widespread use of non-tested pharmacological and aggressive respiratory support therapies, even in intensive care units (ICUs). The COVID-19 pandemic has predominantly affected adult populations, while children appear to be relatively spared of severe disease. Notwithstanding, paediatric intensive care (PICU) clinicians may already have been influenced by changes in practices of adult ICUs, and these changes may pose unintended consequences to the vulnerable population in the PICU. In this article, we analyse several potential iatrogenic causes of the detrimental effects of the current pandemic to children and highlight the risks underlying a sudden change of clinical practice.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Critical Care ; Critical Illness/therapy ; Evidence-Based Medicine ; Humans ; Iatrogenic Disease/prevention & control ; Intensive Care Units, Pediatric ; Medical Errors ; Pandemics ; Pediatrics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.14989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Variability in care for children with severe acute asthma in Latin America.

    Monteverde-Fernandez, Nicolas / Diaz-Rubio, Franco / Vásquez-Hoyos, Pablo / Rotta, Alexandre T / González-Dambrauskas, Sebastián

    Pediatric pulmonology

    2020  Volume 56, Issue 2, Page(s) 384–391

    Abstract: Background: Care variability for children with severe acute asthma has been well documented in high-income countries, yet data from low- and middle-income regions are lacking. We sought to characterize the magnitude of practice variability in the care ... ...

    Abstract Background: Care variability for children with severe acute asthma has been well documented in high-income countries, yet data from low- and middle-income regions are lacking. We sought to characterize the magnitude of practice variability in the care of Latin American children to identify opportunities for standardization of care.
    Methods: A cross-sectional study performed through a retrospective analysis of contemporaneously collected data of children with severe acute asthma admitted to a center contributing to the LARed Network registry between May 2017 and May 2019. Centers were grouped by geographic location: Atlantic (AT), South Pacific (SP), and North Central (NC).
    Results: Among 434 children, most received care in hospitals in the AT group (54% [235/434]), followed by the NC (23% [101/434]) and SP (23% [98/434]) groups. The majority of children in the AT (92% [215/235]) and SP (91% [89/98]) groups received nebulized salbutamol/albuterol, while metered-dose inhalers were preferred in the NC group (72% [73/101]). There was a wide variation in the use of antibiotics: AT (57% [135/235]), SP (48% [47/98]), and NC (14% [14/101]). The same was true for ipratropium bromide: AT (67% [157/235]), SP (90% [88/98]), and NC (17% [17/101]), and aminophylline: AT (57% [135/235]), NC (5% [5/101]), and SP (0% [0/98]). High-flow nasal cannula was the preferred respiratory support modality in the AT (60% [141/235]) and NC (40% [40/101]) groups, while bilevel positive airway pressure (BiPAP) use was more common in the SP group (80% [78/98]).
    Conclusion: We identified significant variability in care for severe acute asthma. Our findings will help to inform the design of future studies, quality improvement initiatives, and development of practice guidelines within Latin America.
    MeSH term(s) Adolescent ; Albuterol/therapeutic use ; Aminophylline/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Asthma/therapy ; Bronchodilator Agents/therapeutic use ; Cannula ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Hospitalization ; Humans ; Ipratropium/therapeutic use ; Male ; Metered Dose Inhalers ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents ; Bronchodilator Agents ; Aminophylline (27Y3KJK423) ; Ipratropium (GR88G0I6UL) ; Albuterol (QF8SVZ843E)
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Protecting children from iatrogenic harm during COVID19 pandemic

    Camporesi, Anna / Díaz-Rubio, Franco / Carroll, Christopher L / González-Dambrauskas, Sebastián

    J Paediatr Child Health

    Abstract: Critical care management of patients with COVID-19 has been influenced by a mixture of public, media and societal pressure, as well as clinical and anecdotal observations from many prominent researchers and key opinion leaders. These factors may have ... ...

    Abstract Critical care management of patients with COVID-19 has been influenced by a mixture of public, media and societal pressure, as well as clinical and anecdotal observations from many prominent researchers and key opinion leaders. These factors may have affected the principles of evidence-based medicine and encouraged the widespread use of non-tested pharmacological and aggressive respiratory support therapies, even in intensive care units (ICUs). The COVID-19 pandemic has predominantly affected adult populations, while children appear to be relatively spared of severe disease. Notwithstanding, paediatric intensive care (PICU) clinicians may already have been influenced by changes in practices of adult ICUs, and these changes may pose unintended consequences to the vulnerable population in the PICU. In this article, we analyse several potential iatrogenic causes of the detrimental effects of the current pandemic to children and highlight the risks underlying a sudden change of clinical practice.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #627212
    Database COVID19

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  8. Article ; Online: Protecting children from iatrogenic harm during COVID19 pandemic

    Camporesi, Anna / Díaz‐Rubio, Franco / Carroll, Christopher L / González‐Dambrauskas, Sebastián

    Journal of Paediatrics and Child Health

    2020  Volume 56, Issue 7, Page(s) 1010–1012

    Keywords Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.14989
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Recommendations for the initial management of multisystem inflammatory syndrome temporally related to COVID-19, in children and adolescents.

    Kohn-Loncarica, Guillermo / Fustiñana, Ana / Díaz-Rubio, Franco / Jaramillo-Bustamante, Juan C / González-Dambrauskas, Sebastián / Vásquez-Hoyos, Pablo / Fernández-Sarmiento, Jaime / González, Gustavo / Mansur, Alejandro / Ponce, Javier / Jabornisky, Roberto

    Archivos argentinos de pediatria

    2020  Volume 118, Issue 6, Page(s) e514–e526

    Abstract: Multisystem inflammatory syndrome temporally related to COVID-19 in children and adolescents is a clinical presentation of SARS-CoV-2 infection. It shares some features with Kawasaki disease, toxic shock, sepsis, macrophage activation syndrome, and ... ...

    Title translation Recomendaciones para el manejo inicial del síndrome inflamatorio multisistémico relacionado temporalmente con COVID-19, en niños y adolescentes.
    Abstract Multisystem inflammatory syndrome temporally related to COVID-19 in children and adolescents is a clinical presentation of SARS-CoV-2 infection. It shares some features with Kawasaki disease, toxic shock, sepsis, macrophage activation syndrome, and myocarditis. Few publications have addressed its initial management, which is similar to that proposed for septic shock. This review analyzes such approach based on the characteristics typical of multisystem inflammatory syndrome related to COVID-19 in accordance with the paradigm of an "institutional practice guideline" and suggests therapeutic approach strategies, including early detection, stabilization, referral, specific treatment, and process analysis.
    MeSH term(s) Adolescent ; COVID-19/physiopathology ; COVID-19/therapy ; Child ; Humans ; Practice Guidelines as Topic ; Referral and Consultation ; Shock, Septic/physiopathology ; Shock, Septic/therapy ; Systemic Inflammatory Response Syndrome/physiopathology ; Systemic Inflammatory Response Syndrome/therapy
    Language Spanish
    Publishing date 2020-11-24
    Publishing country Argentina
    Document type Journal Article ; Review
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.5546/aap.2020.eng.e514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reduced PICU respiratory admissions during COVID-19.

    Vásquez-Hoyos, Pablo / Diaz-Rubio, Franco / Monteverde-Fernandez, Nicolas / Jaramillo-Bustamante, Juan Camilo / Carvajal, Cristobal / Serra, Alberto / Karsies, Todd / Rotta, Alexandre Tellechea / González-Dambrauskas, Sebastián

    Archives of disease in childhood

    2020  

    Abstract: Background: The COVID-19 pandemic reached the Southern Hemisphere in the autumn of 2020, thus coinciding with its expected annual viral respiratory season. The potential impact of national strategies aimed at mitigating COVID-19 during the pandemic on ... ...

    Abstract Background: The COVID-19 pandemic reached the Southern Hemisphere in the autumn of 2020, thus coinciding with its expected annual viral respiratory season. The potential impact of national strategies aimed at mitigating COVID-19 during the pandemic on the incidence of other critical viral lower respiratory tract infections (LRTIs) in children is unknown.
    Methods: We analysed admission data for LRTIs from 22 paediatric intensive care units (PICUs) in four countries, part of a large international Latin American registry of children with acute respiratory failure (Red Colaborativa Pediátrica de Latinoamérica [LARed Network]).
    Results: Between January and August, there were 83% fewer PICU admissions for LRTIs in 2020 compared to the 2018/2019 average over the same period. Similar decreases were noted for PICU admissions due to respiratory syncytial virus and influenza (92% and 78%, respectively).
    Conclusion: We observed a striking reduction in PICU admissions due to viral LRTIs over winter, during the COVID-19 pandemic in South America.
    Keywords covid19
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-320469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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