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  1. Article ; Online: Lupus nephritis and thin glomerular basement membrane coexistence: case report and review of the literature.

    Acosta, Adriana / Arroyo, David / Díaz-Crespo, Francisco Javier / Goicoechea, Marian

    International urology and nephrology

    2021  Volume 54, Issue 5, Page(s) 1163–1165

    MeSH term(s) Glomerular Basement Membrane/pathology ; Humans ; Lupus Nephritis/complications ; Lupus Nephritis/diagnosis ; Lupus Nephritis/pathology
    Language English
    Publishing date 2021-07-15
    Publishing country Netherlands
    Document type Case Reports ; Letter ; Review
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-021-02959-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 733: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Cell-Free DNA Dynamic Concentration and Other Variables Are Predictors of Early Progression after Chimeric Antigen Receptor T Cell Therapy in Patients with Diffuse Large B Cell Lymphoma.

    Bastos-Oreiro, Mariana / Sanz-Villanueva, Laura / Muñiz, Paula / Bailén, Rebeca / Chicano, María / Oarbeskoa, Gillen / Gómez, Isabel / Gutiérrez, Antonio / Iglesia, Ismael de la / Carbonell, Diego / Diaz-Crespo, Francisco Javier / Menarguez, Javier / Diez-Martín, José Luis / Kwon, Mi / Buño, Ismael / Martínez-Laperche, Carolina

    Transplantation and cellular therapy

    2023  Volume 29, Issue 7, Page(s) 472.e1–472.e4

    Abstract: We propose a novel biomarker that can identify patients at high risk of early progression after chimeric antigen receptor (CAR) T cell therapy. Calculation of cell-free DNA (cfDNA) with a pre-apheresis (PA) and pre-lymphodepletion (PL) sample allows ... ...

    Abstract We propose a novel biomarker that can identify patients at high risk of early progression after chimeric antigen receptor (CAR) T cell therapy. Calculation of cell-free DNA (cfDNA) with a pre-apheresis (PA) and pre-lymphodepletion (PL) sample allows monitoring of tumor dynamics (∆cfDNA). In the present study, ∆cfDNA and other biomarkers and clinical variables were evaluated in 58 patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL). ∆cfDNA (>11 ng/mL plasma; P =.003), C-reactive protein (CRP) PL (>1.06 mg/dL; P = .004), lactate dehydrogenase (LDH) PL (>304; P = .006), disease status PL (progressive disease; P = .035) and sex (male; P = .016) were highly correlated with 1 month progression. After adjusting for ∆cfDNA, CRP PL, and LDH PL, disease status PL, and sex, ∆cfDNA remained associated with 1-month progression after CAR T cell infusion.
    MeSH term(s) Humans ; Male ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/therapeutic use ; Cell-Free Nucleic Acids/therapeutic use ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/therapy ; Immunotherapy, Adoptive/adverse effects ; Biomarkers ; Cell- and Tissue-Based Therapy
    Chemical Substances Receptors, Chimeric Antigen ; Cell-Free Nucleic Acids ; Biomarkers
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.03.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5082: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Contrast Enhanced Ultrasound (CEUS) efficiency in renal graft complications evaluation.

    García Roch, Carmen / Muñoz Cepeda, Miguel Ángel / García García, Fernando / Ciampi Dopazo, Juan José / Pinto Varela, José María / Díaz Crespo, Francisco Javier

    Nefrologia

    2018  Volume 38, Issue 4, Page(s) 444–446

    Title translation Rendimiento de la ecografía con contraste (CEUS) en la valoración de las complicaciones del injerto renal.
    MeSH term(s) Contrast Media ; Female ; Humans ; Kidney Diseases/diagnostic imaging ; Kidney Transplantation ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Retrospective Studies ; Ultrasonography/methods
    Chemical Substances Contrast Media
    Language Spanish
    Publishing date 2018-06-06
    Document type Letter ; Observational Study
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefro.2017.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incorporation of next-generation sequencing in clinical practice using solid and liquid biopsy for patients with non-Hodgkin's lymphoma.

    Bastos-Oreiro, Mariana / Suárez-González, Julia / Andrés-Zayas, Cristina / Carrión, Natalia Carolina / Moreno, Solsiré / Carbonell, Diego / Chicano, María / Muñiz, Paula / Sanz, Laura / Diaz-Crespo, Francisco Javier / Menarguez, Javier / Diez-Martín, José Luis / Buño, Ismael / Martínez-Laperche, Carolina

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 22815

    Abstract: Although next-generation sequencing (NGS) data on lymphomas require further validation before being implemented in daily practice, the clinical application of NGS can be considered right around the corner. The aim of our study was to validate an NGS ... ...

    Abstract Although next-generation sequencing (NGS) data on lymphomas require further validation before being implemented in daily practice, the clinical application of NGS can be considered right around the corner. The aim of our study was to validate an NGS lymphoid panel for tissue and liquid biopsy with the most common types of non-Hodgkin's lymphoma [follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)]. In this series, 372 somatic alterations were detected in 93.6% (44/47) of the patients through tissue biopsy. In FL, we identified 93 somatic alterations, with a median of 7.4 mutations per sample. In DLBCL, we detected 279 somatic variants with a median of 8.6 mutations (range 0-35). In 92% (24/26) of the cases, we were able to detect some variant in the circulating tumor DNA. We detected a total of 386 variants; 63.7% were detected in both types of samples, 13.2% were detected only in the circulating tumor DNA, and 23% were detected only in the tissue biopsy. We found a correlation between the number of circulating tumor DNA mutations, advanced stage, and bulky disease. The genetic alterations detected in this panel were consistent with those previously described at diagnosis. The liquid biopsy sample is therefore a complementary tool that can provide new genetic information, even in cases where a solid biopsy cannot be performed or an insufficient sample was obtained. In summary, we describe and analyze in this study the findings and difficulties encountered when incorporating liquid biopsy into clinical practice in non-Hodgkin's lymphoma at diagnosis.
    MeSH term(s) Biomarkers, Tumor/genetics ; DNA Mutational Analysis ; High-Throughput Nucleotide Sequencing ; Humans ; Liquid Biopsy ; Lymphoma, Follicular/genetics ; Lymphoma, Follicular/pathology ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Mutation ; Predictive Value of Tests ; Reproducibility of Results
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-11-24
    Publishing country England
    Document type Comparative Study ; Journal Article ; Validation Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-02362-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients.

    Mur, Pilar / Rodríguez de Lope, Ángel / Díaz-Crespo, Francisco Javier / Hernández-Iglesias, Teresa / Ribalta, Teresa / Fiaño, Concepción / García, Juan Fernando / Rey, Juan Antonio / Mollejo, Manuela / Meléndez, Bárbara

    Journal of neuro-oncology

    2015  Volume 122, Issue 3, Page(s) 441–450

    Abstract: Clinical and molecular prognostic factors in gliomas include age, IDH mutation, the glioma CpG island methylator phenotype (G-CIMP+) and promoter methylation of the O(6)-methylguanine DNA-methyltransferase (MGMT) gene. Among these markers, a predictive ... ...

    Abstract Clinical and molecular prognostic factors in gliomas include age, IDH mutation, the glioma CpG island methylator phenotype (G-CIMP+) and promoter methylation of the O(6)-methylguanine DNA-methyltransferase (MGMT) gene. Among these markers, a predictive value was reported in glioblastomas (GBM) for MGMT promoter methylation, in particular in elderly GBM patients. In this study, methylation data from 46 glioma samples with the Illumina 450K platform were obtained and extended using external data to include a total of 247 glioma samples. Methylation analysis of the whole MGMT gene with this platform revealed two strongly survival-associated CpG regions within the promoter and the gene body, which were confirmed in a reported dataset of high grade-gliomas. Methylation at the promoter (CpG 25, cg12981137 and the prognostic model MGMT-STP27) and at the gene body CpG 165 (cg07933035), were significantly associated with better overall survival, and strongly correlated with G-CIMP+ status. In this series, the prognostic value of MGMT methylation at the promoter was not observed in G-CIMP- cases, although around 50 % of them were MGMT-methylated. These results were also obtained in an homogeneously-treated series of chemoradiated G-CIMP- GBMs analyzed by MSP and qMSP, and confirmed in a reported pyrosequencing-analyzed series of gliomas. Interestingly, in contrast to the MGMT promoter, gene body methylation was of prognostic value in G-CIMP-patients older than 65 years. Our study highlights the relevance of the prognostic value of the different regions of methylation throughout the MGMT gene that could be affected by specific G-CIMP profiles and age groups.
    MeSH term(s) Adult ; Age Factors ; Aged ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; CpG Islands/genetics ; DNA Methylation/genetics ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Female ; Gene Expression Profiling ; Glioma/diagnosis ; Glioma/genetics ; Glioma/mortality ; Humans ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Principal Component Analysis ; Prognosis ; Promoter Regions, Genetic/genetics ; Survival Analysis ; Tumor Suppressor Proteins/genetics ; Young Adult
    Chemical Substances Tumor Suppressor Proteins ; DNA Modification Methylases (EC 2.1.1.-) ; MGMT protein, human (EC 2.1.1.63) ; DNA Repair Enzymes (EC 6.5.1.-)
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-015-1738-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Bullous necrotizing cellulitis in kidney transplant recipient.

    Neild, G H / Diaz-Crespo, Francisco Javier / Galeano, Cristina / Fernandez-Rodriguez, Ana Maria / Marcen Letosa, Roberto / Quereda Rodriguez-Navarro, Carlos

    NDT plus

    2011  Volume 4, Issue 6, Page(s) 451

    Language English
    Publishing date 2011-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2410383-4
    ISSN 1753-0784
    ISSN 1753-0784
    DOI 10.1093/ndtplus/sfr111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6587: Show issues Location:
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    Zs.MO 562: Show issues

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