Article ; Online: Neutropenia febril posquimioterapia. Estancia hospitalaria y experiencia en nuestro medio.
2019 Volume 92, Issue 3, Page(s) 141–146
Abstract: Introduction: Infections are significant cause of morbidity and mortality in cancer patients (mortality is estimated at around 3%). Febrile neutropenia often leads to the hospitalisation of cancer patients, increasing the risk of nosocomial infection, ... ...
| Title translation | Post chemoterapy febrile neutropenia. Length of stay and experience in our population. |
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| Abstract | Introduction: Infections are significant cause of morbidity and mortality in cancer patients (mortality is estimated at around 3%). Febrile neutropenia often leads to the hospitalisation of cancer patients, increasing the risk of nosocomial infection, as well as health costs due to the hospital admission. Methods: An ambispective (01 July 2015 - 12 July 2018) observational study was conducted on all episodes of chemotherapy-induced febrile neutropenia in a paediatric population. A record was made of age, gender, weight percentile (WHO), length of hospital stay (days), temperature (oC), microbial isolation, infectious source, antibiotic or antifungal prophylaxis, haemoglobin (g/dl), platelets (/mm Results: The study included 69 patients, and 101 episodes were recorded. The mean stay was 7.43 days (median 6 days). Microbial isolation was found in 44.6% of the episodes, with no infectious source identified in 36% of them. An inverse correlation was found between haemoglobin, platelets, and lymphocytes on admission and the hospital stay (-0.356: P=.001, -0.216: P=.042, and -0.216: P=.042, respectively). The mean stay was greater if there was a CRP>90mg/L (10.94 vs. 6.66 days, P=.017), if PCT>1ng/ml (16.50 vs. 6.77 days, P=.0002), if ≤ 100 neutrophils (8.27 vs. 5.04 days P=.039) on admission, and if there was microbe isolation (9.54 vs. 5.78 days P=.006). Conclusion: The relationship between haemoglobin, platelets, and lymphocytes on admission and the mean stay is inversely proportional. In addition, those patients with ≤100 neutrophils, CRP>90mg/L, and PCT>1ng/ml on admission had a longer hospital stay. |
| MeSH term(s) | Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Child ; Febrile Neutropenia/chemically induced ; Febrile Neutropenia/epidemiology ; Febrile Neutropenia/therapy ; Female ; Humans ; Infections/epidemiology ; Infections/microbiology ; Length of Stay ; Male ; Neoplasms/drug therapy ; Prospective Studies ; Retrospective Studies ; Risk Factors |
| Chemical Substances | Antineoplastic Agents |
| Language | Spanish |
| Publishing date | 2019-06-22 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2830901-7 |
| ISSN | 2341-2879 ; 2341-2879 |
| ISSN (online) | 2341-2879 |
| ISSN | 2341-2879 |
| DOI | 10.1016/j.anpedi.2019.05.008 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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