LIVIVO - Search results -

Search results

Result 1 - 10 of total 50

Search options

Article ; Online: Preoperative liver regeneration with CD133+ infusion in patients with colorectal liver metastases: proof-of concept trial.

García-Botella, Alejandra / Martín, Paz / Méndez, Ramiro / Ortega, Luis / Méndez, Jose / Sastre, Javier / Diez-Valladares, Luis / Torres, Antonio J

HPB : the official journal of the International Hepato Pancreato Biliary Association

2024 Volume 26, Issue 4, Page(s) 603–605

MeSH term(s)	Humans ; Liver Regeneration ; Liver Neoplasms/surgery ; Biomarkers, Tumor ; Colorectal Neoplasms/surgery
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Letter
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2024.01.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6326: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Aryl hydrocarbon receptor interacting protein (AIP) significantly influences prognosis of pancreatic carcinoma.

Fernández-Aceñero, M J / Barderas, R / Peláez García, A / Martínez-Useros, J / Díez-Valladares, L / Pérez-Aguirre / Ortega Medina, L / de la Serna Esteban, S / García-Botella, S / Díaz Del Arco, C / Galindo, C

Annals of diagnostic pathology

2021 Volume 53, Page(s) 151742

Abstract: Introduction: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor. Aryl hydrocarbon receptor interacting protein (AIP) in one of AHR ligands. The aim of this study is to analyze the prognostic influence of AIP in pancreatic ... ...

Abstract	Introduction: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor. Aryl hydrocarbon receptor interacting protein (AIP) in one of AHR ligands. The aim of this study is to analyze the prognostic influence of AIP in pancreatic carcinoma. Material and methods: Retrospective case series with immunohistochemical analysis of AIP. We have estimated a multivariate Cox's model for the outcome (progression free and overall survival). Results: 204 patients were included in the study. As expected prognosis was poor and 67.8% died of disease. As for AIP 9.8% of the cases showed nuclear staining of the epithelial tumor cells and 59.4% a cytoplasmic one. Stroma was stained in 53.1% of the cases. Univariate survival analysis revealed a significantly worse prognosis of patients with cytoplasmic AIP expression (stroma and epithelium), but nuclear expression was associated to a better prognosis. In the multivariate analysis stromal AIP expression was an independent prognosticator of progression free survival, together with pT stage, histological grade and history of diabetes. Discussion: AIP Is a conserved cochaperone protein binding to many proteins. AIP has been proposed as a potential tumor suppressor gene. To date, no study has analyzed the immunohistochemical expression of AIP in pancreatic carcinoma. Our results indicate that both epithelial and stromal cytoplasmic expression of AIP is associated to bad prognosis, while nuclear translocation seems to improve prognosis. Conclusion: Although we must deepen into the complex signaling pathways underlying this potential association, our results open a way to inhibiting AHR as a potential target against pancreatic carcinoma.
MeSH term(s)	Aged ; Female ; Humans ; Immunohistochemistry/methods ; Intracellular Signaling Peptides and Proteins/metabolism ; MAP Kinase Signaling System/genetics ; Male ; Margins of Excision ; Middle Aged ; Molecular Targeted Therapy ; Neoplasm Staging/methods ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Prognosis ; Progression-Free Survival ; Receptors, Aryl Hydrocarbon/drug effects ; Receptors, Aryl Hydrocarbon/metabolism ; Retrospective Studies ; Survival Analysis ; Pancreatic Neoplasms
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Receptors, Aryl Hydrocarbon ; aryl hydrocarbon receptor-interacting protein
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2021.151742
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5463: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: CD133 + cell infusion in patients with colorectal liver metastases going to be submitted to a major liver resection (CELLCOL): A randomized open label clinical trial.

Garcia-Botella, Alejandra / Sáez-Carlin, Patricia / Méndez, Ramiro / Martin, Maria Paz / Ortega, Luis / Méndez, Jose Vicente / García-Paredes, Beatriz / Diez-Valladares, L / Torres, Antonio Jose

Surgical oncology

2019 Volume 33, Page(s) 224–230

Abstract: Background: Treatment of liver metastases of colorectal carcinoma is surgical resection. However, only 10-15% of the patients in this context will be candidate for curative resection arising other 10-13% after response to neoadyuvant chemotherapy. In ... ...

Abstract	Background: Treatment of liver metastases of colorectal carcinoma is surgical resection. However, only 10-15% of the patients in this context will be candidate for curative resection arising other 10-13% after response to neoadyuvant chemotherapy. In order to perform the liver metastases surgery, it is necessary to have a sufficient remnant liver volume (RLV) which allows maintaining an optimal liver function after resection. Studies on liver regeneration have determined that CD133 + stem cells are involved in liver hypertrophy developed after an hepatectomy with encouraging results. As presented in previous studies, CD133 + stem cells can be selected from peripheral blood after stimulation with G-CSF, being able to obtain a large number of them. We propose to treat patients who do not meet criteria for liver metastases surgery because of insufficient RLV (<40%) with CD133 + cells together with portal embolization, in order to achieve enough liver volume which avoids liver failure. Methods: /Design: The aim of this study is to evaluate the effectiveness of preoperative PVE plus the administration of CD133 + mobilized from peripheral blood with G-CSF compared to PVE only. SECONDARY AIMS ARE: to compare the grade of hypertrophy, speed and changes in liver function, anatomopathological study of hypertrophied liver, to determine the safety of the treatment and analysis of postoperative morbidity and surveillance. Study design: Prospective randomized longitudinal phase IIb clinical trial, open, to evaluate the efficacy of portal embolization (PVE) together with the administration of CD133 + cells obtained from peripheral blood versus PVE alone, in patients with hepatic metastasis of colorectal carcinoma (CCRHM). Discussion: The number of CD133 + obtained from peripheral blood after G -CSF stimulation will be far greater than the number obtained with direct puncture of bone marrow. This will allow a greater intrahepatic infusion, which could have a direct impact on achieving a larger and quicker hypertrophy. Consequently, it will permit the treatment of a larger number of patients with an increase on their survival. Trial registration: ClinicalTrials.gov, ID NCT03803241.
MeSH term(s)	AC133 Antigen ; Clinical Trials, Phase II as Topic ; Colorectal Neoplasms/pathology ; Embolization, Therapeutic ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Hepatectomy ; Hepatic Insufficiency/prevention & control ; Humans ; Liver/pathology ; Liver/physiology ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Liver Regeneration ; Metastasectomy ; Organ Size ; Portal Vein ; Preoperative Care/methods ; Randomized Controlled Trials as Topic ; Stem Cell Transplantation/methods
Chemical Substances	AC133 Antigen ; Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2019-10-07
Publishing country	Netherlands
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	1107810-8
ISSN	1879-3320 ; 0960-7404
ISSN (online)	1879-3320
ISSN	0960-7404
DOI	10.1016/j.suronc.2019.10.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3409: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Spanish multicenter study of surgical resection of pancreatic tumors infiltrating the celiac axis: does the type of pancreatectomy affect results?

Ramia, J M / de Vicente, E / Pardo, F / Sabater, L / Lopez-Ben, S / Quijano, Y / Villegas, T / Blanco-Fernandez, G / Diez-Valladares, L / Lopez-Rojo, I / Martin-Perez, E / Pereira, F / Gonzalez, A J / Herrera, J / García-Domingo, M I / Serradilla, M

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2020 Volume 23, Issue 2, Page(s) 318–324

Abstract: Background: Pancreatectomy plus celiac axis resection (CAR) is performed in patients with locally advanced pancreatic cancer. The morbidity rates are high, and no survival benefit has been confirmed. It is not known at present whether it is the type of ... ...

Abstract	Background: Pancreatectomy plus celiac axis resection (CAR) is performed in patients with locally advanced pancreatic cancer. The morbidity rates are high, and no survival benefit has been confirmed. It is not known at present whether it is the type of pancreatectomy, or CAR itself, that is the reason for the high complication rates. Methods: Observational retrospective multicenter study. Inclusion criteria: patient undergoing TP, PD or DP plus CAR for a pancreatic cancer. Results: Sixty-two patients who had undergone pancreatic cancer surgery (PD,TP or DP) plus CAR were studied. Group 1: 17 patients who underwent PD/TP-CAR (13TP/4PD); group 2: 45 patients who underwent DP-CAR. Groups were mostly homogeneous. Operating time was longer in the PD/TP group, while operative complications did not differ statistically in the two groups. The number of lymph nodes removed was higher in the PD/TP group (26.5 vs 17.3), and this group also had a higher positive node ratio (17.9% vs 7.6%). There were no statistical differences in total or disease-free survival between the two groups. Conclusion: It seems that CAR, and not the type of pancreatectomy, influences morbidity and mortality in this type of surgery. International multicenter studies with larger numbers of patients are now needed to validate the data presented here.
MeSH term(s)	Body Mass Index ; Celiac Artery/surgery ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Lymph Node Excision/statistics & numerical data ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Operative Time ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Pancreatectomy/mortality ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Postoperative Complications ; Retrospective Studies ; Spain ; Treatment Outcome
Language	English
Publishing date	2020-06-26
Publishing country	Italy
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-020-02423-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6644: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Still a place for conventional histopathological analysis in the era of molecular medicine: predicting prognosis of resectable ductal pancreatic adenocarcinoma.

Fernández Aceñero, M J / Martínez-Useros, J / Díez-Valladares, L / García-Botella, S / Ortega Medina, L / Pérez Aguirre, E / de la Serna Esteban, S / Latorre, E / Neelsen, L

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2018 Volume 21, Issue 7, Page(s) 954–959

Abstract: Introduction: Our aim is to find features that define prognosis in surgically resected ductal pancreatic adenocarcinoma readily accessible in everyday practice.: Materials and methods: Longitudinal retrospective case series of pancreatic ... ...

Abstract	Introduction: Our aim is to find features that define prognosis in surgically resected ductal pancreatic adenocarcinoma readily accessible in everyday practice. Materials and methods: Longitudinal retrospective case series of pancreatic adenocarcinoma operated with a curative intent in a large tertiary hospital in Madrid between 2009 and 2015. Results: 162 were enrolled. 40.8% survived less than 1 year. Multivariate Cox's regression model revealed that gender, presence of symptoms, T and N stage independently influenced progression-free survival, while overall survival was determined by gender, smoking, presence of symptoms and N stage. Logistic regression analysis revealed that only symptoms at diagnosis could predict death, while gender, symptoms, histopathological type, vessel invasion, T stage and necrosis could independently predict recurrence. Discussion: Our series show that patients with symptomatic disease at the time of diagnosis and females showed a shorter progression-free and overall survival. We herein propose a regression model to predict outcome.
MeSH term(s)	Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Molecular Medicine ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/methods ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2018-12-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-018-02008-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6644: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The Clinical Significance of PIWIL3 and PIWIL4 Expression in Pancreatic Cancer.

Li, Weiyao / Martinez-Useros, Javier / Garcia-Carbonero, Nuria / Fernandez-Aceñero, Maria J / Orta, Alberto / Ortega-Medina, Luis / Garcia-Botella, Sandra / Perez-Aguirre, Elia / Diez-Valladares, Luis / Celdran, Angel / García-Foncillas, Jesús

Journal of clinical medicine

2020 Volume 9, Issue 5

Abstract: P-element-induced wimpy testis (PIWI) proteins have been described in several cancers. PIWIL1 and PIWIL2 have been recently evaluated in pancreatic cancer, and elevated expression of PIWIL2 conferred longer survival to patients. However, PIWIL3's and ... ...

Abstract	P-element-induced wimpy testis (PIWI) proteins have been described in several cancers. PIWIL1 and PIWIL2 have been recently evaluated in pancreatic cancer, and elevated expression of PIWIL2 conferred longer survival to patients. However, PIWIL3's and PIWIL4's role in carcinogenesis is rather controversial, and their clinical implication in pancreatic cancer has not yet been investigated. In the present study, we evaluated PIWIL1, PIWIL2, PIWIL3 and PIWIL4 expression in pancreatic cancer-derived cell lines and in one non-tumor cell line as healthy control. Here, we show a differential expression in tumor and non-tumor cell lines of PIWIL3 and PIWIL4. Subsequently, functional experiments with PIWIL3 and/or PIWIL4 knockdown revealed a decrease in the motility ratio of tumor and non-tumor cell lines through downregulation of mesenchymal factors in pro of epithelial factors. We also observed that PIWIL3 and/or PIWIL4 silencing impaired undifferentiated phenotype and enhanced drug toxicity in both tumor- and non-tumor-derived cell lines. Finally, PIWIL3 and PIWIL4 evaluation in human pancreatic cancer samples showed that patients with low levels of PIWIL4 protein expression presented poor prognosis. Therefore, PIWIL3 and PIWIL4 proteins may play crucial roles to keep pancreatic cell homeostasis not only in tumors but also in healthy tissues.
Language	English
Publishing date	2020-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9051252
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Dissemination of hepatocellular carcinoma in subcutaeous tissue after fine needle aspiration cytology (FNAC).

Carlin, Sáez P / García-Botella, A / Diez-Valladares, L / Perez-Aguirre, E / Ortega, L / Mendez, R / Torres, A J

Hepato-gastroenterology

2013 Volume 60, Issue 128, Page(s) 1839–1840

Abstract: The hepatocellular carcinoma (HCC) is the fifth most frequent tumor in the world, and the third cause of death related to cancer. Histological samples obtained from diseased liver likely to have HCC are currently prescribed in selected patients in whose ... ...

Abstract	The hepatocellular carcinoma (HCC) is the fifth most frequent tumor in the world, and the third cause of death related to cancer. Histological samples obtained from diseased liver likely to have HCC are currently prescribed in selected patients in whose imaging studies and tumor markers are not sufficient for the diagnosis. In recent years, a risk of tumoral seeding along needle tract of FNAC to obtain histological samples has been reported. We present a case of tumor implantation of HCC cells in the needle tract, a year and four months after a percutaneous fine needle aspiration cytology (FNAC).
MeSH term(s)	Aged ; Biopsy, Fine-Needle/adverse effects ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/surgery ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Neoplasm Seeding ; Reoperation ; Soft Tissue Neoplasms/secondary ; Soft Tissue Neoplasms/surgery ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2013-11
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	801013-4
ISSN	0172-6390
ISSN	0172-6390
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui V Zs.50: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Splenic volume as a biomarker of hepatic damage after chemotherapy in patients with resected colorectal liver metastases (CRLM).

Saez-Carlin, P / García-Botella, A / Diez-Valladares, L I / Ortega Medina, L / Méndez, R / González, J C M / Bernal, I / Serrano García, I / Avellana, R / Torres García, A J

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2019 Volume 22, Issue 7, Page(s) 1180–1186

Abstract: Background: Chemotherapy-associated liver injury (CALI) is a matter of concern for hepatobiliary surgeons as it can entail postoperative liver failure after an extensive hepatectomy. Recent studies have taken special interest in liver function ... ...

Abstract	Background: Chemotherapy-associated liver injury (CALI) is a matter of concern for hepatobiliary surgeons as it can entail postoperative liver failure after an extensive hepatectomy. Recent studies have taken special interest in liver function parameters which can correlate with CALI to decrease this adverse event. Therefore, the current study investigates the usefulness of splenic volume as a biomarker of CALI through a portal hypertension mechanism, in patients with colorectal liver metastases (CRLM). Study design: We carried out a study in patients with CRLM operated on between 2009 and 2014 in our center. All samples of healthy liver were graded for non-alcoholic fatty liver disease (NAFLD) and sinusoidal obstructive syndrome. Computarized tomography scans for spleen volumetry were analyzed for each patient at CRLM diagnosis, after neoadjuvant chemotherapy, 1 and 6 months after resection. Results: A group of 65 consecutive patients with CRLM of large bowel adenocarcinoma submitted to liver resection were included. Patients receiving neoadjuvant chemotherapy had a greater spleen volume increase than those who did not receive treatment (p = 0.053), finding a statistically significant spleen growth in patients with NAFLD (p = 0.036). There was no correlation between spleen enlargement and postoperative complications or average stay. However, survival was decreased in patients with spleen growth and CALI. Conclusions: Patients who receive neoadjuvant chemotherapy for liver metastasis surgery have a greater splenic volume increase, which correlates with NAFLD and a lower survival.
MeSH term(s)	Adenocarcinoma/secondary ; Adenocarcinoma/therapy ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/pathology ; Colorectal Neoplasms/pathology ; Fatty Liver/chemically induced ; Fatty Liver/pathology ; Hepatectomy ; Hepatic Veno-Occlusive Disease/chemically induced ; Hepatic Veno-Occlusive Disease/pathology ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Metastasectomy ; Neoadjuvant Therapy ; Non-alcoholic Fatty Liver Disease/chemically induced ; Non-alcoholic Fatty Liver Disease/pathology ; Organ Size ; Oxaliplatin/adverse effects ; Oxaliplatin/therapeutic use ; Postoperative Complications ; Spleen/diagnostic imaging ; Spleen/pathology ; Survival Rate ; Tomography, X-Ray Computed
Chemical Substances	Antineoplastic Agents ; Oxaliplatin (04ZR38536J)
Language	English
Publishing date	2019-11-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-019-02245-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6644: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The Prognosis Value of PIWIL1 and PIWIL2 Expression in Pancreatic Cancer.

Li, Weiyao / Martinez-Useros, Javier / Garcia-Carbonero, Nuria / Fernandez-Aceñero, Maria J / Ortega-Medina, Luis / Garcia-Botella, Sandra / Perez-Aguirre, Elia / Diez-Valladares, Luis / Garcia-Foncillas, Jesus

Journal of clinical medicine

2019 Volume 8, Issue 9

Abstract: Pancreatic cancer is a highly aggressive manifestation of cancer, and currently presents poor clinical outcome due to its late diagnosis with metastasic disease. Surgery is the only approach with a curative intend; however, the survival rates seen in ... ...

Abstract	Pancreatic cancer is a highly aggressive manifestation of cancer, and currently presents poor clinical outcome due to its late diagnosis with metastasic disease. Surgery is the only approach with a curative intend; however, the survival rates seen in this type of patient are still low. After surgery, there is a lack of predictive prognosis biomarkers to predict treatment response and survival to establish a personalized medicine. Human P-element-induced wimpy testis 1 (PIWIL1) and P-element-induced wimpy testis 2 (PIWIL2) proteins act as protectors of germline, and their aberrant expression has been described in several types of tumors. In this study, we aimed to assess an association between PIWIL1 and PIWIL2 expression and the prognosis of biliopancreatic cancer patients. For this, we analyzed protein expression in complete resected tumor samples, and found a significant association between PIWIL2 expression and both progression-free and overall survival (
Language	English
Publishing date	2019-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8091275
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Supervivencia prolongada tras la resección de una metástasis hepática de un tumor neuroendocrino del páncreas.

Cano-Valderrama, O / Díez-Valladares, L / Domínguez-Serrano, I / Cerdán-Santacruz, C / Torres-García, A J

Cirugia espanola

2011 Volume 89, Issue 5, Page(s) 322–323

Title translation	Prolonged survival after resection of liver metastasis of a pancreatic neuroendocrine tumour.
MeSH term(s)	Female ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Middle Aged ; Neuroendocrine Tumors/mortality ; Neuroendocrine Tumors/secondary ; Neuroendocrine Tumors/surgery ; Pancreatic Neoplasms/pathology ; Survival Rate ; Time Factors
Language	Spanish
Publishing date	2011-05
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	730701-9
ISSN	1578-147X ; 0009-739X
ISSN (online)	1578-147X
ISSN	0009-739X
DOI	10.1016/j.ciresp.2010.04.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 96: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito