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  1. Article: Minimálisan invazív és O-arm asszisztált en bloc gerincdaganat-reszekciók.

    Szabó, Viktor / Lakosi, Ferenc / Nagy, Máté / Dóczi, Tamás / Büki, András / Schwarcz, Attila

    Ideggyogyaszati szemle

    2022  Volume 75, Issue 1-02, Page(s) 65–72

    Abstract: Background and purpose: The en bloc resection of spinal tumors is required in primary spine tumors and in selected cases of secondary spine tumors, where the primary disease is under control and long survival time is expected. Three cases are presented, ...

    Title translation Minimally invasive and O-arm assisted en bloc spinal tumor resections.
    Abstract Background and purpose: The en bloc resection of spinal tumors is required in primary spine tumors and in selected cases of secondary spine tumors, where the primary disease is under control and long survival time is expected. Three cases are presented, applying O-arm assisted navigation or minimally invasive anterior approaches for en bloc tumor removal.
    Methods: O-arm navigation assisted osteotomies were carried out to remove a Th.V. breast tumor metastasis en bloc, intact bony part of the Th.V. vertebra was spared. Vertebral corpectomies of a patient with L.IV. chordoma and of a patient with L.V. carcinoid were also performed using minimally invasive, microscope assisted, anterior approaches to the lumbar spine.
    Results: No morbidity or local recurrence were detected in the patient with breast cancer 1 year after the operation. Nevertheless, new spinal metastasis were revealed 1 year after surgery despite the appropriate oncological treatment. The patient with L.IV. chordoma is still tumor free (last follow-up: 18 month after surgery), but post operatively detected lower limb paresis and gait disturbances are persisted. The posterior healthy bony parts of the spinal column remained intact, since only anterior approaches were used for en bloc L.IV. corpectomy. No morbidity or recurrence was detected in patient with L.V. carcinoid tumor on 1 year follow-up.
    Conclusion: Both the O-arm navigation assisted surgery and the minimally invasive anterior approaches to the spine can help to reduce surgical morbidity and to spare healthy bony structures of the spine. The later could play important role to provide long term spine stability. The presented new surgical technologies can be accepted only, if they produce at least the same oncological results on longer follow-ups as conventional surgical approaches.
    MeSH term(s) Humans ; Imaging, Three-Dimensional ; Lumbar Vertebrae/surgery ; Spinal Neoplasms/surgery ; Surgery, Computer-Assisted ; Tomography, X-Ray Computed
    Language Hungarian
    Publishing date 2022-02-02
    Publishing country Hungary
    Document type Case Reports
    ZDB-ID 2240317-6
    ISSN 0019-1442
    ISSN 0019-1442
    DOI 10.18071/isz.75.0065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Everyday Physical Education

    Vamos Ảgnes / Doczi Tamas

    Physical Culture and Sport : Studies and Research, Vol 67, Iss 1, Pp 20-

    Functional and Dysfunctional Consequences in Hungarian Public Education

    2015  Volume 30

    Abstract: In Participation in physical education is considered to be a fundamental right of pupils all over the world. In Hungary, where the rich elite sports traditions of the country are paralleled by the population’s moderate physical activity, the challenge ... ...

    Abstract In Participation in physical education is considered to be a fundamental right of pupils all over the world. In Hungary, where the rich elite sports traditions of the country are paralleled by the population’s moderate physical activity, the challenge posed by non-communicable diseases and growing obesity figures among youth was addressed by the introduction of daily P.E. in public education starting in the 2012/13 academic year. The objective of the present paper is to discuss, based on empirical research, the intended and unintended consequences of this measure in an educational and social context using the qualitative analysis of the views of key stakeholders and the quantitative analysis of statistical data on the infrastructural and personal conditions of P.E. The results indicate that neither before nor after the enforcement of the Act on Public Education were the infrastructural and personal conditions of daily P.E. created and, in addition to the intended consequences, a number of unintended consequences have also been encountered by various stakeholders. The study can also be regarded as an attempt to reveal these dysfunctions in order to contribute to positive changes in the area.
    Keywords physical education ; Hungary,public education ; Geography. Anthropology. Recreation ; G ; Recreation. Leisure ; GV1-1860 ; Sports ; GV557-1198.995
    Subject code 796
    Publishing date 2015-09-01T00:00:00Z
    Publisher De Gruyter Open
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pregnancy and deep brain stimulation therapy for epilepsy.

    Bóné, Beáta / Kovács, Norbert / Balás, István / Horváth, Réka A / Dóczi, Tamás / Janszky, József

    Epileptic disorders : international epilepsy journal with videotape

    2021  Volume 23, Issue 4, Page(s) 633–638

    Abstract: Neuromodulation therapy -vagus nerve stimulation (VNS) and deep brain stimulation (DBS)- is one of the therapeutic options for drug-resistant epilepsy. With the increasing number of DBS implantations in women with epilepsy, it has become a burning issue ... ...

    Abstract Neuromodulation therapy -vagus nerve stimulation (VNS) and deep brain stimulation (DBS)- is one of the therapeutic options for drug-resistant epilepsy. With the increasing number of DBS implantations in women with epilepsy, it has become a burning issue whether DBS is safe in pregnancy. We report here two women with epilepsy who gave birth to healthy children with DBS therapy. We describe two cases, a 30-year-old woman and a 37-year-old woman. Both were implanted with DBS due to drug-resistant epilepsy. Both of our patients showed a significant improvement after DBS implantation and thereafter gave birth to a healthy child with DBS treatment. The severity and frequency of epileptic seizures did not change during pregnancy and after childbirth. Although a Caesarean section was performed in one case, pregnancies and births were essentially problem-free. At present, the two- and four-year-old children are healthy. Considering these cases, previously described VNS cases, and DBS cases with non-epileptic indications; we suggest that pregnancy and childbirth are safe in epilepsy patients with DBS, moreover, DBS treatment has probably no effect on foetal abnormalities or breastfeeding.
    MeSH term(s) Adult ; Cesarean Section ; Child, Preschool ; Deep Brain Stimulation ; Drug Resistant Epilepsy/therapy ; Epilepsy/therapy ; Female ; Humans ; Pharmaceutical Preparations ; Pregnancy ; Treatment Outcome ; Vagus Nerve Stimulation
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-07-19
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1684/epd.2021.1304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Minimálisan invazív, extrapleuralis, anterolateralis gerincfeltárás.

    Szabó, Viktor / Büki, András / Dóczi, Tamás / Schwarcz, Attila

    Ideggyogyaszati szemle

    2018  Volume 71, Issue 9-10, Page(s) 293–301

    Abstract: In spine surgery, minimally invasive approaches (MIS) are getting accepted and more popular worldwide during the last decades. It is due to the reduced intraoperative blood loss, decreased infection rate, less postoperative pain and earlier discharge ... ...

    Title translation Minimally invasive, extrapleural-anterolateral approach to the spine.
    Abstract In spine surgery, minimally invasive approaches (MIS) are getting accepted and more popular worldwide during the last decades. It is due to the reduced intraoperative blood loss, decreased infection rate, less postoperative pain and earlier discharge from hospital compared to traditional approaches. The present paper puts forward a minimally invasive extrapleural approach to the thoracic spine that is not applied in Hungary. This new approach, in contrast to the standard costotransversectomy, provides direct visual control over the ventral surface of the dural sac. Furthermore, contrary to the transthoracic way, following minimally invasive extrapleural surgery thoracic drainage and intensive care are not necessary. The approach can be applied safely in treatment of ventral or ventrolateral pathologies of the thoracic spine.
    MeSH term(s) Blood Loss, Surgical ; Humans ; Hungary ; Lumbar Vertebrae/surgery ; Minimally Invasive Surgical Procedures/methods ; Orthopedic Procedures/methods ; Pain ; Pain Measurement ; Pleura/surgery ; Thoracic Vertebrae/surgery ; Treatment Outcome
    Language Hungarian
    Publishing date 2018-10-18
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 2240317-6
    ISSN 0019-1442
    ISSN 0019-1442
    DOI 10.18071/isz.71.0293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of Regional Inequalities on the Sporting Activity of School Pupils

    Vámos Ágnes / Foldesi Gyongyi S. / Doczi Tamas

    Physical Culture and Sport : Studies and Research, Vol 70, Iss 1, Pp 18-

    The Hungarian Case

    2016  Volume 27

    Abstract: In this study, the sporting activity of Hungarian school pupils is investigated with a focus on regional differences. The objective of the paper is to answer the following questions: Are there regional differences in pupils’ sporting activity, and, if ... ...

    Abstract In this study, the sporting activity of Hungarian school pupils is investigated with a focus on regional differences. The objective of the paper is to answer the following questions: Are there regional differences in pupils’ sporting activity, and, if yes, what is their relationship with the socio-cultural background of the pupils and the infrastructural and staffing conditions of schools? Has the 2012 introduction of daily physical education had a different effect on pupils’ leisure-time sporting activity in disadvantaged and affluent regions? Can the trends in the sporting activity of pupils be characterized as convergent or divergent since the introduction of daily physical education? The paper is based on an extensive study that relies on the most comprehensive database on physical education in schools, the National Assessment of Basic Competencies (NABC). The present study statistically analyzed eighth-grade pupil and school data from the 2010 and 2014 NABC. The results present the regional differences in pupils’ participation in sporting activity, their recent modification, and the main reasons behind the changes. In conclusion, the authors state that social, economic, and cultural inequalities are not clearly reflected in the sporting activity of students; however, certain data still call attention to the need to examine regional differences.
    Keywords sports participation ; school-aged children ; regional inequalities ; National Assessment of Basic Competencies (NABC) ; education ; Geography. Anthropology. Recreation ; G ; Recreation. Leisure ; GV1-1860 ; Sports ; GV557-1198.995
    Subject code 910
    Publishing date 2016-06-01T00:00:00Z
    Publisher De Gruyter Open
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Tirotropintermelő hypophysisadenoma.

    Sohár, Gábor / Györkös, Andrea / Dóczi, Tamás / Kajtár, Béla / Piski, Zalán / Kovács, Mónika

    Orvosi hetilap

    2020  Volume 161, Issue 12, Page(s) 474–478

    Abstract: Thyrotropin-secreting pituitary tumors are rare causes of hyperthyroidism and account for less than 1% of all pituitary adenomas. The number of reported cases increased over the last few years as a consequence of the routine use of ultrasensitive ... ...

    Title translation Thyrotropin-secreting pituitary adenoma.
    Abstract Thyrotropin-secreting pituitary tumors are rare causes of hyperthyroidism and account for less than 1% of all pituitary adenomas. The number of reported cases increased over the last few years as a consequence of the routine use of ultrasensitive immunometric assays for measuring thyrotropin levels. In the clinical practice, thyrotropin secreting adenomas must be considered in case of inappropriately normal to elevated thyrotropin in the presence of elevated free serum thyroid hormone levels. The authors present the case history of a middle aged female patient, who suffered from hyperthyreodism caused by a thyrotropin-secreting pituitary macroadenoma. After transient thyreostatic treatment, radical neurosurgical removal of the tumor was performed. The pituitary surgery was effective in restoring the patient's euthyreodism. The postoperative pituitary function remained intact. During follow-up, the recurrence of the disease was not detected. In our case report, the difficulties in the differential diagnoses are also discussed. Orv Hetil. 2020; 161(12): 474-478.
    MeSH term(s) Adenoma/metabolism ; Adenoma/pathology ; Adenoma/surgery ; Female ; Humans ; Hyperthyroidism/etiology ; Middle Aged ; Neoplasm Recurrence, Local ; Pituitary Neoplasms/metabolism ; Pituitary Neoplasms/pathology ; Pituitary Neoplasms/surgery ; Thyroid Function Tests ; Thyrotropin/blood ; Thyrotropin/metabolism ; Treatment Outcome
    Chemical Substances Thyrotropin (9002-71-5)
    Language Hungarian
    Publishing date 2020-03-04
    Publishing country Hungary
    Document type Case Reports ; Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2020.31697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gray Matter Changes Following Mild COVID-19: An MR Morphometric Study in Healthy Young People.

    Perlaki, Gábor / Darnai, Gergely / Arató, Ákos / Alhour, Husamalddin Ali / Szente, Anna / Áfra, Eszter / Nagy, Szilvia Anett / Horváth, Réka / Kovács, Norbert / Dóczi, Tamás / Orsi, Gergely / Janszky, József

    Journal of magnetic resonance imaging : JMRI

    2023  Volume 59, Issue 6, Page(s) 2152–2161

    Abstract: Background: Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID ... ...

    Abstract Background: Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.
    Purpose: To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.
    Study type: Prospective.
    Population: Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).
    Field strength/sequence: Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.
    Assessment: MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.
    Statistical tests: Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.
    Results: In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η
    Data conclusion: Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.
    Level of evidence: 2 TECHNICAL EFFICACY: Stage 3.
    MeSH term(s) Humans ; COVID-19/diagnostic imaging ; Male ; Female ; Magnetic Resonance Imaging/methods ; Adult ; Prospective Studies ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Young Adult ; SARS-CoV-2 ; Neuropsychological Tests ; Case-Control Studies ; Brain/diagnostic imaging ; Brain/pathology
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.28970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats.

    Nagy, Szilvia Anett / Ivic, Ivan / Tóth, Péter / Komoly, Sámuel / Kiss, Tamás / Pénzes, Máté / Málnási-Csizmadia, András / Dóczi, Tamás / Perlaki, Gábor / Orsi, Gergely

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5598

    Abstract: Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We ... ...

    Abstract Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10
    MeSH term(s) Rats ; Male ; Animals ; Magnetic Resonance Imaging ; Stroke ; Diffusion Magnetic Resonance Imaging ; Infarction, Middle Cerebral Artery/pathology ; Reperfusion ; Diffusion ; Disease Models, Animal ; Brain Ischemia/pathology
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32679-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Detection of silent cerebral microcirculatory abnormalities in patients with manifest ischemic coronary disease: a perfusion brain MRI study combined with dipyridamole stress.

    Molnar, Tihamer / Horvath, Andrea / Szabo, Zsuzsanna / Vamos, Zoltan / Dóczi, Tamas / Illes, Zsolt

    Scandinavian cardiovascular journal : SCJ

    2020  Volume 55, Issue 2, Page(s) 97–101

    Abstract: Objectives: Intravenous dipyridamole (DP) can induce transient perfusion abnormalities in the heart but also the brain indicated by brain SPECT. L-arginine can regulate the vascular tone : Design: A total of nine patients with ischemic coronary ... ...

    Abstract Objectives: Intravenous dipyridamole (DP) can induce transient perfusion abnormalities in the heart but also the brain indicated by brain SPECT. L-arginine can regulate the vascular tone
    Design: A total of nine patients with ischemic coronary disease after myocardial perfusion scintigraphy were selected for this prospective pilot study. Four had DP-induced transient mild neurologic signs during myocardial perfusion scintigraphy, while five had no neurological signs. By using perfusion MRI in both groups in a second stage, we examined CBV in identical areas of the two hemispheres before and during DP stress. Besides, pre-and post-stress L-arginine serum levels were also analyzed by high-performance liquid chromatography. Trial registration: NCT03688815.
    Results: CBV in the sensory-motor area at baseline was significantly higher in patients with DP-induced transient neurological signs compared to patients without signs (
    Conclusions: Intravenous DP changed the CBV accompanied by a systemic elevation of L-arginine: this indicates a direct vasorelaxing effect on brain vessels, and an indirect vasodilator effect through L-arginine release presumably
    MeSH term(s) Brain/diagnostic imaging ; Brain/physiopathology ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/physiopathology ; Dipyridamole ; Humans ; Magnetic Resonance Imaging/methods ; Microcirculation/physiology ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/physiopathology ; Perfusion ; Pilot Projects ; Prospective Studies
    Chemical Substances Dipyridamole (64ALC7F90C)
    Language English
    Publishing date 2020-09-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1379906-x
    ISSN 1651-2006 ; 1401-7431
    ISSN (online) 1651-2006
    ISSN 1401-7431
    DOI 10.1080/14017431.2020.1821911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task.

    Nagy, Szilvia Anett / Kürtös, Zsófia / Németh, Nándor / Perlaki, Gábor / Csernela, Eszter / Lakner, Flóra Elza / Dóczi, Tamás / Czéh, Boldizsár / Simon, Maria

    Neurobiology of stress

    2021  Volume 15, Page(s) 100399

    Abstract: Importance and objectives: Childhood adversity is a strong risk factor for the development of various psychopathologies including major depressive disorder (MDD). However, not all depressed patients experience early life trauma. Functional magnetic ... ...

    Abstract Importance and objectives: Childhood adversity is a strong risk factor for the development of various psychopathologies including major depressive disorder (MDD). However, not all depressed patients experience early life trauma. Functional magnetic resonance imaging (fMRI) studies using facial emotion processing tasks have documented altered blood-oxygen-level-dependent (BOLD) responses in specific cortico-limbic networks both in MDD patients and in individuals with a history of childhood maltreatment (CM). Therefore, a history of maltreatment may represent a key modulating factor responsible for the altered processing of socio-affective stimuli. To test this hypothesis, we recruited MDD patients with and without of maltreatment history to study the long-term consequences of childhood trauma and examined the impact of CM on brain activity using a facial emotion recognition fMRI task.
    Methods: MDD patients with childhood maltreatment (MDD + CM,
    Results: Both MDD and MDD + CM patients displayed impaired accuracy to recognize sad faces. Analysis of brain activity revealed that MDD + CM patients had significantly reduced negative BOLD signals in their right accumbens, subcallosal cortex, and anterior paracingulate gyrus compared to controls. Furthermore, MDD + CM patients had a significantly increased negative BOLD response in their right precentral and postcentral gyri compared to controls. We found little difference between MDD and MDD + CM patients, except that MDD + CM patients had reduced negative BOLD response in their anterior paracingulate gyrus relative to the MDD group.
    Conclusions: Our present data provide evidence that depressed patients with a history of maltreatment are impaired in facial emotion recognition and that they display altered functioning of key reward-related fronto-striatal circuits during a facial emotion matching task.
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2816500-7
    ISSN 2352-2895
    ISSN 2352-2895
    DOI 10.1016/j.ynstr.2021.100399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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