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Article ; Online: Surveillance cardiopulmonary exercise testing can risk-stratify childhood cancer survivors: underlying pathophysiology of poor exercise performance and possible room for improvement.

Tsuda, Takeshi / Davidow, Kimberly / D'Aloisio, Gina / Quillen, Joanne

Cardio-oncology (London, England)

2023 Volume 9, Issue 1, Page(s) 42

Abstract: Background: Asymptomatic childhood cancer survivors (CCS) frequently show decreased exercise performance. Poor exercise performance may indicate impaired future cardiovascular health.: Methods: Cardiopulmonary exercise testing (CPET) was performed in ...

Abstract	Background: Asymptomatic childhood cancer survivors (CCS) frequently show decreased exercise performance. Poor exercise performance may indicate impaired future cardiovascular health. Methods: Cardiopulmonary exercise testing (CPET) was performed in asymptomatic off-treatment CCS (age ≥ 10 years). Patients were divided into Normal and Poor performance groups by %predicted maximum VO2 at 80%. Both peak and submaximal CPET values were analyzed. Results: Thirty-eight males (19 Normal, 19 Poor) and 40 females (18 Normal, 22 Poor) were studied. Total anthracycline dosage was comparable among 4 groups. The body mass index (BMI), although normal, and weight were significantly higher in Poor groups. Peak heart rate (HR) and peak respiratory exchange ratio (RER) were comparable in all four groups. Peak work rate (pWR)/kg, peak oxygen consumption (pVO2)/kg, peak oxygen pulse (pOP)/kg, and ventilatory anaerobic threshold (VAT)/kg were significantly lower, whereas heart rate (HR) increase by WR/kg (ΔHR/Δ[WR/kg] was significantly higher in Poor groups. Simultaneously plotting of weight & pVO2 and ΔHR/ΔWR & ΔVO2/ΔHR revealed a distinct difference between the Normal and Poor groups in both sexes, suggesting decreased skeletal muscle mass and decreased stroke volume reserve, respectively, in Poor CCS. The relationship between VAT and pVO2 was almost identical between the two groups in both sexes. Ventilatory efficiency was mildly diminished in the Poor groups. Conclusions: Decreased skeletal muscle mass, decreased stroke volume reserve, and slightly decreased ventilatory efficiency characterize Poor CCS in both sexes. This unique combined CPET analysis provides useful clinical biomarkers to screen subclinical cardiovascular abnormality in CCS and identifies an area for improvement.
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ISSN	2057-3804
ISSN (online)	2057-3804
DOI	10.1186/s40959-023-00193-y
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Book ; Online: A Decision Tree to Shepherd Scientists through Data Retrievability

Bianchi, Andrea / d'Aloisio, Giordano / Marzi, Francesca / Di Marco, Antinisca

2023

Abstract: Reproducibility is a crucial aspect of scientific research that involves the ability to independently replicate experimental results by analysing the same data or repeating the same experiment. Over the years, many works have been proposed to make the ... ...

Abstract	Reproducibility is a crucial aspect of scientific research that involves the ability to independently replicate experimental results by analysing the same data or repeating the same experiment. Over the years, many works have been proposed to make the results of the experiments actually reproducible. However, very few address the importance of data reproducibility, defined as the ability of independent researchers to retain the same dataset used as input for experimentation. Properly addressing the problem of data reproducibility is crucial because often just providing a link to the data is not enough to make the results reproducible. In fact, also proper metadata (e.g., preprocessing instruction) must be provided to make a dataset fully reproducible. In this work, our aim is to fill this gap by proposing a decision tree to sheperd researchers through the reproducibility of their datasets. In particular, this decision tree guides researchers through identifying if the dataset is actually reproducible and if additional metadata (i.e., additional resources needed to reproduce the data) must also be provided. This decision tree will be the foundation of a future application that will automate the data reproduction process by automatically providing the necessary metadata based on the particular context (e.g., data availability, data preprocessing, and so on). It is worth noting that, in this paper, we detail the steps to make a dataset retrievable, while we will detail other crucial aspects for reproducibility (e.g., dataset documentation) in future works.
Keywords	Computer Science - Digital Libraries
Subject code	006
Publishing date	2023-04-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Modeling Quality and Machine Learning Pipelines through Extended Feature Models

d'Aloisio, Giordano / Di Marco, Antinisca / Stilo, Giovanni

2022

Abstract: The recently increased complexity of Machine Learning (ML) methods, led to the necessity to lighten both the research and industry development processes. ML pipelines have become an essential tool for experts of many domains, data scientists and ... ...

Abstract	The recently increased complexity of Machine Learning (ML) methods, led to the necessity to lighten both the research and industry development processes. ML pipelines have become an essential tool for experts of many domains, data scientists and researchers, allowing them to easily put together several ML models to cover the full analytic process starting from raw datasets. Over the years, several solutions have been proposed to automate the building of ML pipelines, most of them focused on semantic aspects and characteristics of the input dataset. However, an approach taking into account the new quality concerns needed by ML systems (like fairness, interpretability, privacy, etc.) is still missing. In this paper, we first identify, from the literature, key quality attributes of ML systems. Further, we propose a new engineering approach for quality ML pipeline by properly extending the Feature Models meta-model. The presented approach allows to model ML pipelines, their quality requirements (on the whole pipeline and on single phases), and quality characteristics of algorithms used to implement each pipeline phase. Finally, we demonstrate the expressiveness of our model considering the classification problem.
Keywords	Computer Science - Software Engineering ; Computer Science - Machine Learning
Subject code	006
Publishing date	2022-07-15
Publishing country	us
Document type	Book ; Online
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Article: Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake.

D'aloisio, Genesis / Acevedo, María Belén / Angulo-Alcalde, Asier / Trujillo, Verónica / Molina, Juan Carlos

Frontiers in behavioral neuroscience

2022 Volume 16, Page(s) 1031115

Abstract: Early ontogeny of the rat (late gestation and postnatal first week) is a sensitive period to ethanol's positive reinforcing effects and its detrimental effects on respiratory plasticity. Recent studies show that acetaldehyde, the first ethanol metabolite, ...

Abstract	Early ontogeny of the rat (late gestation and postnatal first week) is a sensitive period to ethanol's positive reinforcing effects and its detrimental effects on respiratory plasticity. Recent studies show that acetaldehyde, the first ethanol metabolite, plays a key role in the modulation of ethanol motivational effects. Ethanol brain metabolization into acetaldehyde via the catalase system appears critical in modulating ethanol positive reinforcing consequences. Catalase system activity peak levels occur early in the ontogeny. Yet, the role of ethanol-derived acetaldehyde during the late gestational period on respiration response, ultrasonic vocalizations (USVs), and ethanol intake during the first week of the rat remains poorly explored. In the present study, pregnant rats were given a subcutaneous injection of an acetaldehyde-sequestering agent (D-penicillamine, 50 mg/kg) or saline (0.9% NaCl), 30 min prior to an intragastric administration of ethanol (2.0 g/kg) or water (vehicle) on gestational days 17-20. Respiration rates (breaths/min) and apneic episodes in a whole-body plethysmograph were registered on postnatal days (PDs) 2 and 4, while simultaneously pups received milk or ethanol infusions for 40-min in an artificial lactation test. Each intake test was followed by a 5-min long USVs emission record. On PD 8, immediately after pups completed a 15-min ethanol intake test, brain samples were collected and kept frozen for catalase activity determination. Results indicated that a moderate experience with ethanol during the late gestational period disrupted breathing plasticity, increased ethanol intake, as well brain catalase activity. Animals postnatally exposed to ethanol increased their ethanol intake and exerted differential affective reactions on USVs and apneic episodes depending on whether the experience with ethanol occur prenatal or postnatally. Under the present experimental conditions, we failed to observe, a clear role of acetaldehyde mediating ethanol's effects on respiratory plasticity or affective states, nevertheless gestational acetaldehyde was of crucial importance in determining subsequent ethanol intake affinity. As a whole, results emphasize the importance of considering the participation of acetaldehyde in fetal programming processes derived from a brief moderate ethanol experience early in development, which in turn, argues against "safe or harmless" ethanol levels of exposure.
Language	English
Publishing date	2022-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2022.1031115
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Article ; Online: A Combined Analysis of Peak and Submaximal Exercise Parameters in Delineating Underlying Mechanisms of Sex Differences in Healthy Adolescents.

Kernizan, Daphney / Glass, Austin / D'Aloisio, Gina / Hossain, Jobayer / Tsuda, Takeshi

Pediatric cardiology

2022 Volume 43, Issue 5, Page(s) 1122–1130

Abstract: Peak exercise parameters are considered the gold standard to quantify cardiac reserve in cardiopulmonary exercise testing (CPET). We studied whether submaximal parameters would add additional values in analyzing sex differences in CPET. We reviewed CPET ... ...

Abstract	Peak exercise parameters are considered the gold standard to quantify cardiac reserve in cardiopulmonary exercise testing (CPET). We studied whether submaximal parameters would add additional values in analyzing sex differences in CPET. We reviewed CPET of age-matched healthy male and female adolescents by cycle ergometer. Besides peak parameters, submaximal CPET parameters, including ventilatory anaerobic threshold (VAT), oxygen uptake efficiency slope (OUES), and submaximal slopes of Δoxygen consumption (ΔVO2)/Δwork rate (ΔWR), Δheart rate (ΔHR)/ΔWR, ΔVO2/ΔHR, and Δminute ventilation (ΔVE)/ΔCO2 production (ΔVCO2), were obtained. We studied 35 male and 40 female healthy adolescents. Peak VO2 (pVO2), peak oxygen pulse (pOP), and VAT were significantly lower in females than males (1.9 ± 0.4 vs. 2.5 ± 0.6 L/min; 10 ± 2.0 vs. 13.2 ± 3.5 ml/beat; 1.23 ± 0.3 vs. 1.52 ± 0.5 L/min, respectively, all p < 0.005). Females showed significantly lower pVO2, VAT, and OUES with the same body weight than males, implying higher skeletal muscle mass in males. When simultaneously examining ΔHR/ΔWR and pOP, females showed higher dependency on increases in HR than in stroke volume. Females demonstrated significantly lower pOP with the same levels of ΔVO2/ΔHR, suggesting more limited exercise persistence than males under an anaerobic condition at peak exercise. Oxygen uptake efficiency in relation to peak VE was significantly higher in males. There was no sex difference in either ΔVO2/ΔWR or ΔVE/ΔVCO2. Combinational assessment of peak and submaximal CPET parameters delineates the multiple mechanisms that contribute to the sex differences in exercise performance.
MeSH term(s)	Adolescent ; Exercise/physiology ; Exercise Test ; Female ; Humans ; Male ; Oxygen ; Oxygen Consumption/physiology ; Sex Characteristics
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-022-02832-0
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Article ; Online: Cardiopulmonary Exercise Testing Characterizes Silent Cardiovascular Abnormalities in Asymptomatic Pediatric Cancer Survivors.

Tsuda, Takeshi / Kernizan, Daphney / Glass, Austin / D'Aloisio, Gina / Hossain, Jobayer / Quillen, Joanne

Pediatric cardiology

2022 Volume 44, Issue 2, Page(s) 344–353

Abstract: Late-onset cardiovascular complications are serious concerns for pediatric cancer survivors (PCS) including those who are asymptomatic. We investigated whether cardiopulmonary exercise testing (CPET) can delineate the underlying pathophysiology of ... ...

Abstract	Late-onset cardiovascular complications are serious concerns for pediatric cancer survivors (PCS) including those who are asymptomatic. We investigated whether cardiopulmonary exercise testing (CPET) can delineate the underlying pathophysiology of preclinical cardiovascular abnormalities in PCS. We examined CPET data via cycle ergometer in asymptomatic PCS with normal echocardiogram and age-matched controls. Peak and submaximal parameters were analyzed. Fifty-three PCS and 60 controls were studied. Peak oxygen consumption (VO
MeSH term(s)	Humans ; Child ; Exercise Test ; Cancer Survivors ; Respiratory Function Tests ; Oxygen Consumption ; Oxygen ; Exercise Tolerance ; Neoplasms/complications
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-022-02995-w
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Article ; Online: Co-existence of ethanol-related respiratory and motivational learning processes based on a tactile discrimination procedure in neonatal rats.

D'aloisio, G / Acevedo, M B / Macchione, A F / Anunziata, F / Molina, J C

Alcohol (Fayetteville, N.Y.)

2019 Volume 85, Page(s) 65–76

Abstract: In rats, high ethanol doses during early postnatal life exert deleterious effects upon brain development that impact diverse social and cognitive abilities. This stage in development partially overlaps with the third human gestational trimester, commonly ...

Abstract	In rats, high ethanol doses during early postnatal life exert deleterious effects upon brain development that impact diverse social and cognitive abilities. This stage in development partially overlaps with the third human gestational trimester, commonly referred to as the brain growth spurt period. At this stage in development, human fetuses and rat neonates (postnatal days [PD] 3-9) exhibit relatively high respiratory rates that are affected by subteratogenic ethanol doses. Recent studies suggest conditioned breathing responses in the developing organism, given that there are explicit associations between exteroceptive stimuli and the state of ethanol intoxication. Furthermore, studies performed with near-term rat fetuses suggest heightened sensitivity to ethanol's motivational effects. The present study was meant to analyze the unconditioned effects of ethanol intoxication and the possible co-occurrence of learning mechanisms that can impact respiratory plasticity, and to analyze the preference for cues that signal the state of intoxication as well as the effects of the drug, related with motor stimulation. Neonatal rats were subjected to differential experiences with salient tactile cues explicitly paired or not paired with the effects of vehicle or ethanol (2.0 g/kg). A tactile discrimination procedure applied during PDs 3, 5, 7, and 9 allowed the identification of the emergence of ethanol-derived non-associative and associative learning processes that affect breathing plasticity, particularly when considering apneic disruptions. Ethanol was found to partially inhibit the disruptions that appeared to be intimately related with stressful circumstances defined by the experimental procedure. Tactile cues paired with the drug's effects were also observed to exert an inhibitory effect upon these breathing disruptions. The level of contingency between a given tactile cue and ethanol intoxication also resulted in significant changes in the probability of seeking this cue in a tactile preference test. In addition, the state of intoxication exerted motor-stimulating effects. When contrasting the data obtained via the analysis of the different dependent variables, it appears that most ethanol-derived changes are modulated by positive and/or negative (anti-anxiety) reinforcing effects of the drug. As a whole, the study indicates co-existence of ethanol-related functional changes in the developing organism that simultaneously affect respiratory plasticity and preference patterns elicited by stimuli that signal ethanol's motivational effects. These results emphasize the need to consider significant alterations due to minimal ethanol experiences that argue against "safe" levels of exposure in a critical stage in brain development.
MeSH term(s)	Alcoholic Intoxication/physiopathology ; Animals ; Animals, Newborn ; Conditioning, Classical/drug effects ; Cues ; Ethanol/pharmacology ; Learning/drug effects ; Motivation ; Rats ; Reinforcement, Psychology ; Respiration/drug effects
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2019-11-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605912-0
ISSN	1873-6823 ; 0741-8329
ISSN (online)	1873-6823
ISSN	0741-8329
DOI	10.1016/j.alcohol.2019.11.001
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Article: Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies.

Miranda-Morales, Roberto Sebastián / D'Aloisio, Genesis / Anunziata, Florencia / Abate, Paula / Molina, Juan Carlos

Frontiers in behavioral neuroscience

2020 Volume 14, Page(s) 33

Abstract: The anatomo-physiological disruptions inherent to different categories of the Fetal Alcohol Spectrum Disorder do not encompass all the negative consequences derived from intrauterine ethanol (EtOH) exposure. Preclinical, clinical and epidemiological ... ...

Abstract	The anatomo-physiological disruptions inherent to different categories of the Fetal Alcohol Spectrum Disorder do not encompass all the negative consequences derived from intrauterine ethanol (EtOH) exposure. Preclinical, clinical and epidemiological studies show that prenatal EtOH exposure also results in early programming of alcohol affinity. This affinity has been addressed through the examination of how EtOH prenatally exposed organisms recognize and prefer the drug's chemosensory cues and their predisposition to exhibit heightened voluntary EtOH intake during infancy and adolescence. In altricial species these processes are determined by the interaction of at least three factors during stages equivalent to the 2nd and 3rd human gestational trimester: (i) fetal processing of the drug's olfactory and gustatory attributes present in the prenatal milieu; (ii) EtOH's recruitment of central reinforcing effects that also imply progressive sensitization to the drug's motivational properties; and (iii) an associative learning process involving the prior two factors. This Pavlovian learning phenomenon is dependent upon the recruitment of the opioid system and studies also indicate a significant role of EtOH's principal metabolite (acetaldehyde, ACD) which is rapidly generated in the brain
Language	English
Publishing date	2020-03-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2020.00033
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Article: Weight loss after laparoscopic sleeve gastrectomy: the 4-years experience at maggiore della carità hospital (novara, piedmont)

Cerri, C. / Cava, E. / Butera, F. / Collo, A. / D'Aloisio, G. / Passera, S.A. / Albertazzi, E. / Capello, E.C. / Scotti, L. / Riso, S. / Gentilli, S.

Nutrition. 2021 Aug., v. 87-88

2021

Abstract: Bariatric surgery is currently considered the most effective longterm treatment to obtain substantial and sustained Weight Loss (WL) in severe and/or morbid obesity. We present data collected by a multi-disciplinary team between July 2016 and September ... ...

Abstract	Bariatric surgery is currently considered the most effective longterm treatment to obtain substantial and sustained Weight Loss (WL) in severe and/or morbid obesity. We present data collected by a multi-disciplinary team between July 2016 and September 2020 at “Maggiore Della Carità” University Hospital (Novara, Piedmont) concerning bariatric procedures performed according to international and national guidelines (1).Among 267 candidates, 92 (34,4%) subjects underwent a bariatric procedure. Laparoscopic Sleeve Gastrectomy (LSG) was performed in 66 (71.7%) subjects, including 4 anti-reflux valves. Other procedures included: 7 (10.6%) Roux-Y Gastric Bypass, 4 (6.1%) Endoscopic Gastric Plication, and 10 (15.2%) Laparoscopic Adjustable Gastric Banding Removal.Among LSG, 35 patients completed at least a 2-year follow-up after surgery: 27 (77.1%) females, 8 (22.9%) males, mean age 44,89 (± 10.1) years old. Table 1 shows significant variations from baseline (p<0.05) after 1, 6, 12, and 24 months observed for body weight, BMI, excess weight, waist circumference, and serum glucose levels. Among complications, no severe adverse events were recorded. Two gastric fistulas were successfully treated by endoscopy.In our multidisciplinary experience, LSG was effective to achieve and maintain a significant weight loss and to improve glucose levels up to 2 years after surgery. Larger cohorts and longer period data will provide further concerns in terms of maintenance, insulin resistance, and long-term metabolic complications decrease.
Keywords	bariatric surgery ; blood glucose ; glucose ; hospitals ; insulin resistance ; nutrition ; obesity ; piedmont ; waist circumference ; weight loss
Language	English
Dates of publication	2021-08
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2021.111322
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Respiratory and emotional reactivity to ethanol odor in human neonates is dependent upon maternal drinking patterns during pregnancy.

Anunziata, Florencia / Macchione, Ana Fabiola / Mitrano, Adriana Sofía / D'aloisio, Génesis / Ferreyra, Mirta Elena / Pontoriero, Ricardo David / Ahumada, Luis Alberto / Molina, Juan Carlos

Drug and alcohol dependence

2020 Volume 213, Page(s) 108100

Abstract: Background: Beyond the well-known deleterious effects of ethanol defining Fetal Alcohol Spectrum Disorders (FASD), the notion of fetal alcohol programming has gained scientific support. This phenomenon implies early neural plasticity relative to ... ...

Abstract	Background: Beyond the well-known deleterious effects of ethanol defining Fetal Alcohol Spectrum Disorders (FASD), the notion of fetal alcohol programming has gained scientific support. This phenomenon implies early neural plasticity relative to learning mechanisms comprising ethanol´s sensory cues and physiological effects of the drug; among others, its reinforcing properties and its depressant effects upon respiration. In this study, as a function of differential ethanol exposure during gestation, we analyzed neonatal physiological and behavioral responsiveness recruited by the odor of the drug. Methods: A factorial design defined by maternal ethanol intake during pregnancy (Low, n = 38; Moderate, n = 18 or High, n = 19) and olfactory stimulation (ethanol odor and/or or a novel scent) served as the basis of the study. Neonatal respiratory and cardiac frequencies, oxygen saturation levels and appetitive or aversive facial expressions, served as dependent variables. Results: Newborns of High drinkers exhibited significant physiological and behavioral signs indicative of alcohol odor recognition; specifically, respiratory depressions and exacerbated appetitive facial reactions coupled with diminished aversive expressions. Respiratory depressions were not accompanied by heart rate accelerations (cardiorespiratory dysautonomia). According to ROC curve analyses respiratory and behavioral reactivity were predictive of high maternal intake patterns. Conclusions: These results validate the notion of human fetal alcohol programming that is detected immediately after birth. The reported early functional signs indicative of relatively high alcohol gestational exposure should broaden our capability of diagnosing FASD and lead to appropriate primary or secondary clinical interventions (Registry of Health Research N.3201- RePIS, Córdoba, Argentina).
Language	English
Publishing date	2020-06-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2020.108100
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