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Article: Protection Measures, Dental Education, and Covid-19 Spread: A Brief Narrative Review.

D'Agostino, Silvia / D'Agostino, Luca / Dolci, Marco

Journal of International Society of Preventive & Community Dentistry

2021 Volume 11, Issue 1, Page(s) 1–5

Abstract: Objectives: The aim of the study was to evaluate and check the international literature for Covid-19 prevention and dental education.: Materials and methods: A review of the international literature was performed, including articles in English about ... ...

Abstract	Objectives: The aim of the study was to evaluate and check the international literature for Covid-19 prevention and dental education. Materials and methods: A review of the international literature was performed, including articles in English about different aspects of transmission, preventive actions, and educational topics. Results: As a result, it seems that the better way to avoid contagion was represented by the use of personal protective equipment and handwashing in conjunction with social distancing and treatment limitation. Conclusions: Dental treatment limitation to emergencies, social distancing, and online teaching seemed to be the key to limit the Covid-19 outbreak, although there was no evidence of a universal guideline. This suggests that we have to establish general guidelines to avoid a second rush of contagion and limit the spread of infection in the future.
Language	English
Publishing date	2021-01-30
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2734043-0
ISSN	2250-1002 ; 2231-0762
ISSN (online)	2250-1002
ISSN	2231-0762
DOI	10.4103/jispcd.JISPCD_325_20
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Article ; Online: Beyond acute appendicitis: a single-institution experience of unexpected pathology findings after 989 consecutive emergency appendectomy.

Fransvea, Pietro / Puccioni, Caterina / Altieri, Gaia / D'Agostino, Luca / Costa, Gianluca / Tropeano, Giuseppe / La Greca, Antonio / Brisinda, Giuseppe / Sganga, Gabriele

Langenbeck's archives of surgery

2024 Volume 409, Issue 1, Page(s) 87

Abstract: Introduction: Appendiceal neoplasms (ANs) are rare, with an estimated incidence of around 1%: neuroendocrine tumours (NETs) and low-grade appendiceal mucinous neoplasms (LAMNs) comprise most cases. Most tumours are cured by appendectomy alone, although ... ...

Abstract	Introduction: Appendiceal neoplasms (ANs) are rare, with an estimated incidence of around 1%: neuroendocrine tumours (NETs) and low-grade appendiceal mucinous neoplasms (LAMNs) comprise most cases. Most tumours are cured by appendectomy alone, although some require right hemicolectomy and intra-operative chemotherapy. The aim of the present study is to evaluate our institution's experience in terms of the prevalence of AN, their histological types, treatment and outcomes in adult patients undergoing emergency appendectomy. Material and methods: Single-centre retrospective cohort analysis of patients treated for acute appendicitis at a large academic medical centre. Patients with a diagnosis of acute appendicitis (AA) where further compared with patients with acute appendicitis and a histologically confirmed diagnosis of appendiceal neoplasm (AN). Results: A diagnosis of acute appendicitis was made in 1200 patients. Of these, 989 patients underwent emergency appendectomy. The overall incidence of appendiceal neoplasm was 9.3% (92 patients). AN rate increased with increasing age. Patients under the age of 30 had a 3.8% (14/367 patients) rate of occult neoplasm, whereas patients between 40 and 89 years and older had a 13.0% rate of neoplasm. No difference was found in clinical presentations and type of approach while we found a lower complicated appendicitis rate in the AN group. Conclusion: ANs are less rare with respect to the literature; however, clinically, there are no specific signs of suspicious and simple appendicectomy appears to be curative in most cases. However, age plays an important role; older patients are at higher risk for AN. ANs still challenge the non-operative management concept introduced into the surgical literature.
MeSH term(s)	Adult ; Humans ; Appendicitis/epidemiology ; Appendicitis/surgery ; Appendiceal Neoplasms/epidemiology ; Appendiceal Neoplasms/surgery ; Appendectomy ; Retrospective Studies ; Acute Disease
Language	English
Publishing date	2024-03-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-024-03277-0
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Article ; Online: Application of fluorescence-guided surgery in the acute care setting: a systematic literature review.

Fransvea, Pietro / Fico, Valeria / Puccioni, Caterina / D'Agostino, Luca / Costa, Gianluca / Biondi, Alberto / Brisinda, Giuseppe / Sganga, Gabriele

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 375

Abstract: Purpose: Fluorescence-based imaging has found application in several fields of elective surgery, but there is still a lack of evidence in the literature about its use in emergency setting. The present review critically summarizes currently available ... ...

Abstract	Purpose: Fluorescence-based imaging has found application in several fields of elective surgery, but there is still a lack of evidence in the literature about its use in emergency setting. The present review critically summarizes currently available applications and limitations of indocyanine green (ICG) fluorescence in abdominal emergencies including acute cholecystitis, mesenteric ischemia, and trauma surgery. Methods: A systematic review was performed according to the PRISMA statement identifying articles about the use of ICG fluorescence in the management of the most common general surgery emergency. Only studies focusing on the use of ICG fluorescence for the management of acute surgical conditions in adults were included. Results: Thirty-six articles were considered for qualitative analysis. The most frequent disease was occlusive or non-occlusive mesenteric ischemia followed by acute cholecystitis. Benefits from using ICG for acute cholecystitis were reported in 48% of cases (clear identification of biliary structures and a safer surgical procedure). In one hundred and twenty cases that concerned the use of ICG for occlusive or non-occlusive mesenteric ischemia, ICG injection led to a modification of the surgical decision in 44 patients (36.6%). Three studies evaluated the use of ICG in trauma patients to assess the viability of bowel or parenchymatous organs in abdominal trauma, to evaluate the perfusion-related tissue impairment in extremity or craniofacial trauma, and to reassess the efficacy of surgical procedures performed in terms of vascularization. ICG injection led to a modification of the surgical decision in 50 patients (23.9%). Conclusion: ICG fluorescence is a safe and feasible tool also in an emergency setting. There is increasing evidence that the use of ICG fluorescence during abdominal surgery could facilitate intra-operative decision-making and improve patient outcomes, even in the field of emergency surgery.
MeSH term(s)	Adult ; Humans ; Fluorescence ; Mesenteric Ischemia ; Surgery, Computer-Assisted ; Elective Surgical Procedures ; Cholecystitis, Acute ; Indocyanine Green
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-09-25
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-03109-7
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Article ; Online: Transanal Endoscopic Microsurgery Versus Total Mesorectal Excision in ypT0-1 Rectal Cancer After Preoperative Radiochemotherapy: Postoperative Morbidity, Functional Results, and Long-term Oncologic Outcome.

Rizzo, Gianluca / Pafundi, Donato P / Sionne, Francesco / Pietricola, Giulia / D'Agostino, Luca / Gambacorta, Maria A / Valentini, Vincenzo / Coco, Claudio

Diseases of the colon and rectum

2022 Volume 65, Issue 11, Page(s) 1306–1315

MeSH term(s)	Follow-Up Studies ; Humans ; Morbidity ; Neoplasm Staging ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery ; Retrospective Studies ; Transanal Endoscopic Microsurgery
Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000002255
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Article ; Online: Gastric cancer with peritoneal metastases: a single center outline and comparison of different surgical and intraperitoneal treatments.

Santullo, Francesco / Ferracci, Federica / Abatini, Carlo / Halabieh, Miriam Attalla El / Lodoli, Claudio / D'Annibale, Giorgio / Di Cesare, Ludovica / D'Agostino, Luca / Pecere, Silvia / Di Giorgio, Andrea / Strippoli, Antonia / Pacelli, Fabio

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 437

Abstract: Introduction: Gastric cancer with peritoneal metastasis (GCPM) has an unfavourable prognosis. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC) are promising ... ...

Abstract	Introduction: Gastric cancer with peritoneal metastasis (GCPM) has an unfavourable prognosis. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC) are promising treatment options that have been shown to improve survival. The aim of this study was to assess the impact of different treatments such as systemic chemotherapy, systemic chemotherapy + PIPAC, and CRS + HIPEC in patients with GCPM. Material and methods: This single-centre retrospective study included 82 patients with GCPM treated between January 2016 and June 2021. After first-line chemotherapy, depending on disease response and burden, the patients were divided into three treatment groups: chemotherapy alone, chemotherapy + PIPAC, and CRS + HIPEC. The primary outcome was overall survival (OS) from diagnosis, which was compared among the treatment groups. Results: Thirty-seven (45.1%) patients were administered systemic chemotherapy alone, 25 (30.4%) received chemotherapy + PIPAC, and 20 (24.4%) underwent CRS + HIPEC. The CRS + HIPEC group had better OS (median 24 months) than the PIPAC group (15 months, p = 0.01) and chemotherapy group (5 months, p = 0.0001). Following CRS + HIPEC, the postoperative grade 3-4 complication rate was 25%, and no postoperative in-hospital deaths occurred. The median disease-free survival (DFS) was 12 months. Multivariate analysis identified peritoneal carcinomatosis index (PCI) > 7 as an independent predictor of worse DFS. No independent predictors of OS were identified. Conclusion: Among patients with GCPM, we identified a highly selected population with oligometastatic disease. In this group, CRS + HIPEC provided a significant survival advantage with an acceptable major complication rate compared with other available therapies (systemic chemotherapy alone or in combination with PIPAC).
MeSH term(s)	Humans ; Stomach Neoplasms/pathology ; Peritoneal Neoplasms/drug therapy ; Combined Modality Therapy ; Retrospective Studies ; Chemotherapy, Cancer, Regional Perfusion ; Cytoreduction Surgical Procedures ; Postoperative Complications/therapy ; Hyperthermia, Induced ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Survival Rate
Language	English
Publishing date	2023-11-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-03163-1
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Article ; Online: HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs.

Cohen, Justin / D'Agostino, Luca / Tuzer, Ferit / Torres, Claudio

Mechanisms of ageing and development

2018 Volume 175, Page(s) 74–82

Abstract: Developments in medicine have led to a significant increase in the average human lifespan. This increase in aging is most readily apparent in the case of HIV where antiretroviral therapy has shifted infection from a terminal to a chronic but manageable ... ...

Abstract	Developments in medicine have led to a significant increase in the average human lifespan. This increase in aging is most readily apparent in the case of HIV where antiretroviral therapy has shifted infection from a terminal to a chronic but manageable disease. Despite this advance, patients suffer from co-morbidities best described as an accelerated aging phenotype. A potential contributor is cellular senescence, an aging-associated growth arrest, which has already been linked to other HIV co-morbidities such as lipodystrophies and osteoporosis in response to antiretroviral drugs. We have previously demonstrated that astrocytes senescence in response to antiretroviral drugs. As endothelial cells play a critical role regulating the blood brain barrier (BBB) and senescence could severely impact barrier permeability, we investigate the role of a commonly used combination of HIV reverse transcriptase inhibitors on the senescence program of human umbilical vein endothelial cells (HUVECs). Our studies indicate that HUVECs underwent premature senescence associated with inflammation, oxidative stress and altered eNOS activation. Treated cells had detrimental paracrine effects on astrocytes including paracrine senescence, suggesting that senescent HUVECs could influence astrocytes, which line the other side of the BBB. These results may have implications for HIV-associated neurocognitive disorders (HAND), a set of neurological deficits.
MeSH term(s)	Anti-HIV Agents/toxicity ; Astrocytes/drug effects ; Astrocytes/metabolism ; Astrocytes/pathology ; Cell Proliferation/drug effects ; Cells, Cultured ; Cellular Senescence/drug effects ; Emtricitabine/toxicity ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Inflammation Mediators/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Paracrine Communication/drug effects ; Tenofovir/toxicity
Chemical Substances	Anti-HIV Agents ; Inflammation Mediators ; Tenofovir (99YXE507IL) ; NOS3 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Emtricitabine (G70B4ETF4S)
Language	English
Publishing date	2018-07-25
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	183915-9
ISSN	1872-6216 ; 0047-6374
ISSN (online)	1872-6216
ISSN	0047-6374
DOI	10.1016/j.mad.2018.07.008
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Book ; Conference proceedings: Fluid dynamics of cavitation and cavitating turbopumps

D'Agostino, Luca

(CISM courses and lectures / International Centre for Mechanical Sciences ; 496)

2007

Event/congress	Course on the Fluid Dynamics of Cavitation and Cavitating Turbopumps (2005.07, Udine)
Author's details	ed. by Luca d' Agostino
Series title	CISM courses and lectures / International Centre for Mechanical Sciences ; 496
Keywords	Cavitation ; Fluid dynamics ; Turbine pumps
Language	English
Size	351 S.
Publisher	Springer
Publishing place	Wien u.a.
Document type	Book ; Conference proceedings
ISBN	9783211766682 ; 3211766685
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma.

D'Agostino, Luca / Giordano, Antonio

Oncotarget

2011 Volume 2, Issue 12, Page(s) 1055–1074

Abstract: NSP 5a3a is a novel structural protein found to be over-expressed in certain cancer cell lines in-vitro such as Hela, Saos-2, and MCF-7 while barely detectable levels in normal body tissues except for Testis. This particular isoform has been known to ... ...

Abstract	NSP 5a3a is a novel structural protein found to be over-expressed in certain cancer cell lines in-vitro such as Hela, Saos-2, and MCF-7 while barely detectable levels in normal body tissues except for Testis. This particular isoform has been known to interact with cyto- nuclear proteins B23, known to be involved in multi-faceted cellular processes such as cell division, apoptosis, ribosome biogenesis, and rRNA processing, as well as with hnRNP-L, known to be involved with RNA metabolism and rRNA processing. A previous preliminary investigation of NSP 5a3a as a potential target in Head and Neck Carcinoma revealed a novel p73 dependent mechanism through which NSP 5a3a induced apoptosis in Head and Neck cell lines when over-expressed in-vitro. Our present investigation further elucidated a novel dual axis signaling point by which NSP 5a3a induces apoptosis in Head and Neck cell line HN30 through p73-DAXX and TRAF2-TRADD. Interestingly, this novel mechanism appears independent of canonical caspases involved in the intrinsic mitochondrial pathway as well as those in the death receptor pathway thru TRAF2 and TRADD.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Apoptosis ; Carcinoma, Squamous Cell/metabolism ; Cell Cycle Proteins ; Cell Division ; Cell Line, Tumor ; Co-Repressor Proteins ; Cytoskeletal Proteins ; DNA-Binding Proteins/metabolism ; Head and Neck Neoplasms/metabolism ; Humans ; Molecular Chaperones ; Nuclear Proteins/metabolism ; Signal Transduction ; Squamous Cell Carcinoma of Head and Neck ; TNF Receptor-Associated Death Domain Protein/metabolism ; TNF Receptor-Associated Factor 2/metabolism ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism ; Tumor Protein p73 ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cell Cycle Proteins ; Co-Repressor Proteins ; Cytoskeletal Proteins ; DAXX protein, human ; DNA-Binding Proteins ; Molecular Chaperones ; Nuclear Proteins ; SPECC1 protein, human ; TNF Receptor-Associated Death Domain Protein ; TNF Receptor-Associated Factor 2 ; TP73 protein, human ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins ; Tumor Protein p73 ; Tumor Suppressor Proteins ; nucleophosmin (117896-08-9)
Language	English
Publishing date	2011-12-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.306
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Article ; Online: NSP 5a3a: a potential novel cancer target in head and neck carcinoma.

D'agostino, Luca / Giordano, Antonio

Oncotarget

2011 Volume 1, Issue 6, Page(s) 423–435

Abstract: NSP 5a3a along with three other distinct though similar splice variants were initially identified corresponding to locus HCMOGT-1 on chromosome 17p11.2 [1]. Secondary structure analysis of the novel structural protein (NSP) isoforms revealed similarity ... ...

Abstract	NSP 5a3a along with three other distinct though similar splice variants were initially identified corresponding to locus HCMOGT-1 on chromosome 17p11.2 [1]. Secondary structure analysis of the novel structural protein (NSP) isoforms revealed similarity to Spectrin like proteins containing coiled coil domains [1]. The NSP 5a3a isoform had been found to be highly expressed in-vitro in particular cancer cell lines while very low to un-detectable levels in normal body tissues [1]. Subsequent investigation of this isoform revealed its novel interaction with B23 [2], a multifunctional nucleolar protein involved in ribosome biogenesis, rRNA transcription, mitosis, cell growth control, and apoptosis [3]. Subsequent investigation, elucidated NSP 5a3a's potential involvement in cellular processes such as ribosome biogenesis and rRNA processing by validating NSP 5a3a's novel interaction with B23 and ribonuclear protein hnRNP-L possibly implicating NSP 5a3a's involvement in cellular activities such as RNA metabolism and processing [4]. In this preliminary investigation, we wanted to observe the effect that over-expressing NSP 5a3a may have on cell cycle and its potential application in cancer treatment in aggressive cancers such as head and neck carcinomas. Over-expressed NSP 5a3a in HN30 cells induced a significant degree of apoptosis, an average of a 10.85 fold increase compared to controls 3 days post-transfection. This effect was more significant then the apoptosis observed between Fadu cells over-expressing NSP 5a3a and its controls. Though, the apoptosis induced in the WI38 control cell line showed an average of a 13.2 fold increase between treated and controls comparable to the HN30 cell line 3 days post-transfection. Molecular analysis indentified a novel p73 dependent mechanism independent of p53 and caspase 3 activity through which NSP 5a3a is inducing apoptosis. We propose NSP 5a3a as a potential therapeutic target for site directed cancer treatment in perhaps certain head and neck carcinomas by induction of apoptosis.
MeSH term(s)	Apoptosis ; Blotting, Western ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Cycle ; Cell Cycle Proteins ; Cytoskeletal Proteins ; Fibroblasts/metabolism ; Flow Cytometry ; Gene Expression Regulation, Neoplastic/physiology ; Genetic Vectors ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/pathology ; Humans ; Lung/cytology ; Lung/metabolism ; Nuclear Proteins/genetics ; Transfection ; Tumor Cells, Cultured
Chemical Substances	Cell Cycle Proteins ; Cytoskeletal Proteins ; Nuclear Proteins ; SPECC1 protein, human
Language	English
Publishing date	2011-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.176
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Article ; Online: RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity.

Goswami, Sayantani / Balasubramanian, Iyshwarya / D'Agostino, Luca / Bandyopadhyay, Sheila / Patel, Radha / Avasthi, Shail / Yu, Shiyan / Goldenring, James R / Bonder, Edward M / Gao, Nan

The Journal of biological chemistry

2021 Volume 297, Issue 1, Page(s) 100848

Abstract: Within the intestinal epithelium, regulation of intracellular protein and vesicular trafficking is of utmost importance for barrier maintenance, immune responses, and tissue polarity. RAB11A is a small GTPase that mediates the anterograde transport of ... ...

Abstract	Within the intestinal epithelium, regulation of intracellular protein and vesicular trafficking is of utmost importance for barrier maintenance, immune responses, and tissue polarity. RAB11A is a small GTPase that mediates the anterograde transport of protein cargos to the plasma membrane. Loss of RAB11A-dependent trafficking in mature intestinal epithelial cells results in increased epithelial proliferation and nuclear accumulation of Yes-associated protein (YAP), a key Hippo-signaling transducer that senses cell-cell contacts and regulates tissue growth. However, it is unclear how RAB11A regulates YAP intracellular localizations. In this report, we examined the relationship of RAB11A to epithelial junctional complexes, YAP, and the associated consequences on colonic epithelial tissue repair. We found that RAB11A controls the biochemical associations of YAP with multiple components of adherens and tight junctions, including α-catenin, β-catenin, and Merlin, a tumor suppressor. In the absence of RAB11A and Merlin, we observed enhanced YAP-β-catenin complex formation and nuclear translocation. Upon chemical injury to the intestine, mice deficient in RAB11A were found to have reduced epithelial integrity, decreased YAP localization to adherens and tight junctions, and increased nuclear YAP accumulation in the colon epithelium. Thus, RAB11A-regulated trafficking regulates the Hippo-YAP signaling pathway for rapid reparative response after tissue injury.
MeSH term(s)	Adherens Junctions/genetics ; Animals ; Caco-2 Cells ; Cell Cycle Proteins/genetics ; Cell Proliferation/genetics ; Colitis/chemically induced ; Colitis/genetics ; Colitis/pathology ; Colon/growth & development ; Colon/pathology ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Epithelium/growth & development ; Epithelium/pathology ; Humans ; Mice ; Neurofibromin 2/genetics ; Tight Junctions/genetics ; Transcription Factors/genetics ; alpha Catenin/genetics ; beta Catenin/genetics ; rab GTP-Binding Proteins/genetics
Chemical Substances	CTNNB1 protein, human ; Cell Cycle Proteins ; Neurofibromin 2 ; Transcription Factors ; YY1AP1 protein, human ; alpha Catenin ; beta Catenin ; Dextran Sulfate (9042-14-2) ; rab11 protein (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2021-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100848
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