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  1. Article: Multiresidue method for the determination of organophosphorus pesticides in cereal matrixes.

    Mariani, Maurizio Boccacci / D'Aiuto, Virginia / Giannetti, Vanessa

    Journal of AOAC International

    2010  Volume 93, Issue 3, Page(s) 999–1006

    Abstract: Our research was focused on a preliminary comparison of three cleanup procedures for the determination of 26 organophosphorus (OP) pesticide residues in cereal matrixes. The aim of the study was to reduce the analytical problems associated with the ... ...

    Abstract Our research was focused on a preliminary comparison of three cleanup procedures for the determination of 26 organophosphorus (OP) pesticide residues in cereal matrixes. The aim of the study was to reduce the analytical problems associated with the presence of high-molecular-weight compounds in these matrixes in order to improve the efficiency of the chromatographic separation. The method was based on the extraction of OP pesticides from the samples with the use of petroleum ether, acetone, and dichloromethane, and on three different cleanup procedures, followed by GC identification. The first procedure was carried out with a multicartridge system; the second procedure consisted of a low-temperature lipid precipitation; for the third procedure, acid and neutral alumina were used for cleanup of the extract. The use of deactivated acidic alumina as the adsorbent medium and the use of n-hexane-dichloromethane-ethyl acetate (6 + 3 + 1, v/v/v) as the eluting system were preferred. After purification, the residue was injected into a gas chromatograph for separation followed by nitrogen-phosphorus detection; the identities of the OP pesticides in positive samples were confirmed by GC/MS. The proposed method could be extended to the determination of other OP pesticides in various food matrixes in routine analysis.
    MeSH term(s) Chromatography, Gas ; Edible Grain/chemistry ; Gas Chromatography-Mass Spectrometry ; Organophosphorus Compounds/analysis ; Pesticide Residues/analysis
    Chemical Substances Organophosphorus Compounds ; Pesticide Residues
    Language English
    Publishing date 2010-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1229: Show issues Location:
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  2. Article: Development of a headspace-solid phase microextraction-gas chromatography method to determine organohalogen contamination in drinking water.

    Mariani, Maurizio Boccacci / Giannetti, Vanessa / Testani, Elena / D'Aiuto, Virginia

    Journal of AOAC International

    2012  Volume 95, Issue 1, Page(s) 222–226

    Abstract: The formation of organohalogen compounds in waters treated by chlorination has drawn increasing scientific attention due to the potentially hazardous health effects of this class of substances. Today, chlorination is the most widely used technology for ... ...

    Abstract The formation of organohalogen compounds in waters treated by chlorination has drawn increasing scientific attention due to the potentially hazardous health effects of this class of substances. Today, chlorination is the most widely used technology for civil water disinfection. In this study, headspace-solid phase microextraction coupled with GC-electron capture detector was used to determine organohalogen compounds in drinking water sampled from aqueducts and artesian wells in Italy. Experimental parameters, such as sample volume, stirring, salting out, extraction temperature, and extraction time, were evaluated and optimized. The LODs ranged from 1 to 10 ng/L and LOQs from 5 to 50 ng/L. A linear response was confirmed by correlation coefficients ranging from 0.9443 to 0.9999. Quantifiable organohalogen residues were found in 11 water samples, with concentration up to 11.3 +/- 0.5 microg/L for the sum of all trihalomethanes and 0.66 +/- 0.03 microg/L for the sum of trichloroethylene and tetrachloroethylene. These concentrations are lower than the current regulatory limits in Italy.
    MeSH term(s) Calibration ; Chromatography, Gas/methods ; Drinking Water/analysis ; Electrochemistry ; Groundwater/analysis ; Hydrocarbons, Halogenated/analysis ; Indicators and Reagents ; Italy ; Limit of Detection ; Reproducibility of Results ; Solid Phase Microextraction/methods ; Temperature ; Trihalomethanes/analysis ; Water Pollutants, Chemical/analysis ; Water Wells
    Chemical Substances Drinking Water ; Hydrocarbons, Halogenated ; Indicators and Reagents ; Trihalomethanes ; Water Pollutants, Chemical
    Language English
    Publishing date 2012-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    DOI 10.5740/jaoacint.10-417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2.

    Brufani, Mario / Rizzi, Nicoletta / Meda, Clara / Filocamo, Luigi / Ceccacci, Francesca / D'Aiuto, Virginia / Bartoli, Gabriele / Bella, Angela La / Migneco, Luisa M / Bettolo, Rinaldo Marini / Leonelli, Francesca / Ciana, Paolo / Maggi, Adriana

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 2510

    Abstract: Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds. However, current estrogenic molecules have undesired systemic effects, ... ...

    Abstract Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds. However, current estrogenic molecules have undesired systemic effects, thus the aim of our studies is to generate new molecules for topic administration that are devoid of systemic effects. Following a preliminary study, the new 17β-estradiol derivatives 1 were synthesized. The estrogenic activity of these novel compounds was evaluated in vitro using the cell line ERE-Luc B17 stably transfected with an ERE-Luc reporter. Among the 17β-estradiol derivatives synthesized, compounds 1e and 1f showed the highest transactivation potency and were therefore selected for the study of their systemic estrogenic activity. The study of these compounds in the ERE-Luc mouse model demonstrated that both compounds lack systemic effects when administered in the wound area. Furthermore, wound-healing experiments showed that 1e displays a significant regenerative and anti-inflammatory activity. It is therefore confirmed that this class of compounds are suitable for topical administration and have a clear beneficial effect on wound healing.
    MeSH term(s) Administration, Topical ; Animals ; Cells, Cultured ; Estradiol/administration & dosage ; Estradiol/analogs & derivatives ; Estradiol/chemical synthesis ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Replacement Therapy ; Estrogens/metabolism ; Estrone/metabolism ; Female ; Humans ; Mice ; Ovariectomy ; Skin/drug effects ; Skin/injuries ; Skin/pathology ; Wound Healing/drug effects ; Wound Healing/physiology
    Chemical Substances Estrogen Receptor alpha ; Estrogens ; Estrone (2DI9HA706A) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2017-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-02820-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Multiresidue Method for the Determination of Organophosphorus Pesticides in Cereal Matrixes

    Boccacci Mariani, Maurizio / D'Aiuto, Virginia / Giannetti, Vanessa

    Journal of AOAC International. 2010 May-June, v. 93, no. 3

    2010  

    Abstract: Our research was focused on a preliminary comparison of three cleanup procedures for the determination of 26 organophosphorus (OP) pesticide residues in cereal matrixes. The aim of the study was to reduce the analytical problems associated with the ... ...

    Abstract Our research was focused on a preliminary comparison of three cleanup procedures for the determination of 26 organophosphorus (OP) pesticide residues in cereal matrixes. The aim of the study was to reduce the analytical problems associated with the presence of high-molecular-weight compounds in these matrixes in order to improve the efficiency of the chromatographic separation. The method was based on the extraction of OP pesticides from the samples with the use of petroleum ether, acetone, and dichloromethane, and on three different cleanup procedures, followed by GC identification. The first procedure was carried out with a multicartridge system; the second procedure consisted of a low-temperature lipid precipitation; for the third procedure, acid and neutral alumina were used for cleanup of the extract. The use of deactivated acidic alumina as the adsorbent medium and the use of n-hexane-dichloromethane-ethyl acetate (6 + 3 + 1, v/v/v) as the eluting system were preferred. After purification, the residue was injected into a gas chromatograph for separation followed by nitrogen-phosphorus detection; the identities of the OP pesticides in positive samples were confirmed by GC/MS. The proposed method could be extended to the determination of other OP pesticides in various food matrixes in routine analysis.
    Language English
    Dates of publication 2010-05
    Size p. 999-1006.
    Document type Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 862: Show issues

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  5. Article ; Online: Role of the hydrophilic spacer of glucosylated amphiphiles included in liposome formulations in the recognition of Concanavalin A.

    Mauceri, Alessandro / Fracassi, Alessandro / D'Abramo, Marco / Borocci, Stefano / Giansanti, Luisa / Piozzi, Antonella / Galantini, Luciano / Martino, Antonio / D'Aiuto, Virginia / Mancini, Giovanna

    Colloids and surfaces. B, Biointerfaces

    2015  Volume 136, Page(s) 232–239

    Abstract: The functionalization of liposomes with glycosylated amphiphiles is an optimal strategy for targeted drug delivery, leading to enhanced efficacy as well as to reduced side effects of drugs. In fact, the presence of natural or synthetic glycolipids in ... ...

    Abstract The functionalization of liposomes with glycosylated amphiphiles is an optimal strategy for targeted drug delivery, leading to enhanced efficacy as well as to reduced side effects of drugs. In fact, the presence of natural or synthetic glycolipids in vesicle formulations might increase their specificity toward lectins, a class of non-enzymatic sugar-binding proteins involved in cellular recognition and adhesion. The capability of a new glucosylated synthetic amphiphile to interact with Concanavalin A (Con A), a plant lectin used as model system, was investigated by a synergic experimental and computational approach, both as pure component and in formulation with a natural phospholipid. The comparison of the affinity with Con A of the new glucosylated amphiphile with respect to that of a previously described structural analogue demonstrates that the hydrophilic spacer length controls the exposure of the glucose residue on liposome surface, and consequently the recognition by the lectin.
    MeSH term(s) Concanavalin A/chemistry ; Glucose/chemistry ; Hydrophobic and Hydrophilic Interactions ; Lipid Bilayers ; Liposomes ; Molecular Dynamics Simulation ; Surface-Active Agents/chemistry
    Chemical Substances Lipid Bilayers ; Liposomes ; Surface-Active Agents ; Concanavalin A (11028-71-0) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2015-12-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2015.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Performance Assessment in Fingerprinting and Multi Component Quantitative NMR Analyses.

    Gallo, Vito / Intini, Nicola / Mastrorilli, Piero / Latronico, Mario / Scapicchio, Pasquale / Triggiani, Maurizio / Bevilacqua, Vitoantonio / Fanizzi, Paolo / Acquotti, Domenico / Airoldi, Cristina / Arnesano, Fabio / Assfalg, Michael / Benevelli, Francesca / Bertelli, Davide / Cagliani, Laura R / Casadei, Luca / Cesare Marincola, Flaminia / Colafemmina, Giuseppe / Consonni, Roberto /
    Cosentino, Cesare / Davalli, Silvia / De Pascali, Sandra A / D'Aiuto, Virginia / Faccini, Andrea / Gobetto, Roberto / Lamanna, Raffaele / Liguori, Francesca / Longobardi, Francesco / Mallamace, Domenico / Mazzei, Pierluigi / Menegazzo, Ileana / Milone, Salvatore / Mucci, Adele / Napoli, Claudia / Pertinhez, Thelma / Rizzuti, Antonino / Rocchigiani, Luca / Schievano, Elisabetta / Sciubba, Fabio / Sobolev, Anatoly / Tenori, Leonardo / Valerio, Mariacristina

    Analytical chemistry

    2015  Volume 87, Issue 13, Page(s) 6709–6717

    Abstract: An interlaboratory comparison (ILC) was organized with the aim to set up quality control indicators suitable for multicomponent quantitative analysis by nuclear magnetic resonance (NMR) spectroscopy. A total of 36 NMR data sets (corresponding to 1260 NMR ...

    Abstract An interlaboratory comparison (ILC) was organized with the aim to set up quality control indicators suitable for multicomponent quantitative analysis by nuclear magnetic resonance (NMR) spectroscopy. A total of 36 NMR data sets (corresponding to 1260 NMR spectra) were produced by 30 participants using 34 NMR spectrometers. The calibration line method was chosen for the quantification of a five-component model mixture. Results show that quantitative NMR is a robust quantification tool and that 26 out of 36 data sets resulted in statistically equivalent calibration lines for all considered NMR signals. The performance of each laboratory was assessed by means of a new performance index (named Qp-score) which is related to the difference between the experimental and the consensus values of the slope of the calibration lines. Laboratories endowed with a Qp-score falling within the suitable acceptability range are qualified to produce NMR spectra that can be considered statistically equivalent in terms of relative intensities of the signals. In addition, the specific response of nuclei to the experimental excitation/relaxation conditions was addressed by means of the parameter named NR. NR is related to the difference between the theoretical and the consensus slopes of the calibration lines and is specific for each signal produced by a well-defined set of acquisition parameters.
    Language English
    Publishing date 2015-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.5b00919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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