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  1. Article ; Online: Fluorescence and Ultrasound-guided Laparoscopic Resection of Caudate Lobe for Hepatocellular Carcinoma Located in the Retrocaval Portion.

    Santambrogio, Roberto / D'Alessandro, Valentina / Iacob, Giulio / Zappa, Marco A

    Surgical laparoscopy, endoscopy & percutaneous techniques

    2021  Volume 31, Issue 6, Page(s) 812–814

    Abstract: Background: Contrast-enhanced intraoperative ultrasonography (CEIOUS) and indocyanine green fluorescence were interesting tool for the visualization of intrahepatic neoplastic nodules. The combinations of the 2 technologies could increase tumor ... ...

    Abstract Background: Contrast-enhanced intraoperative ultrasonography (CEIOUS) and indocyanine green fluorescence were interesting tool for the visualization of intrahepatic neoplastic nodules. The combinations of the 2 technologies could increase tumor detection and the radicality of resection, allowing the use of a pure laparoscopic approach.
    Methods: The patient was an 81-year-old man with a history of hypertension and treated hepatitis C infection, with a sustained serological response from 2018, previously undergoing laparotomic resection for hepatocellular carcinoma (HCC) in segment 8.During his regular hepatological follow-up, a 25 mm nodule was detected in segment 1, in a retrocaval position. Considering clinical presentation, good liver function (Child A5-MELD 8) and imaging, pure laparoscopic resection of the caudate lobe was performed using fluorescence imaging and CEIOUS navigation guidance.
    Results: The operation last for 205 minutes. Blood loss was 100 mL and no blood transfusion was required. She resumed diet on the next day and was discharged 4 days after the operation. Histopathologic examination showed 27 mm HCC with a clear margin. Contrast computed tomography scan performed 3 months after the operation showed no recurrence of the disease.
    Conclusions: A laparoscopic isolated caudate resection for HCC located in the retrocaval portion of the cirrhotic liver seems to be feasible in selected patients and fluorescence imaging and CEIOUS navigation guidance could guarantee a safe and successful surgery.
    MeSH term(s) Aged, 80 and over ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/surgery ; Child ; Female ; Hepatectomy ; Humans ; Laparoscopy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Male ; Ultrasonography ; Ultrasonography, Interventional
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1475108-2
    ISSN 1534-4908 ; 1530-4515 ; 1051-7200
    ISSN (online) 1534-4908
    ISSN 1530-4515 ; 1051-7200
    DOI 10.1097/SLE.0000000000000970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treatment of haemorrhoids in pregnancy: A retrospective review.

    Fiordaliso, Michele / De Marco, Flavia Antonia / D'Alessandro, Valentina / Risio, Domenico / Panaccio, Paolo / Liberatore, Edoardo

    Annali italiani di chirurgia

    2023  Volume 94, Page(s) 274–280

    Abstract: Aim: Haemorrhoids are varicose veins of the rectum covered by mucosa at or near the anal canal. They are normally asymptomatic, can occur at any age and affect both males and females. Haemorrhoids are common in young women and commoner during pregnancy ... ...

    Abstract Aim: Haemorrhoids are varicose veins of the rectum covered by mucosa at or near the anal canal. They are normally asymptomatic, can occur at any age and affect both males and females. Haemorrhoids are common in young women and commoner during pregnancy and the puerperium. In this review, we address the issue of the approach of the obstetrician and surgeons to haemorrhoids and their management. This is significant because there are currently no recommendations for pregnant patients with hemorrhoids.
    Methods: The literature search comprised all the inherent published original papers; also abstract were included. No language selection was done. Search terms used were: "hemorrhoid", "hemorrhoid therapy", "hemorrhoid in pregnancy", "hemorrhoid complication". Data research was conducted using MEDLINE, EMBASE, Web of Sciences, Scopus, Clinical Trial. gov, OVID and Cochrane Library querying for all articles related to treatment of hemorrhoidis in pregnancy.
    Results: Fiber supplement, stool softener and mild laxatives are generally safe for pregnant women. Topical medication or oral phlebotonics may be used with special caution because the strong evidence of their safety and efficacy in pregnancy is lacking. In case of massive bleeding, anal packing could be a simple and useful maneuver. Hemorrhoidectomy is reserved in strangulated or extensively thrombosed hemorrhoids, and hemorrhoids with intractable bleeding.
    Key words: Hemorrhoid, Hemorrhoid Therapy, Hemorrhoid in Pregnancy, Hemorrhoid Complication.
    MeSH term(s) Male ; Humans ; Female ; Pregnancy ; Hemorrhoids/surgery ; Retrospective Studies ; Hemorrhoidectomy ; Anal Canal ; Ligation ; Laxatives ; Treatment Outcome
    Chemical Substances Laxatives
    Language English
    Publishing date 2023-08-02
    Publishing country Italy
    Document type Review ; Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Validation of proprotein convertase furin as potential target in rhabdomyosarcoma

    D'Alessandro, Valentina

    2012  

    Author's details by Valentina D'Alessandro
    Language English
    Size Online-Ressource (107 S), Ill
    Publisher ETH
    Publishing place Zürich
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 20677--Zürich, 2067
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: Comparing two-year outcomes of balloon-expandable Myval and self-expanding Evolut R in severe aortic valve stenosis.

    Moscarella, Elisabetta / Ielasi, Alfonso / Montonati, Carolina / Pellegrini, Dario / Pellicano, Mariano / Briguglia, Daniele / D'Alessandro, Valentina / Giannini, Francesco / Gamardella, Marco / Medda, Massimo / Guagliumi, Giulio / Banfi, Carlo / Glauber, Mattia / Tespili, Maurizio

    International journal of cardiology

    2023  Volume 400, Page(s) 131701

    Abstract: Background: The new balloon-expandable (BE) Myval transcatheter heart valves (THV) has shown promising early results with low paravalvular leak (PVL) and permanent pacemaker implantation (PPI) rates. Limited data are available regarding its long-term ... ...

    Abstract Background: The new balloon-expandable (BE) Myval transcatheter heart valves (THV) has shown promising early results with low paravalvular leak (PVL) and permanent pacemaker implantation (PPI) rates. Limited data are available regarding its long-term performance. We aimed to compare the 2-year clinical and echocardiographic outcomes of transcatheter aortic valve replacement (TAVR) using the self-expanding (SE) Evolut R and the BE Myval THVs.
    Methods: The EVAL study included 166 patients with severe aortic valve stenosis who underwent TAVR either with SE Evolut R (n = 108) or BE Myval (n = 58) THV. Primary objectives include comparison on clinical efficacy (freedom from all-cause mortality, stroke, and cardiovascular hospitalization), echocardiographic performance and PPI rates between the two THVs.
    Results: At 2-year the BE Myval group showed higher clinical efficacy (86% vs. 66%,HR:2.62, 95%CI 2.2-5.1;p = 0.006), with fewer cardiac hospitalizations (3.4% vs. 13.9%,p = 0.03). No significant differences in all-cause mortality, cardiovascular mortality, or stroke rates were observed. The proportion of patients with ≥moderate PVL was significantly lower in the BE Myval compared to the SE Evolut R group (4%vs. 22%,p = 0.008). The mean transvalvular gradient was significantly higher in the SE group compared to the BE group (9.5 ± 4.3 vs. 6.9 ± 2.2 mmHg,p < 0.001), however there was no difference in the percentage of patients with a mean gradient ≥20 mmHg between the two groups.
    Conclusions: Both THVs offer similar 2-year clinical outcomes. The BE Myval THV demonstrated advantages with higher clinical efficacy and lower PVL incidence. Longer follow-up and randomized trials are needed to validate these results and assess Myval's sustained performance and durability.
    MeSH term(s) Humans ; Heart Valve Prosthesis ; Prosthesis Design ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Transcatheter Aortic Valve Replacement ; Treatment Outcome ; Stroke/surgery
    Language English
    Publishing date 2023-12-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Guidelines Adaptation to the COVID-19 Outbreak for the Management of Hepatocellular Carcinoma.

    Santambrogio, Roberto / Farina, Gabriella / D'Alessandro, Valentina / Iacob, Giulio / Gemma, Marco / Zappa, Marco Antonio

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2020  Volume 31, Issue 3, Page(s) 266–272

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/surgery ; Comorbidity ; Disease Management ; Female ; Guideline Adherence ; Hepatectomy/methods ; Humans ; Laparoscopy/methods ; Length of Stay ; Liver Neoplasms/epidemiology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Operative Time ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2020.0559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Micronvasive behaviour of single small hepatocellular carcinoma: which treatment?

    Santambrogio, Roberto / Barabino, Matteo / D'Alessandro, Valentina / Iacob, Giulio / Opocher, Enrico / Gemma, Marco / Zappa, Marco Antonio

    Updates in surgery

    2021  Volume 73, Issue 4, Page(s) 1359–1369

    Abstract: Background: Microinvasion (MI), defined as infiltration of the portal or hepatic vein or bile duct and intrahepatic metastasis are accurate indicators of a poor prognosis for mall hepatocellular carcinomas (HCC). A previous study showed that ... ...

    Abstract Background: Microinvasion (MI), defined as infiltration of the portal or hepatic vein or bile duct and intrahepatic metastasis are accurate indicators of a poor prognosis for mall hepatocellular carcinomas (HCC). A previous study showed that intraoperative ultrasound (IOUS) definition of MI-HCC had a high concordance with histological findings. Aim of this study is to evaluate overall survival and recurrence patterns of patients with MI-HCC submitted to hepatic resection (HR) or laparoscopic ablation therapies (LAT).
    Methods: A total of 171 consecutive patients (78 h; 93 LAT) with single, small HCC (< 3 cm) with a MI pattern at IOUS examination were compared analyzing overall survival and recurrence patterns using univariate and multivariate analysis and weighting by propensity score.
    Results: Overall recurrences were similar in the 2 groups (HR: 51 patients (65%); LAT: 66 patients (71%)). The rate of local tumor progression in the HR group was very low (5 pts; 6%) in comparison to LAT group (22 pts; 24%; p = 0.002). The overall survival curves of HR are significantly better than that of the LAT group (p = 0.0039). On the propensity score Cox model, overall mortality was predicted by the surgical treatment with a Hazard ratio 1.68 (1.08-2.623) (p = 0.022).
    Conclusions: If technically feasible and in patients fit for surgery, HR with an adequate tumor margin should be preferred to LAT in patients with MI-HCC at IOUS evaluation, to eradicate MI features near the main nodule, which are relatively frequent even in small HCC (< 3 cm).
    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Catheter Ablation ; Hepatectomy ; Humans ; Liver Neoplasms/surgery ; Neoplasm Recurrence, Local/surgery ; Proportional Hazards Models ; Retrospective Studies ; Treatment Outcome ; Ultrasonography
    Language English
    Publishing date 2021-04-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-01036-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Validation of proprotein convertase furin as potential target in rhabdomyosarcoma

    D'Alessandro, Valentina

    2012  

    Abstract: Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 20677, ... ...

    Abstract Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 20677, 2012
    Keywords RHABDOMYOSARKOME (PATHOLOGIE) ; THERAPIEN + THERAPEUTIK (MEDIZIN) ; BAKTERIOPHAGEN (VIROLOGIE) ; PROTEINANALYTIK + PEPTIDANALYTIK (BIOCHEMIE) ; PROTEINE ; POLYPEPTIDE ; ENZYME ; ENZYMINHIBITOREN ; PEPTIDE (PHARMAZIE) ; ZIELGERICHTETE ARZNEIMITTEL (PHARMAKOLOGIE)
    Language English
    Publisher Zürich, ETH
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Thesis ; Online: Validation of proprotein convertase furin as potential target in rhabdomyosarcoma

    D'Alessandro, Valentina

    2012  

    Keywords RHABDOMYOSARKOME (PATHOLOGIE) ; THERAPIEN + THERAPEUTIK (MEDIZIN) ; BAKTERIOPHAGEN (VIROLOGIE) ; PROTEINANALYTIK + PEPTIDANALYTIK (BIOCHEMIE) ; PROTEINE ; POLYPEPTIDE ; ENZYME ; ENZYMINHIBITOREN ; PEPTIDE (PHARMAZIE) ; ZIELGERICHTETE ARZNEIMITTEL (PHARMAKOLOGIE) ; RHABDOMYOSARCOMATA (PATHOLOGY) ; THERAPIES + THERAPEUTICS (MEDICINE) ; BACTERIOPHAGES (VIROLOGY) ; PROTEIN ANALYSIS + PEPTIDE ANALYSIS (BIOCHEMISTRY) ; PROTEINS ; POLYPEPTIDES ; ENZYMES ; ENZYME INHIBITORS ; PEPTIDES (PHARMACY) ; TARGETED DRUGS (PHARMACOLOGY) ; info:eu-repo/classification/ddc/610 ; Medical sciences ; medicine
    Language English
    Publisher ETH
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Laparoscopic thermoablation for hepatocellular carcinoma in patients with liver cirrhosis: an effective procedure for tricky tumors.

    Santambrogio, Roberto / Barabino, Matteo / D'Alessandro, Valentina / Galfrascoli, Elisa / Zappa, Marco Antonio / Piccolo, Gaetano / Zuin, Massimo / Opocher, Enrico

    Medical oncology (Northwood, London, England)

    2020  Volume 37, Issue 4, Page(s) 32

    Abstract: The optimal treatment for hepatocellular carcinoma (HCC) is surgical resection. However, only a small percentage of patients are amenable to this option. Percutaneous radiofrequency interstitial thermal ablation (TA) proved to be effective in the ... ...

    Abstract The optimal treatment for hepatocellular carcinoma (HCC) is surgical resection. However, only a small percentage of patients are amenable to this option. Percutaneous radiofrequency interstitial thermal ablation (TA) proved to be effective in the treatment of unresectable HCC. Recent advances in laparoscopic ultrasound have improved the accuracy in detecting small intrahepatic HCC nodules missed by pre-operative imaging techniques. Our objective was to evaluate an operative combination of laparoscopic ultrasound with laparoscopic thermoablation (LTA) in the treatment of HCC not amenable to liver resection. The aim of our review was to evaluate the advantages and limits of the laparoscopic approach according the criteria of the evidence-based medicine. LTA of HCC proved to be a safe and effective technique both in the short- and long-term follow-up period. This technique may be indicated in selected cases when the percutaneous approach to the lesion is very difficult or contraindicated.
    MeSH term(s) Adult ; Aged ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Catheter Ablation ; Female ; Humans ; Laparoscopy ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Liver Cirrhosis/surgery ; Liver Neoplasms/complications ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Surgery, Computer-Assisted ; Treatment Outcome ; Ultrasonography, Interventional
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-020-1342-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Guidelines Adaptation to the COVID-19 Outbreak for the Management of Hepatocellular Carcinoma

    Santambrogio, Roberto / Farina, Gabriella / D'Alessandro, Valentina / Iacob, Giulio / Gemma, Marco / Zappa, Marco Antonio

    Journal of Laparoendoscopic & Advanced Surgical Techniques ; ISSN 1092-6429 1557-9034

    2020  

    Keywords Surgery ; covid19
    Language English
    Publisher Mary Ann Liebert Inc
    Publishing country us
    Document type Article ; Online
    DOI 10.1089/lap.2020.0559
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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