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  1. Article ; Online: Is it time to refine HCC surveillance strategies in HCV cured patients?

    D'Ambrosio, Roberta / Lampertico, Pietro

    Hepatology (Baltimore, Md.)

    2022  Volume 76, Issue 1, Page(s) 9–11

    MeSH term(s) Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Humans ; Liver Cirrhosis/epidemiology ; Liver Neoplasms/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-03-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32430
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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: 2022 open day in the University of Milan: An opportunity for HCV screening.

    Aldinio, Giovanni / D'Ambrosio, Roberta / Perrone, Pier M / Castaldi, Silvana

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 4, Page(s) 945–946

    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Mass Screening
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15505
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    Zs.A 1632: Show issues Location:
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  3. Article: Predicting Hepatocellular Carcinoma Risk in Patients with Chronic HCV Infection and a Sustained Virological Response to Direct-Acting Antivirals.

    D'Ambrosio, Roberta / Degasperi, Elisabetta / Lampertico, Pietro

    Journal of hepatocellular carcinoma

    2021  Volume 8, Page(s) 713–739

    Abstract: Chronic infection with hepatitis C virus (HCV) may complicate with hepatocellular carcinoma (HCC), especially in patients with cirrhosis. Although the achievement of a sustained virological response (SVR) had been associated with a reduction in the risk ... ...

    Abstract Chronic infection with hepatitis C virus (HCV) may complicate with hepatocellular carcinoma (HCC), especially in patients with cirrhosis. Although the achievement of a sustained virological response (SVR) had been associated with a reduction in the risk of HCC already in the Interferon era, some concerns initially raised following the use of direct-acting antivirals (DAA), as their use was associated with increased risk of HCC development and aggressiveness. However, studies demonstrated that the risk of HCC was strongly influenced by pre-treatment fibrosis stage and, eventually, prior HCC history more than the type of antiviral therapy. According to published studies, rates of de-novo HCC ranged between 1.4% and 13.6% in patients with cirrhosis or advanced fibrosis vs 0.9% and 5.9% in those with chronic hepatitis C (CHC). Conversely, rates of recurrent HCC were higher, ranging between 3.2% and 49% in cirrhotics vs 0% and 40% in CHC patients. Most studies tried to identify predictors of HCC development, either de-novo or recurrent, and some authors were also able to build predictive scores for HCC risk stratification, which however still need prospective validation. Whereas some clinical features, such as age, gender, presence of comorbidities and fibrosis stage, may influence both de-novo and recurrent HCC, previous tumour burden before DAA seems to prevail over these features in recurrent HCC risk prediction.
    Language English
    Publishing date 2021-06-29
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2780784-8
    ISSN 2253-5969
    ISSN 2253-5969
    DOI 10.2147/JHC.S292139
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  4. Article ; Online: Hepatocellular Carcinoma Risk, Outcomes, and Screening After Hepatitis C Eradication.

    D'Ambrosio, Roberta / Ioannou, George N

    Hepatology communications

    2021  Volume 5, Issue 9, Page(s) 1465–1468

    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Editorial
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1733
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  5. Article ; Online: Editorial: the role for PIVKA-II measurement after HCV elimination by direct-acting antivirals in terms of prediction of hepatocellular carcinoma-authors' reply.

    Degasperi, Elisabetta / D'Ambrosio, Roberta / Lampertico, Pietro

    Alimentary pharmacology & therapeutics

    2021  Volume 55, Issue 1, Page(s) 124–125

    MeSH term(s) Antiviral Agents/therapeutic use ; Biomarkers ; Carcinoma, Hepatocellular/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Liver Neoplasms/drug therapy ; Protein Precursors ; Prothrombin
    Chemical Substances Antiviral Agents ; Biomarkers ; Protein Precursors ; acarboxyprothrombin (53230-14-1) ; Prothrombin (9001-26-7)
    Language English
    Publishing date 2021-12-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16710
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    Zs.A 2206: Show issues Location:
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  6. Article ; Online: Reappraisal of the conventional hemostasis tests as predictors of perioperative bleeding in the era of rebalanced hemostasis in cirrhosis.

    Tripodi, Armando / Primignani, Massimo / D'Ambrosio, Roberta / Tosetti, Giulia / La Mura, Vincenzo / Lampertico, Pietro / Peyvandi, Flora

    Hepatology (Baltimore, Md.)

    2024  

    Abstract: New global laboratory procedures mimicking the in vivo hemostasis process led to the changing paradigm of cirrhosis from the prototype of hemorrhagic diseases to a condition in which hemostasis is normal but fragile, thus justifying the hemorrhagic/ ... ...

    Abstract New global laboratory procedures mimicking the in vivo hemostasis process led to the changing paradigm of cirrhosis from the prototype of hemorrhagic diseases to a condition in which hemostasis is normal but fragile, thus justifying the hemorrhagic/thrombotic tendencies that affect these patients. The new paradigm was instrumental to change the management of cirrhosis. For example, international guidelines warn against the entrenched practice of testing patients with conventional hemostasis tests and infusing those with abnormalities with fresh-frozen plasma, coagulation factor concentrates, or platelets, prior to surgery/invasive procedures. These recommendations are, however, largely disattended. The practice of testing patients with the prothrombin time or viscoelastometry and using arbitrary cutoffs to make decisions on perioperative prophylaxis is still common and probably driven by medicolegal issues. There is no doubt that prothrombin time and congeners tests are unable to predict bleeding in cirrhosis. However, it cannot be excluded that some tests may be useful in patients who are severely decompensated. Large prospective collaborative studies are warranted. Enrolled patients should be randomized to receive perioperative prophylaxis based on laboratory testing (eg, viscoelastometry, thrombomodulin-modified thrombin generation) or to usual care. However, for these trials to be useful, a third group of patients who do not receive prophylaxis should be included. In conclusion, until results from these studies are available, physicians attending cirrhosis should refrain from using laboratory tests with arbitrary cutoffs to make decision on perioperative prophylaxis. Decision should be made by considering the clinical history of individual patients and the risk of hemorrhage of specific procedures.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000756
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  7. Article: Nonalcoholic fatty liver disease: is the IFNL4 rs368234815 variant protective from liver damage?

    Galmozzi, Enrico / D'Ambrosio, Roberta

    Hepatobiliary surgery and nutrition

    2018  Volume 7, Issue 3, Page(s) 209–211

    Language English
    Publishing date 2018-07-03
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2018.03.06
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  8. Article ; Online: Combination of CLIF-OF and CCI predicts survival in patients with cirrhosis and COVID-19.

    Iavarone, Massimo / D'Ambrosio, Roberta / Lampertico, Pietro

    Gut

    2020  Volume 70, Issue 9, Page(s) 1798–1799

    MeSH term(s) Acute-On-Chronic Liver Failure ; COVID-19 ; Fibrosis ; Humans ; Liver Cirrhosis/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2020-322929
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  9. Article ; Online: Reply to: Correspondence on "High rates of 30-day mortality in patients with cirrhosis and COVID-19".

    Iavarone, Massimo / D'Ambrosio, Roberta / Lampertico, Pietro

    Journal of hepatology

    2020  Volume 73, Issue 6, Page(s) 1570–1571

    MeSH term(s) COVID-19 ; Carcinoma, Hepatocellular ; Humans ; Liver Cirrhosis/epidemiology ; Liver Neoplasms ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.08.001
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    Zs.A 2027: Show issues Location:
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  10. Article ; Online: Suboptimal accuracy of GES score to stratify post-SVR HCC risk in a single center cohort of European cirrhotics infected with any HCV genotype.

    Bergna, Irene / Degasperi, Elisabetta / D'Ambrosio, Roberta

    Liver international : official journal of the International Association for the Study of the Liver

    2020  Volume 41, Issue 5, Page(s) 1152–1153

    MeSH term(s) Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Genotype ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Humans ; Liver Cirrhosis/drug therapy ; Liver Neoplasms/drug therapy ; Sustained Virologic Response
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14700
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