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  1. Book ; Audio / Video ; Online: Production of beneficial insects in the Ramacca Biofactory for Biocontrol in citrus fruits (BIOFRUITNET Video)

    Alföldi, Thomas / Verrastro, Vincenzo / D'Angelo, Dario / Calcaterra, Salvatore

    2023  

    Abstract: The Ramacca Biofactory in Sicily breeds beneficial insects for citrus farming. This video presents some of the insects that are produced: The first is a parasitoid called Aphytis melinus. The second is a predator, a ladybird. It is called Cryptolaemus ... ...

    Abstract The Ramacca Biofactory in Sicily breeds beneficial insects for citrus farming. This video presents some of the insects that are produced: The first is a parasitoid called Aphytis melinus. The second is a predator, a ladybird. It is called Cryptolaemus montrouzieri. We will also look at the two species on which these two useful insects are bred (Aspidiotus nerii and Planococcus citri).
    Keywords Biodiversity and ecosystem services ; Fruit and berries ; Crop health ; quality ; protection
    Language English
    Publishing country dk
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Online: Production of beneficial insects in the Ramacca Biofactory for Biocontrol in citrus fruits (BIOFRUITNET Video)

    Alföldi, Thomas / Verrastro, Vincenzo / D'Angelo, Dario / Strano, Antonio / Calcaterra, Salvatore

    2023  

    Abstract: The Ramacca Biofactory in Sicily breeds beneficial insects for citrus farming. This video presents some of the insects that are produced: The first is a parasitoid called Aphytis melinus. The second is a predator, a ladybird. It is called Cryptolaemus ... ...

    Abstract The Ramacca Biofactory in Sicily breeds beneficial insects for citrus farming. This video presents some of the insects that are produced: The first is a parasitoid called Aphytis melinus. The second is a predator, a ladybird. It is called Cryptolaemus montrouzieri. We will also look at the two species on which these two useful insects are bred (Aspidiotus nerii and Planococcus citri).
    Keywords Biodiversity and ecosystem services ; Fruit and berries ; Crop health ; quality ; protection
    Language Italian
    Publishing country dk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells.

    Soprano, Maria / Sorriento, Daniela / Rusciano, Maria Rosaria / Maione, Angela Serena / Limite, Gennaro / Forestieri, Pietro / D'Angelo, Dario / D'Alessio, Matteo / Campiglia, Pietro / Formisano, Pietro / Iaccarino, Guido / Bianco, Roberto / Illario, Maddalena

    PloS one

    2016  Volume 11, Issue 6, Page(s) e0155970

    Abstract: The discovery of the anti-proliferative activity of nelfinavir in HIV-free models has encouraged its investigation as anticancer drug. Although the molecular mechanism by which nelfinavir exerts antitumor activity is still unknown, its effects have been ... ...

    Abstract The discovery of the anti-proliferative activity of nelfinavir in HIV-free models has encouraged its investigation as anticancer drug. Although the molecular mechanism by which nelfinavir exerts antitumor activity is still unknown, its effects have been related to Akt inhibition. Here we tested the effects of nelfinavir on cell proliferation, viability and death in two human breast cancer cell lines and in human normal primary breast cells. To identify the mechanism of action of nelfinavir in breast cancer, we evaluated the involvement of the Akt pathway as well as the effects of nelfinavir on reactive oxygen species (ROS) production and ROS-related enzymes activities. Nelfinavir reduced breast cancer cell viability by inducing apoptosis and necrosis, without affecting primary normal breast cells. The antitumor activity of nelfinavir was related to alterations of the cell redox state, coupled with an increase of intracellular ROS production limited to cancer cells. Nelfinavir treated tumor cells also displayed a downregulation of the Akt pathway due to disruption of the Akt-HSP90 complex, and subsequent degradation of Akt. These effects resulted to be ROS dependent, suggesting that ROS production is the primary step of nelfinavir anticancer activity. The analysis of ROS-producers and ROS-detoxifying enzymes revealed that nelfinavir-mediated ROS production was strictly linked to flavoenzymes activation. We demonstrated that ROS enhancement represents the main molecular mechanism required to induce cell death by nelfinavir in breast cancer cells, thus supporting the development of new and more potent oxidizing molecules for breast cancer therapy.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Female ; HIV Protease Inhibitors/pharmacology ; Humans ; Nelfinavir/pharmacology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Tumor Cells, Cultured
    Chemical Substances Antineoplastic Agents ; HIV Protease Inhibitors ; Reactive Oxygen Species ; Nelfinavir (HO3OGH5D7I)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0155970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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