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  1. AU="D'Angelo, Lisa"
  2. AU="Woolfork, De'Marcus D"
  3. AU="Niikura, Masahiro"
  4. AU="Casula, Katia"
  5. AU="Monica Capogiri"
  6. AU="Seon-Hwa Kim"
  7. AU="de Souza, Sibele Pinheiro"
  8. AU="Agnès Sartor"
  9. AU="Donda, Alena"
  10. AU="Park, B H"
  11. AU="Leishman, Stuart"
  12. AU="Somma McGivney, Melissa A"
  13. AU="Li, Zhongmei"
  14. AU="Tal Noy-Porat"
  15. AU="Via, Jeremy"
  16. AU="Farshad Moradi Kashkooli"
  17. AU="Doaa Ebrahim"
  18. AU="Rangarajan, Amith"
  19. AU="Alonso-Sánchez, Jesús"
  20. AU="Zhuo, J C"
  21. AU="Pazurek, Angelica" AU="Pazurek, Angelica"
  22. AU=Sundararaman T
  23. AU="Singla, Amit Kumar"
  24. AU="Shu, Ran"
  25. AU="Kim, Jiha"
  26. AU="MacDonald, Suzanne E."
  27. AU="Heather Limburg"
  28. AU="Gross, Boris"
  29. AU="Perkins, George H"
  30. AU="Jormanainen, J"
  31. AU="Pichardo-González, Priamo A"
  32. AU="Cannegieter, Suzanne"
  33. AU="Trocino, Giuseppe"
  34. AU="Emiliano, Thais Moura"
  35. AU=Sinelli Mariateresa
  36. AU="De-guo LÜ"
  37. AU="Benoit-Pilven, Clara"
  38. AU="Lanza, Stefania"
  39. AU="Chilingarian, A"
  40. AU="Baldovini, Nicolas"
  41. AU="López Rodríguez, David"
  42. AU="Alexander König"
  43. AU="Jakobsen, Henrik L"
  44. AU="Yong-Zhao Dai"
  45. AU="Tara L. Pukala"
  46. AU="Addo‐Danso, Shalom D."
  47. AU=Ficheux Q.
  48. AU="Tomoyo Sawada"
  49. AU="Mohammad Kawsar Sharif Siam"
  50. AU=Kushnareva Yulia
  51. AU="Canova, Christopher T"
  52. AU="Hasnaoui, Naoual"
  53. AU="Maradana, Jhansi"
  54. AU="Raggini, Elisa"
  55. AU="Baxter, A."
  56. AU="Jackson, Shirnae"
  57. AU="Schenzle, Lisa"
  58. AU="Veronica Phillips"
  59. AU="Braun, Jörg"
  60. AU="Cassandra E. Holbert"
  61. AU="Trevisan Alexandra"

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  1. Artikel: Unusual Cardiac Manifestations of a Pheochromocytoma in a Girl.

    D'Angelo, Lisa / Parent, Anne-Simone / Derwael, Céline / Hustinx, Roland / Seghaye, Marie-Christine

    Pediatric reports

    2023  Band 15, Heft 1, Seite(n) 237–244

    Abstract: We report the case of an 11-year-old girl who complained about severe asthenia, orthostatic dizziness and abdominal pain for 4 weeks. The primary investigation concluded on febrile urinary tract infection treated by antibiotics. Symptom persistence ... ...

    Abstract We report the case of an 11-year-old girl who complained about severe asthenia, orthostatic dizziness and abdominal pain for 4 weeks. The primary investigation concluded on febrile urinary tract infection treated by antibiotics. Symptom persistence prompted cardiological and endocrinological investigations. A fluctuation in blood pressure, long QT interval, dilation of the aortic root and left ventricular hypertrophy were documented. Elevated levels of urinary catecholamines together with the presence of a right-sided adrenal mass shown via abdominal ultrasound and magnetic resonance imaging were highly suggestive of a pheochromocytoma. This was confirmed by through iodine-123-metaiodobenzylguathdine ([
    Sprache Englisch
    Erscheinungsdatum 2023-03-17
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric15010019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Playing a first-person shooter video game induces neuroplastic change.

    Wu, Sijing / Cheng, Cho Kin / Feng, Jing / D'Angelo, Lisa / Alain, Claude / Spence, Ian

    Journal of cognitive neuroscience

    2012  Band 24, Heft 6, Seite(n) 1286–1293

    Abstract: Playing a first-person shooter (FPS) video game alters the neural processes that support spatial selective attention. Our experiment establishes a causal relationship between playing an FPS game and neuroplastic change. Twenty-five participants completed ...

    Abstract Playing a first-person shooter (FPS) video game alters the neural processes that support spatial selective attention. Our experiment establishes a causal relationship between playing an FPS game and neuroplastic change. Twenty-five participants completed an attentional visual field task while we measured ERPs before and after playing an FPS video game for a cumulative total of 10 hr. Early visual ERPs sensitive to bottom-up attentional processes were little affected by video game playing for only 10 hr. However, participants who played the FPS video game and also showed the greatest improvement on the attentional visual field task displayed increased amplitudes in the later visual ERPs. These potentials are thought to index top-down enhancement of spatial selective attention via increased inhibition of distractors. Individual variations in learning were observed, and these differences show that not all video game players benefit equally, either behaviorally or in terms of neural change.
    Mesh-Begriff(e) Adolescent ; Adult ; Evoked Potentials, Visual/physiology ; Female ; Humans ; Male ; Neuronal Plasticity/physiology ; Photic Stimulation/methods ; Play and Playthings/psychology ; Psychomotor Performance/physiology ; Video Games/psychology ; Visual Perception/physiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2012-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_00192
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Metabotropic glutamate receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca²⁺ wave-dependent activation of SK and TRPC channels.

    El-Hassar, Lynda / Hagenston, Anna M / D'Angelo, Lisa Bertetto / Yeckel, Mark F

    The Journal of physiology

    2011  Band 589, Heft Pt 13, Seite(n) 3211–3229

    Abstract: Group I metabotropic glutamate receptors (mGluRs) play an essential role in cognitive function. Their activation results in a wide array of cellular and molecular responses that are mediated by multiple signalling cascades. In this study, we focused on ... ...

    Abstract Group I metabotropic glutamate receptors (mGluRs) play an essential role in cognitive function. Their activation results in a wide array of cellular and molecular responses that are mediated by multiple signalling cascades. In this study, we focused on Group I mGluR activation of IP3R-mediated intracellular Ca2+ waves and their role in activating Ca2+-dependent ion channels in CA1 pyramidal neurons. Using whole-cell patch-clamp recordings and high-speed Ca2+ fluorescence imaging in acute hippocampal brain slices, we show that synaptic and pharmacological stimulation of mGluRs triggers intracellular Ca2+ waves and a biphasic electrical response composed of a transient Ca2+-dependent SK channel-mediated hyperpolarization and a TRPC-mediated sustained depolarization. The generation and magnitude of the SK channel-mediated hyperpolarization depended solely on the rise in intracellular Ca2+ concentration ([Ca2+]i), whereas the TRPC channel-mediated depolarization required both a small rise in [Ca2+]i and mGluR activation. Furthermore, the TRPC-mediated current was suppressed by forskolin-induced rises in cAMP. We also show that SK- and TRPC-mediated currents robustly modulate pyramidal neuron excitability by decreasing and increasing their firing frequency, respectively. These findings provide additional evidence that mGluR-mediated synaptic transmission makes an important contribution to regulating the output of hippocampal neurons through intracellular Ca2+ wave activation of SK and TRPC channels. cAMP provides an additional level of regulation by modulating TRPC-mediated sustained depolarization that we propose to be important for stabilizing periods of sustained firing.
    Mesh-Begriff(e) Action Potentials/physiology ; Animals ; CA1 Region, Hippocampal/physiology ; Calcium Signaling/physiology ; Male ; Neurons/physiology ; Pyramidal Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/physiology ; Small-Conductance Calcium-Activated Potassium Channels/physiology ; TRPC Cation Channels/physiology
    Chemische Substanzen Receptors, Metabotropic Glutamate ; Small-Conductance Calcium-Activated Potassium Channels ; TRPC Cation Channels ; metabotropic glutamate receptor type 1
    Sprache Englisch
    Erscheinungsdatum 2011-05-16
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2011.209783
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Inositol-1,4,5-trisphosphate receptor-mediated Ca2+ waves in pyramidal neuron dendrites propagate through hot spots and cold spots.

    Fitzpatrick, John S / Hagenston, Anna M / Hertle, Daniel N / Gipson, Keith E / Bertetto-D'Angelo, Lisa / Yeckel, Mark F

    The Journal of physiology

    2009  Band 587, Heft Pt 7, Seite(n) 1439–1459

    Abstract: We studied inositol-1,4,5-trisphosphate (IP(3)) receptor-dependent intracellular Ca(2+) waves in CA1 hippocampal and layer V medial prefrontal cortical pyramidal neurons using whole-cell patch-clamp recordings and Ca(2+) fluorescence imaging. We observed ...

    Abstract We studied inositol-1,4,5-trisphosphate (IP(3)) receptor-dependent intracellular Ca(2+) waves in CA1 hippocampal and layer V medial prefrontal cortical pyramidal neurons using whole-cell patch-clamp recordings and Ca(2+) fluorescence imaging. We observed that Ca(2+) waves propagate in a saltatory manner through dendritic regions where increases in the intracellular concentration of Ca(2+) ([Ca(2+)](i)) were large and fast ('hot spots') separated by regions where increases in [Ca(2+)](i) were comparatively small and slow ('cold spots'). We also observed that Ca(2+) waves typically initiate in hot spots and terminate in cold spots, and that most hot spots, but few cold spots, are located at dendritic branch points. Using immunohistochemistry, we found that IP(3) receptors (IP(3)Rs) are distributed in clusters along pyramidal neuron dendrites and that the distribution of inter-cluster distances is nearly identical to the distribution of inter-hot spot distances. These findings support the hypothesis that the dendritic locations of Ca(2+) wave hot spots in general, and branch points in particular, are specially equipped for regenerative IP(3)R-dependent internal Ca(2+) release. Functionally, the observation that IP(3)R-dependent [Ca(2+)](i) rises are greater at branch points raises the possibility that this novel Ca(2+) signal may be important for the regulation of Ca(2+)-dependent processes in these locations. Futhermore, the observation that Ca(2+) waves tend to fail between hot spots raises the possibility that influences on Ca(2+) wave propagation may determine the degree of functional association between distinct Ca(2+)-sensitive dendritic domains.
    Mesh-Begriff(e) Action Potentials ; Animals ; Calcium Signaling/drug effects ; Dendrites/drug effects ; Dendrites/metabolism ; Electric Stimulation ; Excitatory Amino Acid Agonists/pharmacology ; Immunohistochemistry ; In Vitro Techniques ; Inositol 1,4,5-Trisphosphate/metabolism ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Kinetics ; Male ; Microscopy, Fluorescence ; Patch-Clamp Techniques ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/metabolism ; Synaptic Transmission/drug effects
    Chemische Substanzen Excitatory Amino Acid Agonists ; Inositol 1,4,5-Trisphosphate Receptors ; Receptors, Metabotropic Glutamate ; Inositol 1,4,5-Trisphosphate (85166-31-0)
    Sprache Englisch
    Erscheinungsdatum 2009-02-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2009.168930
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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