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  1. Article ; Online: Smartphone Screen Integrated Optical Breathalyzer.

    Lapointe, Jerome / Bécotte-Boutin, Hélène-Sarah / Gagnon, Stéphane / Levasseur, Simon / Labranche, Philippe / D'Auteuil, Marc / Abdellatif, Manel / Li, Ming-Jun / Vallée, Réal

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 12

    Abstract: One third of fatal car accidents and so many tragedies are due to alcohol abuse. These sad numbers could be mitigated if everyone had access to a breathalyzer anytime and anywhere. Having a breathalyzer built into a phone or wearable technology could be ... ...

    Abstract One third of fatal car accidents and so many tragedies are due to alcohol abuse. These sad numbers could be mitigated if everyone had access to a breathalyzer anytime and anywhere. Having a breathalyzer built into a phone or wearable technology could be the way to get around reluctance to carry a separate device. With this goal, we propose an inexpensive breathalyzer that could be integrated in the screens of mobile devices. Our technology is based on the evaporation rate of the fog produced by the breath on the phone screen, which increases with increasing breath alcohol content. The device simply uses a photodiode placed on the side of the screen to measure the signature of the scattered light intensity from the phone display that is guided through the stress layer of the Gorilla glass screen. A part of the display light is coupled to the stress layer via the evanescent field induced at the edge of the breath microdroplets. We demonstrate that the intensity signature measured at the detector can be linked to blood alcohol content. We fabricated a prototype in a smartphone case powered by the phone's battery, controlled by an application installed on the smartphone, and tested it in real-world environments. Limitations and future work toward a fully operational device are discussed.
    MeSH term(s) Blood Alcohol Content ; Breath Tests ; Light ; Smartphone ; Wearable Electronic Devices
    Chemical Substances Blood Alcohol Content
    Language English
    Publishing date 2021-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21124076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Watt-level erbium-doped all-fiber laser at 3.44 μm.

    Fortin, Vincent / Maes, Frédéric / Bernier, Martin / Bah, Souleymane Toubou / D'Auteuil, Marc / Vallée, Réal

    Optics letters

    2016  Volume 41, Issue 3, Page(s) 559–562

    Abstract: We demonstrate a 3.44 μm all-fiber laser emitting a maximum of 1.5 W at room temperature, the highest continuous power ever generated from a mid-IR fiber oscillator clearly beyond 3 μm. The laser operates on the 4F(9/2)→4I(9/2) transition of erbium-doped ...

    Abstract We demonstrate a 3.44 μm all-fiber laser emitting a maximum of 1.5 W at room temperature, the highest continuous power ever generated from a mid-IR fiber oscillator clearly beyond 3 μm. The laser operates on the 4F(9/2)→4I(9/2) transition of erbium-doped fluoride glasses and relies on a dual pumping scheme at 974 and 1976 nm. By combining a dichroic mirror deposited on the input fiber tip and a fiber Bragg grating as an output coupler, a stable laser emission is produced with a FWHM bandwidth of less than 0.6 nm. The laser cavity has an efficiency of 19% with respect to the launched pump power at 1976 nm and no saturation is observed provided 974 nm co-pumping is sufficient. The joint effect of the two pumps is also investigated.
    MeSH term(s) Erbium ; Lasers, Semiconductor ; Optical Fibers
    Chemical Substances Erbium (77B218D3YE)
    Language English
    Publishing date 2016-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.41.000559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fabrication of high-quality VO2 thin films by ion-assisted dual ac magnetron sputtering.

    Ba, Cheikhou / Bah, Souleymane T / D'Auteuil, Marc / Ashrit, P V / Vallée, Réal

    ACS applied materials & interfaces

    2013  Volume 5, Issue 23, Page(s) 12520–12525

    Abstract: The technique of cathodic ac dual magnetron sputtering along with the high energy ionic bombardment is known to yield high-quality thin films in terms of their uniformity and high density. This technique has been applied for the first time to achieve ... ...

    Abstract The technique of cathodic ac dual magnetron sputtering along with the high energy ionic bombardment is known to yield high-quality thin films in terms of their uniformity and high density. This technique has been applied for the first time to achieve thermochromic VO2 thin films that show a high optical and electrical contrast between normal and switched states. In this two-step process Vanadium metal films were deposited and subsequently oxidized in optimum conditions to achieve stoichiometric VO2 films. Typical films switched between more than 40 % to less than 5 % transmission in the infrared region while undergoing an electrical sheet resistance change between 1 × 10(5) and 1 × 10(2) Ω/cm(2). The application potential of such VO2 films in integrated optics is deemed high.
    Language English
    Publishing date 2013-12-11
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/am403807u
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Improvement of the lateral-mode discrimination of broad-area diode lasers with a profiled reflectivity output facet.

    Stryckman, D / Rousseau, G / D'Auteuil, M / McCarthy, N

    Applied optics

    1996  Volume 35, Issue 30, Page(s) 5955–5959

    Abstract: The emission of a broad-area laser always contains several lateral modes (along the junction plane) even at low drive levels. To increase the discrimination against high-order lateral modes, we developed simple techniques for depositing a profiled thin ... ...

    Abstract The emission of a broad-area laser always contains several lateral modes (along the junction plane) even at low drive levels. To increase the discrimination against high-order lateral modes, we developed simple techniques for depositing a profiled thin layer of SiO on the output facet of a broad-area laser that has a 75-μm-wide injection current stripe. The profiled coating provided a nearly Gaussian reflectivity in the lateral direction (parallel to the junction plane). The resolved near-field spectra of the uncoated and coated lasers have been compared. The maximum output power in the single-lateral-mode regime was pushed to 25 mW with the profiled coating, compared with a corresponding power of less than 1 mW before deposition. Experimental results have confirmed the behavior predicted by our numerical simulations. This method is scalable to higher-power lasers.
    Language English
    Publishing date 1996-10-20
    Publishing country United States
    Document type Journal Article
    ISSN 1559-128X
    ISSN 1559-128X
    DOI 10.1364/AO.35.005955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.

    Sleckman, B P / Bassing, C H / Hughes, M M / Okada, A / D'Auteuil, M / Wehrly, T D / Woodman, B B / Davidson, L / Chen, J / Alt, F W

    Proceedings of the National Academy of Sciences of the United States of America

    2000  Volume 97, Issue 14, Page(s) 7975–7980

    Abstract: T cell receptor (TCR) beta variable region genes are assembled in progenitor T cells from germ-line Vbeta, Dbeta, and Jbeta segments via an ordered two-step process in which Dbeta to Jbeta rearrangements occur on both alleles before appendage of a Vbeta ... ...

    Abstract T cell receptor (TCR) beta variable region genes are assembled in progenitor T cells from germ-line Vbeta, Dbeta, and Jbeta segments via an ordered two-step process in which Dbeta to Jbeta rearrangements occur on both alleles before appendage of a Vbeta to a preexisting DJbeta complex. Direct joining of Vbeta segments to nonrearranged Dbeta or Jbeta segments, while compatible with known restrictions on the V(D)J recombination mechanism, are infrequent within the endogenous TCRbeta locus. We have analyzed mechanisms that mediate ordered Vbeta, Dbeta, and Jbeta assembly via an approach in which TCRbeta minilocus recombination substrates were introduced into embryonic stem cells and then analyzed for rearrangement in normal thymocytes by recombinase-activating gene 2-deficient blastocyst complementation. These analyses demonstrated that Vbeta segments are preferentially targeted for rearrangement to Dbeta as opposed to Jbeta segments. In addition, we further demonstrated that Vbeta segments can be appended to nonrearranged endogenous Dbeta segments in which we have eliminated the ability of Dbeta segments to join to Jbeta segments. Our findings are discussed in the context of the mechanisms that regulate the ordered assembly and utilization of V, D, and J segments.
    MeSH term(s) Animals ; Cell Lineage ; Chimera ; DNA-Binding Proteins/genetics ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor ; Genes, T-Cell Receptor beta ; Genetic Complementation Test ; Mice ; Models, Genetic ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Recombination, Genetic
    Chemical Substances DNA-Binding Proteins ; Rag2 protein, mouse ; Receptors, Antigen, T-Cell, alpha-beta ; V(D)J recombination activating protein 2
    Language English
    Publishing date 2000-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.130190597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

    Bassing, C H / Alt, F W / Hughes, M M / D'Auteuil, M / Wehrly, T D / Woodman, B B / Gärtner, F / White, J M / Davidson, L / Sleckman, B P

    Nature

    2000  Volume 405, Issue 6786, Page(s) 583–586

    Abstract: The genes encoding the variable regions of lymphocyte antigen receptors are assembled from variable (V), diversity (D) and joining (J) gene segments. V(D)J recombination is initiated by the recombinase activating gene (RAG)-1 and -2 proteins, which ... ...

    Abstract The genes encoding the variable regions of lymphocyte antigen receptors are assembled from variable (V), diversity (D) and joining (J) gene segments. V(D)J recombination is initiated by the recombinase activating gene (RAG)-1 and -2 proteins, which introduce DNA double-strand breaks between the V, D and J segments and their flanking recombination signal sequences (RSSs). Generally expressed DNA repair proteins then carry out the joining reaction. The conserved heptamer and nonamer sequences of the RSSs are separated by non-conserved spacers of 12 or 23 base pairs (forming 12-RSSs and 23-RSSs). The 12/23 rule, which is mediated at the level of RAG-1/2 recognition and cutting, specifies that V(D)J recombination occurs only between a gene segment flanked by a 12-RSS and one flanked by a 23-RSS. Vbeta segments are appended to DJbeta rearrangements, with little or no direct Vbeta to Jbeta joining, despite 12/23 compatibility of Vbeta 23-RSSs and Jbeta12-RSSs. Here we use embryonic stem cells and mice with a modified T-cell receptor (TCR)beta locus containing only one Dbeta (Dbeta1) gene segment and one Jbeta (Jbeta1) gene cluster to show that the 5' Dbeta1 12-RSS, but not the Jbeta1 12-RSSs, targets rearrangement of a diverse Vbeta repertoire. This targeting is precise and position-independent. This additional restriction on V(D)J recombination has important implications for the regulation of variable region gene assembly and repertoire development.
    MeSH term(s) Alleles ; Animals ; Cell Line ; Chimera ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor ; Hybridomas ; Mice ; Multigene Family ; Mutagenesis ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Recombination, Genetic ; Stem Cells
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2000-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/35014635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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