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Article ; Online: SARS-CoV-2 as a Trigger for De Novo Ulcerative Colitis.

Imperatore, Nicola / Bennato, Raffaele / D'Avino, Alfredo / Lombardi, Giovanni / Manguso, Francesco

2021 Volume 27, Issue 7, Page(s) e87–e88

MeSH term(s)	COVID-19/complications ; COVID-19/transmission ; COVID-19/virology ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/etiology ; Colitis, Ulcerative/pathology ; Humans ; Male ; Middle Aged ; Prognosis ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-02-16
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izab040
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Article ; Online: Vasari Scoring System in Discerning between Different Degrees of Glioma and IDH Status Prediction: A Possible Machine Learning Application?

Gemini, Laura / Tortora, Mario / Giordano, Pasqualina / Prudente, Maria Evelina / Villa, Alessandro / Vargas, Ottavia / Giugliano, Maria Francesca / Somma, Francesco / Marchello, Giulia / Chiaramonte, Carmela / Gaetano, Marcella / Frio, Federico / Di Giorgio, Eugenio / D'Avino, Alfredo / Tortora, Fabio / D'Agostino, Vincenzo / Negro, Alberto

Journal of imaging

2023 Volume 9, Issue 4

Abstract: 1) The aim of our study is to evaluate the capacity of the Visually AcceSAble Rembrandt Images (VASARI) scoring system in discerning between the different degrees of glioma and Isocitrate Dehydrogenase (IDH) status predictions, with a possible ... ...

Abstract	(1) The aim of our study is to evaluate the capacity of the Visually AcceSAble Rembrandt Images (VASARI) scoring system in discerning between the different degrees of glioma and Isocitrate Dehydrogenase (IDH) status predictions, with a possible application in machine learning. (2) A retrospective study was conducted on 126 patients with gliomas (M/F = 75/51; mean age: 55.30), from which we obtained their histological grade and molecular status. Each patient was analyzed with all 25 features of VASARI, blinded by two residents and three neuroradiologists. The interobserver agreement was assessed. A statistical analysis was conducted to evaluate the distribution of the observations using a box plot and a bar plot. We then performed univariate and multivariate logistic regressions and a Wald test. We also calculated the odds ratios and confidence intervals for each variable and the evaluation matrices with receiver operating characteristic (ROC) curves in order to identify cut-off values that are predictive of a diagnosis. Finally, we did the Pearson correlation test to see if the variables grade and IDH were correlated. (3) An excellent ICC estimate was obtained. For the grade and IDH status prediction, there were statistically significant results by evaluation of the degree of post-contrast impregnation (F4) and the percentage of impregnated area (F5), not impregnated area (F6), and necrotic (F7) tissue. These models showed good performances according to the area under the curve (AUC) values (>70%). (4) Specific MRI features can be used to predict the grade and IDH status of gliomas, with important prognostic implications. The standardization and improvement of these data (aim: AUC > 80%) can be used for programming machine learning software.
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2824270-1
ISSN	2313-433X ; 2313-433X
ISSN (online)	2313-433X
ISSN	2313-433X
DOI	10.3390/jimaging9040075
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Article: Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors.

Di Francia, Raffaele / Berretta, Massimiliano / Benincasa, Giulio / D'Avino, Alfredo / Facchini, Sergio / Costagliola, Domenico / Rossi, Paola

Cells

2019 Volume 8, Issue 6

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Dietary Supplements ; Drug Interactions ; Humans ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/physiopathology ; Pharmacogenetics ; Vascular Endothelial Growth Factor A/genetics
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2019-05-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409
ISSN	2073-4409
DOI	10.3390/cells8060522
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Article: Potential role of electrochemotherapy for the treatment of soft tissue sarcoma: first insights from preclinical studies in animals.

Spugnini, Enrico P / Citro, Gennaro / D'Avino, Alfredo / Baldi, Alfonso

The international journal of biochemistry & cell biology

2008 Volume 40, Issue 2, Page(s) 159–163

Abstract: Local management of soft tissue sarcoma in humans generally involves multi-modality approaches whose cornerstones are surgery combined with radiation therapy. The usual radiation protocols are based on preoperative, intraoperative, or postoperative ... ...

Abstract	Local management of soft tissue sarcoma in humans generally involves multi-modality approaches whose cornerstones are surgery combined with radiation therapy. The usual radiation protocols are based on preoperative, intraoperative, or postoperative external beam treatment or adjuvant brachytherapy. The aim of these strategies is to maximize tumor control while minimizing side effects, especially in the case of limb sarcomas. Unfortunately, the rate of local wound complication associated with aggressive surgical management and radiation therapy are still elevated. Electrochemotherapy is an anticancer technique that gained popularity over the past 15 years. It involves the administration of anticancer agents to the application of permeabilizing pulses so to increase the uptake of antitumor molecules. Goal of this review is to underline the advances in this field obtained from animal studies in order to point out the possible therapeutic applications of this technique for the treatment of soft tissue sarcomas in humans.
MeSH term(s)	Animals ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Electrochemotherapy ; Humans ; Models, Biological ; Sarcoma/drug therapy ; Sarcoma/pathology ; Soft Tissue Neoplasms/drug therapy ; Soft Tissue Neoplasms/pathology
Language	English
Publishing date	2008
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1228429-4
ISSN	1878-5875 ; 1357-2725
ISSN (online)	1878-5875
ISSN	1357-2725
DOI	10.1016/j.biocel.2007.10.005
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Article ; Online: Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance

Citro Gennaro / Mudrov Nikolay / Dotsinsky Ivan / Spugnini Enrico P / D'Avino Alfredo / Baldi Alfonso

Journal of Experimental & Clinical Cancer Research, Vol 27, Iss 1, p

Sticker sarcoma

2008 Volume 58

Abstract: Abstract Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic spread. The most common locations ... ...

Abstract	Abstract Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic spread. The most common locations are the genitals, the nose, the perianal area. Standard treatment consists with chemotherapy with vincristine, however other therapies such as, cryotherapy, immunotherapy or, in selected cases, radiation therapy, have been reported. In this article we describe the outcome of a small cohort of canine patients, with chemotherapy resistant transmissible venereal tumor (TVT), treated with bleomycin selectively driven by trains of biphasic pulses (electrochemotherapy). Three canine patients, with refractory TVT, entered the study and received two sessions of ECT under sedation. The pets had local injection of bleomycin at the concentration of 1.5 mg/ml and five minutes after the chemotherapy, trains of 8 biphasic electric pulses lasting 50 + 50 μs each, with 1 ms interpulse intervals, were delivered by means of modified caliper or, for difficult districts, through paired needle electrode. All the patients responded to the treatment and are still in remission at different times. Electrochemotherapy appears as a safe and efficacious modality for the treatment of TVT and warrants further investigations.
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2008-11-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Rectovaginal septum endometriosis: an immunohistochemical analysis of 62 cases.

Signorile, Pietro G / Campioni, Mara / Vincenzi, Bruno / D'Avino, Alfredo / Baldi, Alfonso

In vivo (Athens, Greece)

2009 Volume 23, Issue 3, Page(s) 459–464

Abstract: Deep infiltrating endometriosis of rectovaginal septum is a particular form of endometriosis located under the peritoneal surface. This kind of lesions are very active and strongly associated with pelvic pain symptoms. A study on 62 cases of rectovaginal ...

Abstract	Deep infiltrating endometriosis of rectovaginal septum is a particular form of endometriosis located under the peritoneal surface. This kind of lesions are very active and strongly associated with pelvic pain symptoms. A study on 62 cases of rectovaginal septum endometriosis by means of immunohistochemistry was conducted in order to evaluate the oestrogen and progesterone receptor levels in these cases and to correlate them to the level of vascularization (CD34 expression) and the amount of nerve fibres (S100 expression). Data showed great heterogeneity in the expression of all the parameters analyzed. Nevertheless, by using Spearman correlation test to assess relationship among oestrogen and progesterone receptors, S100 and CD34 staining, a significant direct correlation was found between all the parameters analyzed. These observations sustain the hypothesis that oestrogen and progesterone play an important role in the genesis of endometriotic glands, in the vascularization and in the proliferation of nerves.
MeSH term(s)	Endometriosis/metabolism ; Endometriosis/pathology ; Female ; Humans ; Immunohistochemistry ; Rectum/pathology ; Retrospective Studies ; Vagina/pathology
Language	English
Publishing date	2009-05
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
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Article ; Online: Embryologic origin of endometriosis: analysis of 101 human female fetuses.

Signorile, Pietro G / Baldi, Feliciano / Bussani, Rossana / Viceconte, Rosa / Bulzomi, Pamela / D'Armiento, Mariarosaria / D'Avino, Alfredo / Baldi, Alfonso

Journal of cellular physiology

2012 Volume 227, Issue 4, Page(s) 1653–1656

Abstract: The etiology of endometriosis, a gynecological disease characterized by the presence of endometrial glands and stroma outside the uterine cavity, is still unknown. Our research group has recently demonstrated the presence of ectopic endometrium in human ... ...

Abstract	The etiology of endometriosis, a gynecological disease characterized by the presence of endometrial glands and stroma outside the uterine cavity, is still unknown. Our research group has recently demonstrated the presence of ectopic endometrium in human female fetuses at different gestational ages. In this manuscript we describe four new cases of fetal endometriosis found among a series of 52 female fetuses analyzed at autopsy. The anatomical localization of this ectopic endometrium, and its histological and immunohistochemical characteristics are depicted. We suggest that endometriosis is caused by dislocation of primitive endometrial tissue outside the uterine cavity during organogenesis. The clinical and pathological implications of these findings are discussed.
MeSH term(s)	Endometriosis/embryology ; Endometriosis/etiology ; Endometriosis/metabolism ; Endometriosis/pathology ; Female ; Genitalia, Female/embryology ; Gestational Age ; Humans ; Immunohistochemistry ; Neprilysin/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects ; Receptors, Estrogen/metabolism
Chemical Substances	Receptors, Estrogen ; Neprilysin (EC 3.4.24.11)
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.22888
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Article ; Online: Intraoral lymphoepithelial carcinoma of the minor salivary glands.

Menditti, Dardo / Laino, Luigi / Milano, Massimiliano / Caputo, Cristian / Boccellino, Mariarosaria / D'Avino, Alfredo / Baldi, Alfonso

In vivo (Athens, Greece)

2012 Volume 26, Issue 6, Page(s) 1087–1089

Abstract: The occurrence of lymphoepithelial carcinoma in the oral cavity is extremely rare and a case with involvement of minor salivary glands is very uncommon. We describe a case of LELC of the oral cavity with involvement of the upper lip and of minor salivary ...

Abstract	The occurrence of lymphoepithelial carcinoma in the oral cavity is extremely rare and a case with involvement of minor salivary glands is very uncommon. We describe a case of LELC of the oral cavity with involvement of the upper lip and of minor salivary glands. The tumour was described at the clinical and instrumental level; moreover, its histopathological phenotype was defined. Finally, the problems of differential diagnosis and the most appropriate therapeutic approaches are discussed.
MeSH term(s)	Carcinoma/diagnosis ; Carcinoma/pathology ; Carcinoma/surgery ; Diagnosis, Differential ; Herpesvirus 4, Human ; Humans ; Lip/pathology ; Lip/surgery ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/pathology ; Salivary Gland Neoplasms/surgery ; Salivary Glands, Minor/pathology ; Salivary Glands, Minor/surgery
Language	English
Publishing date	2012-11
Publishing country	Greece
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
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Article ; Online: Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance: Sticker sarcoma.

Spugnini, Enrico P / Dotsinsky, Ivan / Mudrov, Nikolay / Citro, Gennaro / D'Avino, Alfredo / Baldi, Alfonso

Journal of experimental & clinical cancer research : CR

2008 Volume 27, Page(s) 58

Abstract: Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic spread. The most common locations are the ... ...

Abstract	Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic spread. The most common locations are the genitals, the nose, the perianal area. Standard treatment consists with chemotherapy with vincristine, however other therapies such as, cryotherapy, immunotherapy or, in selected cases, radiation therapy, have been reported. In this article we describe the outcome of a small cohort of canine patients, with chemotherapy resistant transmissible venereal tumor (TVT), treated with bleomycin selectively driven by trains of biphasic pulses (electrochemotherapy). Three canine patients, with refractory TVT, entered the study and received two sessions of ECT under sedation. The pets had local injection of bleomycin at the concentration of 1.5 mg/ml and five minutes after the chemotherapy, trains of 8 biphasic electric pulses lasting 50 + 50 mus each, with 1 ms interpulse intervals, were delivered by means of modified caliper or, for difficult districts, through paired needle electrode. All the patients responded to the treatment and are still in remission at different times. Electrochemotherapy appears as a safe and efficacious modality for the treatment of TVT and warrants further investigations.
MeSH term(s)	Anal Gland Neoplasms/drug therapy ; Anal Gland Neoplasms/pathology ; Animals ; Antibiotics, Antineoplastic/therapeutic use ; Bleomycin/therapeutic use ; Combined Modality Therapy ; Disease Models, Animal ; Dog Diseases/drug therapy ; Dog Diseases/pathology ; Dogs ; Electrochemotherapy/veterinary ; Male ; Sarcoma/drug therapy ; Sarcoma/pathology ; Sarcoma/veterinary ; Venereal Tumors, Veterinary/drug therapy
Chemical Substances	Antibiotics, Antineoplastic ; Bleomycin (11056-06-7)
Language	English
Publishing date	2008-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/1756-9966-27-58
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Article ; Online: Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy

Bonetto Francesco / D'Avino Alfredo / Feroce Florinda / Mellone Pasquale / Baldi Feliciano / Spugnini Enrico P / Vincenzi Bruno / Citro Gennaro / Baldi Alfonso

Journal of Translational Medicine, Vol 5, Iss 1, p

preclinical data for the standardization of this treatment in pets and humans

2007 Volume 48

Abstract: Abstract Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of appropriate waveforms. The ... ...

Abstract	Abstract Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of appropriate waveforms. The increased uptake of chemotherapy leads to apoptotic death of the neoplasm thus resulting in prolonged local control and extended survival. In this paper we describe the histological features of a broad array of spontaneous tumors of companion animals receiving pulse-mediated chemotherapy. Multivariate statistical analysis of the percentage of necrosis and apoptosis in the tumors before and after ECT treatment, shows that only a high percentage of necrosis and apoptosis after the ECT treatment were significantly correlated with longer survivals of the patients (p < 0.0001 and p = 0.004, respectively). Further studies on this topic are warranted in companion animals with spontaneous tumors to identify new molecular targets for electrochemotherapy and to the develop new therapeutical protocols to be translated to humans.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2007-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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