LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article: Continuous dopaminergic stimulation in a patient treated with daytime Levodopa-carbidopa intestinal gel and overnight Rotigotine: a case report.

    Imbriani, Paola / Schirinzi, Tommaso / D'Elia, Alessio / Pisani, Antonio

    Acta bio-medica : Atenei Parmensis

    2017  Volume 88, Issue 2, Page(s) 190–195

    Abstract: Patients with Parkinson's disease (PD) receiving long-term L-Dopa therapy eventually develop motor complications with unpredictable "on-off" response fluctuations and involuntary movements, leading to progressive disability. Hence, the search for ... ...

    Abstract Patients with Parkinson's disease (PD) receiving long-term L-Dopa therapy eventually develop motor complications with unpredictable "on-off" response fluctuations and involuntary movements, leading to progressive disability. Hence, the search for alternative therapeutic choices based on continuous dopaminergic stimulation (CDS) becomes crucial for the treatment of advanced PD. Here, we describe the case of a 70-year-old man with a 9-year history of PD, treated with daytime levodopa-carbidopa intestinal gel (LCIG) and overnight Rotigotine transdermal patch. LCIG monotherapy significantly reduced motor fluctuations and prevented the appearance of unpredictable off periods; concurrently, overnight Rotigotine improved his sleep quality and morning akinesia. Both LCIG and Rotigotine induce CDS, which conceptually mimics physiologic striatal dopamine receptor function. Hence, they both represent a good therapeutic option for the treatment of advanced PD.
    MeSH term(s) Aged ; Carbidopa/administration & dosage ; Drug Combinations ; Gels ; Humans ; Levodopa/administration & dosage ; Male ; Parkinson Disease/drug therapy ; Parkinson Disease/physiopathology ; Receptors, Dopamine/drug effects ; Receptors, Dopamine/physiology ; Tetrahydronaphthalenes/administration & dosage ; Thiophenes/administration & dosage ; Transdermal Patch
    Chemical Substances Drug Combinations ; Gels ; Receptors, Dopamine ; Tetrahydronaphthalenes ; Thiophenes ; carbidopa, levodopa drug combination ; Levodopa (46627O600J) ; rotigotine (87T4T8BO2E) ; Carbidopa (MNX7R8C5VO)
    Language English
    Publishing date 2017-08-23
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2114240-3
    ISSN 0392-4203
    ISSN 0392-4203
    DOI 10.23750/abm.v88i2.5038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 925: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Cerebrospinal fluid biomarkers profile of idiopathic normal pressure hydrocephalus.

    Schirinzi, Tommaso / Sancesario, Giulia Maria / Di Lazzaro, Giulia / D'Elia, Alessio / Imbriani, Paola / Scalise, Simona / Pisani, Antonio

    Journal of neural transmission (Vienna, Austria : 1996)

    2018  Volume 125, Issue 4, Page(s) 673–679

    Abstract: Idiopathic normal pressure hydrocephalus (iNPH) is a disabling neurological disorder whose potential treatability is significantly limited by diagnostic uncertainty. In fact, typical clinical presentation occurs at late phases of disease, when CSF ... ...

    Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a disabling neurological disorder whose potential treatability is significantly limited by diagnostic uncertainty. In fact, typical clinical presentation occurs at late phases of disease, when CSF shunting could be ineffective. In recent years, measurement of different CSF proteins, whose concentration directly reflects neuropathological changes of CNS, has significantly improved both diagnostic timing and accuracy of neurodegenerative disease. Unfortunately iNPH lacks neuropathological hallmarks allowing the identification of specific disease biomarkers. However, neuropathology of iNPH is so rich and heterogeneous that many processes can be tracked in CSF, including Alzheimer's disease core pathology, subcortical degeneration, neuroinflammation and vascular dysfunction. Indeed, a huge number of CSF biomarkers have been analyzed in iNPH patients, but a unifying profile has not been provided yet. In this brief survey, we thus attempted to summarize the main findings in the field of iNPH CSF biomarkers, aimed at outlining a synthetic model. Although defined cut-off values for biomarkers are not available, a better knowledge of CSF characteristics may definitely assist in diagnosing the disease.
    MeSH term(s) Biomarkers/cerebrospinal fluid ; Humans ; Hydrocephalus, Normal Pressure/cerebrospinal fluid ; Hydrocephalus, Normal Pressure/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-01-20
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-018-1842-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Efficacy and tolerability of perampanel and levetiracetam as first add-on therapy in patients with epilepsy: A retrospective single center study.

    Liguori, Claudio / Izzi, Francesca / Manfredi, Natalia / D'Elia, Alessio / Mari, Luisa / Mercuri, Nicola Biagio / Fabio, Placidi

    Epilepsy & behavior : E&B

    2018  Volume 80, Page(s) 173–176

    Abstract: Perampanel (PER) is a third generation antiepileptic drug (AED), recently approved as add-on therapy in both focal and generalized seizures. Levetiracetam (LEV) is a second generation AED, widely used in patients with epilepsy because of its favorable ... ...

    Abstract Perampanel (PER) is a third generation antiepileptic drug (AED), recently approved as add-on therapy in both focal and generalized seizures. Levetiracetam (LEV) is a second generation AED, widely used in patients with epilepsy because of its favorable safety and efficacy profiles. Perampanel and LEV treatments have been associated with the occurrence of similar adverse events (AEs) (sleepiness, irritability, depression, anxiety, aggressiveness). The aim of the present retrospective single center study was to verify the efficacy and tolerability of PER and LEV used as first add-on therapy in patients with epilepsy affected by secondarily generalized seizures. We collected data from 15 patients treated with PER and 26 patients treated with LEV and followed at our site with follow-up visits at 3, 6, and 12months. This retrospective study documented the comparable efficacy of PER and LEV as first add-on treatments in patients affected by uncontrolled secondarily generalized seizures. However, more patients withdrawn LEV because of AEs compared with PER at the 3- and 12-month follow-up visits. The better tolerability of PER observed in this study could be related to the low therapeutic dose of PER prescribed when it is used as first adjunctive treatment for better controlling secondarily generalized seizures.
    MeSH term(s) Adult ; Aggression ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Anxiety ; Depression ; Dizziness/chemically induced ; Drug-Related Side Effects and Adverse Reactions ; Epilepsy/drug therapy ; Epilepsy/epidemiology ; Female ; Humans ; Irritable Mood/drug effects ; Levetiracetam/administration & dosage ; Levetiracetam/adverse effects ; Levetiracetam/therapeutic use ; Male ; Middle Aged ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Pyridones/therapeutic use ; Retrospective Studies ; Seizures/drug therapy ; Treatment Outcome ; Wakefulness
    Chemical Substances Anticonvulsants ; Pyridones ; Levetiracetam (44YRR34555) ; perampanel (H821664NPK)
    Language English
    Publishing date 2018-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2018.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Occurrence of Writing Tremor in Patients With Scans Without Evidence of Dopaminergic Deficit.

    Schirinzi, Tommaso / Imbriani, Paola / D'Elia, Alessio / Bentivoglio, Anna Rita / Pisani, Antonio

    Movement disorders clinical practice

    2015  Volume 3, Issue 4, Page(s) 421–424

    Abstract: Asymmetric rest tremor is one of the main features of patients diagnosed with scans without evidence of dopaminergic deficit (SWEDD). Clinical and neurophysiological evidence suggests a dystonic origin of this tremor, although the underlying ... ...

    Abstract Asymmetric rest tremor is one of the main features of patients diagnosed with scans without evidence of dopaminergic deficit (SWEDD). Clinical and neurophysiological evidence suggests a dystonic origin of this tremor, although the underlying pathophysiology is still unclear. Dystonic tremor has a great tendency to vary with different postures or voluntary motor tasks. Here, we performed a phenomenological analysis of tremor in 14 patients with normal scans and in 14 tremor-dominant Parkinson's disease (PD) patients by assessing the presence of writing tremor. The Wilcoxon-Mann-Whitney's test revealed that patients with normal scans exhibit writing tremor more frequently, regardless of the side mostly affected by motor disturbances in handwriting (
    Language English
    Publishing date 2015-12-24
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.12302
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Rotigotine may control drooling in patients with Parkinson's Disease: Preliminary findings.

    Schirinzi, Tommaso / Imbriani, Paola / D'Elia, Alessio / Di Lazzaro, Giulia / Mercuri, Nicola Biagio / Pisani, Antonio

    Clinical neurology and neurosurgery

    2017  Volume 156, Page(s) 63–65

    Abstract: Objective: To evaluate the efficacy of rotigotine in controlling the drooling of Parkinson's Disease (PD) patients.: Patients and methods: We assessed 7 PD patients (Hoehn and Yahr scale >2.5) with three different clinical scores (Drooling Severity ... ...

    Abstract Objective: To evaluate the efficacy of rotigotine in controlling the drooling of Parkinson's Disease (PD) patients.
    Patients and methods: We assessed 7 PD patients (Hoehn and Yahr scale >2.5) with three different clinical scores (Drooling Severity and Frequency Scale - DSFS, Drooling Rating Scale - DRS and Sialorrhea Clinical Scale for PD - SCS) before and after 4 weeks of therapy. Statistical differences were analyzed with Wilcoxon signed-rank test.
    Results: We observed that rotigotine significantly improves drooling as measured by the lowering of the three scores (p<0.05).
    Conclusions: Among non-motor symptoms of PD, drooling is one of the most embarrassing and disabling for patients. Current treatments are unsatisfactory and novel approaches are thus desirable. In this open-label pilot study we demonstrated on a small sample of patients that up to 4mg/24h of rotigotine, a non-ergolinic dopamine agonist with continuous transdermal delivery, may be helpful in the management of drooling in advanced PD.
    MeSH term(s) Administration, Cutaneous ; Aged ; Antiparkinson Agents/administration & dosage ; Antiparkinson Agents/therapeutic use ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Pilot Projects ; Sialorrhea/drug therapy ; Sialorrhea/etiology ; Tetrahydronaphthalenes/administration & dosage ; Tetrahydronaphthalenes/therapeutic use ; Thiophenes/administration & dosage ; Thiophenes/therapeutic use ; Treatment Outcome
    Chemical Substances Antiparkinson Agents ; Dopamine Agonists ; Tetrahydronaphthalenes ; Thiophenes ; rotigotine (87T4T8BO2E)
    Language English
    Publishing date 2017-03-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2017.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.53: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Outlining a Population "at Risk" of Parkinson's Disease: Evidence from a Case-Control Study.

    Schirinzi, Tommaso / Martella, Giuseppina / D'Elia, Alessio / Di Lazzaro, Giulia / Imbriani, Paola / Madeo, Graziella / Monaco, Leonardo / Maltese, Marta / Pisani, Antonio

    Parkinson's disease

    2016  Volume 2016, Page(s) 9646057

    Abstract: The multifactorial pathogenesis of Parkinson's Disease (PD) requires a careful identification of populations "at risk" of developing the disease. In this case-control study we analyzed a large Italian population, in an attempt to outline general criteria ...

    Abstract The multifactorial pathogenesis of Parkinson's Disease (PD) requires a careful identification of populations "at risk" of developing the disease. In this case-control study we analyzed a large Italian population, in an attempt to outline general criteria to define a population "at risk" of PD. We enrolled 300 PD patients and 300 controls, gender and age matched, from the same urban geographical area. All subjects were interviewed on demographics, family history of PD, occupational and environmental toxicants exposure, smoking status, and alcohol consumption. A sample of 65 patients and 65 controls also underwent serum dosing of iron, copper, mercury, and manganese by means of Inductively Coupled-Plasma-Mass-Spectrometry (ICP-MS). Positive family history, toxicants exposure, non-current-smoker, and alcohol nonconsumer status occurred as significant risk factors in our population. The number of concurring risk factors overlapping in the same subject impressively increased the overall risk. No significant differences were measured in the metal serum levels. Our findings indicate that combination of three to four concurrent PD-risk factors defines a condition "at risk" of PD. A simple stratification, based on these questionnaires, might be of help in identifying subjects suitable for neuroprotective strategies.
    Language English
    Publishing date 2016-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573854-9
    ISSN 2042-0080 ; 2090-8083
    ISSN (online) 2042-0080
    ISSN 2090-8083
    DOI 10.1155/2016/9646057
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top