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  1. Article: CAR-T Cell Therapy for Follicular Lymphomas.

    Testa, Ugo / D'Alò, Francesco / Pelosi, Elvira / Castelli, Germana / Leone, Giuseppe

    Mediterranean journal of hematology and infectious diseases

    2024  Volume 16, Issue 1, Page(s) e2024012

    Abstract: Follicular lymphoma is the second most diagnosed lymphoma in Western Europe. Significant advancements have considerably improved the survival of FL patients. However, 10-20% of these patients are refractory to standard treatments, and most of them will ... ...

    Abstract Follicular lymphoma is the second most diagnosed lymphoma in Western Europe. Significant advancements have considerably improved the survival of FL patients. However, 10-20% of these patients are refractory to standard treatments, and most of them will relapse. The treatment of follicular lymphoma patients with multiply relapsed or refractory disease represents an area of high-unmet needing new treatments with stronger efficacy. Chimeric antigen receptor (CAR)-T cell therapy targeting B-cell antigens, such as CD19 or CD20, is emerging as an efficacious treatment for R/R follicular lymphoma patients, particularly for those with early relapse and refractory to alkylating agents and to anti-CD20 monoclonal antibodies, resulting in a high rate of durable responses in a high proportion of patients.
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2024.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Case of metastatic melanoma in bone marrow smear.

    Frioni, Filippo / Za, Tommaso / D'alò, Francesco / Zini, Gina

    International journal of laboratory hematology

    2022  Volume 44, Issue 6, Page(s) 976–977

    MeSH term(s) Humans ; Bone Marrow/pathology ; Melanoma/diagnosis ; Melanoma/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Neoplasms, Second Primary
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Case Reports
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1499: Show issues Location:
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  3. Article ; Online: 'Here comes the story of the Hurricane': a case report of AL cardiac amyloidosis and myocardial bridging.

    Cappannoli, Luigi / Ciliberti, Giuseppe / Restivo, Attilio / Palumbo, Pierpaolo / D'Alò, Francesco / Sanna, Tommaso / Crea, Filippo / D'Amario, Domenico

    European heart journal. Case reports

    2022  Volume 6, Issue 7, Page(s) ytac225

    Abstract: Background: Cardiac amyloidosis (CA) is a rapidly progressive infiltrative cardiomyopathy, whose role is emerging as a not-so-rare disorder leading to heart failure (HF). Myocardial bridge (MB) is the most common inborn coronary artery variant, and its ... ...

    Abstract Background: Cardiac amyloidosis (CA) is a rapidly progressive infiltrative cardiomyopathy, whose role is emerging as a not-so-rare disorder leading to heart failure (HF). Myocardial bridge (MB) is the most common inborn coronary artery variant, and its clinical relevance is still matter of debate. The exceptional coexistence of these two conditions could accelerate disease progression and worsen the already compromised clinical conditions.
    Case summary: We present the case of a 76-year-old female patient experiencing relapsing HF decompensation and presenting to our centre with dyspnoea at rest and severe peripheral congestion. Echocardiogram showed severe concentric hypertrophy, severe biventricular contractile dysfunction, and third-degree diastolic dysfunction. Coronary angiography excluded epicardial atherosclerotic disease, though displaying a long intramyocardial course of left anterior descending artery. Physiological invasive test was achieved in terms of instantaneous wave-free ratio (iFR), both at baseline and after inotropic and chronotropic stimuli, and attested haemodynamic significance. Concurrently, the diagnostic flow chart for CA was accomplished, by means of both invasive (periumbilical fat biopsy, bone marrow aspiration) and non-invasive tests (
    Discussion: Our clinical case shows a unique interaction between infiltrative cardiomyopathy and coronary artery abnormality. Amyloidosis can contribute to the ischaemic burden of the MB and this may, in turn, abbreviate the path to HF decompensation.
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac225
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  4. Article ; Online: Predicting time to treatment in follicular lymphoma on watchful waiting using baseline metabolic tumour burden.

    Leccisotti, Lucia / Maccora, Daria / Malafronte, Rosalia / D'Alò, Francesco / Maiolo, Elena / Annunziata, Salvatore / Rufini, Vittoria / Giordano, Alessandro / Hohaus, Stefan

    Journal of cancer research and clinical oncology

    2022  Volume 149, Issue 7, Page(s) 2783–2791

    Abstract: Purpose: Asymptomatic patients with follicular lymphoma (FL) and a low tumour burden can be followed without initial therapy, a strategy called watchful waiting (WW). Prediction of the time to treatment (TTT) is still a challenge. We investigated the ... ...

    Abstract Purpose: Asymptomatic patients with follicular lymphoma (FL) and a low tumour burden can be followed without initial therapy, a strategy called watchful waiting (WW). Prediction of the time to treatment (TTT) is still a challenge. We investigated the prognostic value of baseline total metabolic tumour volume (TMTV) and whole-body total lesion glycolysis (WB-TLG) to predict TTT in patients with FL on WW.
    Methods: We conducted a retrospective study of 54 patients with FL (grade 1-3a) diagnosed between June 2013 and December 2019, staged with FDG PET/CT, and managed on WW. Median age was 62 years (range 34-85), stage was advanced (III-IV) in 57%, and FLIPI score was intermediate to high (≥ 2) in 52% of the patients.
    Results: The median TMTV and WB-TLG were 7.1 and 43.3, respectively. With a median follow-up of 59 months, 41% of patients started immuno-chemotherapy. The optimal cut-points to identify patients with TTT within 24 months were 14 for TMTV (AUC 0.70; 95% CI 51-88) and 64 for WB-TLG (AUC 0.71; 95% CI 52-89) (p < 0.005). The probability of not having started treatment within 24 months was 87% for TMTV < 14 and 53% for TMTV ≥ 14 (p < 0.005). TMTV was independent of the FLIPI score for TTT prediction. Patients with both FLIPI ≥ 2 and TMTV ≥ 14 had only an 18% probability of not having started treatment at 36 months, while this probability was 75% in patients with TMTV < 14.
    Conclusion: Metabolic tumour volume parameters may add information to clinical scores to better predict TTT and better stratify patients for interventional studies.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Positron Emission Tomography Computed Tomography ; Lymphoma, Follicular/therapy ; Tumor Burden ; Fluorodeoxyglucose F18 ; Retrospective Studies ; Time-to-Treatment ; Watchful Waiting ; Prognosis
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-07-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-04138-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.10: Show issues Location:
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  5. Article: Burkitt Lymphoma as Fourth Neoplasia in a Patient Affected by Cowden Syndrome with a Novel PTEN Germline Pathogenic Variant.

    Galli, Eugenio / Malafronte, Rosalia / Brugnoletti, Fulvia / Zollino, Marcella / Hohaus, Stefan / D'Alò, Francesco

    Mediterranean journal of hematology and infectious diseases

    2020  Volume 12, Issue 1, Page(s) e2020034

    Language English
    Publishing date 2020-07-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2020.034
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  6. Article ; Online: Peyronie's disease in patients with Hodgkin lymphoma.

    Autore, Francesco / Massini, Giuseppina / Hohaus, Stefan / Cuccaro, Annarosa / D'Alò, Francesco / Teofili, Luciana

    Leukemia research

    2020  Volume 96, Page(s) 106427

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Hodgkin Disease/drug therapy ; Hodgkin Disease/pathology ; Humans ; Male ; Middle Aged ; Penile Induration/chemically induced ; Penile Induration/pathology ; Prognosis
    Language English
    Publishing date 2020-07-23
    Publishing country England
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2020.106427
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    Zs.A 1321: Show issues Location:
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  7. Article: Endoscopic Ultrasound-Guided Fine Needle Biopsy in the Diagnostic Work-Up of Deep-Seated Lymphadenopathies and Spleen Lesions: A Monocentric Experience.

    Bellisario, Flaminia / Attili, Fabia / Campana, Fabrizia / Borrelli de Andreis, Federica / Bellesi, Silvia / Maiolo, Elena / Alma, Eleonora / Malafronte, Rosalia / Macis, Giuseppe / Larocca, Luigi Maria / Annunziata, Salvatore / D'Alò, Francesco / Hohaus, Stefan

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 17

    Abstract: EUS-FNB has been introduced in clinical practice as a less invasive diagnostic approach with respect to surgery. We performed a single-center retrospective study on the diagnostic efficacy of EUS-guided FNB, including 171 patients with lymph nodes, ... ...

    Abstract EUS-FNB has been introduced in clinical practice as a less invasive diagnostic approach with respect to surgery. We performed a single-center retrospective study on the diagnostic efficacy of EUS-guided FNB, including 171 patients with lymph nodes, splenic, and extranodal lesions that underwent EUS for FNB at our institution. Excluding 12 patients who did not undergo FNB and 25 patients with a previous diagnosis of a solid tumor, we included 134 patients with clinical/radiological suspect of a lymphoproliferative disease, including 20 patients with a previous history of lymphoma. Out of the 134 biopsies, material of diagnostic quality was obtained in 111 procedures (84.3%). Histological examination of the EUS-FNB samples produced an actionable diagnosis in 100 cases (74.6%). Among the patients without an actionable diagnosis, a second, different diagnostic procedure produced a further eight diagnoses of lymphoma. Therefore, the sensitivity of EUS-FNB for diagnosing lymphomas was calculated to be 86.4% (51/59). Assignment of lymphomas to WHO classification subtypes was possible in 47/51 (92%) of the cases. In conclusion, EUS-FNB is an effective procedure for the histological characterization of lesions that are suspected to be lymphoproliferative disease, allowing for an actionable diagnosis in 75% of cases.
    Language English
    Publishing date 2023-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13172839
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  8. Article: Anopheline mosquito saliva contains bacteria that are transferred to a mammalian host through blood feeding.

    Accoti, Anastasia / Damiani, Claudia / Nunzi, Emilia / Cappelli, Alessia / Iacomelli, Gloria / Monacchia, Giulia / Turco, Antonella / D'Alò, Francesco / Peirce, Matthew J / Favia, Guido / Spaccapelo, Roberta

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1157613

    Abstract: Introduction: Malaria transmission occurs when : Methods: Using both 16S rRNA sequencing and MALDI-TOF approaches, we characterized the composition of the saliva microbiome of : Results: To eliminate the possible detection of non-mosquito-derived ... ...

    Abstract Introduction: Malaria transmission occurs when
    Methods: Using both 16S rRNA sequencing and MALDI-TOF approaches, we characterized the composition of the saliva microbiome of
    Results: To eliminate the possible detection of non-mosquito-derived bacteria, we used a transgenic, fluorescent strain of one of the identified bacteria,
    Discussion: These data thus document the presence of bacteria in mosquito saliva, their transfer to, and growth in a mammalian host as well as possible interactions with
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1157613
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  9. Article: Severe CMV Infection after Chemo-Immunotherapy with Dose-Reduced Bendamustine and Rituximab in a Mantle Cell Lymphoma Old Patient.

    Magliano, Gabriele / Cuccaro, Annarosa / d'Alo', Francesco / Maiolo, Elena / Bellesi, Silvia / Hohaus, Stefan / Bacigalupo, Andrea / Pagano, Livio

    Mediterranean journal of hematology and infectious diseases

    2021  Volume 13, Issue 1, Page(s) e2021054

    Language English
    Publishing date 2021-09-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2021.054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Safety and efficacy of SARS-Cov2 neutralizing monoclonal antibodies after stem cell transplant or CAR-T cell infusion.

    Metafuni, Elisabetta / Cingolani, Antonella / Fantoni, Massimo / Chiusolo, Patrizia / Giammarco, Sabrina / Sorà, Federica / Galli, Eugenio / Hohaus, Stefan / D'Alò, Francesco / Bellesi, Silvia / Maiolo, Elena / Alma, Eleonora / Laurenti, Luca / Innocenti, Idanna / Autore, Francesco / Limongiello, Maria Assunta / Santangelo, Rosaria / Marchetti, Simona / Ricci, Rosalba /
    Sica, Simona

    Hematological oncology

    2023  Volume 41, Issue 3, Page(s) 563–566

    MeSH term(s) Humans ; Antibodies, Monoclonal/therapeutic use ; COVID-19 ; SARS-CoV-2 ; RNA, Viral ; Stem Cell Transplantation ; T-Lymphocytes
    Chemical Substances Antibodies, Monoclonal ; RNA, Viral
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Letter
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3119
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    Zs.A 1816: Show issues Location:
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