Article ; Online: Quercetin: A flavonol with multifaceted therapeutic applications?
2015 Volume 106, Page(s) 256–271
Abstract: Great interest is currently centered on the biologic activities of quercetin a polyphenol belonging to the class of flavonoids, natural products well known for their beneficial effects on health, long before their biochemical characterization. In ... ...
| Abstract | Great interest is currently centered on the biologic activities of quercetin a polyphenol belonging to the class of flavonoids, natural products well known for their beneficial effects on health, long before their biochemical characterization. In particular, quercetin is categorized as a flavonol, one of the five subclasses of flavonoid compounds. Although flavonoids occur as either glycosides (with attached glycosyl groups) or as aglycones, most altogether of the dietary intake concerning quercetin is in the glycoside form. Following chewing, digestion, and absorption sugar moieties can be released from quercetin glycosides. Several organs contribute to quercetin metabolism, including the small intestine, the kidneys, the large intestine, and the liver, giving rise to glucuronidated, methylated, and sulfated forms of quercetin; moreover, free quercetin (such as aglycone) is also found in plasma. Quercetin is now largely utilized as a nutritional supplement and as a phytochemical remedy for a variety of diseases like diabetes/obesity and circulatory dysfunction, including inflammation as well as mood disorders. Owing to its basic chemical structure themost obvious feature of quercetin is its strong antioxidant activity which potentially enables it to quench free radicals from forming resonance-stabilized phenoxyl radicals. In this review the molecular, cellular, and functional bases of therapy will be emphasized taking strictly into account data appearing in the peer-reviewed literature and summarizing the main therapeutic applications of quercetin; furthermore, the drug metabolism and the main drug interaction as well as the potential toxicity will be also spotlighted. |
|---|---|
| MeSH term(s) | Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Biological Availability ; Drug Interactions ; Fruit/chemistry ; Glycosides/chemistry ; Humans ; Intestines/metabolism ; Kidney/metabolism ; Liver/metabolism ; Molecular Structure ; Quercetin/chemistry ; Quercetin/pharmacology ; Vegetables/chemistry |
| Chemical Substances | Antioxidants ; Glycosides ; Quercetin (9IKM0I5T1E) |
| Language | English |
| Publishing date | 2015-10 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 412385-2 |
| ISSN | 1873-6971 ; 0367-326X |
| ISSN (online) | 1873-6971 |
| ISSN | 0367-326X |
| DOI | 10.1016/j.fitote.2015.09.018 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.B 1873: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.