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  1. AU="D'costa, Maria"
  2. AU="Rauk, Zuzanna"
  3. AU="Bergdall, Valerie"
  4. AU="George Th. Tsangaris"
  5. AU="Maria C Jordan"
  6. AU="Zhang, Zhen-Hai"
  7. AU=Lorenzo-Gomez M F AU=Lorenzo-Gomez M F
  8. AU="Weng, Wei-Chien"
  9. AU="Michael Zauner"
  10. AU="Offin, M."
  11. AU=Burney Ikram A
  12. AU="Sciubba, Adalberto"
  13. AU="Hu, Tony Y"
  14. AU="L'Hoyes, Wouter"
  15. AU="Bernhardt, Sarah M"
  16. AU="Holman, Wayne"
  17. AU="Ghabi, Elie"
  18. AU="Pan, Jia-fu"
  19. AU="Fareed, Zeeshan"
  20. AU="Watkins, A Claire"
  21. AU="Taggart, Michael"
  22. AU="Boone, William J"

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  1. Artikel ; Online: Health professions students' attitude, perception, and readiness toward interprofessional education and practice in Oman.

    D'Costa, Maria P / Jahan, Firdous / Al Shidi, Amal

    Journal of Taibah University Medical Sciences

    2021  Band 17, Heft 2, Seite(n) 248–255

    Abstract: Objectives: Interactive learning through interprofessional education enhances collaborative practice. This study aims to determine the attitude, perception, and readiness of Omani undergraduate health professions students toward interprofessional ... ...

    Abstract Objectives: Interactive learning through interprofessional education enhances collaborative practice. This study aims to determine the attitude, perception, and readiness of Omani undergraduate health professions students toward interprofessional education and practice.
    Methods: A total of 327 Omani undergraduates across different health fields participated in this cross-sectional study. Data was gathered via an online-based survey by using two previously validated and reliable tools: 1) the Student Perceptions of Interprofessional Clinical Education-revised (SPICE-R2) and 2) the Readiness for Interprofessional Education Scale-modified. Data were analysed using descriptive and inferential statistics.
    Results: The overall mean score of the students' attitude and readiness toward interprofessional education was 56.77 (SD = 5.51). The overall mean score of the students' perception toward interprofessional education was 41.42 (SD = 4.56). The overall mean attitude and readiness score and perception score were higher for the pharmacy students than for the rest of the students; however, no statistically significant difference was noted in the scores of attitude and readiness (
    Conclusions: Overall, the study revealed that all the health professionals in Oman, irrespective of the profession, disclosed a favourable attitude, a high state of readiness, and a positive perception toward interprofessional education and practice. Furthermore, all the health professionals considered teamwork and collaboration to be essential for better quality care and practice.
    Sprache Englisch
    Erscheinungsdatum 2021-11-12
    Erscheinungsland Saudi Arabia
    Dokumenttyp Journal Article
    ZDB-ID 2817396-X
    ISSN 1658-3612 ; 1658-3612
    ISSN (online) 1658-3612
    ISSN 1658-3612
    DOI 10.1016/j.jtumed.2021.10.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: CDK regulators-Cell cycle progression or apoptosis-Scenarios in normal cells and cancerous cells.

    Nilmani / D'costa, Maria / Bothe, Anusha / Das, Soumik / Udhaya Kumar, S / Gnanasambandan, R / George Priya Doss, C

    Advances in protein chemistry and structural biology

    2023  Band 135, Seite(n) 125–177

    Abstract: Serine/threonine kinases called cyclin-dependent kinases (CDKs) interact with cyclins and CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA transcription and cell cycle advancement. The ubiquitous overactivity ...

    Abstract Serine/threonine kinases called cyclin-dependent kinases (CDKs) interact with cyclins and CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA transcription and cell cycle advancement. The ubiquitous overactivity of the cell cycle CDKs is caused by a number of genetic and epigenetic processes in human cancer, and their suppression can result in both cell cycle arrest and apoptosis. This review focused on CDKs, describing their kinase activity, their role in phosphorylation inhibition, and CDK inhibitory proteins (CIP/KIP, INK 4, RPIC). We next compared the role of different CDKs, mainly p21, p27, p57, p16, p15, p18, and p19, in the cell cycle and apoptosis in cancer cells with respect to normal cells. The current work also draws attention to the use of CDKIs as therapeutics, overcoming the pharmacokinetic barriers of pan-CDK inhibitors, analyze new chemical classes that are effective at attacking the CDKs that control the cell cycle (cdk4/6 or cdk2). It also discusses CDKI's drawbacks and its combination therapy against cancer patients. These findings collectively demonstrate the complexity of cancer cell cycles and the need for targeted therapeutic intervention. In order to slow the progression of the disease or enhance clinical outcomes, new medicines may be discovered by researching the relationship between cell death and cell proliferation.
    Mesh-Begriff(e) Humans ; Cell Cycle Proteins/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/pharmacology ; Cyclin-Dependent Kinases ; Cell Cycle ; Apoptosis
    Chemische Substanzen Cell Cycle Proteins ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinases (EC 2.7.11.22)
    Sprache Englisch
    Erscheinungsdatum 2023-02-06
    Erscheinungsland Netherlands
    Dokumenttyp Review ; Journal Article
    ISSN 1876-1631 ; 1876-1623
    ISSN (online) 1876-1631
    ISSN 1876-1623
    DOI 10.1016/bs.apcsb.2022.11.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Identification of dysregulated canonical pathways associated with pathogenesis and progression of Amyotrophic Lateral Sclerosis-An integrated bioinformatics approach.

    Datta, Ankur / Udhaya Kumar, S / D'costa, Maria / Bothe, Anusha / Thirumal Kumar, D / Zayed, Hatem / George Priya Doss, C

    Advances in protein chemistry and structural biology

    2023  Band 134, Seite(n) 21–52

    Abstract: The mechanisms responsible for the pathogenesis and progression of Amyotrophic Lateral Sclerosis (ALS) remain poorly understood, making the diagnosis of ALS challenging. We aimed to find the novel gene biomarkers via computationally analyzing microarray ... ...

    Abstract The mechanisms responsible for the pathogenesis and progression of Amyotrophic Lateral Sclerosis (ALS) remain poorly understood, making the diagnosis of ALS challenging. We aimed to find the novel gene biomarkers via computationally analyzing microarray expression studies, in three different cell lineages, namely myotube cells, astrocyte cells and oligodendrocyte cells. Microarray gene expression profiles were obtained and analyzed for three cell types: myotube cell lineage (GSE122261), astrocyte, and oligodendrocyte cell lineage (GSE87385). A comprehensive computational pipeline, tailored explicitly for microarray gene expression profiling studies, was devised to analyze the sample groups, wherein the myotube sample group comprised of six control (GSM3462697, GSM3462698, GSM3462699, GSM3462700, GSM3462701, GSM3462702) & six diseased (GSM3462691, GSM3462692, GSM3462693, GSM3462694, GSM3462695, GSM3462696) samples were considered. Similarly, for the astrocyte sample group two samples each for the control (GSM2330040, GSM2330042) and the diseased (GSM2330039, GSM2330041), and for the oligodendrocyte sample group, 2 control (GSM2330043, GSM2330045) samples and two diseased (GSM2330044, GSM2330046) samples were considered for the current study. The in-depth interaction of these DEGs was studied using MCODE and subjected to preliminary functional analysis using ClueGO/CluePedia plug-in. Qiagen's IPA software was employed for enrichment analysis, which generated the key canonical pathways and a list of potential biomarker molecules specific to each sample group. The preliminary analysis yielded 512 DEGs across all 3-sample groups, wherein 139 DEGs belonged to the myotube sample group, 216 DEGs for the astrocyte sample group, and 157 DEGs for the oligodendrocytes sample group. The data suggests growth hormone signaling and its activity, ErbB signaling pathway, and JAK/STAT signaling pathway are some of the pathways that are significantly dysregulated and play a crucial role in the development and progression of ALS. KISS1R and CSHL1 are potential genes that could act as diagnostic biomarkers in myotube cell types. Also, KRAS, TGFB2, JUN, and SMAD6 genes may be used as prognostic biomarkers to differentiate between early and late-stage ALS-diseased patients.
    Mesh-Begriff(e) Humans ; Amyotrophic Lateral Sclerosis/metabolism ; Computational Biology ; Gene Expression Profiling ; Signal Transduction
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 1876-1631 ; 1876-1623
    ISSN (online) 1876-1631
    ISSN 1876-1623
    DOI 10.1016/bs.apcsb.2022.11.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats.

    do Nascimento, Ravena P / de Jesus, Lívia B / Oliveira-Junior, Markley S / Almeida, Aurea M / Moreira, Eduardo L T / Paredes, Bruno D / David, Jorge M / Souza, Bruno S F / de Fátima D Costa, Maria / Butt, Arthur M / Silva, Victor Diogenes A / Costa, Silvia L

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 858190

    Abstract: Agathisflavone is a flavonoid with anti-neuroinflammatory and myelinogenic properties, being also capable to induce neurogenesis. This study evaluated the therapeutic effects of agathisflavone-both as a pharmacological therapy ... ...

    Abstract Agathisflavone is a flavonoid with anti-neuroinflammatory and myelinogenic properties, being also capable to induce neurogenesis. This study evaluated the therapeutic effects of agathisflavone-both as a pharmacological therapy administered
    Sprache Englisch
    Erscheinungsdatum 2022-04-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.858190
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.

    de Araújo, Fillipe M / Ferreira, Rafael S / Souza, Cleide S / Dos Santos, Cleonice Creusa / Rodrigues, Tácio L R S / E Silva, Juliana Helena C / Gasparotto, Juciano / Gelain, Daniel Pens / El-Bachá, Ramon S / D Costa, Maria de Fátima / Fonseca, José Claudio M / Segura-Aguilar, Juan / Costa, Silvia L / Silva, Victor Diogenes A

    Neurotoxicology

    2018  Band 66, Seite(n) 98–106

    Abstract: Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, oxidative stress, dysfunction of ... ...

    Abstract Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, oxidative stress, dysfunction of proteasomal and lysosomal systems, endoplasmic reticulum stress and disruption of the microtubule network, but until now there has been no evidence of effects on production of cytokines and neurotrophic factors, that are mechanisms involved in neuronal loss in Parkinson's disease (PD). This study examines the potential role of aminochrome on the regulation of NGF, GDNF, TNF-α and IL-1β production and microglial activation in organotypic midbrain slice cultures from P8 - P9 Wistar rats. We demonstrated aminochrome (25 μM, for 24 h) induced reduction of GFAP expression, reduction of NGF and GDNF mRNA levels, morphological changes in Iba1
    Mesh-Begriff(e) Animals ; Encephalitis/chemically induced ; Encephalitis/metabolism ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Indolequinones/toxicity ; Interleukin-1beta/metabolism ; Mesencephalon/drug effects ; Mesencephalon/metabolism ; Microglia/drug effects ; Microglia/metabolism ; Nerve Growth Factor/metabolism ; Parkinson Disease/metabolism ; Rats, Wistar ; Tissue Culture Techniques ; Tumor Necrosis Factor-alpha/metabolism ; Tyrosine 3-Monooxygenase/metabolism
    Chemische Substanzen Glial Cell Line-Derived Neurotrophic Factor ; Indolequinones ; Interleukin-1beta ; Tumor Necrosis Factor-alpha ; aminochrome 1 (39984-17-3) ; Nerve Growth Factor (9061-61-4) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
    Sprache Englisch
    Erscheinungsdatum 2018-03-26
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2018.03.009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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