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  1. Article ; Online: Rituximab seems a promising therapeutic option in granulomatosis with polyangiitis with intestinal perforation: a case report and literature review.

    Dag, Muhammet Sait / Pehlivan, Yavuz / Tutar, Ediz / Kisacik, Bunyamin

    BMJ case reports

    2013  Volume 2013

    Abstract: Granulomatosis with polyangiitis (Wegener's) (GPA) is a chronic disease of unknown aetiology that leads to necrotising vasculitis in small and medium-sized vessels characterised by respiratory system and kidney involvement. Intestinal involvement is rare ...

    Abstract Granulomatosis with polyangiitis (Wegener's) (GPA) is a chronic disease of unknown aetiology that leads to necrotising vasculitis in small and medium-sized vessels characterised by respiratory system and kidney involvement. Intestinal involvement is rare and perforation is even rarer in GPA. In this study, we are presenting a literature review of related cases, and a 29-year-old man referred from the emergency department with a multiple distal ileal perforation that was diagnosed with GPA, and successfully treated with rituximab.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Murine-Derived/administration & dosage ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Colonoscopy ; Diagnosis, Differential ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/drug therapy ; Humans ; Ileal Diseases/diagnosis ; Ileal Diseases/etiology ; Ileal Diseases/therapy ; Immunologic Factors/administration & dosage ; Immunologic Factors/therapeutic use ; Injections, Intravenous ; Intestinal Perforation/diagnosis ; Intestinal Perforation/drug therapy ; Intestinal Perforation/etiology ; Male ; Rituximab ; Systemic Vasculitis/complications ; Systemic Vasculitis/diagnosis ; Systemic Vasculitis/drug therapy
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2013-01-22
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2012-007518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cetuximab-induced esophageal ulcer: the first report in literature.

    Babacan, Taner / Turkbeyler, Ibrahim Halil / Dag, Muhammet Sait / Dilli, Ismail / Balakan, Ozan / Altundag, Kadri

    The Libyan journal of medicine

    2014  Volume 9, Issue 1, Page(s) 23723

    MeSH term(s) Abdomen, Acute/etiology ; Adenocarcinoma/complications ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Adenocarcinoma/secondary ; Adenocarcinoma/therapy ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Cetuximab ; Chemoradiotherapy ; Colostomy ; Esophagitis/chemically induced ; Esophagitis/metabolism ; Esophagitis/therapy ; Esophagoscopy ; Fluorouracil/administration & dosage ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Irinotecan ; Male ; Middle Aged ; Molecular Targeted Therapy/adverse effects ; Molecular Targeted Therapy/methods ; Organoplatinum Compounds/administration & dosage ; Oxaliplatin ; Proctoscopy ; Proto-Oncogene Proteins/drug effects ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins p21(ras) ; Rectal Neoplasms/complications ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/genetics ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Treatment Outcome ; Ulcer/chemically induced ; Ulcer/metabolism ; Ulcer/therapy ; Vascular Endothelial Growth Factor A/drug effects ; Vascular Endothelial Growth Factor A/metabolism ; Vomiting/etiology ; ras Proteins/drug effects ; ras Proteins/genetics
    Chemical Substances Antibodies, Monoclonal, Humanized ; KRAS protein, human ; Organoplatinum Compounds ; Proto-Oncogene Proteins ; Vascular Endothelial Growth Factor A ; Oxaliplatin (04ZR38536J) ; Irinotecan (7673326042) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; ras Proteins (EC 3.6.5.2) ; Cetuximab (PQX0D8J21J) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2014-02-24
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2273005-9
    ISSN 1819-6357 ; 1819-6357
    ISSN (online) 1819-6357
    ISSN 1819-6357
    DOI 10.3402/ljm.v9.23723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: NADPH oxidase p22phox gene expression in ulcerative colitis.

    Bülbül, Neşe / Pala, Elif / İğci, Yusuf Ziya / Göğebakan, Bülent / Öztuzcu, Serdar / Cengiz, Beyhan / Bayraktar, Recep / Dağ, Muhammet Sait / Aydınlı, Musa

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2014  Volume 25, Issue 6, Page(s) 634–638

    Abstract: Background/aims: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which catalyzes the formation of reactive oxygen species (ROS) in phagocytic cells, has five subunits: p67phox ("phox"refers to "phagocyte oxidase"), p47phox, p40phox, p22phox, ...

    Abstract Background/aims: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which catalyzes the formation of reactive oxygen species (ROS) in phagocytic cells, has five subunits: p67phox ("phox"refers to "phagocyte oxidase"), p47phox, p40phox, p22phox, and gp91phox (catalytic subunit). Oxidative stress resulting from the accumulation of ROS and/or defective removal of ROS by antioxidants has detrimental effects on cellular functions and may contribute to chronic inflammation. Disruption of the colonic mucosa due to the dysregulation of antioxidants or transformation enzymes may play a role in the pathogenesis of ulcerative colitis (UC) and influence the clinical features of this disease. In this study, we examined the expression of the gene encoding NADPH oxidase subunit p22phox cytochrome b-245, alphapolypeptidein the colonic mucosa to test its possible contribution in the pathogenesis of UC.
    Materials and methods: Expression levels of mRNA in the inflamed and non-inflamed colonic mucosa (determined using colonoscopy)of 22 patients with UC and in the normal mucosa of 22 healthy controls were analyzed using real-time polymerase chain reaction.
    Results: Expression levels of mRNA were not significantly different between patients with inflamed and non-inflamed colonic mucosa (p>0.05) and betweenpatients with inflamed colonicmucosa and healthy controls (p>0.05).
    Conclusion: Although our data suggest that expression of the gene encoding p22phox is not associated with chronic inflammation in patients with UC, other mechanisms can affect oxidative stress in these patients.
    MeSH term(s) Adult ; Aged ; Colitis, Ulcerative/genetics ; Female ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; NADPH Oxidases/genetics ; Young Adult
    Chemical Substances NADPH Oxidases (EC 1.6.3.-) ; CYBA protein, human (EC 1.6.3.1)
    Language English
    Publishing date 2014-12
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2014.5926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Prevalence and significance of MEFV gene mutations in a cohort of patients with rheumatoid arthritis.

    Koca, Suleyman Serdar / Etem, Ebru Onalan / Isik, Bahar / Yuce, Huseyin / Ozgen, Metin / Dag, Muhammet Sait / Isik, Ahmet

    Joint bone spine

    2009  Volume 77, Issue 1, Page(s) 32–35

    Abstract: Objectives: Pyrin/marenostrin, an inhibitory regulator of inflammation, is encoded by MEditerranean FeVer (MEFV) gene. Mutations of this gene are the cause of familial Mediterranean fever (FMF). A connection between MEFV gene mutations and rheumatic ... ...

    Abstract Objectives: Pyrin/marenostrin, an inhibitory regulator of inflammation, is encoded by MEditerranean FeVer (MEFV) gene. Mutations of this gene are the cause of familial Mediterranean fever (FMF). A connection between MEFV gene mutations and rheumatic diseases has been suggested. The aim of this study was to explore the frequency and clinical significance of MEFV gene mutations in a cohort of Turkish patients with rheumatoid arthritis (RA).
    Methods: The study included 103 patients with RA and 103 age-, sex- and origin-matched healthy controls (HC). In all participants, genomic DNA was isolated and genotyped using amplification refractory mutation system or restriction fragment length polymorphism for the eight MEFV gene mutations (E148Q, M694V, M694I, M680I, V726A, A744S, R761H, and P369S). In the RA group, disease activity was determined using the disease activity score-28 (DAS-28), and radiological damage was evaluated by the modified Larsen scoring method.
    Results: Carrier rates of MEFV gene mutations were 26/103 (25.2%) and 24/103 (23.3%) in the RA and HC groups, respectively (p>0.05, OR: 0.9, 95% CI: 0.48-1.71). In the RA group, while deformed joint count was significantly higher in the mutation carrier group than those of the non-carrier group (p<0.05), the level of C-reactive protein, DAS-28 and modified-Larsen scores were slightly but not significantly higher in the carrier group.
    Conclusion: The results of this study suggest that MEFV gene mutations appear to be an aggravating factor for the severity of RA, and consequently, patients with RA might be screened for MEFV gene mutations in countries where FMF is frequent. Whether the searching of MEFV gene mutations in RA patients is cost-effective deserves further investigations.
    MeSH term(s) Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/physiopathology ; C-Reactive Protein/analysis ; Cohort Studies ; Cytoskeletal Proteins/genetics ; DNA/analysis ; Female ; Gene Frequency ; Genetic Carrier Screening ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Male ; Middle Aged ; Mutation ; Peptides, Cyclic/blood ; Peptides, Cyclic/immunology ; Pyrin ; Radiography ; Severity of Illness Index ; Turkey ; Wrist Joint/diagnostic imaging ; Wrist Joint/physiopathology
    Chemical Substances Cytoskeletal Proteins ; MEFV protein, human ; Peptides, Cyclic ; Pyrin ; cyclic citrullinated peptide ; C-Reactive Protein (9007-41-4) ; DNA (9007-49-2)
    Language English
    Publishing date 2009-12-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2009.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4590: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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