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  1. Article ; Online: Assessment of early and long-COVID related retinal neurodegeneration with optical coherence tomography.

    Dağ Şeker, Esra / Erbahçeci Timur, İnci Elif

    International ophthalmology

    2022  Volume 43, Issue 6, Page(s) 2073–2081

    Abstract: Purpose: The aim of this study is to investigate short-term and long-term effects of coronovirus 19 disease (COVID-19) at inner and outer retinal layers of patients recovered from COVID-19 with Spectral Domain Optical Coherence Tomography (SD-OCT) and ... ...

    Abstract Purpose: The aim of this study is to investigate short-term and long-term effects of coronovirus 19 disease (COVID-19) at inner and outer retinal layers of patients recovered from COVID-19 with Spectral Domain Optical Coherence Tomography (SD-OCT) and compare these to healthy subjects.
    Methods: Twenty-seven patients recovered from COVID-19, and age- and gender-matched 27 healthy controls were included in this study. Macular and peripapillary retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), inner nuclear layer (INL), outer plexiform layer (OPL) and outer nuclear layer (ONL) were analyzed with SD-OCT 1 month (V
    Results: Macular RNFL thickness in outer ring was thinner at V
    Conclusion: Subclinical localized changes in macular and peripapillary RNFL and outer nuclear layer were demonstrated in early and 12-months follow-up after COVID-19 recovery.
    MeSH term(s) Humans ; Tomography, Optical Coherence/methods ; Retinal Ganglion Cells ; Post-Acute COVID-19 Syndrome ; Nerve Fibers ; COVID-19/complications
    Language English
    Publishing date 2022-12-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-022-02607-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Choroidal vascularity index in adult patients with familial meditteranean fever.

    Timur, İnci Elif Erbahçeci / Atalar, Ebru / Maraş, Yüksel / Dağ Şeker, Esra / Yüzbaşıoğlu, Sema / Uğurlu, Nagihan

    Photodiagnosis and photodynamic therapy

    2023  Volume 42, Page(s) 103350

    Abstract: Purpose: This study aimed to evaluate choroidal vascular status by the choroidal vascularity index (CVI) in adult patients with familial Mediterranean fever (FMF) in remission period.: Materials-methods: 86 patients diagnosed with FMF and 54 healthy ... ...

    Abstract Purpose: This study aimed to evaluate choroidal vascular status by the choroidal vascularity index (CVI) in adult patients with familial Mediterranean fever (FMF) in remission period.
    Materials-methods: 86 patients diagnosed with FMF and 54 healthy controls were recruited in this study. Retinal, ganglion cell complex and peripapillary retinal nerve fibre layer thicknesses were obtained using Spectralis domain-optical coherence (SD-OCT) tomography. Choroid images were obtained with the enhanced depth imaging mode of SD-OCT, and binarization was applied to the images using ImageJ software. CVI was described as the proportion of the luminal area to the total choroidal area. Blood-derived inflammation markers were calculated by the complete blood count.
    Results: The subfoveal choroidal thickness and nasal and temporal directions from fovea centralis at 500 μm, 1000 μm and 1500 μm were reduced in patients with FMF in comparison to healthy controls (p<0.001, each comparison). CVI was significantly decreased in patients with FMF compared to controls (62.28±2.2 and 64.79±4.3, p<0.001).
    Conclusion: We concluded that the choroidal vasculature structure may be affected prior to retinal changes in patients with FMF.
    MeSH term(s) Humans ; Adult ; Photochemotherapy/methods ; Photosensitizing Agents ; Choroid/diagnostic imaging ; Choroid/blood supply ; Retina/diagnostic imaging ; Retinal Vessels/diagnostic imaging ; Tomography, Optical Coherence/methods
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2023-02-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19: more than a respiratory virus, an optical coherence tomography study.

    Dag Seker, Esra / Erbahceci Timur, Inci Elif

    International ophthalmology

    2021  Volume 41, Issue 11, Page(s) 3815–3824

    Abstract: Purpose: The purpose of this study is to investigate anatomic and morphologic features of inner and outer retinal layers in patients recovered from COVID-19 with Spectral Domain Optical Coherence Tomography (SD-OCT), whether correlate with any symptoms ... ...

    Abstract Purpose: The purpose of this study is to investigate anatomic and morphologic features of inner and outer retinal layers in patients recovered from COVID-19 with Spectral Domain Optical Coherence Tomography (SD-OCT), whether correlate with any symptoms during disease process.
    Methods: 32 patients recovered from COVID-19 and age- and gender-matched 36 healthy controls were included in this cross-sectional study. Ganglion cell-inner plexiform layer, macular and peripapiller retinal nerve fiber layer (RNFL), inner nuclear layer (INL), outer nuclear layer (ONL), outer plexiform layer (OPL) and the outer retinal hyperreflective bands including external limiting membrane (ELM), ellipsoid zone (EZ) and interdigitation zone (IZ) were examined with SD-OCT. The differences of each retinal layers thickness among subgroup analysis of ocular pain and headache were also compared.
    Results: Macular RNFL of inner and outer nasal and outer inferior quadrants were thinner in COVID-19 patients compared to healthy control group (p = 0.046, p = 0.014 and p = 0.016, respectively). Thinning in outer superior quadrant of GCIPL and INL quadrants were detected in patients with headache (p = 0.026 and p = 0.01). Superonasal and inferotemporal sectors of pRNFL were thinner in patients with ocular pain compared to patients without ocular pain (p = 0.024 and p = 0.015). Integrity of EZ, ELM and IZ was evaluated as continuous line and protected on each OCT scans.
    Conclusion: The study demonstrated convincing evidence that SARS-CoV-2 can affect the inner and outer retinal layers, with subclinical localized alterations, particularly in patients with headache and ocular pain symptoms during COVID-19 period.
    MeSH term(s) COVID-19 ; Cross-Sectional Studies ; Humans ; Nerve Fibers ; Retinal Ganglion Cells ; SARS-CoV-2 ; Tomography, Optical Coherence
    Language English
    Publishing date 2021-07-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-021-01952-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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