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  1. Article ; Online: Which Spatial Elements Influence Waterfront Space Vitality the Most?—A Comparative Tracking Study of the Maozhou River Renewal Project in Shenzhen, China

    Yating Fan / Da Kuang / Wei Tu / Yu Ye

    Land, Vol 12, Iss 1260, p

    2023  Volume 1260

    Abstract: Urban waterfront renewal, especially public space improvement, is important for regaining waterfront space vitality. However, existing studies constrained by sparse and hard-to-access data are hard to explore how changes in spatial elements during ... ...

    Abstract Urban waterfront renewal, especially public space improvement, is important for regaining waterfront space vitality. However, existing studies constrained by sparse and hard-to-access data are hard to explore how changes in spatial elements during waterfront renewal would affect space vitality. Waterfront space vitality comprises social vitality represented by public behaviors and economic vitality represented by urban functional facilities. Taking the Maozhou River renewal project in China as an example, we collect spatial elements and vitality on corresponding periods in 2018 and 2020 (before and after the renewal construction) and use multiple linear regression models to assess the relationships. We find that the functional diversity (e.g., commercial and cultural facilities) and design quality (e.g., path density and the shoreline’s proximity to the water) are the two most influential spatial elements affecting space vitality during waterfront renewal. Overall, the use of two-time datasets has generated strong evidence for measuring waterfront revitalization.
    Keywords urban waterfront ; vitality ; spatial elements ; spatio-temporal differentiation ; multi-sourced urban data ; Agriculture ; S
    Subject code 720
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Effect of Psychological Capital of Volunteers on Volunteering Behavior: The Chained Mediation Role of Perceived Social Support and Volunteer Motivation.

    Xu, Li Ping / Liao, Jin Bao / Wu, Yu Shen / da Kuang, Hong

    Frontiers in psychology

    2021  Volume 12, Page(s) 657877

    Abstract: This study explored the role of perceived social support and voluntary motivation in the effect of psychological capital of volunteers on volunteering behavior. A sample of 1,165 volunteers who were registered in the China Voluntary Service Information ... ...

    Abstract This study explored the role of perceived social support and voluntary motivation in the effect of psychological capital of volunteers on volunteering behavior. A sample of 1,165 volunteers who were registered in the China Voluntary Service Information System was investigated using a self-reported questionnaire, showing that the psychological capital, perceived social support, voluntary motivation, and volunteering behavior of the volunteers were significantly and positively related to each other. The psychological capital of the volunteers affected volunteering behavior not only directly, but also indirectly through the mediating role of voluntary motivation. Moreover, perceived social support and voluntary motivation also played a chain role in the relationship between the psychological capital and volunteering behavior of the volunteers. Therefore, increasing the psychological capital of the volunteers should promote their perceived social support and inspire voluntary motivation, in turn affecting their volunteering behavior.
    Language English
    Publishing date 2021-09-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.657877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Crime topic modeling

    Da Kuang / P. Jeffrey Brantingham / Andrea L. Bertozzi

    Crime Science, Vol 6, Iss 1, Pp 1-

    2017  Volume 20

    Abstract: Abstract The classification of crime into discrete categories entails a massive loss of information. Crimes emerge out of a complex mix of behaviors and situations, yet most of these details cannot be captured by singular crime type labels. This ... ...

    Abstract Abstract The classification of crime into discrete categories entails a massive loss of information. Crimes emerge out of a complex mix of behaviors and situations, yet most of these details cannot be captured by singular crime type labels. This information loss impacts our ability to not only understand the causes of crime, but also how to develop optimal crime prevention strategies. We apply machine learning methods to short narrative text descriptions accompanying crime records with the goal of discovering ecologically more meaningful latent crime classes. We term these latent classes ‘crime topics’ in reference to text-based topic modeling methods that produce them. We use topic distributions to measure clustering among formally recognized crime types. Crime topics replicate broad distinctions between violent and property crime, but also reveal nuances linked to target characteristics, situational conditions and the tools and methods of attack. Formal crime types are not discrete in topic space. Rather, crime types are distributed across a range of crime topics. Similarly, individual crime topics are distributed across a range of formal crime types. Key ecological groups include identity theft, shoplifting, burglary and theft, car crimes and vandalism, criminal threats and confidence crimes, and violent crimes. Though not a replacement for formal legal crime classifications, crime topics provide a unique window into the heterogeneous causal processes underlying crime.
    Keywords Machine learning ; Non-negative matrix factorization ; Text mining ; Crime ; Science (General) ; Q1-390 ; Social pathology. Social and public welfare. Criminology ; HV1-9960
    Subject code 360
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Hierarchical community detection via rank-2 symmetric nonnegative matrix factorization

    Rundong Du / Da Kuang / Barry Drake / Haesun Park

    Computational Social Networks, Vol 4, Iss 1, Pp 1-

    2017  Volume 26

    Abstract: Abstract Background Community discovery is an important task for revealing structures in large networks. The massive size of contemporary social networks poses a tremendous challenge to the scalability of traditional graph clustering algorithms and the ... ...

    Abstract Abstract Background Community discovery is an important task for revealing structures in large networks. The massive size of contemporary social networks poses a tremendous challenge to the scalability of traditional graph clustering algorithms and the evaluation of discovered communities. Methods We propose a divide-and-conquer strategy to discover hierarchical community structure, nonoverlapping within each level. Our algorithm is based on the highly efficient rank-2 symmetric nonnegative matrix factorization. We solve several implementation challenges to boost its efficiency on modern computer architectures, specifically for very sparse adjacency matrices that represent a wide range of social networks. Conclusions Empirical results have shown that our algorithm has competitive overall efficiency and leading performance in minimizing the average normalized cut, and that the nonoverlapping communities found by our algorithm recover the ground-truth communities better than state-of-the-art algorithms for overlapping community detection. In addition, we present a new dataset of the DBLP computer science bibliography network with richer meta-data and verifiable ground-truth knowledge, which can foster future research in community finding and interpretation of communities in large networks.
    Keywords Community detection ; Nonnegative matrix factorization ; Constrained low rank approximation ; Graph clustering ; Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes

    Jian Tian / Chao Cheng / Shi-Da Kuang / Chao Su / Xin Zhao / Yi-lin Xiong / Yu-Sheng Li / Shu-Guang Gao

    Pain Research and Management, Vol

    2020  Volume 2020

    Abstract: Objectives. A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by ... ...

    Abstract Objectives. A recent work has reported that the elevated osteopontin (OPN) levels in the articular cartilage and synovial fluid are correlated with the progressive osteoarthritis (OA) joint damage, and OPN has a protective effect against OA by suppressing the expressions of OA-associated genes. The present study examined whether the OPN deficiency was susceptible to OA through the regulation of chondrocyte senescence and apoptosis and the expressions of OA-associated genes. Methods. The mRNA levels of COL2A1 and OPN were compared between human OA chondrocytes and normal chondrocytes. The effects of OPN siRNA on the SA-β-Gal expressions and the percentage of apoptotic chondrocytes were examined by using SA-β-Gal staining and apoptosis assay, and the effects on the expressions of COL2A1 and OA-associated genes (COL10A1, IL-1β, TNF-ɑ, MMP-13, and ADAMTS5) were examined by western blot analysis and quantitative real-time RT-PCR. Furthermore, an in vivo OA model was established to examine the effects of OPN siRNA on the senescence and apoptosis of OA chondrocytes and the expressions of OA-associated genes. Results. The mRNA levels of COL2A1 and OPN were decreased in knee OA chondrocytes in comparison with those in normal chondrocytes. The OPN deficiency enhanced the senescence and apoptosis of OA chondrocytes and increased the expressions of COL10A1, IL-1β, TNF-ɑ, MMP-13, and ADAMTS5 but decreased the expression of COL2A1. Meanwhile, OPN deficiency could result in severe, accelerated OA in vivo, which was also associated with enhanced senescence and apoptosis of chondrocytes and elevated expressions of OA-associated genes. Conclusions. The findings of this study suggest that the OPN deficiency can result in accelerated OA, which is associated with enhanced senescence and apoptosis of OA chondrocytes and the upregulated expressions of OA-associated genes.
    Keywords Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The 3D Genome Browser

    Yanli Wang / Fan Song / Bo Zhang / Lijun Zhang / Jie Xu / Da Kuang / Daofeng Li / Mayank N. K. Choudhary / Yun Li / Ming Hu / Ross Hardison / Ting Wang / Feng Yue

    Genome Biology, Vol 19, Iss 1, Pp 1-

    a web-based browser for visualizing 3D genome organization and long-range chromatin interactions

    2018  Volume 12

    Abstract: Abstract Here, we introduce the 3D Genome Browser, http://3dgenome.org, which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types. We design a new binary data format for Hi-C ... ...

    Abstract Abstract Here, we introduce the 3D Genome Browser, http://3dgenome.org, which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types. We design a new binary data format for Hi-C data that reduces the file size by at least a magnitude and allows users to visualize chromatin interactions over millions of base pairs within seconds. Our browser provides multiple methods linking distal cis-regulatory elements with their potential target genes. Users can seamlessly integrate thousands of other omics data to gain a comprehensive view of both regulatory landscape and 3D genome structure.
    Keywords Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions

    Dae-Kyum Kim / Jennifer J. Knapp / Da Kuang / Aditya Chawla / Patricia Cassonnet / Hunsang Lee / Dayag Sheykhkarimli / Payman Samavarchi-Tehrani / Hala Abdouni / Ashyad Rayhan / Roujia Li / Oxana Pogoutse / Étienne Coyaud / Sylvie van der Werf / Caroline Demeret / Anne-Claude Gingras / Mikko Taipale / Brian Raught / Yves Jacob /
    Frederick P. Roth

    G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3399-

    2020  Volume 3402

    Abstract: The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a ... ...

    Abstract The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.
    Keywords sars-cov-2 ; coding sequence collection ; gateway-compatible ; tev (tobacco etch virus) sequence ; Genetics ; QH426-470 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Genetics Society of America
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response

    Ding, Yong / Alex Gregor / Ardalan Bozorgzad / Chris Zealey / Da Kuang / Daheng Liu / Elizabeth Yue / Jun Liu / Justice Igweze / Lei Zhang / Mario Ostrowski / P. Chen / Shariq Mujib / Sheng Lu / Wen Xu

    Journal of controlled release. 2016 Aug. 28, v. 236

    2016  

    Abstract: Peptide based vaccine that incorporates one or several highly conserved CD8+ T cells epitopes to induce potent cytotoxic T lymphocyte (CTL) response is desirable for some infectious diseases, such as HIV-1 (human immunodeficiency virus-1), and cancers. ... ...

    Abstract Peptide based vaccine that incorporates one or several highly conserved CD8+ T cells epitopes to induce potent cytotoxic T lymphocyte (CTL) response is desirable for some infectious diseases, such as HIV-1 (human immunodeficiency virus-1), and cancers. However, the CD8+ T cells epitope is often weakly immunogenic, and thus requires a specific adjuvant or delivery system to enhance the efficiency. Here we investigated the use of self-assembling peptide EAK16-II based platform to achieve the co-delivery of CD8+ T cells epitope and TLR7/8 agonists (R848 or R837) for augmenting DCs maturation and HIV-1 specific CTL response. HIV-1 CTL epitope SL9 was conjugated with EAK16-II to obtain SL9-EAK16-II, which further spontaneously co-assembled with R848 or R837 in aqueous solution, forming co-assembled nanofibers. Fluorescence spectra and calorimetrical titration revealed the interaction between SL9-EAK16-II assemblies and R848 or R837 via hydrogen bonding and hydrophobic interaction, with the binding affinity (dissociation constant Kd) of 0.62μM or 0.53μM, respectively. Ex vivo generated DCs from HIV-1+ patients pulsed with the SL9-EAK16-II/R848 nanofibers stimulated significantly more polyfunctional SL9 specific CTLs, compared to the DCs pulsed with SL9 alone or the mixture of SL9 and TLR agonist. Furthermore, the nanofibers elicited stronger SL9 specific CTL response in vaccinated mice. Our findings suggest the self-assembling peptide EAK16-II might be used as a new delivery system for peptide based vaccines.
    Keywords adjuvants ; agonists ; aqueous solutions ; binding capacity ; CD8-positive T-lymphocytes ; dendritic cells ; dissociation ; epitopes ; fluorescence emission spectroscopy ; Human immunodeficiency virus 1 ; hydrogen bonding ; hydrophobic bonding ; infectious diseases ; mice ; monocytes ; nanofibers ; neoplasms ; patients ; titration ; Toll-like receptors ; vaccines
    Language English
    Dates of publication 2016-0828
    Size p. 22-30.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2016.06.019
    Database NAL-Catalogue (AGRICOLA)

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