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Article ; Online: High-dose-rate Brachytherapy Monotherapy in Patients With Localised Prostate Cancer: Dose Modelling and Optimisation Using Computer Algorithms.

Dabic-Stankovic, K / Rajkovic, K / Stankovic, J / Marosevic, G / Kolarevic, G / Pavicar, B

Clinical oncology (Royal College of Radiologists (Great Britain))

2024 Volume 36, Issue 6, Page(s) 378–389

Abstract: Aims: Interstitial high-dose-rate brachytherapy (HDR-BT) is an effective therapy modality for patients with localized prostate carcinoma. The objectives of the study were to optimise the therapy regime variables using two models: response surface ... ...

Abstract	Aims: Interstitial high-dose-rate brachytherapy (HDR-BT) is an effective therapy modality for patients with localized prostate carcinoma. The objectives of the study were to optimise the therapy regime variables using two models: response surface methodology (RSM) and artificial neural network (ANN). Materials and methods: Thirty-one studies with 5651 patients were included (2078 patients presented as low-risk, 3077 patients with intermediate-risk, and 496 patients with high-risk). A comparison of these therapy schedules was carried out using an effective biologically effective dose (BED Results: An optimal treatment schedule (BFS = 97%) for patients presented with low-risk biochemical recurrence would be D = 26 Gy applied in one application, 2 fractions at least 6 h apart, within an overall treatment time of 1 day (BED Conclusions: The RSM and ANN models determine almost the same optimal values for the set of predicted therapy parameters that make a feasible selection of an optimal treatment regime.
MeSH term(s)	Humans ; Male ; Brachytherapy/methods ; Prostatic Neoplasms/radiotherapy ; Radiotherapy Dosage ; Algorithms ; Neural Networks, Computer
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2024.03.009
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Zs.A 2774: Show issues

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Article ; Online: Modelling and optimisation of treatment parameters in high-dose-rate mono brachytherapy for localised prostate carcinoma using a multilayer artificial neural network and a genetic algorithm: Pilot study.

Rajković, Katarina M / Dabić-Stanković, Kata / Stanković, Jovan / Aćimović, Miodrag / Đukanović, Nina / Nikolin, Borislava

Computers in biology and medicine

2020 Volume 126, Page(s) 104045

Abstract: Background: High-dose-rate mono brachytherapy (HDR-MB) is employed in the treatment of prostate carcinoma (CaP). As an ideal plan of CaP brachytherapy cannot be created, it is necessary to identify a reliable tool to optimise the parameters of HDR-MB. ... ...

Abstract	Background: High-dose-rate mono brachytherapy (HDR-MB) is employed in the treatment of prostate carcinoma (CaP). As an ideal plan of CaP brachytherapy cannot be created, it is necessary to identify a reliable tool to optimise the parameters of HDR-MB. This paper applies a multilayer artificial neural network (MANN) and a genetic algorithm (GA) to optimise brachytherapy parameters based on an individual dose-volumetric analysis. Methods: Patients with localised CaP of various risks were treated with HDR-MB. Consecutive levels of the biochemical control parameter (prostate specific antigen (PSA) nadir) have been collected after completion of HDR-MB in the range 2-9 years. The Kaplan-Meier regression analysis of biochemical-free survival (BFS) was applied. The clinical risk of recurrent CaP (RCaP), the therapy dose (TD), TD coverage index (CI Results: In the low-risk group, BFS was achieved in 100% of treated patients, while in the group of patients with high risk, BFS was achieved in 95.8% of treated patients. The MANN-GA model optimises a TD of 47.3 Gy and CI Conclusions: The developed MANN-GA model presents a method for optimising the treatment parameters in radiation therapy, which could be a valuable tool in planning of the HDR-MB.
MeSH term(s)	Algorithms ; Brachytherapy ; Carcinoma ; Follow-Up Studies ; Humans ; Male ; Neural Networks, Computer ; Pilot Projects ; Prostate ; Prostatic Neoplasms/radiotherapy
Language	English
Publishing date	2020-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2020.104045
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Article: Preoperative Gleason score, percent of positive prostate biopsies and PSA in predicting biochemical recurrence after radical prostatectomy.

Acimovic, M / Dabic-Stankovic, K / Pejcic, T / Dzamic, Z / Rafailovic, D / Hadzi-Djokic, J

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2014 Volume 18, Issue 4, Page(s) 954–960

Abstract: Purpose: To determine the factors that can improve the prediction of biochemical recurrence after radical prostatectomy for the patients with prostate adenocarcinoma.: Methods: Our study included 182 patients with prostate adenocarcinoma who were ... ...

Abstract	Purpose: To determine the factors that can improve the prediction of biochemical recurrence after radical prostatectomy for the patients with prostate adenocarcinoma. Methods: Our study included 182 patients with prostate adenocarcinoma who were biopsied and underwent radical surgical treatment at the Clinic of Urology, Clinical Center of Serbia, Medical Faculty in Belgrade from 1994 to 2004. Patients were prospectively followed-up and monitored for a minimum of 8 years and data were statistically processed by multivariate regression analysis. We arranged the predictors into 3 regressive models. In the first model the predictors were clinical stage of the disease, preoperative Gleason score, F/T PSA ratio and PSA. In the second model these predictors were accompanied with the number of positive biopsies and percent of positive prostate biopsies. In the third model, patient follow-up was added to the predictors. In all 3 models biochemical recurrence was considered as a dependent variable. Results: On multivariate analysis, patient follow-up (p<0.0001), percent of positive prostate biopsies (p<0.0001), bioptic Gleason score (p<0.0001) and preoperative PSA (p<0.003) were significant independent predictors of biochemical recurrence. The most successful prediction of recurrence that provided accurate prognosis for 80% of the patients was obtained by the third model using the percent of positive prostate biopsies, PSA and patient follow-up. Conclusion: As stated in multivariate analysis, the independent predictors according to the significance are the follows: patient follow-up, percent of positive prostate biopsies, bioptic Gleason score and preoperative PSA, whereas preoperative F/T PSA ratio is dependent predictor. The number of positive biopsies and clinical stage of the disease are of no significance.
MeSH term(s)	Adenocarcinoma/blood ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Biopsy ; Chi-Square Distribution ; Disease-Free Survival ; Humans ; Kallikreins/blood ; Linear Models ; Male ; Multivariate Analysis ; Neoplasm Grading ; Neoplasm Staging ; Odds Ratio ; Prospective Studies ; Prostate-Specific Antigen/blood ; Prostatectomy/adverse effects ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Risk Assessment ; Risk Factors ; Serbia ; Time Factors ; Treatment Outcome
Chemical Substances	KLK3 protein, human (EC 3.4.21.-) ; Kallikreins (EC 3.4.21.-) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2014-01-08
Publishing country	Cyprus
Document type	Journal Article
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Zs.A 5438: Show issues

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Article: External beam radiotherapy plus brachytherapy boost in treatment of anal canal carcinoma.

Stojanović, S / Radosević-Jelić, Ij / Dabić-Stanković, K / Popov, I / Josifovski, J

Acta chirurgica Iugoslavica

2007 Volume 54, Issue 3, Page(s) 33–38

Abstract: Purpose: Radiotherapy has been the standard treatment of anal canal carcinoma for the last three decades. However, there are still many open questions such as optimal radiation technique, adequate boost dose or best chemotherapy regimen. Beside cure and ...

Abstract	Purpose: Radiotherapy has been the standard treatment of anal canal carcinoma for the last three decades. However, there are still many open questions such as optimal radiation technique, adequate boost dose or best chemotherapy regimen. Beside cure and local control, other important goals are sphincter salvage and avoidance of a permanent colostomy, i.e. morbidity minimization. Material and methods: At the Institute for Oncology and Radiology of Serbia, between March 1997 and May 2004, patients with anal canal carcinoma were treated with combined external beam radiotherapy and brachytherapy boost as primary treatment modality. Initially, external beam radiotherapy was applied with two opposed parallel fields and dose ranged from 40-50 Gy and after that patient continued the treatment with brachytherapy boost (intraluminal or interstitial) with doses ranged from 10-25 Gy. Total tumor dose in combined radiotherapy treatment ranged from 55-70 Gy. Results: Out of 21 patients, acute complications were registered in 15 patients (71.4%) and the most frequent was dermatitis. Complete response after radiotherapy was registered in 17 patients (81%). In the median follow up time of 42 months, five-year overall survival was 71% and disease free survival was 61%. Late sequelas were registered in 14 patients (66.7%), but they were low grade. Conclusions: Our study shows results using external beam radiotherapy and brachytherapy boost as single modality treatment, but we need more randomized trial to improve better local control and minimize toxicity.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anus Neoplasms/radiotherapy ; Brachytherapy ; Female ; Humans ; Male ; Middle Aged ; Radiotherapy Dosage
Language	English
Publishing date	2007-10-30
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
DOI	10.2298/aci0703033s
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Zs.B 1188: Show issues

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Article ; Online: Conventional conformal radiotherapy vs intracavitary brachytherapy for the adjuvant postoperative treatment of cervical cancer

Mileusnić D.S. / Stanković J.B. / Dabić-Stanković K.M. / Milošević N.T.

Acta Chirurgica Iugoslavica, Vol 56, Iss 4, Pp 189-

A comparative dosimetric study

2009 Volume 194

Abstract: Objectives. The aim of this pilot study is to evaluate the feasibility of 3D-conformal radiotherapy (3D-CRT) in the adjuvant postoperative radiotherapy of the vaginal cuff and upper third of present vaginal tissue. Methods. The representative patient ( ... ...

Abstract	Objectives. The aim of this pilot study is to evaluate the feasibility of 3D-conformal radiotherapy (3D-CRT) in the adjuvant postoperative radiotherapy of the vaginal cuff and upper third of present vaginal tissue. Methods. The representative patient (FIGO IB; PH: squamous cell carcinoma) was referred for adjuvant post-hysterectomy radiotherapy. A whole pelvis irradiation with concomitant high-dose-rate intracavitary brachytherapy (HDR-ICBT) was applied. HDR-ICBT total dose of 24 Gy in four fractions/one fraction per week was delivered to the vaginal cuff using two Fletcher-Suit ovoids. The feasibility of change from HDR-ICBT to CRT was evaluated by generating of three different plans using 10 MV photon beams shaped by multileaf collimator. Results and discussion. The referent volume received HDR-ICBT prescribed dose. The maximum ICBT percentage dose to the rectum and urinary bladder was 101% and 106% respectively. In all 3D-CRT plans almost 100% of planning target volume (PTV) was covered by 95% therapy isodose surface. From 12 - 13% of the rectum and 1-3% urinary bladder volume were covered by 100% isodose surface, with the highest maximum dose of 104% and 101%, respectively. Comparison of the PTV dose coverage and the maximum dose to the rectum and urinary bladder for HDR-ICBT and 3D-CRT plans showed no major difference. Conclusion. 3D-CRT could be considered as adequate replacement for ICBT in the adjuvant postoperative treatment of the vaginal cuff and upper third of present vaginal tissue. Time-dose-fractionation pattern for HDR-ICBT may be safely applied for 3D-CRT.
Keywords	cervical cancer ; conformal radiothrapy ; brachytherapy ; radiotherapy ; treatment planning ; Surgery ; RD1-811 ; Medicine ; R ; DOAJ:Surgery ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	616
Language	Serbian
Publishing date	2009-01-01T00:00:00Z
Publisher	Klinički centar Srbije, Institut za bolesti digestivnog sistema
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Conventional conformal radiotherapy vs intracavitary brachytherapy for the adjuvant postoperative treatment of cervical cancer: a comparative dosimetric study.

Milosević, N T / Dabić-Stanković, K M / Stanković, J B / Mileusnić, D S

Acta chirurgica Iugoslavica

2010 Volume 56, Issue 4, Page(s) 189–194

Abstract: Objectives: The aim of this pilot study is to evaluate the feasibility of 3D-conformal radiotherapy (3D-CRT) in the adjuvant postoperative radiotherapy of the vaginal cuff and upper third of present vaginal tissue.: Methods: The representative ... ...

Abstract	Objectives: The aim of this pilot study is to evaluate the feasibility of 3D-conformal radiotherapy (3D-CRT) in the adjuvant postoperative radiotherapy of the vaginal cuff and upper third of present vaginal tissue. Methods: The representative patient (FIGO IB; PH: squamous cell carcinoma) was referred for adjuvant post-hysterectomy radiotherapy. A whole pelvis irradiation with concomitant high-dose-rate intracavitary brachytherapy (HDR-ICBT) was applied. HDR-ICBT total dose of 24 Gy in four fractions/one fraction per week was delivered to the vaginal cuff using two Fletcher-Suit ovoids. The feasibility of change from HDR-ICBT to CRT was evaluated by generating of three different plans using 10 MV photon beams shaped by multileaf collimator. Results and discussion: The referent volume received HDR-ICBT prescribed dose. The maximum ICBT percentage dose to the rectum and urinary bladder was 101% and 106% respectively. In all 3D-CRT plans almost 100% of planning target volume (PTV) was covered by 95% therapy isodose surface. From 12 - 13% of the rectum and 1-3% urinary bladder volume were covered by 100% isodose surface, with the highest maximum dose of 104% and 101%, respectively. Comparison of the PTV dose coverage and the maximum dose to the rectum and urinary bladder for HDR-ICBT and 3D-CRT plans showed no major difference. CONCLUSION; 3D-CRT could be considered as adequate replacement for ICBT in the adjuvant postoperative treatment of the vaginal cuff and upper thi-rd of present vaginal tissue. Time-dose-fractionation pattern for HDR-ICBT may be safely applied for 3D-CRT.
MeSH term(s)	Brachytherapy ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Female ; Humans ; Radiotherapy Dosage ; Radiotherapy, Adjuvant ; Radiotherapy, Conformal ; Uterine Cervical Neoplasms/radiotherapy ; Uterine Cervical Neoplasms/surgery
Language	English
Publishing date	2010-04-23
Publishing country	Serbia
Document type	Comparative Study ; Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
DOI	10.2298/aci0904189m
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Article ; Online: External beam radiotherapy plus brachytherapy boost in treatment of anal canal carcinoma

Josifovski J. / Popov I. / Dabić-Stanković K. / Radošević-Jelić Lj. / Stojanović S.

Acta Chirurgica Iugoslavica, Vol 54, Iss 3, Pp 33-

2007 Volume 38

Abstract	Purpose: Radiotherapy has been the standard treatment of anal canal carcinoma for the last three decades. However, there are still many open questions such as optimal radiation technique, adequate boost dose or best chemotherapy regimen. Beside cure and local control, other important goals are sphincter salvage and avoidance of a permanent colostomy, i.e. morbidity minimization. Material and methods: At the Institute for Oncology and Radiology of Serbia, between March 1997 and May 2004, patients with anal canal carcinoma were treated with combined external beam radiotherapy and brachytherapy boost as primary treatment modality. Initially, external beam radiotherapy was applied with two opposed parallel fields and dose ranged from 40-50 Gy and after that patient continued the treatment with brachytherapy boost (intraluminal or interstitial) with doses ranged from 10-25 Gy. Total tumor dose in combined radiotherapy treatment ranged from 55-70 Gy. Results: Out of 21 patients, acute complications were registered in 15 patients (71.4%) and the most frequent was dermatitis. Complete response after radiotherapy was registered in 17 patients (81%). In the median follow up time of 42 months, five-year overall survival was 71% and disease free survival was 61%. Late sequelas were registered in 14 patients (66.7%), but they were low grade. Conclusions: Our study shows results using external beam radiotherapy and brachytherapy boost as single modality treatment, but we need more randomized trial to improve better local control and minimize toxicity.
Keywords	anal canal cancer ; radiotherapy ; brachytherapy ; Surgery ; RD1-811 ; Medicine ; R ; DOAJ:Surgery ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	616
Language	Serbian
Publishing date	2007-01-01T00:00:00Z
Publisher	Klinički centar Srbije, Institut za bolesti digestivnog sistema
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Jonometrijske metode kalibracije iridijumskih (192Ir) brahiterapijskih izvora zracenja visokih aktivnosti.

Milosević, Nebojsa T / Stanković, Jovan B / Dabić-Stanković, Kata

Vojnosanitetski pregled

2003 Volume 60, Issue 4, Page(s) 479–485

Title translation	Radiometric methods of calibrating high dose iridium (192Ir) brachytherapy.
MeSH term(s)	Brachytherapy/methods ; Calibration ; Humans ; Iridium Radioisotopes/therapeutic use ; Radiometry/methods ; Radiotherapy Dosage
Chemical Substances	Iridium Radioisotopes
Language	Serbian
Publishing date	2003-08-14
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	123795-0
ISSN	0042-8450
ISSN	0042-8450
DOI	10.2298/vsp0304479m
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