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Article: Thalidomide as an effective treatment for adult multiple xanthogranuloma.

Debois, Deborah / Marot, Liliane / Andre, Marc / Dachelet, Claire

2018 Volume 4, Issue 9, Page(s) 896–898

Language	English
Publishing date	2018-10-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2018.05.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Linear IgA dermatosis in association with angioimmunoblastic T-cell lymphoma infiltrating the skin: A case report with literature review.

Colmant, Caroline / Camboni, Alessandra / Dekeuleneer, Valérie / Marot, Liliane / Dachelet, Claire / Baeck, Marie

Journal of cutaneous pathology

2019 Volume 47, Issue 3, Page(s) 251–256

Abstract: Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive form of peripheral T-cell lymphoma, characterized by systemic symptoms, diffuse lymphadenopathy, hepatosplenomegaly and immunodysregulation. Half of AITL is associated with cutaneous symptoms, ... ...

Abstract	Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive form of peripheral T-cell lymphoma, characterized by systemic symptoms, diffuse lymphadenopathy, hepatosplenomegaly and immunodysregulation. Half of AITL is associated with cutaneous symptoms, but only few cases with bullous eruption have been described. Association with a linear IgA dermatosis is extremely rare. Linear IgA dermatosis can be idiopathic, or linked with drug intake or neoplastic disorders. Some cases of linear IgA dermatosis presenting as toxic epidermal necrolysis (TEN) have been described, most of them being drug induced. We here present the case of a 72-year-old man recently diagnosed with AITL who developed a bullous eruption, presenting as TEN. Histopathology showed deep cutaneous involvement of the lymphoma with a sub-epidermal blistering and direct immunofluorescence revealed a heavy IgA linear deposit on the dermal-epidermal junction. A diagnosis of linear IgA dermatosis associated with cutaneous involvement of an angioimmunoblastic T-cell lymphoma was made. Chemotherapy and corticosteroids allowed cutaneous improvement but the patient died of his lymphoma shortly after.
MeSH term(s)	Aged ; Humans ; Linear IgA Bullous Dermatosis/etiology ; Linear IgA Bullous Dermatosis/pathology ; Lymphoma, T-Cell, Peripheral/complications ; Lymphoma, T-Cell, Peripheral/pathology ; Male
Language	English
Publishing date	2019-10-27
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.13576
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Article: CD30+ Cutaneous Anaplastic Large-Cell Lymphoma of the Upper Eyelid: A Case Report.

Olivier, Stéphanie / Dachelet, Claire / Theate, Ivan / Tromme, Isabelle / Baeck, Marie

Case reports in dermatology

2017 Volume 9, Issue 3, Page(s) 206–210

Abstract: CD30+ cutaneous anaplastic large-cell lymphoma is part of the CD30+ T-cell lymphoproliferative disorders. This type of lymphoma is in most cases indolent, with a high survival rate. We report the case of a 59-year-old patient with a 1-month lasting ... ...

Abstract	CD30+ cutaneous anaplastic large-cell lymphoma is part of the CD30+ T-cell lymphoproliferative disorders. This type of lymphoma is in most cases indolent, with a high survival rate. We report the case of a 59-year-old patient with a 1-month lasting crusty lesion of the upper eyelid. Eyelid involvement is very uncommon, as the most frequent locations are the trunk and the limbs.
Language	English
Publishing date	2017-10-20
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2505300-0
ISSN	1662-6567
ISSN	1662-6567
DOI	10.1159/000481771
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Article ; Online: Chilblains observed during the COVID-19 pandemic cannot be distinguished from classic, cold-related chilblains

De Greef, Axel / Choteau, Mathilde / Herman, Anne / Bouzin, Caroline / Marot, Liliane / Dachelet, Claire / Lelotte, Julie / Hoton, Delphine / Dumoutier, Laure / Baeck, Marie

European journal of dermatology : EJD

2022 Volume 32, Issue 3, Page(s) 377–383

Abstract: Background: Type 1 interferon (IFN-I) response induced by SARS-CoV-2 has been hypothesized to explain the association between chilblain lesions (CL) and SARS-CoV-2 infection.: Objective: To explore direct cytopathogenicity of SARS-CoV-2 in CL and to ... ...

Title translation	Chilblains observed during the COVID-19 pandemic cannot be distinguished from classic, cold-related chilblains.
Abstract	Background: Type 1 interferon (IFN-I) response induced by SARS-CoV-2 has been hypothesized to explain the association between chilblain lesions (CL) and SARS-CoV-2 infection. Objective: To explore direct cytopathogenicity of SARS-CoV-2 in CL and to focus on IFN-I expression in patients with chilblains. Materials & methods: A monocentric cohort of 43 patients presenting with CL from April 2020 to May 2021 were included. During this period, all CL were, a priori, considered to be SARS-CoV-2-related. RT-qPCR on nasopharyngeal swabs and measurements of anti-SARS-CoV-2 antibodies were performed. Anti-SARS-CoV-2 immunostainings as well as SARS-CoV-2 RT-qPCR were performed on biopsy specimens of CL and controls. Expression of MX1 and IRF7 was analysed on patients’ biopsy specimens and/or PBMC and compared with controls and/or chilblains observed before the pandemic. Serum IFN-α was also measured. Results: RT-qPCR was negative in all patients and serological tests were positive in 11 patients. Immunostaining targeting viral proteins confirmed the lack of specificity. SARS-CoV-2 RNA remained undetected in all CL specimens. MX1 immunostaining was positive in CL and in pre-pandemic chilblains compared to controls. MX1 and IRF7 expression was significantly increased in CL specimens but not in PBMC. Serum IFN-α was undetected in CL patients. Conclusion: CL observed during the pandemic do not appear to be directly related to SARS-CoV-2 infection, either based on viral cytopathogenicity or high IFN-I response induced by the virus.
MeSH term(s)	COVID-19/complications ; Chilblains/diagnosis ; Humans ; Interferon Regulatory Factor-7 ; Interferon-alpha ; Leukocytes, Mononuclear/immunology ; Myxovirus Resistance Proteins ; Pandemics ; RNA, Viral ; SARS-CoV-2
Chemical Substances	IRF7 protein, human ; Interferon Regulatory Factor-7 ; Interferon-alpha ; MX1 protein, human ; Myxovirus Resistance Proteins ; RNA, Viral
Language	English
Publishing date	2022-09-05
Publishing country	France
Document type	Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2022.4260
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Article ; Online: Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic.

Herman, Anne / Peeters, Caroline / Verroken, Alexia / Tromme, Isabelle / Tennstedt, Dominique / Marot, Liliane / Dachelet, Claire / Gruson, Damien / Hermans, Cedric / Baeck, Marie

JAMA dermatology

2020 Volume 156, Issue 9, Page(s) 998–1003

Abstract: Importance: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported.: Objective: To determine if chilblains are associated with COVID-19.: Design, setting, and participants: This monocentric case ... ...

Abstract	Importance: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported. Objective: To determine if chilblains are associated with COVID-19. Design, setting, and participants: This monocentric case series was conducted at the Department of Dermatology at Cliniques universitaires Saint-Luc, a tertiary care hospital in Brussels, Belgium, between April 10 and April 17, 2020. We evaluated a total of 31 referred patients who had recently developed chilblains. Main outcomes and measures: Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA on nasopharyngeal swabs for all patients and in skin biopsy specimens for 22 patients. Blood samples from all patients were tested for specific anti-SARS-CoV-2 immunoglobulin (Ig) M and IgG antibodies. All patients had extended blood analyses. Histologic (22 patients) and immunofluorescence examinations (15 patients) were performed on the skin biopsy specimens. Results: The 31 patients were generally in good health; most were teenagers or young adults, and 19 were women. Histopathologic analysis of skin biopsy specimens (22 patients) confirmed the diagnosis of chilblains and showed occasional lymphocytic or microthrombotic phenomena. Immunofluorescence analyses showed vasculitis of small-diameter vessels in 7 patients. In all patients, SARS-CoV-2 RNA remained undetected by RT-PCR on nasopharyngeal swabs and in biopsy samples of the skin lesions. The IgM and IgG antibody titers were negative for SARS-CoV-2 in all patients (<1.0 arbitrary unit/mL). No significant abnormalities in blood test results were suggestive of systemic disease. Antinuclear antibody titers were low in 7 patients and higher in 1 patient. Conclusions and relevance: Chilblains appeared not to be directly associated with COVID-19 in this case series. Lifestyle changes associated with community containment and lockdown measures are a possible explanation for these lesions.
MeSH term(s)	Adolescent ; Adult ; Aged ; Belgium/epidemiology ; Biopsy ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Chilblains/diagnosis ; Chilblains/etiology ; Child ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Real-Time Polymerase Chain Reaction ; Young Adult
Chemical Substances	COVID-19 Vaccines ; Covid-19 aAPC vaccine
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2020.2368
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Article ; Online: Primary cutaneous CD8+ and CD30+ T-cell lymphoproliferative disorders: case reports and clinical implications.

Baldin, Pamela / Shwe, Myat Marla / Marot, Liliane / Eeckout, Pascal Van Van / Dachelet, Claire / Sacré, Laurine / Berners, Aline / Olivier, Stephanie / Camboni, Alessandra

European journal of dermatology : EJD

2019 Volume 29, Issue 1, Page(s) 39–44

Abstract: Background: CD8+ CD30+ primary cutaneous T-cell lymphomas (PCTCL) are rare entities with overlapping pathological features and variable outcome.: Objectives: We sought to highlight the importance of correlation between pathological findings and ... ...

Abstract	Background: CD8+ CD30+ primary cutaneous T-cell lymphomas (PCTCL) are rare entities with overlapping pathological features and variable outcome. Objectives: We sought to highlight the importance of correlation between pathological findings and clinical presentation for correct classification of the disease. Materials & methods: Two cases of CD8+ CD30+ PCTCL were investigated. The first patient presented with a multiple necro-erythematous lesion of the limb and the second with a papulo-necrotic lesion of the eyelid. Results: Despite a different clinical presentation, pathological findings were similar in both cases. Clinico-pathological correlation led to a diagnosis of primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma in the first case and primary cutaneous anaplastic large-cell lymphoma in the second. The first patient died shortly after diagnosis and the second is alive without recurrence. Conclusions: Clinico-pathological correlation is essential for the correct identification of these rare diseases.
MeSH term(s)	Aged ; CD8 Antigens/immunology ; Fatal Outcome ; Female ; Humans ; Ki-1 Antigen/immunology ; Lymphoma/immunology ; Lymphoma/pathology ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/pathology ; Middle Aged ; Prognosis ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology
Chemical Substances	CD8 Antigens ; Ki-1 Antigen
Language	English
Publishing date	2019-01-19
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2018.3493
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Zs.A 3484: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: CD30+ Cutaneous Anaplastic Large-Cell Lymphoma of the Upper Eyelid: A Case Report

Olivier, Stéphanie / Dachelet, Claire / Theate, Ivan / Tromme, Isabelle / Baeck, Marie

Case Reports in Dermatology

2017 Volume 9, Issue 3, Page(s) 206–210

Institution	Department of Dermatology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium Department of Dermatology, CHU UCL Namur, Yvoir, Belgium Department of Pathology, Institut de Pathologie et de Génétique (IPG), Gosselies, Belgium
Abstract	CD30+ cutaneous anaplastic large-cell lymphoma is part of the CD30+ T-cell lymphoproliferative disorders. This type of lymphoma is in most cases indolent, with a high survival rate. We report the case of a 59-year-old patient with a 1-month lasting crusty lesion of the upper eyelid. Eyelid involvement is very uncommon, as the most frequent locations are the trunk and the limbs.
Keywords	T-cell lymphoma ; Lymphoma ; CD30+ cutaneous anaplastic large-cell lymphoma ; Eyelid
Language	English
Publishing date	2017-10-20
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Single Case ; This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
ZDB-ID	2505300-0
ISSN	1662-6567 ; 1662-6567
ISSN (online)	1662-6567
ISSN	1662-6567
DOI	10.1159/000481771
Database	Karger publisher's database

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Article: Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic

Herman, Anne / Peeters, Caroline / Verroken, Alexia / Tromme, Isabelle / Tennstedt, Dominique / Marot, Liliane / Dachelet, Claire / Gruson, Damien / Hermans, Cedric / Baeck, Marie

JAMA dermatol. (Chic. Ill., Print)

Abstract: Importance: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported. Objective: To determine if chilblains are associated with COVID-19. Design, Setting, and Participants: This monocentric case series was ... ...

Abstract	Importance: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported. Objective: To determine if chilblains are associated with COVID-19. Design, Setting, and Participants: This monocentric case series was conducted at the Department of Dermatology at Cliniques universitaires Saint-Luc, a tertiary care hospital in Brussels, Belgium, between April 10 and April 17, 2020. We evaluated a total of 31 referred patients who had recently developed chilblains. Main Outcomes and Measures: Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA on nasopharyngeal swabs for all patients and in skin biopsy specimens for 22 patients. Blood samples from all patients were tested for specific anti-SARS-CoV-2 immunoglobulin (Ig) M and IgG antibodies. All patients had extended blood analyses. Histologic (22 patients) and immunofluorescence examinations (15 patients) were performed on the skin biopsy specimens. Results: The 31 patients were generally in good health; most were teenagers or young adults, and 19 were women. Histopathologic analysis of skin biopsy specimens (22 patients) confirmed the diagnosis of chilblains and showed occasional lymphocytic or microthrombotic phenomena. Immunofluorescence analyses showed vasculitis of small-diameter vessels in 7 patients. In all patients, SARS-CoV-2 RNA remained undetected by RT-PCR on nasopharyngeal swabs and in biopsy samples of the skin lesions. The IgM and IgG antibody titers were negative for SARS-CoV-2 in all patients (<1.0 arbitrary unit/mL). No significant abnormalities in blood test results were suggestive of systemic disease. Antinuclear antibody titers were low in 7 patients and higher in 1 patient. Conclusions and Relevance: Chilblains appeared not to be directly associated with COVID-19 in this case series. Lifestyle changes associated with community containment and lockdown measures are a possible explanation for these lesions.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32584377
Database	COVID19

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Article ; Online: Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic.

Herman, Anne / Peeters, Caroline / Verroken, Alexia / Tromme, Isabelle / Tennstedt, Dominique / Marot, Liliane / Dachelet, Claire / Gruson, Damien / Hermans, Cédric / Baeck, Marie

JAMA dermatology, Vol. 156, no.9, p. 998-

2020 Volume 1003

Abstract: IMPORTANCE: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported. OBJECTIVE: To determine if chilblains are associated with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: This monocentric case series was ... ...

Abstract	IMPORTANCE: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported. OBJECTIVE: To determine if chilblains are associated with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: This monocentric case series was conducted at the Department of Dermatology at Cliniques universitaires Saint-Luc, a tertiary care hospital in Brussels, Belgium, between April 10 and April 17, 2020. We evaluated a total of 31 referred patients who had recently developed chilblains. MAIN OUTCOMES AND MEASURES: Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA on nasopharyngeal swabs for all patients and in skin biopsy specimens for 22 patients. Blood samples from all patients were tested for specific anti-SARS-CoV-2 immunoglobulin (Ig) M and IgG antibodies. All patients had extended blood analyses. Histologic (22 patients) and immunofluorescence examinations (15 patients) were performed on the skin biopsy specimens. RESULTS: The 31 patients were generally in good health; most were teenagers or young adults, and 19 were women. Histopathologic analysis of skin biopsy specimens (22 patients) confirmed the diagnosis of chilblains and showed occasional lymphocytic or microthrombotic phenomena. Immunofluorescence analyses showed vasculitis of small-diameter vessels in 7 patients. In all patients, SARS-CoV-2 RNA remained undetected by RT-PCR on nasopharyngeal swabs and in biopsy samples of the skin lesions. The IgM and IgG antibody titers were negative for SARS-CoV-2 in all patients (<1.0 arbitrary unit/mL). No significant abnormalities in blood test results were suggestive of systemic disease. Antinuclear antibody titers were low in 7 patients and higher in 1 patient. CONCLUSIONS AND RELEVANCE: Chilblains appeared not to be directly associated with COVID-19 in this case series. Lifestyle changes associated with community containment and lockdown measures are a possible explanation for these lesions.
Keywords	covid19
Subject code	610 ; 616
Language	English
Publisher	American Medical Association
Publishing country	be
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic.

Herman, Anne / Peeters, Caroline / Verroken, Alexia / Tromme, Isabelle / Tennstedt, Dominique / Marot, Liliane / Dachelet, Claire / Gruson, Damien / Hermans, Cédric / Baeck, Marie

JAMA dermatology, Vol. 156, no.9, p. 998-

2020 Volume 1003

Abstract	IMPORTANCE: During the coronavirus disease 2019 (COVID-19) pandemic, several cases of chilblains have been reported. OBJECTIVE: To determine if chilblains are associated with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: This monocentric case series was conducted at the Department of Dermatology at Cliniques universitaires Saint-Luc, a tertiary care hospital in Brussels, Belgium, between April 10 and April 17, 2020. We evaluated a total of 31 referred patients who had recently developed chilblains. MAIN OUTCOMES AND MEASURES: Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA on nasopharyngeal swabs for all patients and in skin biopsy specimens for 22 patients. Blood samples from all patients were tested for specific anti-SARS-CoV-2 immunoglobulin (Ig) M and IgG antibodies. All patients had extended blood analyses. Histologic (22 patients) and immunofluorescence examinations (15 patients) were performed on the skin biopsy specimens. RESULTS: The 31 patients were generally in good health; most were teenagers or young adults, and 19 were women. Histopathologic analysis of skin biopsy specimens (22 patients) confirmed the diagnosis of chilblains and showed occasional lymphocytic or microthrombotic phenomena. Immunofluorescence analyses showed vasculitis of small-diameter vessels in 7 patients. In all patients, SARS-CoV-2 RNA remained undetected by RT-PCR on nasopharyngeal swabs and in biopsy samples of the skin lesions. The IgM and IgG antibody titers were negative for SARS-CoV-2 in all patients (<1.0 arbitrary unit/mL). No significant abnormalities in blood test results were suggestive of systemic disease. Antinuclear antibody titers were low in 7 patients and higher in 1 patient. CONCLUSIONS AND RELEVANCE: Chilblains appeared not to be directly associated with COVID-19 in this case series. Lifestyle changes associated with community containment and lockdown measures are a possible explanation for these lesions.
Keywords	covid19
Language	English
Publisher	American Medical Association
Publishing country	be
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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