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Article ; Online: Neoadjuvant chemoradiotherapy in rectal cancer and anorectal sphincter dysfunction: Review of the literature.

Massaras, Dimitrios / Pantiora, Eirini / Sotirova, Eirini / Dellaportas, Dionysios / Dafnios, Nikolaos / Zygogianni, Anna / Theodosopoulos, Theodosios

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2020 Volume 25, Issue 1, Page(s) 35–39

Abstract: Purpose: The purpose of this article was to review the current medical literature regarding deterioration of anorectal function in patients receiving neoadjuvant chemoradiotherapy before surgery for locally advanced rectal cancer.: Methods: We ... ...

Abstract	Purpose: The purpose of this article was to review the current medical literature regarding deterioration of anorectal function in patients receiving neoadjuvant chemoradiotherapy before surgery for locally advanced rectal cancer. Methods: We reviewed the current literature including research studies, electronic database PUBMED-MEDLINE, published research results and metanalysis papers from high-volume institutes, collecting and comparing the different results. Pathophysiology as well as emerging solutions for treating anorectal sphincter dysfunction were researched in order to provide an insight of this complex issue. Results: All available data suggest that neoadjuvant radiation therapy impairs internal anal sphincter function mostly through nerve damaging mechanisms, as nerves are more susceptible to damage than muscular fibers. Conclusion: Current radiotherapy recommendations are oriented in exclusion of anal canal from radiation field when oncologically safe or using new sphincter-sparing techniques for neoadjuvant radiotherapy aiming to improve the patient quality of life receiving radiation therapy prior to surgery. However, more well designed studies are required to assess the pathophysiology as well as treatment options for this complex matter, which strongly affects the quality of life of rectal cancer patients.
MeSH term(s)	Anus Neoplasms/drug therapy ; Anus Neoplasms/radiotherapy ; Chemoradiotherapy/methods ; Female ; Humans ; Male ; Neoadjuvant Therapy/methods ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy
Language	English
Publishing date	2020-04-25
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article ; Online: Comparison of the laparoscopic versus open surgery in patients aged over 75 years old with colorectal cancer. Short- and Mid-term outcomes.

Sotirova, Ira / Gklavas, Antonios / Nastos, Constantinos / Micha, Georgia / Dafnios, Nikolaos / Dellaportas, Dionysios / Theodosopoulos, Theodosios

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2020 Volume 25, Issue 5, Page(s) 2186–2191

Abstract: Purpose: The benefit of minimally invasive surgery in colorectal cancer patients has been established, however it is not clear whether these advantages apply to older patients as well. The aim of this study was to review short- and mid-term outcomes in ... ...

Abstract	Purpose: The benefit of minimally invasive surgery in colorectal cancer patients has been established, however it is not clear whether these advantages apply to older patients as well. The aim of this study was to review short- and mid-term outcomes in elderly patients, over the age of 75 years, with colorectal cancer. Methods: This was a retrospective study of selected patients over the age of 75 who underwent laparoscopic and open surgery for colorectal cancer between February 2013 and January 2018 in a tertiary referral center. All patients were categorized in two groups: Group 1 included patients who had open procedure (OP) and Group 2 those who underwent laparoscopic procedure (LP). Demographic, clinical, short- and midterm postoperative data were collected and analyzed between the two study groups. Results: A total of 78 patients were included in our cohort; 39 (50%) were operated with LP. The LP was equally safe in comparison with the OP, considering the similar postoperative complications [9 patients (34.6%) in LP and 5 patients (18.5%) in OP (p=0.224)], including anastomotic leakage in 2 patients (7.7%) in LP and 1 patient (3.7%) in OP group (p=0.61). The median postoperative hospital stay favored the laparoscopic approach (6 days in LP group and 8 days in OP group; p=0.001). The number of harvested lymph nodes were without statistically significant differences [LP group retrieved 20.0 nodes in comparison with 20.5 nodes in OP group (p= 0.816)]. The overall survival analysis showed no difference between the two approaches in 12 and 24 postoperative months (p=0.098 and 0.387, respectively).
MeSH term(s)	Aged ; Aged, 80 and over ; Colectomy/methods ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Female ; Humans ; Laparoscopy/methods ; Male ; Postoperative Complications ; Treatment Outcome
Language	English
Publishing date	2020-12-10
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article: Sudden 'cure' of type two diabetes due to pancreatic insulinoma: A case report.

Nastos, Constantinos / Giannoulopoulos, Dimitrios / Dellaportas, Dionysios / Mizamtsidi, Maria / Dafnios, Nikolaos / Klonaris, Nikolaos / Kalogeris, Nikolaos / Vryonidou, Andromachi

Molecular and clinical oncology

2019 Volume 12, Issue 2, Page(s) 174–178

Abstract: Insulinomas are rare tumors of the islet cells of the pancreas and are the most common cause of endogenous hyperinsulinism. Although they usually present with symptoms of hypoglycemia, sometimes they can have vague symptoms. We present the case of a 62- ... ...

Abstract	Insulinomas are rare tumors of the islet cells of the pancreas and are the most common cause of endogenous hyperinsulinism. Although they usually present with symptoms of hypoglycemia, sometimes they can have vague symptoms. We present the case of a 62-year-old diabetic female who was diagnosed with a large insulinoma after being investigated for the 'cure' of her diabetes. We also review the literature regarding insulinomas in patients with diabetic. A 62-year-old, obese woman with type 2 diabetes mellitus was initially investigated for an unexplained normalization of her blood glucose levels after the cessation of antidiabetic medication due to an episode of severe hypoglycemia. She remained without antidiabetics for three months maintaining normoglycemia, and thereafter, she started experiencing frequent but less severe hypoglycemic episodes. She did not change her diet habits or level of activity and did not lose any weight. The patient underwent further investigation with a supervised 72 h fasting test, which resulted in the biochemical diagnosis of endogenous hyperinsulinism. Imaging studies revealed the presence of a large insulinoma in the head of the pancreas. Finally, the patient underwent a pylorus preserving Whipple procedure, which reversed the aforementioned 'normalization' of glucose levels and the underlying diabetes mellitus reappeared. Insulinomas are rare tumors causing hypoglycemia. Even more rarely are found in diabetic patients, making the diagnosis more challenging and probably delayed, as the symptoms are masked by the presence of diabetes, thereby leading to a more advanced disease diagnosis.
Language	English
Publishing date	2019-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2796865-0
ISSN	2049-9469 ; 2049-9450
ISSN (online)	2049-9469
ISSN	2049-9450
DOI	10.3892/mco.2019.1957
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Article: A malignant eccrine poroma in a pregnant woman: case report and review of the literature.

Kairi-Vassilatou, E / Grapsa, D / Dafnios, N / Smyrniotis, V / Hasiakos, D / Kondi-Pafiti, A

European journal of gynaecological oncology

2007 Volume 28, Issue 5, Page(s) 421–422

Abstract: Malignant eccrine poroma is a rare cutaneous neoplasm that originates from the intraepidermal portion of the eccrine gland. It affects mainly elderly people while its occurrence in younger adults is extremely rare. We present the first reported case of a ...

Abstract	Malignant eccrine poroma is a rare cutaneous neoplasm that originates from the intraepidermal portion of the eccrine gland. It affects mainly elderly people while its occurrence in younger adults is extremely rare. We present the first reported case of a malignant eccrine poroma in a pregnant woman, with emphasis on its pathologic and immunohistochemical features. Early diagnosis and treatment of eccrine neoplasms are of crucial importance when pregnancy coexists, because of their tendency to aggravate under the influence of gestation-related changes.
MeSH term(s)	Acrospiroma/metabolism ; Acrospiroma/pathology ; Adult ; Carcinoma, Skin Appendage/pathology ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Neoplastic ; Skin Neoplasms/pathology
Language	English
Publishing date	2007-09-07
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	604589-3
ISSN	0392-2936
ISSN	0392-2936
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Zs.A 1679: Show issues

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Article ; Online: Erratum to: Intermittent Obstructive Jaundice Following Gastric Band Placement.

Arkadopoulos, Nikolaos / Palamarou, Christina / Koureas, Andreas / Sechopoulos, Panagiotis / Marinis, Athanassios / Kostopanagiotou, Konstantinos / Dafnios, Nikolaos / Smyrniotis, Vassilios

Obesity surgery

2016 Volume 26, Issue 5, Page(s) 1151

Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-016-2097-0
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Article: A novel technique for surgical reconstruction of the perineal floor following anteroposterior exenteration of the pelvis--case report and review of the literature.

Kyriazi, M A / Stafyla, V K / Kondi-Pafiti, A / Arkadopoulos, N / Dafnios, N / Hasiakos, D / Fotiou, S / Mastorakos, D / Smyrniotis, V

European journal of gynaecological oncology

2010 Volume 31, Issue 2, Page(s) 201–205

Abstract: Pelvic exenteration is the only potentially curative surgical procedure for patients with recurrent cervical, vaginal, vulvar or rectal cancers, especially following adjuvant chemotherapy or radiotherapy. Morbidity rates, however, remain high, which is ... ...

Abstract	Pelvic exenteration is the only potentially curative surgical procedure for patients with recurrent cervical, vaginal, vulvar or rectal cancers, especially following adjuvant chemotherapy or radiotherapy. Morbidity rates, however, remain high, which is significantly attributed to complications of the pelvic floor reconstruction techniques. We describe a novel reconstruction technique of the pelvic floor, involving a combination of an oblique rectus abdominis myocutaneous flap and a synthetic absorbable mesh as a pelvic sling for additional support, in a 63-year-old female patient with recurrent vulvar carcinoma. Combining the use of myocutaneous flaps and prosthetic mesh material can provide an effective alternative solution to the complications arising from pelvic floor reconstruction of large defects after exenteration procedures, especially in previously irradiated settings. Further studies are necessary to define the long-term outcomes and indications of these techniques, as well as the optimal combination between the available myocutaneous flaps and prosthetic materials.
MeSH term(s)	Carcinoma/surgery ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/surgery ; Pelvic Exenteration/methods ; Pelvis/surgery ; Prosthesis Implantation/methods ; Reconstructive Surgical Procedures/methods ; Suburethral Slings ; Surgical Flaps ; Surgical Mesh ; Vulvar Neoplasms/surgery
Language	English
Publishing date	2010-05-19
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	604589-3
ISSN	0392-2936
ISSN	0392-2936
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Article: Colorectal cancer emergencies during pregnancy case reports.

Theodosopoulos, T / Marinis, A / Dafnios, N / Samanideis, L / Voros, D / Vassiliou, J / Smyrniotis, V

European journal of gynaecological oncology

2006 Volume 27, Issue 4, Page(s) 422–424

Abstract: Colorectal carcinoma emergencies during pregnancy are exceptionally rare. Three women 38, 31 and 36 years old, in the third trimester of gestation received treatment, respectively, for acute abdomen due to perforation of rectal carcinoma, ileus due to a ... ...

Abstract	Colorectal carcinoma emergencies during pregnancy are exceptionally rare. Three women 38, 31 and 36 years old, in the third trimester of gestation received treatment, respectively, for acute abdomen due to perforation of rectal carcinoma, ileus due to a sigmoid tumor, and deep venous thrombosis (DVT) from a cecal tumor compromising the right iliac vein. In the first two patients urgent cesarean sections were carried out with Hartmann's procedure and a loop colostomy was performed to resolve the ensuing intraabdominal sepsis and ileus, respectively. In the third patient, a cesarean section was carried out to treat the underlying DVT more aggressively, while right colectomy was postponed for three weeks. Restoration of the alimentary tract was achieved two months later in the first case, while in the second and third cases total colectomy due to familial polyposis and right colectomy were performed three weeks after the cesarean section. An overview of the clinical features, diagnostic pitfalls and therapeutic approaches to manage complications of colorectal cancer during pregnancy are discussed.
MeSH term(s)	Abdominal Pain/pathology ; Adenocarcinoma/diagnosis ; Adenocarcinoma/etiology ; Adenocarcinoma/therapy ; Adult ; Cesarean Section ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/therapy ; Emergencies ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Neoplastic/diagnosis ; Pregnancy Complications, Neoplastic/surgery
Language	English
Publishing date	2006-09-05
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	604589-3
ISSN	0392-2936
ISSN	0392-2936
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Article ; Online: The Effect of Perioperative Ischemia and Reperfusion on Multiorgan Dysfunction following Abdominal Aortic Aneurysm Repair.

Katseni, Konstantina / Chalkias, Athanasios / Kotsis, Thomas / Dafnios, Nikolaos / Arapoglou, Vassilis / Kaparos, Georgios / Logothetis, Emmanuel / Iacovidou, Nicoletta / Karvouni, Eleni / Katsenis, Konstantinos

BioMed research international

2015 Volume 2015, Page(s) 598980

Abstract: Abdominal aortic aneurysms (AAAs) are relatively common and are potentially life-threatening medical problems. The aim of this review is to provide an overview of the effect of I/R injury on multiorgan failure following AAA repair. The PubMed, CINAHL, ... ...

Abstract	Abdominal aortic aneurysms (AAAs) are relatively common and are potentially life-threatening medical problems. The aim of this review is to provide an overview of the effect of I/R injury on multiorgan failure following AAA repair. The PubMed, CINAHL, EMBASE, Medline, Cochrane Review, and Scopus databases were comprehensively searched for articles concerning the pathophysiology of I/R and its systemic effects. Cross-referencing was performed using the bibliographies from the articles obtained. Articles retrieved were restricted to those published in English. One of the most prominent characteristics of AAA open repair is the double physiological phenomenon of ischemia-reperfusion (I/R) that happens either at the time of clamping or following the aortic clamp removal. Ischemia-reperfusion injury causes significant pathophysiological disturbances to distant organs, increasing the possibility for postoperative multiorgan failure. Although tissue injury is mediated by diverse mechanisms, microvascular dysfunction seems to be the final outcome of I/R.
MeSH term(s)	Animals ; Aortic Aneurysm, Abdominal/pathology ; Aortic Aneurysm, Abdominal/physiopathology ; Aortic Aneurysm, Abdominal/surgery ; Humans ; Multiple Organ Failure/etiology ; Multiple Organ Failure/physiopathology ; Multiple Organ Failure/therapy ; Postoperative Complications/physiopathology ; Reperfusion Injury/etiology ; Reperfusion Injury/pathology ; Reperfusion Injury/physiopathology
Keywords	covid19
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2015/598980
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Article: The effect of warm liver ischaemia & reperfusion injury on circulating plasma lipid levels & lipolytic enzyme activity in rat & the impact of ischaemic preconditioning.

Lanitis, Sophocles / Lolis, Evangelos / Dafnios, Nikolaos / Sgourakis, George / Voros, Dionysios C / Vassiliou, Ioannis

The Indian journal of medical research

2012 Volume 136, Issue 2, Page(s) 272–279

Abstract: Background & objectives: Ischaemia/reperfusion (I/R) associated with major liver surgery compromises liver function. Ischaemic preconditioning (IPC) may be effective in minimizing hepatic I/R injury. This study aimed to investigate the impact of liver ... ...

Abstract	Background & objectives: Ischaemia/reperfusion (I/R) associated with major liver surgery compromises liver function. Ischaemic preconditioning (IPC) may be effective in minimizing hepatic I/R injury. This study aimed to investigate the impact of liver ischaemic manipulations on lipid metabolism in rat during the process of liver recovery after liver surgery. Methods: Sixty three male Wistar rats were assigned to three groups: the sham group, the I/R group which underwent warm ischaemia and reperfusion (I/R), and the IPC group. The animals were subdivided in 3 groups [1 st , 3 rd and 7 th postoperative day (PO)]. Hepatic lipase (HL) and total lipase (TL) activity and the levels of aspartate and alanine transaminases (AST, ALT), triglycerides, HDL and cholesterol were measured in plasma. Results: There was no significant difference in the activity of HL and TL between the groups. Significant higher levels of HDL (P<0.0001) were observed in the IPC group when compared to the other groups on the 3 rd PO day. Triglycerides (P<0.0001) and HDL (P=0.003) in the IPC group were higher than the sham group on the 7 th PO day while HDL was also higher in the I/R group. Significantly higher cholesterol levels were found in the I/R and IPC groups on the 7 th PO day, which were not observed in the sham group. There was a similar curve for triglycerides in the sham and IPC groups while there were significantly higher levels of triglycerides on day 7 for the I/R group. The levels of HDL in the IPC group were higher on the 3 rd and 7 th PO day, compared to day 1. Interpretation & conclusion: Warm ischaemia and I/R injury do not seem to affect lipolytic enzyme activity after the 1 st PO day despite the effects on plasma lipids. IPC seems to prevent accumulation of triglycerides and cholesterol in plasma.
MeSH term(s)	Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Ischemic Preconditioning ; Lipase/metabolism ; Lipids/blood ; Liver/blood supply ; Liver/enzymology ; Liver/pathology ; Liver/surgery ; Male ; Rats ; Rats, Wistar ; Reperfusion Injury/blood ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Warm Ischemia
Chemical Substances	Lipids ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Lipase (EC 3.1.1.3) ; hepatic lipase, rat (EC 3.1.1.3)
Language	English
Publishing date	2012-09-08
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
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Article ; Online: A novel technique for gaining extra length of the abdominal esophagus.

Arkadopoulos, Nikolaos / Marinis, Athanasios / Dafnios, Nikolaos / Theodosopoulos, Theodosios / Smyrniotis, Vassilios

American journal of surgery

2009 Volume 198, Issue 1, Page(s) e10–2

Abstract: During gastrectomies for carcinomas of the esophagogastric junction, it is often desirable to gain additional length of the abdominal esophagus to construct an intra-abdominal esophagojejunal anastomosis. In this report, we describe a technique of ... ...

Abstract	During gastrectomies for carcinomas of the esophagogastric junction, it is often desirable to gain additional length of the abdominal esophagus to construct an intra-abdominal esophagojejunal anastomosis. In this report, we describe a technique of esophageal mobilization that combines transhiatal dissection with transection of both vagus nerves at 3 points: first, at a level 2 cm to 3 cm below tracheal bifurcation; second, 3 cm to 5 cm above the hiatus; and, finally, at the level of the hiatus. Using this technique in 11 patients with carcinoma of the esophagogastric junction, we achieved lengthening of the abdominal esophagus by 3.7 cm +/- 1.2 cm (mean +/- standard deviation). In all cases, the additional esophageal length permitted the completion of an oncologically adequate resection and the execution of a safe intra-abdominal esophagojejunal anastomosis.
MeSH term(s)	Aged ; Aged, 80 and over ; Anastomosis, Surgical ; Carcinoma/diagnosis ; Carcinoma/surgery ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/surgery ; Esophagectomy/methods ; Esophagogastric Junction ; Esophagoplasty/methods ; Esophagus/surgery ; Female ; Follow-Up Studies ; Humans ; Jejunum/surgery ; Male ; Middle Aged ; Retrospective Studies ; Suture Techniques ; Treatment Outcome
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2008.11.042
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