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  1. Article ; Online: The relationship between reduced choroidal thickness due to high plasma asymmetrical dimethylarginine level and increased severity of diabetic retinopathy.

    Dag, Umut / Çaglayan, Mehtap / Alakus, Mehmet Fuat / Öncül, Hasan

    Arquivos brasileiros de oftalmologia

    2022  Volume 86, Issue 1, Page(s) 27–32

    Abstract: Purpose: To evaluate the relationship between subfoveal choroidal thickness and plasma asymmetrical dimethylarginine level and the severity of diabetic retinopathy in patients with type 2 diabetes mellitus.: Methods: A total of 68 cases, including 15 ...

    Abstract Purpose: To evaluate the relationship between subfoveal choroidal thickness and plasma asymmetrical dimethylarginine level and the severity of diabetic retinopathy in patients with type 2 diabetes mellitus.
    Methods: A total of 68 cases, including 15 patients without diabetic retinopathy, 17 patients with nonproliferative diabetic retinopathy, 16 patients with type 2 diabetes mellitus and proliferative diabetic retinopathy, and 20 healthy patients (control group), were enrolled in this study. Subfoveal choroidal thickness was measured manually using the enhanced depth imaging optical coherence tomography scanning program, and plasma asymmetrical dimethylarginine level was measured using a commercial micro enzyme-linked immunosorbent assay kit.
    Results: The subfoveal choroidal thickness values and plasma asymmetrical dimethylarginine levels were significantly different between the four groups (p<0.001 and p<0.001). The subfoveal choroidal thickness values were significantly lower in the proliferative diabetic retinopathy group than in the other three groups (no diabetic retinopathy, nonproliferative diabetic retinopathy, and control groups; p<0.001, p=0.045, and p<0.001, respectively). The plasma asymmetrical dimethylarginine levels were significantly higher in the proliferative diabetic retinopathy group than in the other three groups (p<0.001, p<0.04, and p<0.001, respectively). In addition, a significant negative correlation was also found between plasma asymmetrical dimethylarginine level and subfoveal choroidal thickness (p<0.001, r=-0.479).
    Conclusion: Asymmetrical dimethylarginine is an important marker of endothelial dysfunction and endogenous endothelial nitric oxide synthase inhibitor. The severity of diabetic retinopathy was related to increased plasma asymmetrical dimethylarginine level and reduced subfoveal choroidal thickness in type 2 diabetic patients with diabetic retinopathy.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Social Group
    Language English
    Publishing date 2022-02-16
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.20230007
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  2. Article ; Online: Mask-associated Dry Eye Syndrome in Healthcare Professionals as a New Complication Caused by the Prolonged Use of Masks during Covid-19 Pandemic Period.

    Dag, Umut / Çaglayan, Mehtap / Öncül, Hasan / Vardar, Süleyman / Alaus, Mehmet Fuat

    Ophthalmic epidemiology

    2022  Volume 30, Issue 1, Page(s) 1–6

    Abstract: Purpose: The aim of this study is to demonstrate the prevalence of self-reported mask-associated dry eye (MADE) in health-care professionals and the possible risk factors that give rise to MADE.: Methods: A self-administered questionnaire consisting ... ...

    Abstract Purpose: The aim of this study is to demonstrate the prevalence of self-reported mask-associated dry eye (MADE) in health-care professionals and the possible risk factors that give rise to MADE.
    Methods: A self-administered questionnaire consisting of 12 questions about MADE and possible risk factors that give rise to MADE was created on web-based "google forms" application, and was then sent to 437 healthcare professionals working in a coronavirus-19 (COVID-19) pandemic hospital, using common telecommunication devices.
    Results: Three hundred and thirty-three of the 437 health-care professionals, who answered the questionnaire, were included in the study. The prevalence of self-reported MADE among these health-care professionals was found to be 70% (n = 233). Having at least one of the symptoms of dry eye while not having a mask on and advanced age were determined as the possible risk factors for MADE (
    Conclusion: The high prevalence of self-reported MADE among health-care professionals can be attributed to the prolonged use of masks associated with longer working hours. Therefore, it is important that the ocular complaints of professionals are addressed by ophthalmology consultants/ophthalmologists during these difficult times.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Masks ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/epidemiology ; Dry Eye Syndromes/etiology ; Delivery of Health Care
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1213070-9
    ISSN 1744-5086 ; 0928-6586
    ISSN (online) 1744-5086
    ISSN 0928-6586
    DOI 10.1080/09286586.2022.2053549
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  3. Article ; Online: Central serous chorioretinopathy associated with high-dose follistatin-344: a retrospective case series.

    Dağ, Umut / Çağlayan, Mehtap / Öncül, Hasan / Alakuş, Mehmet Fuat

    International ophthalmology

    2020  Volume 40, Issue 11, Page(s) 3155–3161

    Abstract: Purpose: To present 11 bodybuilding athletes who developed central serous chorioretinopathy (CSCR) following high-dose subcutaneous follistatin-344, a peptide-based performance and image enhancing drug, injections to increase muscle mass.: Methods: ... ...

    Abstract Purpose: To present 11 bodybuilding athletes who developed central serous chorioretinopathy (CSCR) following high-dose subcutaneous follistatin-344, a peptide-based performance and image enhancing drug, injections to increase muscle mass.
    Methods: This is a retrospective case series from one institution. Demographic and clinical data of 11 patients who were admitted to our clinic with decreased visual acuity after high-dose follistatin-344 injections and optical coherence tomography (OCT) findings consistent with CSCR were analyzed.
    Results: All 11 patients were male, and the mean age was 36.8 ± 8.1 years. All patients had a history of injecting complete 1 mg vials of follistatin-344 subcutaneously in the abdomen. There was a history of a single previous high-dose follistatin-344 injection in eight patients and multiple previous injections in three patients. At the time of diagnosis, ten patients had unilateral CSCR findings and one had bilateral CSCR findings. In all eight patients with a history of only one injection, subretinal fluid completely disappeared after an average of 2.3 ± 0.7 months and symptoms regressed. Recurrent CSCR developed in three patients with a history of multiple follistatin-344 injections.
    Conclusion: Follistatin-344 injection can be considered as a risk factor for CSCR. To take medical history from CSCR patients including follistatin-344 use may be important to reveal the CSCR etiology.
    MeSH term(s) Adult ; Central Serous Chorioretinopathy/chemically induced ; Central Serous Chorioretinopathy/diagnosis ; Female ; Fluorescein Angiography ; Follistatin ; Humans ; Male ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity
    Chemical Substances Follistatin
    Language English
    Publishing date 2020-07-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-020-01501-6
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  4. Article ; Online: Corneal and lens densitometry with Pentacam HR in children with vernal keratoconjunctivitis.

    Çağlayan, Mehtap / Öncül, Hasan / Alakus, Mehmet Fuat / Dag, Umut

    Clinical & experimental optometry

    2020  Volume 104, Issue 2, Page(s) 156–161

    Abstract: Clinical relevance: Corneal and lens densitometry measurements provide clinically important information for the evaluation and monitoring of corneal and lens health in patients with vernal keratoconjunctivitis.: Background: To compare the corneal and ...

    Abstract Clinical relevance: Corneal and lens densitometry measurements provide clinically important information for the evaluation and monitoring of corneal and lens health in patients with vernal keratoconjunctivitis.
    Background: To compare the corneal and lens densitometry values between paediatric patients with vernal keratoconjunctivitis (VKC) and healthy individuals.
    Methods: This study included 72 eyes of 72 patients with VKC (25 with mild VKC [Group 1], 22 with moderate VKC [Group 2], and 25 with severe VKC [Group 3]), and 25 eyes of 25 healthy subjects (Group 4). Corneal and lens densitometry values were measured using Pentacam HR as follows: for corneal densitometry in two different corneal zones (0-2 and 2-6-mm) and four different corneal depths (at the total thickness, anterior, central, and posterior layers), and lens densitometry in three different lens zones (Zone 1: 2.0-mm, Zone 2: 4.0-mm, and Zone 3: 6.0-mm).
    Results: In the 0-2-mm corneal zone for the total thickness and all three layers, corneal densitometry values in Group 3 were significantly higher than those in Groups 1, 2, and 4 (for all values p < 0.012). There was no significant difference in the mean corneal densitometry values between Groups 1 and 2 (for all values p > 0.05). In these groups, the mean corneal densitometry values were significantly higher than those in Group 4 for the anterior layer in the 0-2 and 2-6-mm corneal zones (for all values p < 0.012). The mean values for Zone 3 and average lens densitometry values in Groups 2 and 3 were significantly higher than those in Group 4 (p = 0.001 and p = 0.001, respectively).
    Conclusion: The current study showed corneal clarity changes in patients with mild, moderate, and especially severe VKC. An increase in the lens densitometry values was also observed in patients with moderate and severe VKC than in healthy individuals.
    MeSH term(s) Child ; Conjunctivitis, Allergic/diagnosis ; Cornea ; Densitometry ; Humans ; Lens, Crystalline
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1111/cxo.13144
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  5. Article ; Online: The Effect of Chalazion Excision on Corneal Aberrometric and Densitometric Values.

    Oncul, Hasan / Yildirim, Yusuf / Caglayan, Mehtap / Dag, Umut / Alakus, Mehmet Fuat

    Beyoglu eye journal

    2021  Volume 6, Issue 3, Page(s) 191–199

    Abstract: Objectives: The aim of this study was to investigate the effect of chalazion excision on corneal aberrations and corneal densitometry.: Methods: Thirty-six patients with a chalazion in 1 eyelid and 40 healthy subjects were included in the study. ... ...

    Abstract Objectives: The aim of this study was to investigate the effect of chalazion excision on corneal aberrations and corneal densitometry.
    Methods: Thirty-six patients with a chalazion in 1 eyelid and 40 healthy subjects were included in the study. Corneal aberration parameters of total root mean square (RMS), RMS high-order aberration (HOA), horizontal trefoil, oblique trefoil, horizontal coma, vertical coma, and spherical aberration values were measured using Scheimpflug corneal topography (Pentacam HR; Oculus Optikgeräte GmbH, Wetzler, Germany). Corneal densitometry values measured from 4 regions of the cornea (0-2, 2-6, 6-10, and 10-12 mm) and 4 corneal depths (anterior, central, posterior, and total) were recorded. Preoperative measurements of the patients (Group 1), postoperative first-month measurements (Group 2), and control group (Group 3) measurements were compared.
    Results: The total RMS measurement was 1.64±0.48 μm in Group 1, 1.35±0.32 μm in Group 2, and 1.17±0.38 μm in Group 3 (Group 1-2: p=0.007, Group 1-3: p<0.001, Group 2-3: p=0.173). The mean spherical aberration value was 0.183±0.057 μm in Group 1, 0.157±0.048 μm in Group 2, and 0.144±0.050 μm in Group 3 (Group 1-2: p=0.104, Group 1-3: p=0.004, Group 2-3: p=0.781). The total corneal densitometric measurement was 15.95±1.80 gray scale units (GSU) in Group 1, 14.76±1.76 GSU in Group 2, and 14.33±1.49 GSU in Group 3 (Group 1-2: p=0.01, Group 1-3: p<0.001, Group 2-3: p=0.804).
    Conclusion: It was observed that some corneal aberration and corneal densitometry values were higher in patients with a chalazion compared with those of healthy individuals, and there was a decrease in corneal aberration and densitometry values after surgical excision.
    Language English
    Publishing date 2021-09-27
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3031466-5
    ISSN 2587-0394 ; 2459-1777
    ISSN (online) 2587-0394
    ISSN 2459-1777
    DOI 10.14744/bej.2021.62533
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  6. Article ; Online: Removal of Tenon fortified by conjunctival-limbal autograft in treatment of pterygium.

    Ciftci, Suleyman / Dogan, Eyup / Dag, Umut / Ciftci, Leyla

    International ophthalmology

    2017  Volume 37, Issue 4, Page(s) 813–818

    Abstract: Purpose: To describe a simple and effective technique for the prevention of pterygium recurrence.: Methods: This is a retrospective consecutive single-center case series with recurrence rate as the main outcome measure. Dissection of the conjunctiva, ...

    Abstract Purpose: To describe a simple and effective technique for the prevention of pterygium recurrence.
    Methods: This is a retrospective consecutive single-center case series with recurrence rate as the main outcome measure. Dissection of the conjunctiva, the Tenon's layer, and the sclera was continued up to the insertion of medial rectus. The exposed Tenon's layer was excised for 2 to 3 mm. The entire free edges of the conjunctiva was tacked firmly to the sclera. The conjunctival-limbal graft was sutured firmly to the sclera, recipient limbus, and to the conjunctiva incorporating the reciprocal edges.
    Results: We report findings in a total of 36 patients, with 20 (%55.5) males and 16 (%44.4) females. Median age of the patients was 44.5 years (range 16-80). The mean follow-up period was 23.1 ± 6.5 months. The mean size of pterygium in mm length was 3.8 ± 0.7. Recurrence did not occur in any patient. Diplopia was not reported by any patients.
    Conclusions: Conjunctival-limbal autograft combining with selective exicison of Tenon's layer but without damage to any essential tissue such as the semilunar fold or Tenon's capsule pulley is a relatively simple and effective procedure.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Autografts ; Conjunctiva/transplantation ; Corneal Transplantation/methods ; Female ; Follow-Up Studies ; Humans ; Limbus Corneae/surgery ; Male ; Middle Aged ; Ophthalmologic Surgical Procedures/methods ; Pterygium/surgery ; Recurrence ; Retrospective Studies ; Secondary Prevention/methods ; Tenon Capsule/surgery ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2017-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-016-0341-1
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  7. Article ; Online: Changes in choroidal thickness after vitamin D supplementation in patients with vitamin D deficiency.

    Öncül, Hasan / Alakus, Mehmet Fuat / Çağlayan, Mehtap / Öncül, Fatma Yılmaz / Dag, Umut / Arac, Esref

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2020  Volume 55, Issue 6, Page(s) 486–491

    Abstract: Objective: To determine the relationship between vitamin D (vit D) deficiency and choroidal thickness and to investigate changes in choroidal thickness after vit D treatment.: Methods: Sixty-five patients diagnosed with vit D deficiency (group 1) and ...

    Abstract Objective: To determine the relationship between vitamin D (vit D) deficiency and choroidal thickness and to investigate changes in choroidal thickness after vit D treatment.
    Methods: Sixty-five patients diagnosed with vit D deficiency (group 1) and 60 healthy individuals with normal vit D levels (group 2) were included in the study. The choroidal thickness in the subfoveal, nasal, and temporal regions of the fovea were measured manually using enhanced depth imaging optical coherence tomography. The choroidal thickness in the patients in group 1 was re-evaluated after treatment with vit D.
    Results: The groups were similar in terms of age and sex (p = 0.138 and p = 0.198, respectively). The subfoveal, temporal (500 and 1.500 µm), and nasal (500 and 1.500 µm) choroidal thickness values in group 1 were statistically significantly lower than those in group 2 (p < 0.001 for all). After vit D replacement therapy, there was a significant increase in the choroidal thicknesses compared with the pretreatment measurements (p < 0.001 for all). There was a positive correlation between vit D values and subfoveal, temporal (500 and 1.500 µm), and nasal (500 and 1.500 µm) choroidal thickness values (r = 0.558 and p < 0.001, r = 0.415 and p < 0.001, r = 0.352 and p < 0.001, r = 0.349 and p < 0.001, and r = 0.294 and p = 0.001, respectively).
    Conclusion: The choroidal thickness decreased in patients with vit D deficiency. The choroidal thickness values increased after vit D replacement therapy. Serum vit D levels should be assessed in studies evaluating choroidal thickness.
    MeSH term(s) Choroid ; Dietary Supplements ; Humans ; Tomography, Optical Coherence ; Vitamin D ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2020.06.014
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  8. Article ; Online: Evaluation of corneal safety in systemic lupus erythematosus patients undergoing long-term hydroxychloroquine treatment.

    Çağlayan, Mehtap / Akyol, Lütfi / Balcı, Mehmet Ali / Öncül, Hasan / Alakuş, Mehmet Fuat / Dağ, Umut

    Cutaneous and ocular toxicology

    2020  Volume 40, Issue 1, Page(s) 21–25

    Abstract: Purpose: The aim of this study was to examine the effects of long-term use of hydroxychloroquine (HQ) on the pachymetric, aberrometric, and densitometric values of the cornea and corneal endothelium in lupus patients.: Method: Twenty-two eyes (study ... ...

    Abstract Purpose: The aim of this study was to examine the effects of long-term use of hydroxychloroquine (HQ) on the pachymetric, aberrometric, and densitometric values of the cornea and corneal endothelium in lupus patients.
    Method: Twenty-two eyes (study group) of 22 patients using HQ for treatment of lupus and 25 eyes (control group) of 25 healthy individuals were included in this prospective study. A specular microscopy was used to measure corneal endothelial cell density (ECD), percentage of hexagonal cells (HEX%), coefficient of variation of the cell size (CV). Then, a Pentacam® HR corneal tomography system was used to measure central corneal thickness (CCT), corneal aberrometry values in 6-mm pupil diameters and corneal densitometry values in 6-mm corneal zones (0-2 mm and 2-6 mm).
    Results: While ECD was significantly lower in the study group than in the control group (
    Conclusion: Prolonged use of HQ may cause some changes in the cornea. In the follow-up of these cases, detailed examination of the cornea as well as the macula may be important for the protection of corneal health.
    MeSH term(s) Aberrometry ; Adolescent ; Adult ; Cornea/diagnostic imaging ; Cornea/drug effects ; Corneal Diseases/chemically induced ; Corneal Diseases/prevention & control ; Corneal Pachymetry ; Cross-Sectional Studies ; Densitometry ; Endothelium, Corneal/diagnostic imaging ; Endothelium, Corneal/drug effects ; Female ; Healthy Volunteers ; Humans ; Hydroxychloroquine/adverse effects ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Middle Aged ; Prospective Studies ; Tomography, Optical Coherence ; Young Adult
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2020-12-23
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 605635-0
    ISSN 1556-9535 ; 1556-9527 ; 0731-3829
    ISSN (online) 1556-9535
    ISSN 1556-9527 ; 0731-3829
    DOI 10.1080/15569527.2020.1861003
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  9. Article ; Online: Ocular findings in patients with coronavirus disease 2019 (COVID-19) in an outbreak hospital.

    Öncül, Hasan / Öncül, Fatma Y / Alakus, Mehmet F / Çağlayan, Mehtap / Dag, Umut

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 1126–1132

    Abstract: Purpose: The aim of this study was to investigate the ocular findings observed in patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 and to present the relationship between ocular involvement, ... ...

    Abstract Purpose: The aim of this study was to investigate the ocular findings observed in patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 and to present the relationship between ocular involvement, systemic findings, and laboratory results.
    Material and methods: This cross-sectional study was carried out between 1 May and 30 June 2020. The study included 359 patients diagnosed with COVID-19 and assessed by clinical evaluation, nasopharyngeal polymerase chain reaction, and lung computed tomography.
    Results: One hundred ninety-seven (54.9%) of the patients were male and 162 (45.1%) were female. The mean age of the patients was 58.5 years (20-91). Two hundred ninety-four (81.9%) patients were treated in the inpatient clinic and 65 (18.1%) patients were treated in the intensive care unit. Various ocular diseases were observed in 16 (4.5%) of the patients. Although the rate of ocular disease was 12 out of 294 (4.1%) in patients followed up in the inpatient clinic, this rate was 4 out of 65 (6.2%) in intensive care patients. There was no systemic problem in one patient, in whom conjunctival hyperemia was the first and only reason for admission to the hospital. Four patients followed up in the inpatient clinic had conjunctivitis at the time of admission, and conjunctivitis occurred in three patients during hospitalization. Subconjunctival hemorrhage occurred in five patients and vitreous hemorrhage in one patient.
    Conclusion: Ocular diseases are uncommon in COVID-19 patients but may occur during the first period of the disease or during follow-up. Ocular diseases may be the initial or only sign of COVID-19 infection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Conjunctivitis, Viral/complications ; Conjunctivitis, Viral/physiopathology ; Cross-Sectional Studies ; Disease Outbreaks ; Eye/pathology ; Eye/virology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; RNA, Viral/analysis ; Turkey/epidemiology ; Young Adult
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26412
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  10. Article: Investigation of corneal topographic and densitometric properties of Wilson's disease patients with or without a Kayser-Fleischer ring.

    Alakus, Mehmet Fuat / Caglayan, Mehtap / Ekin, Nazım / Oncul, Hasan / Arac, Esref / Dag, Umut / Diri, Halit

    Eye and vision (London, England)

    2021  Volume 8, Issue 1, Page(s) 8

    Abstract: Background: To investigate the topographic measurements and densitometry of corneas in Wilson's disease (WD) patients with or without a Kayser-Fleischer ring (KF-r) compared to healthy individuals.: Methods: This cross-sectional study included 20 WD ... ...

    Abstract Background: To investigate the topographic measurements and densitometry of corneas in Wilson's disease (WD) patients with or without a Kayser-Fleischer ring (KF-r) compared to healthy individuals.
    Methods: This cross-sectional study included 20 WD patients without a KF-r (group I), 18 WD patients with a KF-r (group II), and 20 age-matched controls (group III). The Pentacam high resolution imaging system is used to determine corneal topographic measurements and densitometry.
    Results: Mean age for groups I, II and III was 25.40 ± 6.43 years (14-36 years), 25.38 ± 6.96 years (16-39 years), 23.60 ± 6.56 years (17-35 years), respectively (P = 0.623). There was no significant difference between the groups in terms of the anterior corneal densitometry values (P > 0.05), while the 6-10 mm and 10-12 mm mid stroma and the 2-6 mm, 6-10 mm, and 10-12 mm posterior corneal densitometry values in group II were significantly higher than those in groups I and III (for all values, P <  0.05). However, the 10-12 mm posterior corneal densitometry values in group I were also significantly higher than those in group III (P = 0.038). The central corneal thickness (CCT), thinnest corneal thickness (tCT), and corneal volume (CV) values in groups I and II were significantly lower than those in group III (for CCT values, P = 0.011 and P = 0.009; for tCT values, P = 0.010 and P = 0.005; for CV values, P = 0.043 and P = 0.029).
    Conclusion: In WD patients with a KF-r, corneal transparency decreased in the peripheral posterior and mid stromal corneal layers; for these patients, corneal transparency may be impaired not only in the peripheral cornea but also in the paracentral cornea.
    Language English
    Publishing date 2021-03-11
    Publishing country England
    Document type Journal Article
    ISSN 2326-0254
    ISSN 2326-0254
    DOI 10.1186/s40662-021-00231-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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