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  1. Book ; Online ; E-Book: The role of phytonutrients in metabolic disorders

    Khan, Haroon / Akkol, Esra / Daglia, Maria

    2022  

    Author's details Haroon Khan, Esra Akkol, and Maria Daglia
    Keywords Metabolism/Disorders ; Metabolism/Disorders/Alternative treatment
    Subject code 616.39
    Language English
    Size 1 online resource (454 pages)
    Publisher Academic Press
    Publishing place London, UK
    Document type Book ; Online ; E-Book
    Note Description based upon print version of record.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-85979-8 ; 9780128243565 ; 978-0-323-85979-0 ; 0128243562
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Petroselinum crispum

    Bahramsoltani, Roodabeh / Ahmadian, Roohollah / Daglia, Maria / Rahimi, Roja

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 2, Page(s) 956–972

    Abstract: Petroselinum ... ...

    Abstract Petroselinum crispum
    MeSH term(s) Animals ; Petroselinum/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Oils, Volatile/pharmacology ; Oils, Volatile/chemistry ; Liver ; Terpenes/pharmacology
    Chemical Substances Plant Extracts ; Oils, Volatile ; Terpenes
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c06429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: New advances in biotechnology of phytochemicals.

    Daglia, Maria

    Biotechnology advances

    2019  Volume 38, Page(s) 107445

    MeSH term(s) Biotechnology ; Phytochemicals
    Chemical Substances Phytochemicals
    Language English
    Publishing date 2019-09-03
    Publishing country England
    Document type Editorial
    ZDB-ID 47165-3
    ISSN 1873-1899 ; 0734-9750
    ISSN (online) 1873-1899
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2019.107445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Editorial: Herbal medical products and natural products targeting aging and age-related disorders--ethnopharmacological perspectives.

    Ullah, Hammad / Khan, Haroon / Prieto Lage, Miguel Angel / Daglia, Maria

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1368389

    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1368389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hypoglycaemic effect of total alkaloids extracted from Sambucus wightiana Wall. ex Wight & Arn. in streptozotocin-nicotinamide induced diabetic rats

    Khan, Salman / Ullah, Hammad / Buccato, Daniele Giuseppe / Rengasamy, Kannan RR / Xiao, Jianbo / Daglia, Maria

    SAAB South African Journal of Botany. 20232023 Mar. 07, Feb. 07, v. 154 p.330-335

    2023  

    Abstract: Diabetes mellitus is the most prevalent metabolic disease, and almost 1200 plants are reported with hypoglycaemic potential. Some of these plants are scientifically proven for the hypoglycaemic and antidiabetic effects. This study was designed to assess ... ...

    Abstract Diabetes mellitus is the most prevalent metabolic disease, and almost 1200 plants are reported with hypoglycaemic potential. Some of these plants are scientifically proven for the hypoglycaemic and antidiabetic effects. This study was designed to assess the hypoglycaemic effect of Sambucus wightiana Wall. ex Wight & Arn. extract in streptozotocin-nicotinamide induced diabetic Wistar Albino rats. An acute toxicity study was performed to establish the safe dose of total alkaloids extracted from S. wightiana (TASW). TASW was administered orally (50 mg, 100 mg, and 200 mg/kg body weight per day) to diabetic rats for 21 days. Fasting blood glucose level was determined, along with other associated parameters that may fluctuate in diabetes, consisting of the lipid profile, body weight, serum liver marker enzymes and Hb level. The test groups that were administered TASW at three different doses showed a marked reduction in hyperglycaemia when compared to the control group. Moreover, body weight and food intake improved among test group animals. Administration of TASW also reduced the levels of triglycerides, cholesterol and LDL while increasing HDL and Hb levels. Serum liver enzyme activity is generally increased in diabetes, and this was reduced after dosing with TASW. The findings of this study elucidate that the total alkaloids extracted from S. wightiana are not toxic at the tested doses, and present potential hypoglycaemic activity.
    Keywords Sambucus ; acute toxicity ; albino ; blood glucose ; blood serum ; body weight ; botany ; cholesterol ; diabetes mellitus ; enzyme activity ; food intake ; glycemic effect ; hyperglycemia ; lipid composition ; liver ; Sambucus wightiana ; Diabetes ; Streptozotocin ; Hypoglycaemic activity ; Glibenclamide
    Language English
    Dates of publication 2023-0207
    Size p. 330-335.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 2126918-X
    ISSN 0254-6299
    ISSN 0254-6299
    DOI 10.1016/j.sajb.2023.01.047
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Computational pharmacology and computational chemistry of 4-hydroxyisoleucine: Physicochemical, pharmacokinetic, and DFT-based approaches.

    Ahmad, Imad / Kuznetsov, Aleksey E / Pirzada, Abdul Saboor / Alsharif, Khalaf F / Daglia, Maria / Khan, Haroon

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1145974

    Abstract: Computational pharmacology and chemistry of drug-like properties along with pharmacokinetic studies have made it more amenable to decide or predict a potential drug candidate. 4-Hydroxyisoleucine is a pharmacologically active natural product with ... ...

    Abstract Computational pharmacology and chemistry of drug-like properties along with pharmacokinetic studies have made it more amenable to decide or predict a potential drug candidate. 4-Hydroxyisoleucine is a pharmacologically active natural product with prominent antidiabetic properties. In this study, ADMETLab 2.0 was used to determine its important drug-related properties. 4-Hydroxyisoleucine is compliant with important drug-like physicochemical properties and pharma giants' drug-ability rules like Lipinski's, Pfizer, and GlaxoSmithKline (GSK) rules. Pharmacokinetically, it has been predicted to have satisfactory cell permeability. Blood-brain barrier permeation may add central nervous system (CNS) effects, while a very slight probability of being CYP2C9 substrate exists. None of the well-known toxicities were predicted
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1145974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Interactions of Neutrophils with the Polymeric Molecular Components of the Biofilm Matrix in the Context of Implant-Associated Bone and Joint Infections.

    Campoccia, Davide / Ravaioli, Stefano / Mirzaei, Rasoul / Bua, Gloria / Daglia, Maria / Arciola, Carla Renata

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: In the presence of orthopedic implants, opportunistic pathogens can easily colonize the biomaterial surfaces, forming protective biofilms. Life in biofilm is a central pathogenetic mechanism enabling bacteria to elude the host immune response and survive ...

    Abstract In the presence of orthopedic implants, opportunistic pathogens can easily colonize the biomaterial surfaces, forming protective biofilms. Life in biofilm is a central pathogenetic mechanism enabling bacteria to elude the host immune response and survive conventional medical treatments. The formation of mature biofilms is universally recognized as the main cause of septic prosthetic failures. Neutrophils are the first leukocytes to be recruited at the site of infection. They are highly efficient in detecting and killing planktonic bacteria. However, the interactions of these fundamental effector cells of the immune system with the biofilm matrix, which is the true interface of a biofilm with the host cells, have only recently started to be unveiled and are still to be fully understood. Biofilm matrix macromolecules consist of exopolysaccharides, proteins, lipids, teichoic acids, and the most recently described extracellular DNA. The latter can also be stolen from neutrophil extracellular traps (NETs) by bacteria, who use it to strengthen their biofilms. This paper aims to review the specific interactions that neutrophils develop when they physically encounter the matrix of a biofilm and come to interact with its polymeric molecular components.
    MeSH term(s) Humans ; Extracellular Polymeric Substance Matrix ; Neutrophils ; Biofilms ; Extracellular Traps/metabolism ; Prostheses and Implants ; Arthritis, Infectious/metabolism
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242317042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Synthesis,

    Alam, Waqas / Khan, Haroon / Saeed Jan, Muhammad / Rashid, Umer / Abusharha, Ali / Daglia, Maria

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1222047

    Abstract: Isoxazole belongs to the class of five-membered heterocyclic compounds. The process of developing new drugs has significantly gained attention due to inadequate pharmacokinetic and safety attributes of the available drugs. This study aimed to design a ... ...

    Abstract Isoxazole belongs to the class of five-membered heterocyclic compounds. The process of developing new drugs has significantly gained attention due to inadequate pharmacokinetic and safety attributes of the available drugs. This study aimed to design a new diverse array of ten novel isoxazole derivatives via Claisen Schmidt condensation reaction.
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1222047
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  9. Article: Physicochemical properties, pharmacokinetic studies, DFT approach, and antioxidant activity of nitro and chloro indolinone derivatives.

    Pirzada, Abdul Saboor / Khan, Haroon / Alam, Waqas / Darwish, Hany W / Elhenawy, Ahmed A / Kuznetsov, Aleksey / Daglia, Maria

    Frontiers in chemistry

    2024  Volume 12, Page(s) 1360719

    Abstract: The process of developing of new drugs is greatly hampered by their inadequate physicochemical, pharmacokinetic, and intrinsic characteristics. In this regard, the selected chloro indolinone, (Z)-6-chloro-3-(2-chlorobenzylidene)indolin-2-one (C1), and ... ...

    Abstract The process of developing of new drugs is greatly hampered by their inadequate physicochemical, pharmacokinetic, and intrinsic characteristics. In this regard, the selected chloro indolinone, (Z)-6-chloro-3-(2-chlorobenzylidene)indolin-2-one (C1), and nitro indolinone, (Z)-6-chloro-3-(2-nitrobenzylidene)indolin-2-one (C2), were subjected to SwissADME and density function theory (DFT) analysis. For compounds C1 and C2, the BOILED-Egg pharmacokinetic model predicted intestinal absorption, blood-brain barrier (BBB) penetration, and p-glycoprotein interaction. According to the physicochemical analysis, C1 has exceptional drug-like characteristics suitable for oral absorption. Despite only being substrates for some of the major CYP 450 isoforms, compounds C1 and C2 were anticipated to have strong plasma protein binding and efficient distribution and block these isoforms. The DFT study using the B3LYP/6-311G(d,p) approach with implicit water effects was performed to assess the structural features, electronic properties, and global reactivity parameters (GRP) of C1 and C2. The DFT results provided further support for other studies, implying that C2 is more water-soluble than C1 and that both compounds can form hydrogen bonds and (weak) dispersion interactions with other molecules, such as solvents and biomolecules. Furthermore, the GRP study suggested that C1 should be more stable and less reactive than C2. A concentration-dependent 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity was shown by both C1 and C2. In brief, this finding has provided a strong foundation to explore further the therapeutic potential of these molecules against a variety of human disorders.
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2024.1360719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Changes in the structural, physicochemical and functional properties and

    Xiao, Xiang / Li, Xiaodong / Bai, Juan / Fan, Songtao / Daglia, Maria / Li, Jiaying / Ding, Yiwei / Zhang, Yanshun / Zhao, Yansheng

    Food & function

    2024  Volume 15, Issue 8, Page(s) 4276–4291

    Abstract: Fermentation is an effective method for improving the nutritional quality and functional characteristics of grains. This study investigated changes in the structural, physicochemical, and functional properties of fermented barley dietary fiber (FBDF) ... ...

    Abstract Fermentation is an effective method for improving the nutritional quality and functional characteristics of grains. This study investigated changes in the structural, physicochemical, and functional properties of fermented barley dietary fiber (FBDF) exerted by
    MeSH term(s) Dietary Fiber/metabolism ; Dietary Fiber/analysis ; Hordeum/chemistry ; Fermentation ; Feces/microbiology ; Humans ; Gastrointestinal Microbiome ; Digestion ; Antioxidants/metabolism ; Fatty Acids, Volatile/metabolism ; Lactobacillus plantarum/metabolism ; Phenols/metabolism
    Chemical Substances Dietary Fiber ; Antioxidants ; Fatty Acids, Volatile ; Phenols
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo05605h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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