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  1. Article ; Online: Incidence and impact of hypoattenuated leaflet thickening following aortic valve replacement using a glycerol-preserved bioprosthesis.

    Poitier, Bastien / Dahdah, Pierre / Bernardini, Margaux / Coroyer, Lucas / Nouar, Mohamed / Akar, Ramzi Abi / Bel, Alain / Smadja, David M / Du Puy-Montbrun, Leonora / Achouh, Paul

    JTCVS open

    2024  Volume 18, Page(s) 9–11

    Language English
    Publishing date 2024-01-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluating the heart valve tissue diffusion of amoxicillin in infective endocarditis: a pilot prospective observational non-comparative study.

    Dubert, Marie / Kably, Benjamin / Derobertmasure, Audrey / Podglajen, Isabelle / Munte, Laura / Clauss, Darless / Blez, Damien / Dahdah, Pierre / Billaud, Eliane / Lebeaux, David / Mainardi, Jean-Luc

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 12, Page(s) 2915–2918

    Abstract: Objectives: Treating patients with infective endocarditis (IE) due to streptococci and enterococci currently involves high-dosage antibiotics. Recent literature suggests a 30%-70% diffusion rate could be extrapolated to human heart valve tissue. The ... ...

    Abstract Objectives: Treating patients with infective endocarditis (IE) due to streptococci and enterococci currently involves high-dosage antibiotics. Recent literature suggests a 30%-70% diffusion rate could be extrapolated to human heart valve tissue. The objective of this study was to evaluate the diffusion coefficient of amoxicillin in heart valve tissue of patients operated for IE.
    Methods: Adult patients were prospectively included that underwent surgery at the European Hospital Georges Pompidou for IE due to streptococci and enterococci and had previous IV amoxicillin treatment. Plasma (taken 48 h preoperatively) and heart valve tissue amoxicillin concentrations were measured with a validated LC-MS/MS method. The MIC values of amoxicillin were measured for all available isolates.
    Results: Seventeen patients were included. Eleven (64.7%) patients had native valve IE and six (35.3%) had prosthetic valve IE. Fourteen IE cases (82.4%) were due to streptococci, one (5.9%) was due to enterococci and two (11.8%) were Haemophilus spp, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella kingae group infections. Median (IQR) amoxicillin dose administered was 10.5 (8.0-12.0) g/day corresponding to 138.2 (112.5-160.0) mg/kg/day. The median amoxicillin plasma concentrations pre-surgery and intra-tissular weighted concentrations were 31.9 (25.9-51.9) mg/L and 19.0 (7.9-31.4) µg/g, respectively. Median tissue/plasma concentration ratio was 0.47 (0.24-0.67), with a median amoxicillin plasma/MIC ratio of 487 (179-745), and median amoxicillin tissue/MIC ratio of 42 (14-116).
    Conclusions: With a significant diffusion coefficient, amoxicillin dosage in heart valve tissues showed a concentration/MIC ratio well above current recommendations for bactericidal activity. Our study suggests that lower doses can be considered for susceptible bacteria.
    MeSH term(s) Adult ; Humans ; Amoxicillin/therapeutic use ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Endocarditis ; Streptococcus ; Enterococcus ; Heart Valves/surgery
    Chemical Substances Amoxicillin (804826J2HU)
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1197: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  3. Article ; Online: Chronic anastomotic pseudoaneurysm on a polytetrafluoroethylene axillobifemoral bypass graft.

    Jebara, Victor / Aoun, Tanous / Dahdah, Pierre / Fikani, Amine

    Journal of vascular surgery

    2016  Volume 64, Issue 5, Page(s) 1484

    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2016.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1933: Show issues Location:
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  4. Article ; Online: Lycanthropy as a culture-bound syndrome: a case report and review of the literature.

    Bou Khalil, Rami / Dahdah, Pierre / Richa, Sami / Kahn, David A

    Journal of psychiatric practice

    2012  Volume 18, Issue 1, Page(s) 51–54

    Abstract: Lycanthropy is an unusual belief or delusion that one has been transformed into an animal, or behaviors or feelings suggestive of such a belief. We report a case of lycanthropic delusions of becoming a snake in a 47-year-old woman who suffered from a ... ...

    Abstract Lycanthropy is an unusual belief or delusion that one has been transformed into an animal, or behaviors or feelings suggestive of such a belief. We report a case of lycanthropic delusions of becoming a snake in a 47-year-old woman who suffered from a major depressive disorder with psychotic features. We also present a literature review of articles published on the subject in English or French since 1975 identified via a MedLine search using the terms "lycanthropy" or "werewolf." Many case reports have described lycanthropy as a delusional disorder occurring acutely in patients who think they suffer from a demonic possession as a punishment for their acts. In these cases, symptoms are generally rapidly reversible. Lycanthropy seems to be a nonspecific manifestation of many psychiatric diseases, most commonly major depressive disorder with psychotic features. It is largely influenced by the cultural environment of the patient so that the animal species frequently represents the patient's delusional representation of evil. Lycanthropy could be considered a culture-bound syndrome that occurs in association with Axis I, DSM-IV psychiatric pathology.
    MeSH term(s) Antidepressive Agents/administration & dosage ; Antidepressive Agents/adverse effects ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Aripiprazole ; Behavior Control/methods ; Citalopram/administration & dosage ; Citalopram/adverse effects ; Cultural Characteristics ; Culture ; Delusions/ethnology ; Delusions/etiology ; Delusions/psychology ; Depressive Disorder, Major/complications ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/ethnology ; Depressive Disorder, Major/psychology ; Diagnostic and Statistical Manual of Mental Disorders ; Ethnopsychology/methods ; Female ; Humans ; Lebanon/ethnology ; Middle Aged ; Mythology/psychology ; Piperazines/administration & dosage ; Piperazines/adverse effects ; Psychotic Disorders/complications ; Psychotic Disorders/diagnosis ; Psychotic Disorders/ethnology ; Psychotic Disorders/psychology ; Quinolones/administration & dosage ; Quinolones/adverse effects ; Treatment Outcome
    Chemical Substances Antidepressive Agents ; Antipsychotic Agents ; Piperazines ; Quinolones ; Citalopram (0DHU5B8D6V) ; Aripiprazole (82VFR53I78)
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2022726-7
    ISSN 1538-1145 ; 1527-4160
    ISSN (online) 1538-1145
    ISSN 1527-4160
    DOI 10.1097/01.pra.0000410988.38723.a3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4753: Show issues Location:
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