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Article ; Online: Type A interrupted aortic arch.

Dai, H-L / Zhou, X / Guang, X-F

QJM : monthly journal of the Association of Physicians

2023 Volume 116, Issue 5, Page(s) 379–380

MeSH term(s)	Humans ; Aorta, Thoracic/diagnostic imaging ; Aortic Coarctation
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcac281
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Article ; Online: Turner syndrome.

Dai, H-L / Zhou, X / Guang, X-F

QJM : monthly journal of the Association of Physicians

2022 Volume 116, Issue 2, Page(s) 136–137

MeSH term(s)	Humans ; Turner Syndrome
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcac224
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Article ; Online: TAZ accelerates osteogenesis differentiation of mesenchymal stem cells via targeting PI3K/Akt.

Tan, F-Z / Dai, H-L

European review for medical and pharmacological sciences

2019 Volume 23, Issue 3 Suppl, Page(s) 81–88

Abstract: Objective: To investigate the promoting effects of TAZ on the osteogenic differentiation of mesenchymal stem cells in a rat model of osteoporosis through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signal.: Materials and methods: ... ...

Abstract	Objective: To investigate the promoting effects of TAZ on the osteogenic differentiation of mesenchymal stem cells in a rat model of osteoporosis through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signal. Materials and methods: A total of 12 Sprague-Dawley (SD) rats were randomly divided into normal group (n=6) and model group (n=6). The rats in normal group were not given any treatment, while those in model group were used to establish a model of osteoporosis, and the bone mineral density (BMD) of the femur and lumbar in each group was detected. Then, the bone marrow mesenchymal stem cells were observed, of which those in normal group were divided into normal group and inhibitor group. The bone marrow mesenchymal stem cells in model group were enrolled as model group. Alkaline phosphatase (ALP) staining was adopted to observe the osteogenesis, cell counting kit-8 (CCK-8) was applied to determine the cell proliferation, and immunohistochemistry was performed to measure the expression of TAZ. Western blotting was utilized to detect the relative expressions of phosphorylated Akt (p-Akt) and bone morphogenetic protein 2 (BMP-2) proteins, and quantitative Polymerase Chain Reaction (qPCR) was used to measure the messenger ribonucleic acid (mRNA) expression of TAZ. Results: The average optical density of ALP-positive cells was decreased remarkably in model group and inhibitor group compared with that in normal group (p<0.05), while the cell proliferation rate was increased notably in model group and inhibitor group. In comparison with normal group, model group and inhibitor group had evidently declined positive expression and mRNA expression of TAZ (p<0.05). The relative expressions of p-Akt and BMP-2 proteins in model group and inhibitor group were significantly lower than those in normal group (p<0.05). Conclusions: TAZ promotes the osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis by repressing the PI3K/Akt signal.
MeSH term(s)	Animals ; Bone Density ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Disease Models, Animal ; Female ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Osteogenesis ; Osteoporosis/genetics ; Osteoporosis/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Random Allocation ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Intracellular Signaling Peptides and Proteins ; WWTR1 protein, rat ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-08-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201908_18633
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Zs.A 1887: Show issues

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Article: Predictive value of ABCD3 score combined with vascular stenosis in the progression of TIA to cerebral infarction.

Wang, L / Dai, H L / Tang, X / Yang, Y J / Sun, K Y / Yu, L

Journal of biological regulators and homeostatic agents

2022 Volume 35, Issue 1, Page(s) 289–293

MeSH term(s)	Cerebral Infarction/diagnostic imaging ; Constriction, Pathologic ; Humans ; Ischemic Attack, Transient/diagnosis ; Predictive Value of Tests ; Risk Factors ; Stroke
Language	English
Publishing date	2022-08-03
Publishing country	Italy
Document type	Letter
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
DOI	10.23812/20-659-L
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Zs.A 2270: Show issues

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Article: [Clinical characteristics of patients with acute pulmonary embolism in high altitude area of Yunnan province in China].

Lu, X T / Li, Y / Wang, Z P / Guang, X F / Feng, X L / Zhang, W H / Dai, H L

Zhonghua xin xue guan bing za zhi

2022 Volume 50, Issue 1, Page(s) 36–42

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adolescent ; Altitude ; Biomarkers ; China/epidemiology ; Cross-Sectional Studies ; Humans ; Male ; Natriuretic Peptide, Brain ; Peptide Fragments ; Prognosis ; Pulmonary Embolism/epidemiology ; Retrospective Studies
Chemical Substances	Biomarkers ; Peptide Fragments ; Natriuretic Peptide, Brain (114471-18-0)
Language	Chinese
Publishing date	2022-01-19
Publishing country	China
Document type	Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20211203-01045
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Zs.B 2276: Show issues

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Article ; Online: MicroRNA-198 inhibits metastasis of thyroid cancer by targeting H3F3A.

Fang, J / Zhu, J-M / Dai, H-L / He, L-M / Kong, L

European review for medical and pharmacological sciences

2020 Volume 24, Issue 23, Page(s) 12232–12240

Abstract: Objective: This study was designed to investigate the role of microRNA-198 in thyroid cancer (TCa) progression.: Patients and methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to examine microRNA-198 and H3F3A levels ...

Abstract	Objective: This study was designed to investigate the role of microRNA-198 in thyroid cancer (TCa) progression. Patients and methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to examine microRNA-198 and H3F3A levels in tumor tissue specimens and paracancerous ones collected from 50 patients with TCa, and the interplay between microRNA-198 or H3F3A and some clinical indicators or prognosis of TCa patients was analyzed as well. MicroRNA-198 and H3F3A overexpression models were constructed using lentivirus in TCa cell lines TPC-1 and BHP2-7, and the impacts of microRNA-198 on TCa cell functions were evaluated by using cell counting kit-8 (CCK-8), plate clone formation, and transwell assays. Finally, recovery investigations were conducted to explore the underlying mechanisms as well as the interaction between microRNA-198 and H3F3A. Results: QRT-PCR indicated that in tumor tissues of TCa patients, microRNA-198 showed a remarkably lower expression than in adjacent normal tissue samples. Compared with patients with high expression of microRNA-198, those with microRNA-198 low expression had more advanced tumor stage, larger tumor size, higher lymph node metastasis rate, and lower overall survival rate. Meanwhile, the results of research on H3F3A were just opposite to the above observations on microRNA-198. In in vitro cell experiments, overexpression of microRNA-198 significantly weakened the proliferation and migration ability of thyroid tumor cells. Besides, Luciferase reporter gene experiment revealed that H3F3A was a specific target gene for microRNA-198. Moreover, qRT-PCR indicated that H3F3A and microRNA-198 were negatively correlated in thyroid carcinoma tissues. In addition, compared with NC group, overexpression of H3F3A markedly enhanced the migration and proliferative capacity of TCa cells. Lastly, recovery experiment revealed a mutual regulation between microRNA-198 and H3F3A, the two of which may together participate in the malignant progression of TCa. Conclusions: MicroRNA-198 is remarkably reduced in TCa and inhibits malignant progression of TCa by regulating H3F3A. Meanwhile, microRNA-198 is remarkably associated with pathological stage, tumor size, lymph node metastasis, and poor prognosis of TCa.
MeSH term(s)	Adult ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Female ; Histones/genetics ; Histones/metabolism ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology
Chemical Substances	H3-3A protein, human ; Histones ; MIRN198 microRNA, human ; MicroRNAs
Language	English
Publishing date	2020-12-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202012_24015
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Zs.A 1887: Show issues

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Article: [Classification, diagnosis and treatment status of pulmonary hypertension from 2012 to 2019: a single center study in Yunnan province].

Feng, X L / Lu, Y B / Yang, D / Xue, Q / Zhang, J L / Lin, C R / Gan, P / Zhang, W H / Guang, X F / Dai, H L

Zhonghua xin xue guan bing za zhi

2023 Volume 51, Issue 11, Page(s) 1188–1193

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Child ; Aged ; Adolescent ; Middle Aged ; Humans ; Female ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Retrospective Studies ; China/epidemiology ; Familial Primary Pulmonary Hypertension ; Pulmonary Arterial Hypertension/complications ; Heart Defects, Congenital
Language	Chinese
Publishing date	2023-11-14
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20230919-00173
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Article: Theoretical modeling, wind tunnel measurements, and realistic environment testing of galloping-based electromagnetic energy harvesters

Zhang, L.B / Dai, H.L / Abdelkefi, A / Lin, S.X / Wang, L

Applied energy. 2019 Aug. 11,

2019

Abstract: Extracting energy from environmental airflows and converting it into usable electricity can be a potential approach to realize the self-powering operation of sensors by virtue of energy harvesting technology, which has received great interest in recent ... ...

Abstract	Extracting energy from environmental airflows and converting it into usable electricity can be a potential approach to realize the self-powering operation of sensors by virtue of energy harvesting technology, which has received great interest in recent years. Yet the environmental adaptability and the level of output power are two of important aspects to restrict wide applications of energy harvesters and hence still required to be improved. For this purpose, a novel and efficient electromagnetic energy harvester for airflow power generation is designed, and a theoretical model is constructed and experimentally verified to characterize the design and output performance of the energy harvester. To this end, a bluff body with the cross-section of Y-shape subjected to airflows is considered. Then, the aeroelastic response of bluff body occurs and brings the coil to cut magnetic induction lines. The experimental results show that an average power of 2.5mW is measured at wind speed of 4m/s, which is dominant compared to existing aeroelastic energy harvesters. Furthermore, charging and discharging experiments demonstrate 30 seconds of airflow in wind tunnel under speed of 3.5m/s can drive the sensor of 1.1V working voltage to operate for about one minute. In addition, it is significant that the harvester’s environmental adaptability is revealed under condition of the air-conditioner vent. The present research offers a suggestive guidance on developing an efficient electromagnetic energy harvester for airflow power generation, at the same time it further promotes the realization of self-powering of structural health monitoring sensors applying in buildings and bridges.
Keywords	air conditioning ; air flow ; buildings ; electric potential difference ; electricity ; magnetism ; monitoring ; power generation ; theoretical models ; wind power ; wind speed ; wind tunnels
Language	English
Dates of publication	2019-0811
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	2000772-3
ISSN	0306-2619
ISSN	0306-2619
DOI	10.1016/j.apenergy.2019.113737
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway.

Wang, J / Lu, M L / Dai, H L / Zhang, S P / Wang, H X / Wei, N

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2015 Volume 48, Issue 3, Page(s) 245–253

Abstract: This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium) colorimetric assay. In ... ...

Abstract	This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium) colorimetric assay. In vivo antitumor activity of esculetin was evaluated in a hepatocellular carcinoma mouse model. Seventy-five C57BL/6J mice were implanted with Hepa1-6 cells and randomized into five groups (n=15 each) given daily intraperitoneal injections of vehicle (physiological saline), esculetin (200, 400, or 700 mg·kg-1·day-1), or 5-Fu (200 mg·kg-1·day-1) for 15 days. Esculetin significantly decreased tumor growth in mice bearing Hepa1-6 cells. Tumor weight was decreased by 20.33, 40.37, and 55.42% with increasing doses of esculetin. Esculetin significantly inhibited proliferation of HCC cells in a concentration- and time-dependent manner and with an IC50 value of 2.24 mM. It blocked the cell cycle at S phase and induced apoptosis in SMMC-7721 cells with significant elevation of caspase-3 and caspase-9 activity, but did not affect caspase-8 activity. Moreover, esculetin treatment resulted in the collapse of mitochondrial membrane potential in vitro and in vivo accompanied by increased Bax expression and decreased Bcl-2 expression at both transcriptional and translational levels. Thus, esculetin exerted in vitro and in vivo antiproliferative activity in hepatocellular carcinoma, and its mechanisms involved initiation of a mitochondrial-mediated, caspase-dependent apoptosis pathway.
MeSH term(s)	Animals ; Antioxidants/therapeutic use ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/drug therapy ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Liver Neoplasms/drug therapy ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental ; Random Allocation ; Umbelliferones/therapeutic use
Chemical Substances	Antioxidants ; Umbelliferones ; esculetin (SM2XD6V944)
Language	English
Publishing date	2015-03
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X20144074
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Article: Cotton dust and endotoxin exposure and long-term decline in lung function: Results of a longitudinal study

Dai, H. L.

American J. Industrial Medicine

1999 Volume 35, Issue 4, Page(s) 321–331

Abstract: Background: To evaluate the relationship between long-term exposure to cotton dust and Gram-negative bacterial endotoxin on lung function, the authors conducted an 11-year follow-up study of cotton textile workers in Shanghai, China. Methods: Workers at ... ...

Institution	665 Huntington Avenue, USA-Boston, MA 02115 Harvard School of Public Health, Building I, Room 1405
Abstract	Background: To evaluate the relationship between long-term exposure to cotton dust and Gram-negative bacterial endotoxin on lung function, the authors conducted an 11-year follow-up study of cotton textile workers in Shanghai, China. Methods: Workers at a nearby silk-thread manufacturing mill were used as a referent population. Ninety percent of the original cohort of 445 cotton and 467 silk textile workers - both active and retired - were identified for testing in the 11th year. Questionnaires and spirometric testing were performed, as well as cotton dust and endotoxin sampling at three points over the 11-year follow-up period: at baseline, at Year 5, and at Year 11. After excluding deaths and subjects on sick-leave, 84% of the original cohort had complete health and environmental data. Results: The data were reanalyzed using generalized estimating equations feedback model which allow for subject transfer over time between work areas, various exposure levels to dust and endotoxin, and FEV1. Cotton workers had a larger loss of FEV1 during the first 5 years of study (-40mls/yr) as compared with the second 6 years of follow-up (-18mls/yr). During the same periods, the average decline among silk workers was slightly higher in the first period, but was more consistent (-30mls/yr vs. -27mls/yr), and these differences could not be explained by worker selection or dropout. When cumulative exposure to dust and endotoxin were estimaterd and used in a multivariate model (GEE) for FEV1 loss, cumulative dust, but not endotoxin, was associated with 11-year loss in FEV1 after adjustments for confounders. There was evidence of feedback between dust-exposure levels and FEV1, indicating the existence of a healthy-worker survivor effect. After accounting for a healthy-worker survivor effect, the authors found a significant relationship between dust exposure and FEV1 decline. Conclusions: These results suggest that cotton dust is more strongly associated with chronic airflow limitation than associated endotoxins. Further work is needed to clarify potential reversibility after cessation of exposure, and the relative contributions of dust, endotoxin, and tobacco to chronic respiratory impairment in cotton and other vegetable-exposed workers.
Keywords	Baumwolle ; Staub ; Biotoxin ; Lungenfunktionspruefung ; Textilindustrie ; Zeit ; Sekundenkapazitaet ; Veraenderung ; Lungenkrankheit ; China ; Laengsschnittstudie
Language	English
Document type	Article
ZDB-ID	604538-8
ISSN	1097-0274 ; 0271-3586
ISSN (online)	1097-0274
ISSN	0271-3586
Database	Social Medicine (SOMED)

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