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  1. Article: Computer-aided drug design for virtual-screening and active-predicting of main protease (M

    Dai, Renhui / Gao, Hongwei / Su, Ruiling

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1288363

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1288363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Computer-aided drug design for the pain-like protease (PL

    Gao, Hongwei / Dai, Renhui / Su, Ruiling

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 159, Page(s) 114247

    Abstract: A new coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a highly contagious virus and has caused a massive worldwide health crisis. While large-scale vaccination efforts are underway, the management of population ... ...

    Abstract A new coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a highly contagious virus and has caused a massive worldwide health crisis. While large-scale vaccination efforts are underway, the management of population health, economic impact and asof-yet unknown long-term effects on physical and mental health will be a key challenge for the next decade. The papain-like protease (PL
    MeSH term(s) Humans ; SARS-CoV-2/metabolism ; COVID-19 ; Molecular Docking Simulation ; Peptide Hydrolases ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; Viral Nonstructural Proteins ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Design ; Endopeptidases
    Chemical Substances Peptide Hydrolases (EC 3.4.-) ; Protease Inhibitors ; Viral Nonstructural Proteins ; Antiviral Agents ; Endopeptidases (EC 3.4.-)
    Language English
    Publishing date 2023-01-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Anti-Alzheimer's disease potential of traditional chinese medicinal herbs as inhibitors of BACE1 and AChE enzymes.

    Dai, Renhui / Sun, Yingni / Su, Ruiling / Gao, Hongwei

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 154, Page(s) 113576

    Abstract: Alzheimer's disease (AD) is a common neurodegenerative disease that often occurs in the elderly population. At present, most drugs for AD on the market are single-target drugs, which have achieved certain success in the treatment of AD. However, the ... ...

    Abstract Alzheimer's disease (AD) is a common neurodegenerative disease that often occurs in the elderly population. At present, most drugs for AD on the market are single-target drugs, which have achieved certain success in the treatment of AD. However, the efficacy and safety of single-target drugs have not achieved the expected results because AD is a multifactorial disease. Multi-targeted drugs act on multiple factors of the disease network to improve efficacy and reduce adverse reactions. Therefore, the search for effective dual-target or even multi-target drugs has become a new research trend. Many of results found that the dual-target inhibitors of the beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and acetylcholinesterase (AChE) found from traditional Chinese medicine have a good inhibitory effect on AD with fewer side effects. This article reviews sixty-six compounds extracted from Chinese medicinal herbs, which have inhibitory activity on BACE1 and AChE. This provides a theoretical basis for the further development of these compounds as dual-target inhibitors for the treatment of AD.
    MeSH term(s) Acetylcholinesterase/metabolism ; Aged ; Alzheimer Disease/drug therapy ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Aspartic Acid Endopeptidases/metabolism ; China ; Cholinesterase Inhibitors/metabolism ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Humans ; Neurodegenerative Diseases/drug therapy ; Plants, Medicinal/metabolism
    Chemical Substances Amyloid beta-Peptides ; Cholinesterase Inhibitors ; Acetylcholinesterase (EC 3.1.1.7) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; BACE1 protein, human (EC 3.4.23.46)
    Language English
    Publishing date 2022-08-22
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.113576
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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