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  1. Article ; Online: Genomic Characterization and Molecular Evolution of Sapovirus in Children under 5 Years of Age.

    Ji, Xiaolei / Guo, Chen / Dai, Yaoyao / Chen, Lu / Chen, Yujia / Wang, Shifang / Sun, Yihua

    Viruses

    2024  Volume 16, Issue 1

    Abstract: Sapovirus (SaV) is a type of gastroenteric virus that can cause acute gastroenteritis. It is highly contagious, particularly among children under the age of 5. In this study, a total of 712 stool samples from children under the age of 5 with acute ... ...

    Abstract Sapovirus (SaV) is a type of gastroenteric virus that can cause acute gastroenteritis. It is highly contagious, particularly among children under the age of 5. In this study, a total of 712 stool samples from children under the age of 5 with acute gastroenteritis were collected. Out of these samples, 28 tested positive for SaV, resulting in a detection rate of 3.93% (28/712). Samples with Ct < 30 were collected for library construction and high-throughput sequencing, resulting in the acquisition of nine complete genomes. According to Blast, eight of them were identified as GI.1, while the remaining one was GI.6. The GI.6 strain sequence reported in our study represents the first submission of the GI.6 strain complete genome sequence from mainland China to the Genbank database, thus filling the data gap in our country. Sequence identity analysis revealed significant nucleotide variations between the two genotypes of SaV and their corresponding prototype strains. Phylogenetic and genetic evolution analyses showed no evidence of recombination events in the obtained sequences. Population dynamics analysis demonstrated potential competitive inhibition between two lineages of GI.1. Our study provides insights into the molecular epidemiological and genetic evolution characteristics of SaV prevalent in the Nantong region of China, laying the foundation for disease prevention and control, as well as pathogen tracing related to SaV in this area.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Sapovirus/genetics ; Phylogeny ; Gastroenteritis/epidemiology ; Genotype ; Genomics ; Caliciviridae Infections/epidemiology ; Feces
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16010146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The current application and research progress of vitamin D in improving the efficacy of tuberculosis treatment.

    Dai, Yaoyao / Wei, Ye / Fu, Jian / Han, Yingying / Yang, Juan / Mao, Jiamin / Lu, Rongrong

    Minerva surgery

    2024  

    Language English
    Publishing date 2024-01-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.10201-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 25: Show issues Location:
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  3. Article ; Online: Identifying the outbreak signal of COVID-19 before the response of the traditional disease monitoring system.

    Dai, Yaoyao / Wang, Jianming

    PLoS neglected tropical diseases

    2020  Volume 14, Issue 10, Page(s) e0008758

    Abstract: Synopsis: Early identification of the emergence of an outbreak of a novel infectious disease is critical to generating a timely response. The traditional monitoring system is adequate for detecting the outbreak of common diseases; however, it is ... ...

    Abstract Synopsis: Early identification of the emergence of an outbreak of a novel infectious disease is critical to generating a timely response. The traditional monitoring system is adequate for detecting the outbreak of common diseases; however, it is insufficient for the discovery of novel infectious diseases. In this study, we used COVID-19 as an example to compare the delay time of different tools for identifying disease outbreaks. The results showed that both the abnormal spike in influenza-like illnesses and the peak of online searches of key terms could provide early signals. We emphasize the importance of testing these findings and discussing the broader potential to use syndromic surveillance, internet searches, and social media data together with traditional disease surveillance systems for early detection and understanding of novel emerging infectious diseases.
    MeSH term(s) COVID-19 ; China/epidemiology ; Communicable Diseases/epidemiology ; Coronavirus Infections/epidemiology ; Disease Notification/methods ; Humans ; Influenza, Human/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Sentinel Surveillance ; Social Media
    Keywords covid19
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0008758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota

    Ji, Chenyang / Luo, Yunkai / Yang, Jiawen / Dai, Yaoyao / Miao, Jiahui / Yue, Siqing / Zhao, Meirong

    Journal of environmental sciences (China). 2023 May, v. 127

    2023  

    Abstract: Polyhalogenated carbazoles (PHCZs) have been widely accepted as emerging pollutants, whereas their ecological and health risks remain uncertain. Herein, female and male Sprague-Dawley (SD) mice were treated with four typical PHCZs to investigate their ... ...

    Abstract Polyhalogenated carbazoles (PHCZs) have been widely accepted as emerging pollutants, whereas their ecological and health risks remain uncertain. Herein, female and male Sprague-Dawley (SD) mice were treated with four typical PHCZs to investigate their negative consequences, along with alternations in gut microbiota to indicate underlying mechanisms. In female mice, the relative liver weight ratio increased after four PHCZs exposure; 2-bromocarbazole (2-BCZ) increased urine glucose level; 3-bromocarbazole (3-BCZ) decreased the glucose and total cholesterol levels; 3,6-dichlorocarbazole (3,6-DCCZ) decreased glucose level. The only disturbed biochemical index in male mice was the promoted alkaline phosphatase (ALP) level by 3,6-DCCZ. We also found that the differential blood biochemical indices were correlated with gut microbiota. 3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice, which were correlated with metabolic disorders. Our findings demonstrated the correlation between PHCZs induced potential hepatotoxicity and metabolic disorders may be due to their dioxin-like potentials and endocrine disrupting activities, and the gender differences might result from their estrogenic activities. Overall, data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms.
    Keywords Bacteroidetes ; Proteobacteria ; alkaline phosphatase ; blood ; carbazoles ; cholesterol ; females ; glucose ; hepatotoxicity ; intestinal microorganisms ; liver ; males ; urine ; China
    Language English
    Dates of publication 2023-05
    Size p. 603-614.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1092300-7
    ISSN 1878-7320 ; 1001-0742
    ISSN (online) 1878-7320
    ISSN 1001-0742
    DOI 10.1016/j.jes.2022.06.028
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7630: Show issues

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  5. Article ; Online: Comparing the enantioselective toxicity on cell cycle and apoptosis of DL-glufosinate and L-glufosinate to SH-SY5Y cells.

    Zhu, Yingying / Xu, Yongan / Dai, Yaoyao / Zhang, Guizhen / Ji, Chenyang / Zhang, Quan / Zhao, Meirong

    The Science of the total environment

    2023  Volume 895, Page(s) 165106

    Abstract: Glufosinate (Glu), a broad-spectrum and highly effective non-selective herbicide, behaves in typical chiral features to target organisms. However, the information on the enantioselective toxicity of DL-Glu and L-Glu against non-target organisms is still ... ...

    Abstract Glufosinate (Glu), a broad-spectrum and highly effective non-selective herbicide, behaves in typical chiral features to target organisms. However, the information on the enantioselective toxicity of DL-Glu and L-Glu against non-target organisms is still limited especially at environmental concentrations. In this study, we investigated the potential mechanism accounting for the enantioselective cytotoxicity of Glu based on cell cycle and apoptosis. Results showed that DL-Glu and L-Glu had no suppression on cell viability at 10
    MeSH term(s) Humans ; Stereoisomerism ; Neuroblastoma ; Apoptosis ; Cell Cycle ; Pesticides ; Cell Line, Tumor
    Chemical Substances phosphinothricin (51276-47-2) ; Pesticides
    Language English
    Publishing date 2023-06-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.165106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  6. Article ; Online: Estimating conflict losses and reporting biases.

    Radford, Benjamin J / Dai, Yaoyao / Stoehr, Niklas / Schein, Aaron / Fernandez, Mya / Sajid, Hanif

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 34, Page(s) e2307372120

    Abstract: Determining the number of casualties and fatalities suffered in militarized conflicts is important for conflict measurement, forecasting, and accountability. However, given the nature of conflict, reliable statistics on casualties are rare. Countries or ... ...

    Abstract Determining the number of casualties and fatalities suffered in militarized conflicts is important for conflict measurement, forecasting, and accountability. However, given the nature of conflict, reliable statistics on casualties are rare. Countries or political actors involved in conflicts have incentives to hide or manipulate these numbers, while third parties might not have access to reliable information. For example, in the ongoing militarized conflict between Russia and Ukraine, estimates of the magnitude of losses vary wildly, sometimes across orders of magnitude. In this paper, we offer an approach for measuring casualties and fatalities given multiple reporting sources and, at the same time, accounting for the biases of those sources. We construct a dataset of 4,609 reports of military and civilian losses by both sides. We then develop a statistical model to better estimate losses for both sides given these reports. Our model accounts for different kinds of reporting biases, structural correlations between loss types, and integrates loss reports at different temporal scales. Our daily and cumulative estimates provide evidence that Russia has lost more personnel than has Ukraine and also likely suffers from a higher fatality to casualty ratio. We find that both sides likely overestimate the personnel losses suffered by their opponent and that Russian sources underestimate their own losses of personnel.
    MeSH term(s) Humans ; Warfare ; Military Personnel ; Bias ; Russia ; Ukraine
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2307372120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Identifying the outbreak signal of COVID-19 before the response of the traditional disease monitoring system

    Dai, Yaoyao / Wang, Jianming

    PLOS Neglected Tropical Diseases

    2020  Volume 14, Issue 10, Page(s) e0008758

    Keywords Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
    Language English
    Publisher Public Library of Science (PLoS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0008758
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Identifying the outbreak signal of COVID-19 before the response of the traditional disease monitoring system

    Dai, Yaoyao / Wang, Jianming

    PLoS Negl Trop Dis

    Abstract: SYNOPSIS: Early identification of the emergence of an outbreak of a novel infectious disease is critical to generating a timely response. The traditional monitoring system is adequate for detecting the outbreak of common diseases; however, it is ... ...

    Abstract SYNOPSIS: Early identification of the emergence of an outbreak of a novel infectious disease is critical to generating a timely response. The traditional monitoring system is adequate for detecting the outbreak of common diseases; however, it is insufficient for the discovery of novel infectious diseases. In this study, we used COVID-19 as an example to compare the delay time of different tools for identifying disease outbreaks. The results showed that both the abnormal spike in influenza-like illnesses and the peak of online searches of key terms could provide early signals. We emphasize the importance of testing these findings and discussing the broader potential to use syndromic surveillance, internet searches, and social media data together with traditional disease surveillance systems for early detection and understanding of novel emerging infectious diseases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #810263
    Database COVID19

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  9. Article ; Online: Identification of COVID-19 Outbreak Signals Prior to the Traditional Disease Surveillance System

    Dai, Yaoyao / Wang, Jianming

    SSRN Electronic Journal ; ISSN 1556-5068

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3578808
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Environmental exposure to organophosphate esters and suspected non-alcoholic fatty liver disease among US adults: A mixture analysis.

    Chai, Haisheng / Hu, Weiye / Dai, Yaoyao / Zhu, Xiaohan / Qian, Ping'an / Zhu, Junfeng

    Frontiers in public health

    2022  Volume 10, Page(s) 995649

    Abstract: Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. We evaluated NAFLD using the US FLI to determine whether there is an association between urinary organophosphorus (OPE) levels and the "prevalence" ...

    Abstract Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. We evaluated NAFLD using the US FLI to determine whether there is an association between urinary organophosphorus (OPE) levels and the "prevalence" of NAFLD in US individuals.
    Methods: The current study included 1,102 people aged 20 years and older with information from the 2011-2014 U.S. National Health and Nutrition Examination Survey. NAFLD was assessed using the U.S. FLI. Individual OPE metabolites and OPE combinations were linked to NAFLD using logistic regression and weighted quantile sum (WQS) regression. All analyzes were carried out separately on males and females. The possible impacts of age, serum total testosterone (TT), and menopausal state, as well as the importance of the interaction term with exposure, were investigated using stratified analysis.
    Results: Bis (2-chloroethyl) phosphate and bis (1,3-dichloro-2-propyl) phosphate were associated with NAFLD in all males after adjusting for covariates (
    Conclusions: In this study, environmental exposure to OPE was linked to an elevated risk of NAFLD in males, particularly those over 60 years old or with low TT levels. Aside from the continuous positive connection of a combination of OPEs with NAFLD risk in post-menopausal women, these correlations were weaker in women. However, these findings should be taken with caution and verified in future investigations by collecting numerous urine samples in advance to strengthen OPE exposure estimates.
    MeSH term(s) Adult ; Male ; Female ; Humans ; Middle Aged ; Flame Retardants/analysis ; Flame Retardants/metabolism ; Non-alcoholic Fatty Liver Disease/epidemiology ; Nutrition Surveys ; Plasticizers/analysis ; Plasticizers/metabolism ; Esters/urine ; Organophosphates/metabolism ; Environmental Exposure/adverse effects ; Phosphates/analysis ; Testosterone/analysis
    Chemical Substances Flame Retardants ; Plasticizers ; Esters ; Organophosphates ; Phosphates ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.995649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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