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  1. Article ; Online: [Treatment of perianal fistulas with mesenchymal stem cells].

    Dalby, Helene Rask / Perregaard, Helene / Dige, Anders / Hagen, Kikke Bartholin / Nordholm-Carstensen, Andreas / Lundby, Lilli

    Ugeskrift for laeger

    2022  Volume 184, Issue 14

    Abstract: Treatment of perianal fistulas are challenged by insufficient healing and a high rate of relapse. Existing sphincter-sparing procedures have healing rates of around 50%. Treatment with mesenchymal stem cells of both autologous and allogenic origin and ... ...

    Abstract Treatment of perianal fistulas are challenged by insufficient healing and a high rate of relapse. Existing sphincter-sparing procedures have healing rates of around 50%. Treatment with mesenchymal stem cells of both autologous and allogenic origin and freshly collected autologous adipose tissue show both promising healing rates and few complications and may be offered to patients with complicated fistulas not suited for other treatment modalities.
    MeSH term(s) Anal Canal ; Cutaneous Fistula ; Humans ; Mesenchymal Stem Cell Transplantation/adverse effects ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells ; Organ Sparing Treatments/adverse effects ; Rectal Fistula/etiology ; Rectal Fistula/surgery ; Treatment Outcome
    Language Danish
    Publishing date 2022-04-12
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [Cryptoglandular anal fistulas].

    Perregaard, Helene / Dalby, Helene Rask / Hagen, Kikke Bartholin / Dige, Anders / Lundby, Lilli / Nordholm-Carstensen, Andreas

    Ugeskrift for laeger

    2021  Volume 183, Issue 36

    Abstract: Cryptoglandular anal fistulas (AF) cause recurrent anal abscesses and patients risk multiple surgeries due to low healing rates of sphincter-saving procedures. Knowledge of anal anatomy and imaging with MRI or endoanal sonography is crucial to classify ... ...

    Abstract Cryptoglandular anal fistulas (AF) cause recurrent anal abscesses and patients risk multiple surgeries due to low healing rates of sphincter-saving procedures. Knowledge of anal anatomy and imaging with MRI or endoanal sonography is crucial to classify AF as simple or complex depending on risk of anal incontinence after fistulotomy as summarised in this review. Fistulotomy has healing rates of > 90%, risks incontinence, and the procedure is reserved for simple fistulas. Complex AF are treated with a draining seton and then with sphincter-saving procedures which have long-term healing rates of about 50%.
    MeSH term(s) Anal Canal/diagnostic imaging ; Anal Canal/surgery ; Fecal Incontinence/etiology ; Humans ; Magnetic Resonance Imaging ; Rectal Fistula/diagnostic imaging ; Rectal Fistula/surgery ; Treatment Outcome
    Language Danish
    Publishing date 2021-09-09
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

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