Article ; Online: Reducing rates of
Antimicrobial resistance and infection control
2018 Volume 7, Page(s) 40
Abstract: Background: Clostridium difficile: Methods: Our hospital made a decision to switch from the use of toxin immunoassay to a stand-alone nucleic acid test. This change was accompanied by the provision of clear sampling guidance and rejection criteria ... ...
Abstract | Background: Clostridium difficile Methods: Our hospital made a decision to switch from the use of toxin immunoassay to a stand-alone nucleic acid test. This change was accompanied by the provision of clear sampling guidance and rejection criteria and this study aimed to assess the impact of that change. We analysed sample numbers, numbers of positive results, and the proportion of cases assessed as healthcare acquired over a 6-year period during which the testing method was changed from a toxin A/B immunoassay to a stand-alone commercial nucleic acid test after the first two years. Results: Sample numbers and numbers of cases assessed as healthcare acquired fell following the introduction of the nucleic acid test and sampling guidance, while infection rates in other hospitals in the same region remained relatively stable. Conclusions: It is our opinion that the use of a highly sensitive assay together with clear sampling guidance offers the optimal approach to patient management and best use of isolation facilities. |
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MeSH term(s) | Bacterial Toxins/genetics ; Bacterial Toxins/isolation & purification ; Clostridium Infections/diagnosis ; Clostridium Infections/prevention & control ; Clostridium difficile/genetics ; Clostridium difficile/pathogenicity ; Hospitals ; Humans ; Immunoassay ; Nucleic Acid Amplification Techniques/methods ; Specimen Handling/methods ; Specimen Handling/standards |
Chemical Substances | Bacterial Toxins |
Language | English |
Publishing date | 2018-03-12 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2666706-X |
ISSN | 2047-2994 ; 2047-2994 |
ISSN (online) | 2047-2994 |
ISSN | 2047-2994 |
DOI | 10.1186/s13756-018-0332-2 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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